{"id":"https://openalex.org/W1998424376","doi":"https://doi.org/10.1016/j.bmc.2010.05.023","title":"Synthesis and antiplasmodial activity of lycorine derivatives","display_name":"Synthesis and antiplasmodial activity of lycorine derivatives","publication_year":2010,"publication_date":"2010-05-12","ids":{"openalex":"https://openalex.org/W1998424376","doi":"https://doi.org/10.1016/j.bmc.2010.05.023","mag":"1998424376","pmid":"https://pubmed.ncbi.nlm.nih.gov/20627737"},"language":"en","primary_location":{"id":"doi:10.1016/j.bmc.2010.05.023","doi":"https://doi.org/10.1016/j.bmc.2010.05.023","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmc.2010.05.023","pdf_url":null,"source":{"id":"https://openalex.org/S10422866","display_name":"Bioorganic & Medicinal Chemistry","issn_l":"0968-0896","issn":["0968-0896","1464-3391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1998424376"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055749258","display_name":"Juan Carlos Cedr\u00f3n","orcid":"https://orcid.org/0000-0002-5889-3417","observed_orcids":["https://orcid.org/0000-0002-5889-3417"]},"institutions":[{"id":"https://openalex.org/I4210098709","display_name":"Canary Institute of Cancer Research","ror":"https://ror.org/00xmdg797","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210098709"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan C. Cedr\u00f3n","raw_affiliation_strings":["Instituto Universitario de Bio-Org\u00e1nica 'Antonio Gonz\u00e1lez', Av. Astrof\u00edsico Francisco S\u00e1nchez 2, 38206 La Laguna-Tenerife, Spain","Instituto Canario de Investigaci\u00f3n del C\u00e1ncer (ICIC), http://www.icic.es"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Universitario de Bio-Org\u00e1nica 'Antonio Gonz\u00e1lez', Av. Astrof\u00edsico Francisco S\u00e1nchez 2, 38206 La Laguna-Tenerife, Spain","institution_ids":[]},{"raw_affiliation_string":"Instituto Canario de Investigaci\u00f3n del C\u00e1ncer (ICIC), http://www.icic.es","institution_ids":["https://openalex.org/I4210098709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043341518","display_name":"David Guti\u00e9rrez","orcid":"https://orcid.org/0000-0001-7636-6963","observed_orcids":["https://orcid.org/0000-0001-7636-6963"]},"institutions":[{"id":"https://openalex.org/I122147150","display_name":"Universidad Mayor de San Andr\u00e9s","ror":"https://ror.org/00k4v9x79","country_code":"BO","type":"education","lineage":["https://openalex.org/I122147150"]}],"countries":["BO"],"is_corresponding":false,"raw_author_name":"David Guti\u00e9rrez","raw_affiliation_strings":["Instituto de Investigaciones F\u00e1rmaco Bioqu\u00edmicas, Facultad de Ciencias Farmac\u00e9uticas y Bioqu\u00edmicas, Universidad Mayor de San Andr\u00e9s, Av.Saavedra 2024, 2\u00b0 piso, Miraflores\u2014La Paz, Bolivia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones F\u00e1rmaco Bioqu\u00edmicas, Facultad de Ciencias Farmac\u00e9uticas y Bioqu\u00edmicas, Universidad Mayor de San Andr\u00e9s, Av.Saavedra 2024, 2\u00b0 piso, Miraflores\u2014La Paz, Bolivia","institution_ids":["https://openalex.org/I122147150"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112785386","display_name":"Ninoska Flores","orcid":"https://orcid.org/0000-0002-6718-1702","observed_orcids":["https://orcid.org/0000-0002-6718-1702"]},"institutions":[{"id":"https://openalex.org/I122147150","display_name":"Universidad Mayor de San Andr\u00e9s","ror":"https://ror.org/00k4v9x79","country_code":"BO","type":"education","lineage":["https://openalex.org/I122147150"]}],"countries":["BO"],"is_corresponding":false,"raw_author_name":"Ninoska Flores","raw_affiliation_strings":["Instituto de Investigaciones F\u00e1rmaco Bioqu\u00edmicas, Facultad de Ciencias Farmac\u00e9uticas y Bioqu\u00edmicas, Universidad Mayor de San Andr\u00e9s, Av.Saavedra 2024, 2\u00b0 piso, Miraflores\u2014La Paz, Bolivia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investigaciones F\u00e1rmaco Bioqu\u00edmicas, Facultad de Ciencias Farmac\u00e9uticas y Bioqu\u00edmicas, Universidad Mayor de San Andr\u00e9s, Av.Saavedra 2024, 2\u00b0 piso, Miraflores\u2014La Paz, Bolivia","institution_ids":["https://openalex.org/I122147150"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110104920","display_name":"\u00c1ngel