{"id":"https://openalex.org/W1998322948","doi":"https://doi.org/10.1371/journal.pntd.0002173","title":"Protective Role of Acetylsalicylic Acid in Experimental Trypanosoma cruzi Infection: Evidence of a 15-epi-Lipoxin A4-Mediated Effect","display_name":"Protective Role of Acetylsalicylic Acid in Experimental Trypanosoma cruzi Infection: Evidence of a 15-epi-Lipoxin A4-Mediated Effect","publication_year":2013,"publication_date":"2013-04-18","ids":{"openalex":"https://openalex.org/W1998322948","doi":"https://doi.org/10.1371/journal.pntd.0002173","mag":"1998322948","pmid":"https://pubmed.ncbi.nlm.nih.gov/23638194","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3630130"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pntd.0002173","doi":"https://doi.org/10.1371/journal.pntd.0002173","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0002173","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0002173&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Neglected Tropical Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0002173&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022214120","display_name":"Alfredo Molina\u2010Berr\u00edos","orcid":"https://orcid.org/0000-0001-8351-3239","observed_orcids":["https://orcid.org/0000-0001-8351-3239"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]},{"id":"https://openalex.org/I911713783","display_name":"Universidad Diego Portales","ror":"https://ror.org/03gtdcg60","country_code":"CL","type":"education","lineage":["https://openalex.org/I911713783"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Alfredo Molina-Berr\u00edos","raw_affiliation_strings":["Molecular and Clinical Pharmacology Program, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile","Centro de Investigaci\u00f3n Biom\u00e9dica, Facultad de Medicina, Universidad Diego Portales, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Clinical Pharmacology Program, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]},{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica, Facultad de Medicina, Universidad Diego Portales, Santiago, Chile","institution_ids":["https://openalex.org/I911713783"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081744545","display_name":"Carolina Campos\u2010Estrada","orcid":"https://orcid.org/0000-0001-8693-7539","observed_orcids":["https://orcid.org/0000-0001-8693-7539"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Carolina Campos-Estrada","raw_affiliation_strings":["Molecular and Clinical Pharmacology Program, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Clinical Pharmacology Program, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031336635","display_name":"Natalia Henriquez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Natalia Henriquez","raw_affiliation_strings":["Molecular and Clinical Pharmacology Program, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Clinical Pharmacology Program, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081586056","display_name":"Mario Fa\u00fandez","orcid":"https://orcid.org/0000-0002-5507-3579","observed_orcids":["https://orcid.org/0000-0002-5507-3579"]},"institutions":[{"id":"https://openalex.org/I162148367","display_name":"Pontificia Universidad Cat\u00f3lica de Chile","ror":"https://ror.org/04teye511","country_code":"CL","type":"education","lineage":["https://openalex.org/I162148367"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Mario Fa\u00fandez","raw_affiliation_strings":["Departamento de Farmacia, Facultad de Qu\u00edmica. Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Farmacia, Facultad de Qu\u00edmica. Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile","institution_ids":["https://openalex.org/I162148367"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009425058","display_name":"Gloria Torres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Gloria Torres","raw_affiliation_strings":["Molecular and Clinical Pharmacology Program, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Clinical Pharmacology Program, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053791243","display_name":"Christian Castillo","orcid":"https://orcid.org/0000-0001-8710-6745","observed_orcids":["https://orcid.org/0000-0001-8710-6745"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Christian Castillo","raw_affiliation_strings":["Anatomy and Developmental Biology Program, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomy and Developmental Biology Program, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009957354","display_name":"Sebasti\u00e1n Escanilla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Sebasti\u00e1n Escanilla","raw_affiliation_strings":["Molecular and Clinical Pharmacology Program, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Clinical Pharmacology Program, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014195930","display_name":"Ulrike