{"id":"https://openalex.org/W1998324436","doi":"https://doi.org/10.2176/nmc.50.183","title":"Mechanical Clot Disruption Following Intravenous Recombinant Tissue Plasminogen Activator Administration in Non-Responders","display_name":"Mechanical Clot Disruption Following Intravenous Recombinant Tissue Plasminogen Activator Administration in Non-Responders","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W1998324436","doi":"https://doi.org/10.2176/nmc.50.183","mag":"1998324436","pmid":"https://pubmed.ncbi.nlm.nih.gov/20339266"},"language":"en","primary_location":{"id":"doi:10.2176/nmc.50.183","doi":"https://doi.org/10.2176/nmc.50.183","is_oa":true,"landing_page_url":"https://doi.org/10.2176/nmc.50.183","pdf_url":"https://www.jstage.jst.go.jp/article/nmc/50/3/50_3_183/_pdf","source":{"id":"https://openalex.org/S170822592","display_name":"Neurologia medico-chirurgica","issn_l":"0470-8105","issn":["0470-8105","1349-8029"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313358","host_organization_name":"Japan Neurological Society","host_organization_lineage":["https://openalex.org/P4310313358"],"host_organization_lineage_names":["Japan Neurological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurologia medico-chirurgica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.jstage.jst.go.jp/article/nmc/50/3/50_3_183/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060638711","display_name":"Taichiro Kawakami","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Taichiro KAWAKAMI","raw_affiliation_strings":["Department of Neurosurgery, Osaka City University Graduate School of Medicine","Department of Neurosurgery, Osaka City University Graduate School of Medicine; Osaka, Japan -"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Osaka City University Graduate School of Medicine","institution_ids":["https://openalex.org/I317356780"]},{"raw_affiliation_string":"Department of Neurosurgery, Osaka City University Graduate School of Medicine; Osaka, Japan -","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090256590","display_name":"Yuzo Terakawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuzo TERAKAWA","raw_affiliation_strings":["Department of Neurosurgery, Osaka City University, Graduate School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Osaka City University, Graduate School of Medicine","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057239173","display_name":"Takashi Tsuruno","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takashi TSURUNO","raw_affiliation_strings":["Department of Neurosurgery, Suishokai Murata Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Suishokai Murata Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109376497","display_name":"Takaho Murata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takaho MURATA","raw_affiliation_strings":["Department of Neurosurgery, Suishokai Murata Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Suishokai Murata Hospital","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065938708","display_name":"Akimasa Nishio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akimasa NISHIO","raw_affiliation_strings":["Department of Neurosurgery, Osaka City University, Graduate School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Osaka City University, Graduate School of Medicine","institution_ids":["https://openalex.org/I317356780"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054416068","display_name":"Kenji Ohata","orcid":"https://orcid.org/0000-0001-7334-8321","observed_orcids":["https://orcid.org/0000-0001-7334-8321","https://orcid.org/0009-0007-2914-7507"]},"institutions":[{"id":"https://openalex.org/I317356780","display_name":"Osaka City University","ror":"https://ror.org/02skfsw40","country_code":"JP","type":"education","lineage":["https://openalex.org/I317356780","https://openalex.org/I4387152983"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kenji OHATA","raw_affiliation_strings":["Department of Neurosurgery, Osaka City University, Graduate School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Osaka City University, Graduate School of Medicine","institution_ids":["https://openalex.org/I317356780"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":10000,"currency":"JPY","value_usd":75},"apc_paid":{"value":10000,"currency":"JPY","value_usd":75},"fwci":0.5749,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.68288315,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"50","issue":"3","first_page":"183","last_page":"191"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10420","display_name":"Intracranial