{"id":"https://openalex.org/W1998392610","doi":"https://doi.org/10.1016/0022-510x(91)90218-v","title":"Age-related changes in cerebrospinal fluid protein concentrations","display_name":"Age-related changes in cerebrospinal fluid protein concentrations","publication_year":1991,"publication_date":"1991-07-01","ids":{"openalex":"https://openalex.org/W1998392610","doi":"https://doi.org/10.1016/0022-510x(91)90218-v","mag":"1998392610","pmid":"https://pubmed.ncbi.nlm.nih.gov/1717663"},"language":"en","primary_location":{"id":"doi:10.1016/0022-510x(91)90218-v","doi":"https://doi.org/10.1016/0022-510x(91)90218-v","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0022-510x(91)90218-v","pdf_url":null,"source":{"id":"https://openalex.org/S169054600","display_name":"Journal of the Neurological Sciences","issn_l":"0022-510X","issn":["0022-510X","1878-5883"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Neurological Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109958603","display_name":"Mark J. Garton","orcid":"https://orcid.org/0000-0003-2032-6270","observed_orcids":["https://orcid.org/0000-0003-2032-6270"]},"institutions":[{"id":"https://openalex.org/I2800600548","display_name":"Aberdeen Royal Infirmary","ror":"https://ror.org/02q49af68","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2800600548","https://openalex.org/I4210093322"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"M.J. Garton","raw_affiliation_strings":["Department of Medicine, Aberdeen Royal Infirmary, Foresterhill, U. K","Department of Medicine, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB9 2ZB, U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Aberdeen Royal Infirmary, Foresterhill, U. K","institution_ids":["https://openalex.org/I2800600548"]},{"raw_affiliation_string":"Department of Medicine, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB9 2ZB, U.K","institution_ids":["https://openalex.org/I2800600548"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023889865","display_name":"Geoffrey Keir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G. Keir","raw_affiliation_strings":["The John N. Cumings Laboratory, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The John N. Cumings Laboratory, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG U.K","institution_ids":["https://openalex.org/I4210151618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048353216","display_name":"M Lakshmi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"M.Vijaya Lakshmi","raw_affiliation_strings":["Department of Geriatric Medicine, Clinical Sciences Building, Hope Hospital, Eccles Old Road, Manchester M6 8HD U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Geriatric Medicine, Clinical Sciences Building, Hope Hospital, Eccles Old Road, Manchester M6 8HD U.K","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111664416","display_name":"Edward John Thompson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"E.J. Thompson","raw_affiliation_strings":["The John N. Cumings Laboratory, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG U.K"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The John N. Cumings Laboratory, The National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG U.K","institution_ids":["https://openalex.org/I4210151618"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5109958603"],"corresponding_institution_ids":["https://openalex.org/I2800600548"],"apc_list":{"value":3640,"currency":"USD","value_usd":3640},"apc_paid":null,"fwci":1.3249,"has_fulltext":false,"cited_by_count":97,"citation_normalized_percentile":{"value":0.79288026,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"104","issue":"1","first_page":"74","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.9609000086784363,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11406","display_name":"Cerebrospinal fluid and hydrocephalus","score":0.03519999980926514,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.8109999895095825},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.878000020980835},{"id":"https://openalex.org/keywords/brain-aging","display_name":"brain aging","score":0.6650000214576721},{"id":"https://openalex.org/keywords/alpha-2-macroglobulin","display_name":"alpha2-macroglobulin","score":0.9190000295639038},{"id":"https://openalex.org/keywords/prealbumin","display_name":"prealbumin","score":0.9089999794960022},{"id":"https://openalex.org/keywords/albumin","display_name":"albumin","score":0.9539999961853027},{"id":"https://openalex.org/keywords/igg","display_name":"IgG","score":1.0},{"id":"https://openalex.org/keywords/serum-protein-levels","display_name":"serum protein levels","score":0.6660000085830688},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.41999998688697815}],"concepts":[{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.8778906464576721},{"id":"https://openalex.org/C33619753","wikidata":"https://www.wikidata.org/wiki/Q5014091","display_name":"CSF albumin","level":3,"score":0.5147905349731445},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3565613031387329},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3178870379924774},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2652485966682434}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000511","descriptor_name":"alpha-Macroglobulins","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002556","descriptor_name":"Cerebrospinal Fluid Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002556","descriptor_name":"Cerebrospinal Fluid Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011228","descriptor_name":"Prealbumin","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0022-510x(91)90218-v","doi":"https://doi.org/10.1016/0022-510x(91)90218-v","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0022-510x(91)90218-v","pdf_url":null,"source":{"id":"https://openalex.org/S169054600","display_name":"Journal of the Neurological Sciences","issn_l":"0022-510X","issn":["0022-510X","1878-5883"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Neurological Sciences","raw_type":"journal-article"},{"id":"pmid:1717663","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1717663","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the neurological sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W582695643","https://openalex.org/W1532754033","https://openalex.org/W1535204017","https://openalex.org/W1599295364","https://openalex.org/W1905148217","https://openalex.org/W1976837347","https://openalex.org/W1984423542","https://openalex.org/W2021391478","https://openalex.org/W2036774974","https://openalex.org/W2042975557","https://openalex.org/W2044389533","https://openalex.org/W2056742232","https://openalex.org/W2065417433","https://openalex.org/W2071818990","https://openalex.org/W2091968832","https://openalex.org/W2108020835","https://openalex.org/W2110952719","https://openalex.org/W2139314114","https://openalex.org/W2159467659","https://openalex.org/W2159497229","https://openalex.org/W2225852564"],"related_works":["https://openalex.org/W2046640784","https://openalex.org/W2000520968","https://openalex.org/W1979586081","https://openalex.org/W1987059729","https://openalex.org/W2094149847","https://openalex.org/W1890661093","https://openalex.org/W2057226095","https://openalex.org/W4412451609","https://openalex.org/W2755169970","https://openalex.org/W3012785766"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}