Kemmerling","orcid":"https://orcid.org/0000-0002-0201-1665","observed_orcids":["https://orcid.org/0000-0002-0201-1665"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Ulrike Kemmerling","raw_affiliation_strings":["Anatomy and Developmental Biology Program, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomy and Developmental Biology Program, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004016450","display_name":"Antonio Morello","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":false,"raw_author_name":"Antonio Morello","raw_affiliation_strings":["Molecular and Clinical Pharmacology Program, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Clinical Pharmacology Program, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002594078","display_name":"Rodrigo L\u00f3pez\u2010Mu\u00f1oz","orcid":"https://orcid.org/0000-0003-1825-8563","observed_orcids":["https://orcid.org/0000-0003-1825-8563"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":true,"raw_author_name":"Rodrigo A. L\u00f3pez-Mu\u00f1oz","raw_affiliation_strings":["Molecular and Clinical Pharmacology Program, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Clinical Pharmacology Program, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005203865","display_name":"Juan Diego Maya","orcid":"https://orcid.org/0000-0003-3934-6319","observed_orcids":["https://orcid.org/0000-0003-3934-6319"]},"institutions":[{"id":"https://openalex.org/I69737025","display_name":"University of Chile","ror":"https://ror.org/047gc3g35","country_code":"CL","type":"education","lineage":["https://openalex.org/I69737025"]}],"countries":["CL"],"is_corresponding":true,"raw_author_name":"Juan D. Maya","raw_affiliation_strings":["Molecular and Clinical Pharmacology Program, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular and Clinical Pharmacology Program, ICBM, Faculty of Medicine, University of Chile, Santiago, Chile","institution_ids":["https://openalex.org/I69737025"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5002594078","https://openalex.org/A5005203865"],"corresponding_institution_ids":["https://openalex.org/I69737025"],"apc_list":{"value":2670,"currency":"USD","value_usd":2670},"apc_paid":{"value":2670,"currency":"USD","value_usd":2670},"fwci":4.1419,"has_fulltext":true,"cited_by_count":58,"citation_normalized_percentile":{"value":0.94236908,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"7","issue":"4","first_page":"e2173","last_page":"e2173"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.9610000252723694},{"id":"https://openalex.org/keywords/trypanosoma-cruzi","display_name":"Trypanosoma cruzi","score":0.9739999771118164},{"id":"https://openalex.org/keywords/chagas-disease","display_name":"Chagas disease","score":0.9819999933242798},{"id":"https://openalex.org/keywords/lipoxins","display_name":"lipoxins","score":0.9580000042915344},{"id":"https://openalex.org/keywords/cyclooxygenase-inhibition","display_name":"cyclooxygenase inhibition","score":0.8769999742507935},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.6940000057220459},{"id":"https://openalex.org/keywords/5-lipoxygenase","display_name":"5-lipoxygenase","score":0.8230000138282776},{"id":"https://openalex.org/keywords/leukotriene-b4","display_name":"leukotriene B4","score":0.9300000071525574},{"id":"https://openalex.org/keywords/arachidonic-acid-metabolites","display_name":"arachidonic acid metabolites","score":0.9390000104904175},{"id":"https://openalex.org/keywords/cardiac-injury","display_name":"cardiac injury","score":0.8159999847412109},{"id":"https://openalex.org/keywords/parasitemia","display_name":"parasitemia","score":0.984000027179718},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C2777625466","wikidata":"https://www.wikidata.org/wiki/Q150162","display_name":"Trypanosoma cruzi","level":3,"score":0.8607118129730225},{"id":"https://openalex.org/C2775867548","wikidata":"https://www.wikidata.org/wiki/Q1897162","display_name":"Parasitemia","level":4,"score":0.8269644975662231},{"id":"https://openalex.org/C112418997","wikidata":"https://www.wikidata.org/wiki/Q649558","display_name":"Chagas disease","level":2,"score":0.8153756856918335},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6893848776817322},{"id":"https://openalex.org/C2780415110","wikidata":"https://www.wikidata.org/wiki/Q4329","display_name":"Lipoxin","level":3,"score":0.543784499168396},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5339829921722412},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.5255523920059204},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.4903142750263214},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3832909166812897},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37410110235214233},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3448716998100281},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.329861044883728},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.24082985520362854},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.23784363269805908},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1682804822921753},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.14899829030036926},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.09132343530654907},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.08200249075889587},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014349","descriptor_name":"Trypanosoma