Aneurysms: Treatment and Complications","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11763","display_name":"Intracerebral and Subarachnoid Hemorrhage Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-ischemic-stroke","display_name":"acute ischemic stroke","score":0.8960000276565552},{"id":"https://openalex.org/keywords/treatment-non-responders","display_name":"treatment non-responders","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cerebral-angiography","display_name":"cerebral angiography","score":0.6769999861717224},{"id":"https://openalex.org/keywords/recanalization","display_name":"recanalization","score":0.9120000004768372},{"id":"https://openalex.org/keywords/percutaneous-transluminal-angioplasty","display_name":"percutaneous transluminal angioplasty","score":0.9729999899864197},{"id":"https://openalex.org/keywords/stroke-outcome","display_name":"stroke outcome","score":0.4480000138282776},{"id":"https://openalex.org/keywords/bleeding-complications","display_name":"bleeding complications","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9599147439002991},{"id":"https://openalex.org/C2780931571","wikidata":"https://www.wikidata.org/wiki/Q568775","display_name":"Modified Rankin Scale","level":4,"score":0.748628556728363},{"id":"https://openalex.org/C2776572282","wikidata":"https://www.wikidata.org/wiki/Q416351","display_name":"Tissue plasminogen activator","level":2,"score":0.5464663505554199},{"id":"https://openalex.org/C2780643987","wikidata":"https://www.wikidata.org/wiki/Q468414","display_name":"Angiography","level":2,"score":0.5415675044059753},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5360022187232971},{"id":"https://openalex.org/C2909373784","wikidata":"https://www.wikidata.org/wiki/Q416351","display_name":"T-plasminogen activator","level":3,"score":0.4966779351234436},{"id":"https://openalex.org/C2779581417","wikidata":"https://www.wikidata.org/wiki/Q1931577","display_name":"Thrombolysis","level":3,"score":0.45564043521881104},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3903787136077881},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3636930286884308},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33289891481399536},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.27430999279022217},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.24598655104637146},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000800","descriptor_name":"Angioplasty, Balloon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002533","descriptor_name":"Cerebral Angiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002545","descriptor_name":"Brain Ischemia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005343","descriptor_name":"Fibrinolytic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007275","descriptor_name":"Injections, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010959","descriptor_name":"Tissue Plasminogen Activator","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015912","descriptor_name":"Thrombolytic Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017211","descriptor_name":"Treatment Failure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018579","descriptor_name":"Patient Selection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020521","descriptor_name":"Stroke","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2176/nmc.50.183","doi":"https://doi.org/10.2176/nmc.50.183","is_oa":true,"landing_page_url":"https://doi.org/10.2176/nmc.50.183","pdf_url":"https://www.jstage.jst.go.jp/article/nmc/50/3/50_3_183/_pdf","source":{"id":"https://openalex.org/S170822592","display_name":"Neurologia medico-chirurgica","issn_l":"0470-8105","issn":["0470-8105","1349-8029"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313358","host_organization_name":"Japan Neurological Society","host_organization_lineage":["https://openalex.org/P4310313358"],"host_organization_lineage_names":["Japan Neurological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurologia medico-chirurgica","raw_type":"journal-article"},{"id":"pmid:20339266","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20339266","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurologia medico-chirurgica","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.2176/nmc.50.183","doi":"https://doi.org/10.2176/nmc.50.183","is_oa":true,"landing_page_url":"https://doi.org/10.2176/nmc.50.183","pdf_url":"https://www.jstage.jst.go.jp/article/nmc/50/3/50_3_183/_pdf","source":{"id":"https://openalex.org/S170822592","display_name":"Neurologia medico-chirurgica","issn_l":"0470-8105","issn":["0470-8105","1349-8029"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313358","host_organization_name":"Japan Neurological Society","host_organization_lineage":["https://openalex.org/P4310313358"],"host_organization_lineage_names":["Japan Neurological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurologia medico-chirurgica","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1998324436.pdf","grobid_xml":"https://content.openalex.org/works/W1998324436.