{"id":"https://openalex.org/W1998406444","doi":"https://doi.org/10.1111/j.1755-3768.2010.203.x","title":"Keratocyte\u2010mediated establishment of lamellar structure in corneal development","display_name":"Keratocyte\u2010mediated establishment of lamellar structure in corneal development","publication_year":2010,"publication_date":"2010-09-01","ids":{"openalex":"https://openalex.org/W1998406444","doi":"https://doi.org/10.1111/j.1755-3768.2010.203.x","mag":"1998406444"},"language":"en","primary_location":{"id":"doi:10.1111/j.1755-3768.2010.203.x","doi":"https://doi.org/10.1111/j.1755-3768.2010.203.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1755-3768.2010.203.x","pdf_url":null,"source":{"id":"https://openalex.org/S21165490","display_name":"Acta Ophthalmologica","issn_l":"0001-639X","issn":["0001-639X","1755-375X","1755-3768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Ophthalmologica","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106748947","display_name":"R.H. Young","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"RD YOUNG","raw_affiliation_strings":["Cardiff University School of Optometry & Vision Sciences, Cardiff","Cardiff University; School of Optometry and Vision Sciences, Cardiff"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiff University School of Optometry & Vision Sciences, Cardiff","institution_ids":["https://openalex.org/I79510175"]},{"raw_affiliation_string":"Cardiff University; School of Optometry and Vision Sciences, Cardiff","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037874382","display_name":"Christian Pinali","orcid":"https://orcid.org/0000-0001-9815-6940","observed_orcids":["https://orcid.org/0000-0001-9815-6940"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C PINALI","raw_affiliation_strings":["Cardiff University School of Optometry & Vision Sciences, Cardiff","Cardiff University; School of Optometry and Vision Sciences, Cardiff"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiff University School of Optometry & Vision Sciences, Cardiff","institution_ids":["https://openalex.org/I79510175"]},{"raw_affiliation_string":"Cardiff University; School of Optometry and Vision Sciences, Cardiff","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069867604","display_name":"Ken M. Y. P'ng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"K PNG","raw_affiliation_strings":["The Nanovision Centre, School of Engineering & Materials Science QMUL, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Nanovision Centre, School of Engineering & Materials Science QMUL, London","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008874906","display_name":"AJ BUSHBY","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"AJ BUSHBY","raw_affiliation_strings":["The Nanovision Centre, School of Engineering & Materials Science QMUL, London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Nanovision Centre, School of Engineering & Materials Science QMUL, London","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046052577","display_name":"Keith M. Meek","orcid":"https://orcid.org/0000-0002-9948-7538","observed_orcids":["https://orcid.org/0000-0002-9948-7538"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"KM MEEK","raw_affiliation_strings":["Cardiff University School of Optometry & Vision Sciences, Cardiff","Cardiff University; School of Optometry and Vision Sciences, Cardiff"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiff University School of Optometry & Vision Sciences, Cardiff","institution_ids":["https://openalex.org/I79510175"]},{"raw_affiliation_string":"Cardiff University; School of Optometry and Vision Sciences, Cardiff","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019751830","display_name":"Carlo Knupp","orcid":"https://orcid.org/0000-0001-9127-2252","observed_orcids":["https://orcid.org/0000-0001-9127-2252"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C KNUPP","raw_affiliation_strings":["Cardiff University School of Optometry & Vision Sciences, Cardiff","Cardiff University; School of Optometry and Vision