cruzi","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014349","descriptor_name":"Trypanosoma cruzi","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D014355","descriptor_name":"Chagas Disease","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D044045","descriptor_name":"Lipoxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":14,"locations":[{"id":"doi:10.1371/journal.pntd.0002173","doi":"https://doi.org/10.1371/journal.pntd.0002173","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0002173","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0002173&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Neglected Tropical Diseases","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2641251","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3630130","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:23638194","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23638194","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS neglected tropical diseases","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3630130","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3630130/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Negl Trop Dis","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.816.719","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.816.719","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/32/1f/pntd.0002173.PMC3630130.pdf","raw_type":"text"},{"id":"pmh:oai:americanae.aecid.es:3269259","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3269259","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS NEGLECTED TROPICAL DISEASES","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:americanae.aecid.es:3269260","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3269260","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS NEGLECTED TROPICAL DISEASES","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:americanae.aecid.es:3269262","doi":null,"is_oa":true,"landing_page_url":"http://americanae.aecid.es/americanae/es/registros/registro.do?tipoRegistro=MTD&idBib=3269262","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS NEGLECTED TROPICAL DISEASES","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:b4b4fc8132894227b5cf5bd69ecda939","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/b4b4fc8132894227b5cf5bd69ecda939","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Neglected Tropical Diseases, Vol 7, Iss 4, p e2173 (2013)","raw_type":"article"},{"id":"pmh:oai:localhost:10533/138236","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10533/138236","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS NEGLECTED TROPICAL DISEASES","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:localhost:10533/138237","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10533/138237","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS NEGLECTED TROPICAL DISEASES","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:localhost:10533/138239","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10533/138239","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLOS NEGLECTED TROPICAL DISEASES","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:repositorio.uchile.cl:2250/129302","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.uchile.cl/handle/2250/129302","pdf_url":null,"source":{"id":"https://openalex.org/S4306481413","display_name":"Universidad de Chile","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Art\u00edculo de revista"},{"id":"pmh:oai:repositorio.uchile.cl:2250/165967","doi":null,"is_oa":true,"landing_page_url":"https://repositorio.uchile.cl/handle/2250/165967","pdf_url":null,"source":{"id":"https://openalex.org/S4306481413","display_name":"Universidad de Chile","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Neglected Tropical Diseases","raw_type":"Art\u00edculo de revista"}],"best_oa_location":{"id":"doi:10.1371/journal.pntd.0002173","doi":"https://doi.org/10.1371/journal.pntd.0002173","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0002173","pdf_url":"https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0002173&type=printable","source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Neglected Tropical Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8328767022","display_name":null,"funder_award_id":"U-INICIA VID 2011","funder_id":"https://openalex.org/F4320323458","funder_display_name":"Universidad de Chile"}],"funders":[{"id":"https://openalex.org/F4320323458","display_name":"Universidad de Chile","ror":"https://ror.org/047gc3g35"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1998322948.pdf","grobid_xml":"https://content.openalex.org/works/W1998322948.