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W132472807","https://openalex.org/W1947369509","https://openalex.org/W1967178585","https://openalex.org/W1979250580","https://openalex.org/W1997796302","https://openalex.org/W1998910883","https://openalex.org/W2000931407","https://openalex.org/W2004287928","https://openalex.org/W2004886383","https://openalex.org/W2021752535","https://openalex.org/W2024691831","https://openalex.org/W2032308540","https://openalex.org/W2055441223","https://openalex.org/W2055477368","https://openalex.org/W2056042467","https://openalex.org/W2076751149","https://openalex.org/W2087937646","https://openalex.org/W2087990939","https://openalex.org/W2089225309","https://openalex.org/W2107879320","https://openalex.org/W2122075944","https://openalex.org/W2123894485","https://openalex.org/W2124858463","https://openalex.org/W2138411396","https://openalex.org/W2151989517","https://openalex.org/W2157681943","https://openalex.org/W2159346236","https://openalex.org/W2163164086","https://openalex.org/W2292308933","https://openalex.org/W2399155639","https://openalex.org/W2530163185","https://openalex.org/W2531503442","https://openalex.org/W4285719527","https://openalex.org/W4297738730"],"related_works":["https://openalex.org/W2101858881","https://openalex.org/W637785610","https://openalex.org/W2139068991","https://openalex.org/W7095313220","https://openalex.org/W3028858165","https://openalex.org/W2171072125","https://openalex.org/W2144953162","https://openalex.org/W2101188164","https://openalex.org/W1834024437","https://openalex.org/W2059494930"],"abstract_inverted_index":{"The":[0],"efficacy":[1],"of":[2,43,69,109,115,121,149,167,198],"selecting":[3],"non-responders":[4,190],"to":[5,106,129,164,173,206,213],"intravenous":[6,98,199],"recombinant":[7],"tissue":[8],"plasminogen":[9],"activator":[10],"(rt-PA)":[11],"for":[12,189],"mechanical":[13],"clot":[14],"disruption":[15],"(MCD)":[16],"was":[17,35,64,138,145],"investigated":[18],"based":[19],"on":[20,51],"cerebral":[21,52,193],"angiography":[22,53,194],"in":[23,37,147],"the":[24,150,168,196,204],"acute":[25,218],"stage":[26],"following":[27],"rt-PA":[28,30,57,107,200],"therapy.":[29],"therapy":[31,108],"using":[32],"0.6":[33],"mg/kg":[34],"performed":[36],"eligible":[38],"patients":[39,93,117,124,170,184],"within":[40],"3":[41,90],"hours":[42],"onset.":[44],"Patients":[45],"who":[46],"did":[47],"not":[48],"show":[49],"recanalization":[50,130,144,207,210],"1":[54,80,159],"hour":[55],"after":[56,217],"initiation":[58],"immediately":[59],"underwent":[60,118],"MCD.":[61,119],"Clinical":[62],"outcome":[63,216],"evaluated":[65],"by":[66,83,131,192],"National":[67],"Institutes":[68],"Health":[70],"Stroke":[71],"Scale":[72],"(NIHSS)":[73],"score":[74,88,155],"at":[75,89,158,195],"baseline,":[76],"24":[77],"hours,":[78],"and":[79,82,208],"month,":[81],"modified":[84],"Rankin":[85],"scale":[86],"(mRS)":[87],"months.":[91],"Eighteen":[92],"were":[94,176],"initially":[95],"treated":[96,171],"with":[97,100],"rt-PA,":[99],"mean":[101],"time":[102,205],"from":[103,135,162],"stroke":[104,136],"onset":[105,137],"120":[110],"+/-":[111,140],"27":[112],"minutes.":[113,142],"Eight":[114],"these":[116,122],"Seven":[120],"eight":[123],"had":[125,185],"complete":[126],"recanalization.":[127],"Time":[128],"percutaneous":[132],"transluminal":[133],"angioplasty":[134],"258":[139],"59":[141],"Final":[143],"achieved":[146],"16":[148],"18":[151,169],"patients.":[152],"Baseline":[153],"NIHSS":[154],"improved":[156],"significantly":[157],"month":[160],"(median":[161],"22.5":[163],"4).":[165],"Twelve":[166],"according":[172],"our":[174],"protocol":[175],"classified":[177],"as":[178],"independent":[179],"(mRS":[180],"scores":[181],"0-2).":[182],"No":[183],"symptomatic":[186],"hemorrhage.":[187],"MCD":[188],"determined":[191],"end":[197],"infusion":[201],"can":[202],"decrease":[203],"improve":[209],"rates,":[211],"leading":[212],"good":[214],"clinical":[215],"stroke.":[219]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}