Sciences, Cardiff"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiff University School of Optometry & Vision Sciences, Cardiff","institution_ids":["https://openalex.org/I79510175"]},{"raw_affiliation_string":"Cardiff University; School of Optometry and Vision Sciences, Cardiff","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066035019","display_name":"AJ QUANTOCK","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"AJ QUANTOCK","raw_affiliation_strings":["Cardiff University School of Optometry & Vision Sciences, Cardiff","Cardiff University; School of Optometry and Vision Sciences, Cardiff"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiff University School of Optometry & Vision Sciences, Cardiff","institution_ids":["https://openalex.org/I79510175"]},{"raw_affiliation_string":"Cardiff University; School of Optometry and Vision Sciences, Cardiff","institution_ids":["https://openalex.org/I79510175"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"88","issue":"s246","first_page":"0","last_page":"0"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12989","display_name":"Ocular Disorders and Treatments","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/keratocytes","display_name":"keratocytes","score":0.8450000286102295},{"id":"https://openalex.org/keywords/corneal-stroma","display_name":"corneal stroma","score":0.8809999823570251},{"id":"https://openalex.org/keywords/lamellar-structure","display_name":"lamellar structure","score":0.6880000233650208},{"id":"https://openalex.org/keywords/corneal-development","display_name":"corneal development","score":0.9070000052452087},{"id":"https://openalex.org/keywords/chick-embryo","display_name":"chick embryo","score":0.628000020980835},{"id":"https://openalex.org/keywords/corneal-transparency","display_name":"corneal transparency","score":0.8140000104904175},{"id":"https://openalex.org/keywords/corneal-wound-healing","display_name":"corneal wound healing","score":0.5799999833106995}],"concepts":[{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.6828038692474365},{"id":"https://openalex.org/C52124034","wikidata":"https://www.wikidata.org/wiki/Q557179","display_name":"Stroma","level":3,"score":0.5489731431007385},{"id":"https://openalex.org/C77851909","wikidata":"https://www.wikidata.org/wiki/Q6481705","display_name":"Lamellar structure","level":2,"score":0.5424947738647461},{"id":"https://openalex.org/C136301237","wikidata":"https://www.wikidata.org/wiki/Q3247568","display_name":"Lamella (surface anatomy)","level":2,"score":0.5165730714797974},{"id":"https://openalex.org/C146088050","wikidata":"https://www.wikidata.org/wiki/Q744818","display_name":"Transmission electron microscopy","level":2,"score":0.5154114961624146},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5116274952888489},{"id":"https://openalex.org/C26771246","wikidata":"https://www.wikidata.org/wiki/Q321095","display_name":"Scanning electron microscope","level":2,"score":0.5035509467124939},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.38596081733703613},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3622438311576843},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.22787299752235413},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.2149783968925476},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20058077573776245},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.10368987917900085},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1755-3768.2010.203.x","doi":"https://doi.org/10.1111/j.1755-3768.2010.203.