{"id":"https://openalex.org/W1998412457","doi":"https://doi.org/10.1210/jc.87.8.3667","title":"A Prospective Controlled Study of the Impact of Hyperthyroidism on Reproductive Function in Males","display_name":"A Prospective Controlled Study of the Impact of Hyperthyroidism on Reproductive Function in Males","publication_year":2002,"publication_date":"2002-08-01","ids":{"openalex":"https://openalex.org/W1998412457","doi":"https://doi.org/10.1210/jc.87.8.3667","mag":"1998412457","pmid":"https://pubmed.ncbi.nlm.nih.gov/12161493"},"language":"en","primary_location":{"id":"doi:10.1210/jc.87.8.3667","doi":"https://doi.org/10.1210/jc.87.8.3667","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.87.8.3667","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113544136","display_name":"G. E. Krassas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"G. E. Krassas","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Panagia General Hospital, Thessaloniki 55132;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Panagia General Hospital, Thessaloniki 55132;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017259115","display_name":"Nikolaos Pontikides","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. Pontikides","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Panagia General Hospital, Thessaloniki 55132;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Panagia General Hospital, Thessaloniki 55132;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076062742","display_name":"V. Deligianni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"V. Deligianni","raw_affiliation_strings":["Department of Biochemistry, Medical School, University of Athens (V.D., K.M.), Athens 11527, Greece","Department of Endocrinology and Metabolism, Panagia General Hospital, Thessaloniki 55132;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Medical School, University of Athens (V.D., K.M.), Athens 11527, Greece","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Panagia General Hospital, Thessaloniki 55132;","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045844479","display_name":"Konstantinos Miras","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"K. Miras","raw_affiliation_strings":["Department of Biochemistry, Medical School, University of Athens (V.D., K.M.), Athens 11527, Greece","Department of Endocrinology and Metabolism, Panagia General Hospital, Thessaloniki 55132;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Medical School, University of Athens (V.D., K.M.), Athens 11527, Greece","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Panagia General Hospital, Thessaloniki 55132;","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113544136"],"corresponding_institution_ids":[],"apc_list":{"value":3750,"currency":"USD","value_usd":3750},"apc_paid":null,"fwci":1.3397,"has_fulltext":true,"cited_by_count":91,"citation_normalized_percentile":{"value":0.76775408,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"87","issue":"8","first_page":"3667","last_page":"3671"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.7002000212669373,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.7002000212669373,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.2896000146865845,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hyperthyroidism","display_name":"hyperthyroidism","score":0.9879999756813049},{"id":"https://openalex.org/keywords/male-reproductive-function","display_name":"male reproductive function","score":0.8309999704360962},{"id":"https://openalex.org/keywords/sperm-quality","display_name":"semen quality","score":0.8880000114440918},{"id":"https://openalex.org/keywords/semen-analysis","display_name":"semen analysis","score":0.6700000166893005},{"id":"https://openalex.org/keywords/sperm-motility","display_name":"sperm motility","score":0.9020000100135803},{"id":"https://openalex.org/keywords/sperm-concentration","display_name":"sperm concentration","score":0.9049999713897705},{"id":"https://openalex.org/keywords/sperm-morphology","display_name":"sperm morphology","score":0.9589999914169312},{"id":"https://openalex.org/keywords/seminal-plasma-zinc","display_name":"seminal plasma zinc","score":0.8610000014305115},{"id":"https://openalex.org/keywords/methimazole","display_name":"methimazole","score":0.8180000185966492},{"id":"https://openalex.org/keywords/radioactive-iodine-therapy","display_name":"radioiodine