{"id":"https://openalex.org/W1998416434","doi":"https://doi.org/10.1111/j.1365-2125.2004.02133.x","title":"Acute and clinically relevant drug\u2010induced liver injury: a population based case\u2010control study","display_name":"Acute and clinically relevant drug\u2010induced liver injury: a population based case\u2010control study","publication_year":2004,"publication_date":"2004-06-04","ids":{"openalex":"https://openalex.org/W1998416434","doi":"https://doi.org/10.1111/j.1365-2125.2004.02133.x","mag":"1998416434","pmid":"https://pubmed.ncbi.nlm.nih.gov/15206996","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1884531"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2125.2004.02133.x","doi":"https://doi.org/10.1111/j.1365-2125.2004.02133.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.2004.02133.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.2004.02133.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.2004.02133.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086869616","display_name":"Francisco Jos\u00e9 de Abajo","orcid":"https://orcid.org/0000-0001-9119-8646","observed_orcids":["https://orcid.org/0000-0001-9119-8646"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Francisco J. De Abajo","raw_affiliation_strings":["Division of Pharmacoepidemiology and Pharmacovigilance, Spanish Medicines Agency, Madrid, Spain. fabajo@agemed.es","Division of Pharmacoepidemiology and Pharmacovigilance, Spanish Medicines Agency, Madrid and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacoepidemiology and Pharmacovigilance, Spanish Medicines Agency, Madrid, Spain. fabajo@agemed.es","institution_ids":[]},{"raw_affiliation_string":"Division of Pharmacoepidemiology and Pharmacovigilance, Spanish Medicines Agency, Madrid and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113904087","display_name":"Dolores Montero","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dolores Montero","raw_affiliation_strings":["Division of Pharmacoepidemiology and Pharmacovigilance, Spanish Medicines Agency, Madrid and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacoepidemiology and Pharmacovigilance, Spanish Medicines Agency, Madrid and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003506739","display_name":"Mariano Madurga","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mariano Madurga","raw_affiliation_strings":["Division of Pharmacoepidemiology and Pharmacovigilance, Spanish Medicines Agency, Madrid and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pharmacoepidemiology and Pharmacovigilance, Spanish Medicines Agency, Madrid and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002455373","display_name":"Luis Alberto Garc\u00eda Rodr\u00edguez","orcid":"https://orcid.org/0000-0003-0837-2709","observed_orcids":["https://orcid.org/0000-0003-0837-2709"]},"institutions":[{"id":"https://openalex.org/I4210117725","display_name":"Centro Espa\u00f1ol de Investigaci\u00f3n Farmacoepidemiol\u00f3gica","ror":"https://ror.org/02wxe0t87","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210117725"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Luis A. Garc\u00eda Rodr\u00edguez","raw_affiliation_strings":["Spanish Center for Pharmacoepidemiological Research, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Spanish Center for Pharmacoepidemiological Research, Madrid, Spain","institution_ids":["https://openalex.org/I4210117725"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5086869616"],"corresponding_institution_ids":[],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":4.245,"has_fulltext":true,"cited_by_count":422,"citation_normalized_percentile":{"value":0.94546477,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"58","issue":"1","first_page":"71","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-induced-liver-injury","display_name":"drug-induced liver injury","score":0.9980000257492065},{"id":"https://openalex.org/keywords/incidence","display_name":"incidence","score":0.4950000047683716},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.6930000185966492},{"id":"https://openalex.org/keywords/chlorpromazine","display_name":"chlorpromazine","score":0.8489999771118164},{"id":"https://openalex.org/keywords/amoxicillin-clavulanic-acid","display_name":"amoxicillin-clavulanic