{"id":"https://openalex.org/W1998332012","doi":"https://doi.org/10.1111/j.1476-5381.1974.tb09714.x","title":"EVIDENCE FOR INVOLVEMENT OF 5\u2010HYDROXYTRYPTAMINE IN THE ACTIONS OF AMPHETAMINE","display_name":"EVIDENCE FOR INVOLVEMENT OF 5\u2010HYDROXYTRYPTAMINE IN THE ACTIONS OF AMPHETAMINE","publication_year":1974,"publication_date":"1974-10-01","ids":{"openalex":"https://openalex.org/W1998332012","doi":"https://doi.org/10.1111/j.1476-5381.1974.tb09714.x","mag":"1998332012","pmid":"https://pubmed.ncbi.nlm.nih.gov/4155993","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1776875"},"language":"en","primary_location":{"id":"doi:10.1111/j.1476-5381.1974.tb09714.x","doi":"https://doi.org/10.1111/j.1476-5381.1974.tb09714.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1974.tb09714.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1974.tb09714.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1974.tb09714.x","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110030158","display_name":"George R. Breese","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G.R. BREESE","raw_affiliation_strings":["Departments of Pharmacology, Psychiatry and Anesthesiology, Biological Sciences Research Center, Child Development Institute, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27514, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology, Psychiatry and Anesthesiology, Biological Sciences Research Center, Child Development Institute, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27514, U.S.A","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110399593","display_name":"Barrett R. Cooper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B.R. COOPER","raw_affiliation_strings":["Departments of Pharmacology, Psychiatry and Anesthesiology, Biological Sciences Research Center, Child Development Institute, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27514, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology, Psychiatry and Anesthesiology, Biological Sciences Research Center, Child Development Institute, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27514, U.S.A","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111807691","display_name":"Robert A. Mueller","orcid":"https://orcid.org/0000-0002-4835-6335","observed_orcids":["https://orcid.org/0000-0002-4835-6335"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.A. MUELLER","raw_affiliation_strings":["Departments of Pharmacology, Psychiatry and Anesthesiology, Biological Sciences Research Center, Child Development Institute, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27514, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology, Psychiatry and Anesthesiology, Biological Sciences Research Center, Child Development Institute, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27514, U.S.A","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":6.3111,"has_fulltext":true,"cited_by_count":160,"citation_normalized_percentile":{"value":0.97862129,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"52","issue":"2","first_page":"307","last_page":"314"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.9509999752044678},{"id":"https://openalex.org/keywords/amphetamine","display_name":"amphetamine","score":0.9909999966621399},{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.796999990940094},{"id":"https://openalex.org/keywords/stereotyped-behavior","display_name":"stereotypy","score":0.7070000171661377},{"id":"https://openalex.org/keywords/p-chlorophenylalanine","display_name":"p-chlorophenylalanine","score":0.9430000185966492},{"id":"https://openalex.org/keywords/5-6-dihydroxytryptamine","display_name":"5,6-dihydroxytryptamine","score":0.972000002861023},{"id":"https://openalex.org/keywords/5-hydroxytryptophan","display_name":"5-hydroxytryptophan","score":0.9660000205039978},{"id":"https://openalex.org/keywords/6-hydroxydopamine","display_name":"6-hydroxydopamine","score":0.9490000009536743},{"id":"https://openalex.org/keywords/pargyline","display_name":"pargyline","score":0.8019999861717224},{"id":"https://openalex.org/keywords/dopamine-serotonin-interaction","display_name":"serotonin-dopamine interaction","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C2777193897","wikidata":"https://www.wikidata.org/wiki/Q179452","display_name":"Amphetamine","level":3,"score":0.9617947936058044},{"id":"https://openalex.org/C2777067607","wikidata":"https://www.wikidata.org/wiki/Q781329","display_name":"Pargyline","level":4,"score":0.8358187675476074},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.617542564868927},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5848821401596069},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.5764902830123901},{"id":"https://openalex.org/C2776145449","wikidata":"https://www.wikidata.org/wiki/Q1706418","display_name":"Dextroamphetamine","level":4,"score":0.5187152028083801},{"id":"https://openalex.org/C2779399491","wikidata":"https://www.wikidata.org/wiki/Q238544","display_name":"5-Hydroxytryptophan","level":4,"score":0.45778053998947144},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45419883728027344},{"id":"https://openalex.org/C2775951788","wikidata":"https://www.wikidata.org/wiki/Q418293","display_name":"Tryptophan hydroxylase","level":5,"score":0.4515513479709625},{"id":"https://openalex.org/C159167319","wikidata":"https://www.wikidata.org/wiki/Q420766","display_name":"Tyrosine