G. Ravelo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098709","display_name":"Canary Institute of Cancer Research","ror":"https://ror.org/00xmdg797","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210098709"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"\u00c1ngel G. Ravelo","raw_affiliation_strings":["Instituto Canario de Investigaci\u00f3n del C\u00e1ncer (ICIC), http://www.icic.es","Instituto Universitario de Bio-Org\u00e1nica \u2018Antonio Gonz\u00e1lez\u2019, Av. Astrof\u00edsico Francisco S\u00e1nchez 2, 38206 La Laguna\u2014Tenerife, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Canario de Investigaci\u00f3n del C\u00e1ncer (ICIC), http://www.icic.es","institution_ids":["https://openalex.org/I4210098709"]},{"raw_affiliation_string":"Instituto Universitario de Bio-Org\u00e1nica \u2018Antonio Gonz\u00e1lez\u2019, Av. Astrof\u00edsico Francisco S\u00e1nchez 2, 38206 La Laguna\u2014Tenerife, Spain","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048039956","display_name":"Ana Est\u00e9vez\u2010Braun","orcid":"https://orcid.org/0000-0001-5279-7099","observed_orcids":["https://orcid.org/0000-0001-5279-7099"]},"institutions":[{"id":"https://openalex.org/I4210098709","display_name":"Canary Institute of Cancer Research","ror":"https://ror.org/00xmdg797","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210098709"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Ana Est\u00e9vez-Braun","raw_affiliation_strings":["Instituto Canario de Investigaci\u00f3n del C\u00e1ncer (ICIC), http://www.icic.es","Instituto Universitario de Bio-Org\u00e1nica \u2018Antonio Gonz\u00e1lez\u2019, Av. Astrof\u00edsico Francisco S\u00e1nchez 2, 38206 La Laguna\u2014Tenerife, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto Canario de Investigaci\u00f3n del C\u00e1ncer (ICIC), http://www.icic.es","institution_ids":["https://openalex.org/I4210098709"]},{"raw_affiliation_string":"Instituto Universitario de Bio-Org\u00e1nica \u2018Antonio Gonz\u00e1lez\u2019, Av. Astrof\u00edsico Francisco S\u00e1nchez 2, 38206 La Laguna\u2014Tenerife, Spain","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5048039956","https://openalex.org/A5110104920"],"corresponding_institution_ids":["https://openalex.org/I4210098709"],"apc_list":{"value":3960,"currency":"USD","value_usd":3960},"apc_paid":null,"fwci":1.9224,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.83794627,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"18","issue":"13","first_page":"4694","last_page":"4701"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13124","display_name":"Chemical synthesis and alkaloids","score":0.8389000296592712,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13124","display_name":"Chemical synthesis and alkaloids","score":0.8389000296592712,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13188","display_name":"Synthesis and bioactivity of alkaloids","score":0.0908999964594841,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12685","display_name":"Phytochemical compounds biological activities","score":0.019899999722838402,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiplasmodial-activity","display_name":"antiplasmodial activity","score":0.9390000104904175},{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.9729999899864197},{"id":"https://openalex.org/keywords/antimalarial-drugs","display_name":"antimalarial drugs","score":0.8410000205039978},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6840000152587891},{"id":"https://openalex.org/keywords/hydroxyl-substituents","display_name":"hydroxyl substituents","score":0.7120000123977661},{"id":"https://openalex.org/keywords/ester-substituents","display_name":"ester substituents","score":0.8009999990463257},{"id":"https://openalex.org/keywords/methylenedioxy-group","display_name":"methylenedioxy group","score":0.8040000200271606},{"id":"https://openalex.org/keywords/chloroquine-sensitive-strain","display_name":"chloroquine-sensitive