acid","score":0.9350000023841858},{"id":"https://openalex.org/keywords/flucloxacillin","display_name":"flucloxacillin","score":0.9089999794960022},{"id":"https://openalex.org/keywords/macrolides","display_name":"macrolides","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tetracycline","display_name":"tetracycline","score":0.9860000014305115},{"id":"https://openalex.org/keywords/metoclopramide","display_name":"metoclopramide","score":0.972000002861023},{"id":"https://openalex.org/keywords/chlorpheniramine","display_name":"chlorpheniramine","score":0.949999988079071},{"id":"https://openalex.org/keywords/sulfasalazine","display_name":"sulfasalazine","score":0.9369999766349792},{"id":"https://openalex.org/keywords/azathioprine","display_name":"azathioprine","score":0.9959999918937683},{"id":"https://openalex.org/keywords/diclofenac","display_name":"diclofenac","score":0.9980000257492065},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.4390000104904175},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8963718414306641},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6641724109649658},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5402493476867676},{"id":"https://openalex.org/C2778355172","wikidata":"https://www.wikidata.org/wiki/Q1994556","display_name":"Flucloxacillin","level":4,"score":0.5092836618423462},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.5063499212265015},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5025370121002197},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.4997546672821045},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.44338929653167725},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4220576882362366},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.07848179340362549},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1365-2125.2004.02133.x","doi":"https://doi.org/10.1111/j.1365-2125.2004.02133.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.2004.02133.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.2004.02133.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmid:15206996","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15206996","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of clinical pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1884531","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1884531/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Clin Pharmacol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/j.1365-2125.2004.02133.x","doi":"https://doi.org/10.1111/j.1365-2125.2004.02133.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1365-2125.2004.02133.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1365-2125.2004.02133.x","source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1998416434.pdf","grobid_xml":"https://content.openalex.org/works/W1998416434.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W38847137","https://openalex.org/W207624539","https://openalex.org/W1581232918","https://openalex.org/W1585256489","https://openalex.org/W1691887444","https://openalex.org/W1744955600","https://openalex.org/W1780956271","https://openalex.org/W1991307468","https://openalex.org/W1993657268","https://openalex.org/W1997435071","https://openalex.org/W2004278464","https://openalex.org/W2015544462","https://openalex.org/W2020468791","https://openalex.org/W2031101802","https://openalex.org/W2043371806","https://openalex.org/W2068853053","https://openalex.org/W2111411689","https://openalex.org/W2124012426","https://openalex.org/W2163089452","https://openalex.org/W2475231540","https://openalex.org/W2479703818","https://openalex.org/W2487800018","https://openalex.org/W2504450412","https://openalex.org/W2507088042","https://openalex.org/W2986697985","https://openalex.org/W3135023763","https://openalex.org/W4252379216","https://openalex.org/W4253520552"],"related_works":["https://openalex.org/W1585256489","https://openalex.org/W1995546772","https://openalex.org/W1574311429","https://openalex.org/W4402813002","https://openalex.org/W4408386954","https://openalex.org/W2320830449","https://openalex.org/W1923117400","https://openalex.org/W4312081130","https://openalex.org/W4375856479","https://openalex.org/W2026969166"],"abstract_inverted_index":{"AIMS:":[0],"To":[1],"provide":[2],"quantitative":[3],"information":[4],"about":[5],"the":[6,27,34,50,83,110,127,138,153,272,306,311,320,334],"absolute":[7],"and":[8,13,79,130,144,246,261,289,299],"relative":[9,324],"risks":[10,325],"of":[11,36,40,65,103,112,126,157,265,277,308,326,340],"acute":[12,298],"clinically":[14,300],"relevant":[15,301],"drug-induced":[16],"liver":[17,302],"injury.":[18],"METHODS:":[19],"We":[20],"performed":[21],"a":[22,63,97,120,275,316,343],"population-based":[23],"case-control":[24],"study":[25,113],"using":[26],"UK-based":[28],"General":[29],"Practice":[30],"Research":[31],"Database":[32],"as":[33,149,310],"source":[35],"information.":[37],"A":[38,101,253],"total":[39,64,102],"1,636,792":[41],"persons":[42],"subjects":[43],"aged":[44],"5-75":[45],"years":[46],"old":[47],"registered":[48],"in":[49,319],"database":[51],"from":[52,109],"1":[53,292],"January,":[54],"1994":[55],"to":[56,91,94],"31":[57],"December,":[58],"1999":[59],"were":[60,69,99,106,117,147,171,284],"followed-up":[61],"for":[62,257,286,338],"5,404,705":[66],"person-years.":[67,167],"Cases":[68],"identified":[70],"by":[71,274],"an":[72],"exhaustive":[73],"computer":[74],"search,":[75],"then":[76],"reviewed":[77],"manually":[78],"finally":[80],"validated":[81],"against":[82],"clinical":[84],"records.":[85],"Only":[86],"idiopathic":[87],"cases":[88],"serious":[89],"enough":[90],"be":[92],"referred":[93],"hospital":[95],"or":[96,267],"consultant":[98],"selected.":[100],"5000":[104],"controls":[105],"randomly":[107],"sampled":[108],"person-time":[111],"cohort.":[114],"Current":[115],"users":[116],"defined":[118],"if":[119,132],"prescription":[121,136],"ended":[122],"within":[123],"15":[124,339],"days":[125],"index":[128,139],"date,":[129],"nonusers":[131],"there":[133],"was":[134,255,346],"no":[135],"before":[137],"date.":[140],"RESULTS:":[141],"One":[142],"hundred":[143],"twenty-eight":[145],"patients":[146],"considered":[148],"valid":[150],"cases,":[151],"being":[152],"crude":[154,281,335],"incidence":[155,282,336],"rate":[156],"2.4":[158],"(95%":[159],"confidence":[160],"interval:":[161],"2.0,":[162],"2.8)":[163],"per":[164,293],"100":[165],"000":[166],"The":[168,263,279,323],"strongest":[169],"associations":[170],"found":[172,285],"with":[173,333],"chlorpromazine":[174],"(adjusted":[175],"odds":[176],"ratio":[177],"(AOR);":[178],"95%":[179],"CI":[180],"=":[181,188,194,200,206,212,218,224,230,236,242,249],"416;":[182],"45,":[183],"3840),":[184],"amoxicillin/clavulanic":[185,259],"acid":[186,260],"(AOR":[187,193,199,205,211,217,223,229,235,241,248],"94.8;":[189],"27.8,":[190],"323),":[191],"flucloxacillin":[192],"17.7;":[195],"4.4,":[196],"71.0),":[197],"macrolides":[198],"6.9;":[201],"2.3,":[202],"21.0),":[203],"tetracyclines":[204],"6.2;":[207,213],"2.4,":[208],"15.8);":[209],"metoclopramide":[210],"1.8,":[214],"21.3);":[215],"chlorpheniramine":[216],"9.6;":[219],"1.9,":[220,244,251],"49.7);":[221],"betahistine":[222],"15.3;":[225],"2.9,":[226],"80.7);":[227],"sulphasalazine":[228],"25.5;":[231],"6.0,":[232],"109);":[233],"azathioprine":[234],"10.5;":[237],"1.4,":[238],"76.4),":[239],"diclofenac":[240],"4.1;":[243],"8.8)":[245],"antiepileptics":[247],"5.1;":[250],"13.7).":[252],"dose-effect":[254],"apparent":[256],"diclofenac,":[258],"flucloxacillin.":[262],"combination":[264],"two":[266],"more":[268],"hepatotoxic":[269],"drugs":[270,309],"increased":[271],"risk":[273],"factor":[276],"6.":[278],"highest":[280],"rates":[283,337],"chlorpromazine,":[287],"azathioprine,":[288],"sulfasalazine":[290],"(about":[291],"1000":[294],"users).":[295],"CONCLUSIONS:":[296],"Idiopathic,":[297],"injury,":[303],"which":[304],"has":[305],"use":[307],"most":[312],"probable":[313],"aetiology,":[314],"is":[315],"rare":[317],"event":[318],"general":[321],"population.":[322],"40":[327],"drugs/therapeutic":[328],"classes":[329],"are":[330],"provided,":[331],"along":[332],"them":[341],"where":[342],"statistical":[344],"association":[345],"found.":[347]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":20},{"year":2024,"cited_by_count":18},{"year":2023,"cited_by_count":23},{"year":2022,"cited_by_count":26},{"year":2021,"cited_by_count":28},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":20},{"year":2018,"cited_by_count":18},{"year":2017,"cited_by_count":24},{"year":2016,"cited_by_count":26},{"year":2015,"cited_by_count":23},{"year":2014,"cited_by_count":18},{"year":2013,"cited_by_count":37},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}