hydroxylase","level":3,"score":0.4118339419364929},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.36727917194366455},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.362621545791626},{"id":"https://openalex.org/C37000724","wikidata":"https://www.wikidata.org/wiki/Q50430226","display_name":"Serotonergic","level":4,"score":0.2904961109161377},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2826192378997803},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.05975520610809326}],"mesh":[{"descriptor_ui":"D000311","descriptor_name":"Adrenal Glands","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003913","descriptor_name":"Dextroamphetamine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007490","descriptor_name":"Iproniazid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010134","descriptor_name":"Fenclonine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010293","descriptor_name":"Pargyline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013239","descriptor_name":"Stereotyped Behavior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014446","descriptor_name":"Tyrosine 3-Monooxygenase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1476-5381.1974.tb09714.x","doi":"https://doi.org/10.1111/j.1476-5381.1974.tb09714.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1974.tb09714.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1974.tb09714.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1422351","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1776875","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:1776875","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1776875","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Pharmacol","raw_type":"Text"},{"id":"pmid:4155993","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/4155993","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/j.1476-5381.1974.tb09714.x","doi":"https://doi.org/10.1111/j.1476-5381.1974.tb09714.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1476-5381.1974.tb09714.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1476-5381.1974.tb09714.x","source":{"id":"https://openalex.org/S55107261","display_name":"British Journal of Pharmacology","issn_l":"0007-1188","issn":["0007-1188","1476-5381"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1998332012.pdf","grobid_xml":"https://content.openalex.org/works/W1998332012.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W94044369","https://openalex.org/W1590858195","https://openalex.org/W1604447261","https://openalex.org/W1973911345","https://openalex.org/W1976605273","https://openalex.org/W1977383153","https://openalex.org/W1982967249","https://openalex.org/W1986871147","https://openalex.org/W2009930975","https://openalex.org/W2030847799","https://openalex.org/W2034202726","https://openalex.org/W2034437867","https://openalex.org/W2039328344","https://openalex.org/W2044595141","https://openalex.org/W2050426362","https://openalex.org/W2061789234","https://openalex.org/W2063896365","https://openalex.org/W2087452886","https://openalex.org/W2092732920","https://openalex.org/W2117332035","https://openalex.org/W2149330955","https://openalex.org/W2157616701","https://openalex.org/W2161670042","https://openalex.org/W2220358158","https://openalex.org/W2253953550","https://openalex.org/W2266953608","https://openalex.org/W2271085251","https://openalex.org/W2272293723","https://openalex.org/W2416582794","https://openalex.org/W4247948118","https://openalex.org/W4406989363","https://openalex.org/W4407045030"],"related_works":["https://openalex.org/W1995790835","https://openalex.org/W2064788235","https://openalex.org/W2078014712","https://openalex.org/W2095345901","https://openalex.org/W2461504235","https://openalex.org/W1972006156","https://openalex.org/W2039328344","https://openalex.org/W2244087826","https://openalex.org/W2124119980","https://openalex.org/W1940784142"],"abstract_inverted_index":{"1":[0,3],"Pargyline":[1],"treatment,":[2],"h":[4],"before":[5],"(+)-amphetamine":[6],"(1":[7],"mg/kg),":[8],"reduced":[9],"amphetamine-stimulated":[10,54],"motor":[11],"activity.":[12],"This":[13],"inhibition":[14,52],"was":[15,33,44,61,92],"reversed":[16,45,63],"in":[17,41,46,105],"animals":[18,47],"pretreated":[19,48],"with":[20,25,49,59],"p-chlorophenylalanine":[21],"(PCPA).2":[22],"Following":[23],"treatment":[24,58],"PCPA":[26,65],"or":[27],"5,6-dihydroxytryptamine":[28],"(5,6-DHT),":[29],"amphetamine-induced":[30],"locomotor":[31,55],"activity":[32,56,86],"significantly":[34,93],"potentiated.":[35],"The":[36,51],"increased":[37],"response":[38],"to":[39,74],"amphetamine":[40,70,90],"PCPA-treated":[42],"rats":[43],"5-hydroxytryptophan.3":[50],"of":[53,79,82,100,110],"by":[57,64,69,77,88,95],"6-hydroxydopamine":[60],"not":[62,72],"treatment.4":[66],"Stereotypies":[67],"produced":[68,87],"were":[71],"found":[73],"be":[75],"altered":[76],"depletion":[78],"5-hydroxytryptamine.5":[80],"Induction":[81],"adrenal":[83],"tyrosine":[84],"hydroxylase":[85],"chronic":[89],"administration":[91],"potentiated":[94],"PCPA,":[96],"emphasizing":[97],"the":[98],"involvement":[99],"a":[101],"5-hydroxytryptamine":[102],"inhibitory":[103],"system":[104],"more":[106],"than":[107],"one":[108],"action":[109],"amphetamine.":[111]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}
