{"id":"https://openalex.org/W1998355017","doi":"https://doi.org/10.1016/0006-2952(82)90533-0","title":"In vitro biosynthesis of cyclooxygenase metabolites in ovalbumin-sensitized and control lungs of guinea pigs","display_name":"In vitro biosynthesis of cyclooxygenase metabolites in ovalbumin-sensitized and control lungs of guinea pigs","publication_year":1982,"publication_date":"1982-07-01","ids":{"openalex":"https://openalex.org/W1998355017","doi":"https://doi.org/10.1016/0006-2952(82)90533-0","mag":"1998355017","pmid":"https://pubmed.ncbi.nlm.nih.gov/6812589"},"language":"en","primary_location":{"id":"doi:10.1016/0006-2952(82)90533-0","doi":"https://doi.org/10.1016/0006-2952(82)90533-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-2952(82)90533-0","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040956813","display_name":"Karen G. Rothberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210098204","display_name":"John B. Pierce Laboratory","ror":"https://ror.org/00fq5ev96","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210098204"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Karen G. Rothberg","raw_affiliation_strings":["John B. Pierce Foundation Laboratory, Yale University School of Medicine, New Haven, CT 06519, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John B. Pierce Foundation Laboratory, Yale University School of Medicine, New Haven, CT 06519, U.S.A","institution_ids":["https://openalex.org/I32971472","https://openalex.org/I4210098204"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041553454","display_name":"Margaret Hitchcock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]},{"id":"https://openalex.org/I4210098204","display_name":"John B. Pierce Laboratory","ror":"https://ror.org/00fq5ev96","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210098204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Margaret Hitchcock","raw_affiliation_strings":["John B. Pierce Foundation Laboratory, Yale University School of Medicine, New Haven, CT 06519, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John B. Pierce Foundation Laboratory, Yale University School of Medicine, New Haven, CT 06519, U.S.A","institution_ids":["https://openalex.org/I32971472","https://openalex.org/I4210098204"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040956813"],"corresponding_institution_ids":["https://openalex.org/I32971472","https://openalex.org/I4210098204"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":0.7468,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.67110266,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"31","issue":"14","first_page":"2381","last_page":"2388"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.7548999786376953,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.7548999786376953,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.13680000603199005,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.08290000259876251,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclooxygenase","display_name":"cyclooxygenase","score":0.9559999704360962},{"id":"https://openalex.org/keywords/arachidonic-acid-metabolism","display_name":"arachidonic acid metabolism","score":0.7910000085830688},{"id":"https://openalex.org/keywords/ovalbumin-sensitization","display_name":"ovalbumin sensitization","score":0.9319999814033508},{"id":"https://openalex.org/keywords/anaphylaxis","display_name":"anaphylaxis","score":0.8119999766349792},{"id":"https://openalex.org/keywords/lung-microsomes","display_name":"lung microsomes","score":0.8140000104904175},{"id":"https://openalex.org/keywords/thromboxane-b2","display_name":"thromboxane B2","score":0.9900000095367432},{"id":"https://openalex.org/keywords/prostaglandin-d2","display_name":"prostaglandin D2","score":0.9789999723434448},{"id":"https://openalex.org/keywords/prostacyclin","display_name":"prostacyclin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/prostaglandin-f2alpha","display_name":"prostaglandin F2alpha","score":0.7580000162124634},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.8600000143051147},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.8690000176429749},{"id":"https://openalex.org/keywords/guinea-pig-lung","display_name":"guinea pig lung","score":0.5770000219345093}],"concepts":[{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.8338916897773743},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.7911973595619202},{"id":"https://openalex.org/C2776785769","wikidata":"https://www.wikidata.org/wiki/Q412212","display_name":"Thromboxane","level":3,"score":0.6964800953865051},{"id":"https://openalex.org/C2781128415","wikidata":"https://www.wikidata.org/wiki/Q412050","display_name":"Prostacyclin","level":2,"score":0.6813411116600037},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.6030155420303345},{"id":"https://openalex.org/C2781080829","wikidata":"https://www.wikidata.org/wiki/Q3009646","display_name":"Thromboxane B2","level":3,"score":0.5759143829345703},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.5741464495658875},{"id":"https://openalex.org/C2780664492","wikidata":"https://www.wikidata.org/wiki/Q209717","display_name":"Prostaglandin","level":2,"score":0.556931734085083},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5267959237098694},{"id":"https://openalex.org/C2776946954","wikidata":"https://www.wikidata.org/wiki/Q420291","display_name":"Ovalbumin","level":3,"score":0.5076180696487427},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4659581780433655},{"id":"https://openalex.org/C2778815084","wikidata":"https://www.wikidata.org/wiki/Q79803","display_name":"Guinea pig","level":2,"score":0.44676458835601807},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.4397135078907013},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.429270476102829},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.41414016485214233},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4136120080947876},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35457122325897217},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3159445524215698},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.24909564852714539},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14116841554641724},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1276567578315735},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001095","descriptor_name":"Arachidonic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006967","descriptor_name":"Hypersensitivity","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008861","descriptor_name":"Microsomes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010047","descriptor_name":"Ovalbumin","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011451","descriptor_name":"Prostaglandin-Endoperoxide Synthases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013929","descriptor_name":"Thromboxane B2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0006-2952(82)90533-0","doi":"https://doi.org/10.1016/0006-2952(82)90533-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0006-2952(82)90533-0","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},{"id":"pmid:6812589","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6812589","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3789169975","display_name":"TRAINING IN ENVIRONMENTAL TOXICOLOGY AND PHYSIOLOGY","funder_award_id":"T32ES007086","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W28081689","https://openalex.org/W1775749144","https://openalex.org/W1967885105","https://openalex.org/W1980289837","https://openalex.org/W1987288311","https://openalex.org/W1988617134","https://openalex.org/W1992512151","https://openalex.org/W1996653881","https://openalex.org/W1997527617","https://openalex.org/W2005915093","https://openalex.org/W2008574207","https://openalex.org/W2015117137","https://openalex.org/W2015444698","https://openalex.org/W2015943234","https://openalex.org/W2017228209","https://openalex.org/W2019053988","https://openalex.org/W2021403302","https://openalex.org/W2027233484","https://openalex.org/W2031311321","https://openalex.org/W2035879817","https://openalex.org/W2049629262","https://openalex.org/W2056758736","https://openalex.org/W2058640797","https://openalex.org/W2059335992","https://openalex.org/W2069169679","https://openalex.org/W2069516384","https://openalex.org/W2080098888","https://openalex.org/W2083923976","https://openalex.org/W2083987188","https://openalex.org/W2094629461","https://openalex.org/W2098239891","https://openalex.org/W2119660672","https://openalex.org/W2151153202","https://openalex.org/W2161021393","https://openalex.org/W2334758547","https://openalex.org/W2336077697","https://openalex.org/W4237161013","https://openalex.org/W4252477956"],"related_works":["https://openalex.org/W2095027945","https://openalex.org/W1994939346","https://openalex.org/W153453505","https://openalex.org/W2136073072","https://openalex.org/W2304268059","https://openalex.org/W2043879540","https://openalex.org/W2024273982","https://openalex.org/W2001193292","https://openalex.org/W1995615736","https://openalex.org/W2083015609"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