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W632809972","https://openalex.org/W1619437296","https://openalex.org/W1891720417","https://openalex.org/W1971654593","https://openalex.org/W1972043575","https://openalex.org/W1984499759","https://openalex.org/W1999287819","https://openalex.org/W2005679694","https://openalex.org/W2013087514","https://openalex.org/W2016114644","https://openalex.org/W2020087523","https://openalex.org/W2021934991","https://openalex.org/W2025061417","https://openalex.org/W2025996759","https://openalex.org/W2027584864","https://openalex.org/W2049102964","https://openalex.org/W2052436251","https://openalex.org/W2063524276","https://openalex.org/W2068550114","https://openalex.org/W2068816698","https://openalex.org/W2085868451","https://openalex.org/W2086902920","https://openalex.org/W2089404895","https://openalex.org/W2106223276","https://openalex.org/W2111253176","https://openalex.org/W2112374648","https://openalex.org/W2113203684","https://openalex.org/W2113313714","https://openalex.org/W2127604161","https://openalex.org/W2154840430","https://openalex.org/W2161315258","https://openalex.org/W2162592603","https://openalex.org/W2162985177","https://openalex.org/W2164966838","https://openalex.org/W2167086755","https://openalex.org/W2168459963","https://openalex.org/W2170398222","https://openalex.org/W2223739663","https://openalex.org/W2254057616","https://openalex.org/W2955504961"],"related_works":["https://openalex.org/W2154840430","https://openalex.org/W7096530405","https://openalex.org/W1588901081","https://openalex.org/W4402266179","https://openalex.org/W1721330486","https://openalex.org/W2052166129","https://openalex.org/W2615267021","https://openalex.org/W7098377337","https://openalex.org/W2771937855","https://openalex.org/W2755330752"],"abstract_inverted_index":{"Chagas'":[0],"disease,":[1],"produced":[2],"by":[3],"Trypanosoma":[4],"cruzi,":[5],"affects":[6],"more":[7],"than":[8],"8":[9],"million":[10],"people,":[11],"producing":[12],"approximately":[13],"10,000":[14],"deaths":[15],"each":[16],"year":[17],"in":[18,111,113,135,191,194,206,218,246,253,273,289],"Latin":[19],"America.":[20],"Migration":[21],"of":[22,34,61,78,93,106,116,124,145,159,180,216,228,260,270,282,293],"people":[23],"from":[24],"endemic":[25],"regions":[26],"to":[27,49,102,173],"developed":[28],"countries":[29],"has":[30],"expanded":[31],"the":[32,59,76,91,104,122,142,155,174,178,225,231,250,254,264,268,280,290,294],"risk":[33],"infection,":[35],"transforming":[36],"this":[37,151,169,283],"disease":[38],"into":[39],"a":[40,68,96,257],"globally":[41],"emerging":[42],"problem.":[43],"PGE\u2082":[44],"and":[45,88,118,132,147,161,183,198,243,248],"other":[46],"eicosanoids":[47],"contribute":[48],"cardiac":[50,244],"functional":[51],"deficits":[52],"after":[53],"infection":[54,85,117],"with":[55,121,224,256],"T.":[56,83,136,219,274],"cruzi.":[57],"Thus,":[58],"inhibition":[60],"host":[62],"cyclooxygenase":[63],"(COX)":[64],"enzyme":[65],"emerges":[66],"as":[67,285],"potential":[69],"therapeutic":[70],"target.":[71],"In":[72],"vivo":[73,114,247],"studies":[74],"about":[75],"effect":[77,92,105,152],"acetylsalicylic":[79],"acid":[80,126],"(ASA)":[81],"upon":[82],"cruzi":[84,137,220,275],"are":[86],"controversial,":[87],"always":[89],"report":[90,266],"ASA":[94,107,128,157,233],"at":[95,108,141],"single":[97],"dose.":[98],"Therefore,":[99],"we":[100,185,201],"aimed":[101],"analyze":[103],"different":[109],"doses":[110,144,158,227,234],"an":[112,189,204,286],"model":[115],"correlate":[119],"it":[120],"production":[123,179,193,269],"arachidonic":[125],"metabolites.":[127],"decreased":[129,235],"mortality,":[130,242],"parasitemia,":[131,241],"heart":[133],"damage":[134],"(Dm28c)":[138],"infected":[139,195,221,276],"mice,":[140,277],"low":[143,226],"25":[146],"50":[148],"mg/Kg.":[149],"However,":[150],"disappeared":[153],"when":[154],"high":[156,214,232,258],"75":[160],"100":[162],"mg/Kg":[163],"were":[164],"used.":[165],"We":[166,211],"explored":[167],"whether":[168],"observation":[170],"was":[171],"related":[172],"metabolic":[175],"shift":[176],"toward":[177],"5-lipoxygenase":[181],"derivatives,":[182],"although":[184],"did":[186,202],"not":[187],"observe":[188],"increase":[190,205],"LTB4":[192],"RAW":[196],"cells":[197],"mice":[199,222],"infected,":[200],"find":[203],"15-epi-LXA\u2084":[207,217,236,239],"(an":[208],"ASA-triggered":[209,271],"lipoxin).":[210],"also":[212],"found":[213],"levels":[215],"treated":[223],"ASA,":[229],"while":[230],"levels.":[237],"Importantly,":[238],"prevented":[240],"changes":[245],"restored":[249],"protective":[251],"role":[252,281],"treatment":[255],"dose":[259],"ASA.":[261],"This":[262],"is":[263],"first":[265],"showing":[267],"lipoxins":[272],"which":[278],"demonstrates":[279],"lipid":[284],"anti-inflammatory":[287],"molecule":[288],"acute":[291],"phase":[292],"disease.":[295]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}