therapy","score":0.8190000057220459},{"id":"https://openalex.org/keywords/euthyroidism","display_name":"euthyroidism","score":0.8949999809265137},{"id":"https://openalex.org/keywords/male-infertility","display_name":"male infertility","score":0.5299999713897705},{"id":"https://openalex.org/keywords/semen-volume","display_name":"semen volume","score":0.5009999871253967},{"id":"https://openalex.org/keywords/sperm-count","display_name":"sperm count","score":0.30399999022483826},{"id":"https://openalex.org/keywords/semen-coagulation","display_name":"semen coagulation","score":0.37299999594688416},{"id":"https://openalex.org/keywords/semen-liquefaction-time","display_name":"semen liquefaction time","score":0.4790000021457672}],"concepts":[{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.44242924451828003},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.42516466975212097},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41378524899482727},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.3951825201511383},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3844608962535858},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3575826585292816},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.262462854385376},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.13233330845832825},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.12676560878753662}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005632","descriptor_name":"Fructose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006980","descriptor_name":"Hyperthyroidism","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009845","descriptor_name":"Oligospermia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012661","descriptor_name":"Semen","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012735","descriptor_name":"Sexual Dysfunction, Physiological","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D013076","descriptor_name":"Sperm Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013737","descriptor_name":"Testis","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D013963","descriptor_name":"Thyroid Hormones","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015032","descriptor_name":"Zinc","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1210/jc.87.8.3667","doi":"https://doi.org/10.1210/jc.87.8.3667","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jc.87.8.3667","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"doi:10.1210/jcem.87.8.8714","doi":"https://doi.org/10.1210/jcem.87.8.8714","is_oa":false,"landing_page_url":"https://doi.org/10.1210/jcem.87.8.8714","pdf_url":null,"source":{"id":"https://openalex.org/S205775358","display_name":"The Journal of Clinical Endocrinology & Metabolism","issn_l":"0021-972X","issn":["0021-972X","1945-7197"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Endocrinology &amp; Metabolism","raw_type":"journal-article"},{"id":"pmid:12161493","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12161493","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical endocrinology and metabolism","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W152264252","https://openalex.org/W988037393","https://openalex.org/W1498767139","https://openalex.org/W1916891739","https://openalex.org/W1926045465","https://openalex.org/W1974739004","https://openalex.org/W1978311016","https://openalex.org/W1979895754","https://openalex.org/W2001931740","https://openalex.org/W2002226785","https://openalex.org/W2024880921","https://openalex.org/W2026180048","https://openalex.org/W2029743336","https://openalex.org/W2045767288","https://openalex.org/W2058148258","https://openalex.org/W2064951168","https://openalex.org/W2080046379","https://openalex.org/W2080071004","https://openalex.org/W2097377882","https://openalex.org/W2098674312","https://openalex.org/W2100138743","https://openalex.org/W2130722157","https://openalex.org/W2133157527","https://openalex.org/W2144108372","https://openalex.org/W2327407478","https://openalex.org/W2395567362","https://openalex.org/W2407183638","https://openalex.org/W2411949996","https://openalex.org/W2413058670","https://openalex.org/W2418411824"],"related_works":["https://openalex.org/W1978593773","https://openalex.org/W7214864613","https://openalex.org/W988037393","https