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1755-3768.2010.203.x","pdf_url":null,"source":{"id":"https://openalex.org/S21165490","display_name":"Acta Ophthalmologica","issn_l":"0001-639X","issn":["0001-639X","1755-375X","1755-3768"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Ophthalmologica","raw_type":"journal-article"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/5344510e-2d23-4a03-9250-f8f14e150770","doi":null,"is_oa":false,"landing_page_url":"https://research.manchester.ac.uk/en/publications/5344510e-2d23-4a03-9250-f8f14e150770","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"YOUNG, RD, PINALI, C, PNG, K, BUSHBY, AJ, MEEK, KM, KNUPP, C & QUANTOCK, AJ 2010, 'Keratocyte-mediated establishment of lamellar structure in corneal development', Acta Ophthalmologica, vol. 88, no. s246, 88(s246), pp. 0-0. https://doi.org/10.1111/j.1755-3768.2010.203.x","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G7447282125","display_name":null,"funder_award_id":"EP/F019882/1","funder_id":"https://openalex.org/F4320334627","funder_display_name":"Engineering and Physical Sciences Research Council"}],"funders":[{"id":"https://openalex.org/F4320334627","display_name":"Engineering and Physical Sciences Research Council","ror":"https://ror.org/0439y7842"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1975256748","https://openalex.org/W1838068318","https://openalex.org/W2969646192","https://openalex.org/W2043983669","https://openalex.org/W7112029651","https://openalex.org/W2080982155","https://openalex.org/W2971967904","https://openalex.org/W2418626776","https://openalex.org/W1856894839","https://openalex.org/W4210695982"],"abstract_inverted_index":{"Abstract":[0],"Purpose":[1],"Mechanisms":[2],"by":[3],"which":[4,232],"presumptive":[5],"keratocytes":[6,224],"in":[7,32,36,79,87,101,105,126,216,225],"the":[8,12,17,68,72,116,184,197,203,209,218],"developing":[9,172,226],"cornea":[10,35,228],"engineer":[11],"3\u2010dimensional":[13],"lamellar":[14,69,243],"matrix":[15],"of":[16,62,71,115,171,208,222],"transparent":[18],"stroma":[19,198],"remain":[20],"unknown.":[21],"We":[22],"used":[23,94],"Volume":[24,213],"Scanning":[25],"Electron":[26],"Microscopy":[27],"to":[28,38,95,201],"observe":[29],"lamella":[30],"formation":[31],"embryonic":[33],"avian":[34],"order":[37],"understand":[39],"better":[40],"corneal":[41,174],"stromal":[42],"biosynthesis,":[43],"transparency":[44],"and":[45,56,82,85,147,163,194,205,235],"repair.":[46],"Methods":[47],"Corneas":[48],"were":[49,77,93,119,150,156],"obtained":[50],"from":[51,181],"chick":[52,173,227],"embryos":[53],"at":[54],"E10":[55],"E14,":[57],"when":[58],"a":[59,106,123,127,142],"loose":[60],"structure":[61],"collagen":[63,189,237],"fibril":[64,238],"bundles":[65,239],"condenses":[66],"into":[67,183,240],"organisation":[70,207],"mature":[73],"stroma.":[74,175],"Aldehyde\u2010fixed":[75],"corneas":[76],"contrast\u2010enhanced":[78],"osmium":[80],"ferricyanide":[81],"tannic":[83],"acid":[84],"embedded":[86],"Durcupan":[88],"resin.":[89],"Toluidine":[90],"blue\u2010stained":[91],"sections":[92,104],"locate":[96],"suitable":[97],"sites,":[98],"subsequently":[99],"examined":[100],"unstained":[102],"ultrathin":[103],"Jeol":[107],"1010":[108],"transmission":[109],"electron":[110,166],"microscope.":[111],"The":[112],"polished":[113],"faces":[114],"resin":[117],"blocks":[118],"then":[120],"imaged":[121],"using":[122,158],"BSE":[124],"detector":[125],"Quanta":[128],"3D":[129,217],"FEG":[130],"FIB/SEM":[131],"via":[132],"an":[133,241],"alternate":[134],"slice\u2010and\u2010view":[135],"protocol.":[136],"50nm":[137],"slicing":[138],"was":[139],"performed":[140],"with":[141,191,229],"focused":[143],"gallium":[144],"ion":[145],"beam":[146],"image":[148],"series":[149],"collected":[151],"over":[152],"18h.":[153],"Image":[154],"stacks":[155],"processed":[157],"ImageJ":[159],"software.":[160],"Results":[161],"Transmission":[162],"volume":[164],"scanning":[165],"microscopy":[167],"reveal":[168],"complex":[169,219],"compartmentalisation":[170],"Keratocyte":[176],"filopodia":[177],"extend":[178],"many":[179],"microns":[180],"cells":[182],"extracellular":[185],"space.":[186],"These":[187],"invest":[188],"fibrils,":[190],"varying":[192],"orientations,":[193],"persist":[195],"as":[196],"condenses,":[199],"appearing":[200],"orchestrate":[202],"spatial":[204],"directional":[206],"component":[210],"lamellae.":[211],"Conclusion":[212],"SEM":[214],"reveals":[215],"cellular":[220],"morphology":[221],"prospective":[223],"extensive":[230],"filopodia,":[231],"presumably":[233],"channel":[234],"direct":[236],"emergent":[242],"architecture.":[244]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}