strain","score":0.8199999928474426}],"concepts":[{"id":"https://openalex.org/C2781465977","wikidata":"https://www.wikidata.org/wiki/Q420314","display_name":"Lycorine","level":3,"score":0.9791692495346069},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9551981091499329},{"id":"https://openalex.org/C2780760878","wikidata":"https://www.wikidata.org/wiki/Q6823980","display_name":"Methylenedioxy","level":4,"score":0.791912317276001},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.7500095367431641},{"id":"https://openalex.org/C2778689049","wikidata":"https://www.wikidata.org/wiki/Q898422","display_name":"Substituent","level":2,"score":0.7429698705673218},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5703343749046326},{"id":"https://openalex.org/C2993420144","wikidata":"https://www.wikidata.org/wiki/Q627","display_name":"Nitrogen atom","level":3,"score":0.4992644786834717},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.4426247477531433},{"id":"https://openalex.org/C2777482282","wikidata":"https://www.wikidata.org/wiki/Q342721","display_name":"Acridone","level":2,"score":0.44210952520370483},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4215320646762848},{"id":"https://openalex.org/C2777667214","wikidata":"https://www.wikidata.org/wiki/Q70702","display_name":"Alkaloid","level":2,"score":0.4125428795814514},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.41134917736053467},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.24865496158599854},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11448583006858826},{"id":"https://openalex.org/C2781311116","wikidata":"https://www.wikidata.org/wiki/Q83306","display_name":"Group (periodic table)","level":2,"score":0.09909215569496155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.0},{"id":"https://openalex.org/C46062151","wikidata":"https://www.wikidata.org/wiki/Q19605","display_name":"Halogen","level":3,"score":0.0},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010617","descriptor_name":"Phenanthridines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D010617","descriptor_name":"Phenanthridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010617","descriptor_name":"Phenanthridines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010963","descriptor_name":"Plasmodium falciparum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047151","descriptor_name":"Amaryllidaceae Alkaloids","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D047151","descriptor_name":"Amaryllidaceae Alkaloids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D047151","descriptor_name":"Amaryllidaceae Alkaloids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bmc.2010.05.023","doi":"https://doi.org/10.1016/j.bmc.2010.05.023","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bmc.2010.05.023","pdf_url":null,"source":{"id":"https://openalex.org/S10422866","display_name":"Bioorganic & Medicinal Chemistry","issn_l":"0968-0896","issn":["0968-0896","1464-3391"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:20627737","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20627737","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1456021098","https://openalex.org/W1502939770","https://openalex.org/W1595835254","https://openalex.org/W1604446207","https://openalex.org/W1709109739","https://openalex.org/W1812003545","https://openalex.org/W1969503178","https://openalex.org/W1970812803","https://openalex.org/W1992056352","https://openalex.org/W1993063104","https://openalex.org/W2007407635","https://openalex.org/W2012671411","https://openalex.org/W2013711762","https://openalex.org/W2024697958","https://openalex.org/W2026368124","https://openalex.org/W2026792976","https://openalex.org/W2043678759","https://openalex.org/W2049122105","https://openalex.org/W2050194346","https://openalex.org/W2050499412","https://openalex.org/W2053190690","https://openalex.org/W2086091540","https://openalex.org/W2088288204","https://openalex.org/W2089346820","https://openalex.org/W2135192999","https://openalex.org/W2156465764","https://openalex.org/W2164862526","https://openalex.org/W2170017134","https://openalex.org/W2606815294"],"related_works":["https://openalex.org/W2031675782","https://openalex.org/W2174444163","https://openalex.org/W2016922803","https://openalex.org/W2176603199","https://openalex.org/W2011419101","https://openalex.org/W2050771534","https://openalex.org/W2014289062","https://openalex.org/W2144330394","https://openalex.org/W3019423445"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}