://openalex.org/W2801705007","https://openalex.org/W2058148258","https://openalex.org/W2009904518","https://openalex.org/W7216974947","https://openalex.org/W1967523599","https://openalex.org/W2020188052","https://openalex.org/W1926057921"],"abstract_inverted_index":{"The":[0,167],"aim":[1],"of":[2,12,38,52,271,359,387,392],"this":[3],"prospective":[4],"controlled":[5],"study":[6,361],"was":[7,64,109,117,140,169,187,390],"to":[8,321],"ascertain":[9],"the":[10,40,104,145,322,357,382,393,397],"effect":[11],"hyperthyroidism":[13,367],"on":[14],"sperm":[15,138,172,207,237,347,374,388,414],"quality":[16],"and":[17,33,58,82,128,209,224,257,264,279,291,298,305,316,340,408],"composition.":[18],"We":[19],"studied":[20],"23":[21],"thyrotoxic":[22,190],"male":[23,36,364],"patients,":[24,93,143],"aged":[25],"43.8":[26],"+/-":[27,31,44,125,131,156,160,175,179,196,200,213,217,226,230,243,247,274,277,281,286,289,293,300,303,307],"2.4":[28],"yr":[29],"(mean":[30],"SEM),":[32],"15":[34],"healthy":[35],"controls":[37,129,149,194,263],"approximately":[39],"same":[41,168],"age":[42],"(42.2":[43],"2.2":[45],"yr).":[46],"Two":[47],"semen":[48,97,107,115],"analyses":[49],"at":[50],"intervals":[51],"2-3":[53],"wk":[54],"were":[55,85,329],"obtained":[56],"before":[57,267,331],"about":[59],"5":[60],"months":[61],"after":[62,269,311,333],"euthyroidism":[63,272],"achieved":[65],"either":[66,266],"by":[67],"methimazole":[68,75],"alone":[69],"(14":[70],"patients)":[71],"or":[72,268,332,349,379,417],"(131)I":[73],"plus":[74],"(9":[76],"patients).":[77],"Total":[78],"fructose,":[79,255,314,338,406],"zinc":[80],"(Zn),":[81],"magnesium":[83],"(Mg)":[84],"also":[86],"measured":[87],"in":[88,91,122,142,189,193,370],"seminal":[89,336,371,401],"plasma":[90,337,402],"16":[92],"because":[94],"7":[95],"had":[96],"volume":[98,116],"less":[99],"than":[100,192],"2":[101],"ml.":[102],"In":[103,355],"control":[105],"group":[106],"analysis":[108],"performed":[110],"only":[111],"once.":[112],"Mean":[113,137,252],"(+/-SEM)":[114],"within":[118],"normal":[119],"range":[120],"both":[121],"patients":[123,265,365,383],"(3.3":[124],"0.2":[126],"ml)":[127],"(3.5":[130],"0.4":[132],"ml;":[133],"P":[134,164,181,202,249],"=":[135,165,182,222,250],"NS).":[136,183,251],"density":[139,208],"lower":[141,188],"although":[144],"difference":[146],"compared":[147],"with":[148,171,346,350,366,413],"did":[150,239,259,343,410],"not":[151,240,260,344,411],"reach":[152],"statistical":[153],"significance":[154],"(35.7":[155],"5.3":[157,214],"vs.":[158,177,198,215,228,245,284],"51.5":[159],"6.1":[161],"x":[162,219],"10(6)/ml;":[163],"0.062).":[166],"found":[170,330],"morphology":[173,238],"(68":[174,242],"7%":[176,231,244],"78":[178],"8%;":[180],"Finally,":[184,335],"mean":[185],"motility":[186,210],"males":[191],"(28":[195],"8%":[197,227],"57":[199],"7%;":[201],"<":[203,233],"0.01).":[204],"After":[205],"treatment,":[206],"improved":[211],"[35.7":[212],"43.3":[216],"6.5":[218],"10(6)/ml":[220],"(P":[221,232],"NS)":[223],"28":[225],"45":[229],"0.05),":[234],"respectively],":[235],"but":[236],"change":[241],"70":[246],"6%;":[248],"values":[253],"for":[254,313,396],"Zn,":[256,315,339,407],"Mg":[258,341],"differ":[261],"between":[262],"achievement":[270],"[9.2":[273],"0.7,":[275,301],"3.0":[276,288],"0.5,":[278,290],"4.2":[280],"0.7":[282],"nmol/liter":[283,295,309],"8.6":[285],"0.9,":[287],"4.7":[292],"0.8":[294],"(patients":[296,310],"before)":[297],"9.1":[299],"3.1":[302],"0.6,":[304],"4.5":[306],"0.9":[308],"treatment)":[312],"Mg,":[317,409],"respectively].":[318],"Moreover,":[319,400],"according":[320],"treatment":[323,394],"given,":[324],"no":[325],"statistically":[326],"significant":[327],"differences":[328],"treatment.":[334],"levels":[342],"correlate":[345,412],"parameters":[348,389],"pretreatment":[351],"thyroid":[352],"hormone":[353],"levels.":[354],"conclusion,":[356],"results":[358],"our":[360],"indicate":[362],"that":[363],"have":[368],"abnormalities":[369,377],"parameters,":[372],"mainly":[373],"motility.":[375],"These":[376],"improve":[378],"normalize":[380],"when":[381],"become":[384],"euthyroid.":[385],"Restoration":[386],"independent":[391],"provided":[395],"hyperthyroid":[398],"syndrome.":[399],"elements,":[403],"such":[404],"as":[405],"density,":[415],"motility,":[416],"morphology.":[418]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
