{"id":"https://openalex.org/W1998308376","doi":"https://doi.org/10.1016/j.bbrc.2005.03.190","title":"p53 mutation heterogeneity in cancer","display_name":"p53 mutation heterogeneity in cancer","publication_year":2005,"publication_date":"2005-04-15","ids":{"openalex":"https://openalex.org/W1998308376","doi":"https://doi.org/10.1016/j.bbrc.2005.03.190","mag":"1998308376","pmid":"https://pubmed.ncbi.nlm.nih.gov/15865939"},"language":"en","primary_location":{"id":"doi:10.1016/j.bbrc.2005.03.190","doi":"https://doi.org/10.1016/j.bbrc.2005.03.190","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2005.03.190","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074017962","display_name":"Thierry Soussi","orcid":"https://orcid.org/0000-0001-8184-3293","observed_orcids":["https://orcid.org/0000-0001-8184-3293"]},"institutions":[{"id":"https://openalex.org/I4210166768","display_name":"H\u00f4pital Tenon","ror":"https://ror.org/05h5v3c50","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210166768"]},{"id":"https://openalex.org/I4405264447","display_name":"Universit\u00e9 Pierre-et-Marie-Curie","ror":"https://ror.org/01yvrd251","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081","https://openalex.org/I4405264447"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"T. Soussi","raw_affiliation_strings":["Laboratoire de G\u00e9notoxicologie des tumeurs, EA3493 IC-UPMC, H\u00f4pital Tenon, Dpt Pneumologie, 26 rue d'Ulm, 75005 Paris, France. thierry.soussi@free.fr","Laboratoire de G\u00e9notoxicologie des tumeurs, EA3493 IC-UPMC, H\u00f4pital Tenon, Dpt Pneumologie, 26 rue d\u2019Ulm, 75005 Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire de G\u00e9notoxicologie des tumeurs, EA3493 IC-UPMC, H\u00f4pital Tenon, Dpt Pneumologie, 26 rue d'Ulm, 75005 Paris, France. thierry.soussi@free.fr","institution_ids":["https://openalex.org/I4210166768","https://openalex.org/I4405264447"]},{"raw_affiliation_string":"Laboratoire de G\u00e9notoxicologie des tumeurs, EA3493 IC-UPMC, H\u00f4pital Tenon, Dpt Pneumologie, 26 rue d\u2019Ulm, 75005 Paris, France","institution_ids":["https://openalex.org/I4210166768","https://openalex.org/I4405264447"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076622040","display_name":"Guillermina Lozano","orcid":"https://orcid.org/0000-0001-8985-4886","observed_orcids":["https://orcid.org/0000-0001-8985-4886"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. Lozano","raw_affiliation_strings":["Section of Cancer Genetics, Department of Molecular Genetics, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA","Genetics"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cancer Genetics, Department of Molecular Genetics, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Genetics","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5074017962"],"corresponding_institution_ids":["https://openalex.org/I4210166768","https://openalex.org/I4405264447"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":2.8878,"has_fulltext":false,"cited_by_count":275,"citation_normalized_percentile":{"value":0.93405601,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"331","issue":"3","first_page":"834","last_page":"842"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8619999885559082},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.9269999861717224},{"id":"https://openalex.org/keywords/mutational-heterogeneity","display_name":"mutational heterogeneity","score":0.8550000190734863},{"id":"https://openalex.org/keywords/missense-mutations","display_name":"missense mutations","score":0.8370000123977661},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.972000002861023},{"id":"https://openalex.org/keywords/genotoxic-stress-response","display_name":"genotoxic stress response","score":0.7269999980926514},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.5619999766349792},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.9539999961853027},{"id":"https://openalex.org/keywords/oncogenic-activity","display_name":"oncogenic activity","score":0.7020000219345093},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7670000195503235},{"id":"https://openalex.org/keywords/cell-transformation","display_name":"cell transformation","score":0.8690000176429749}],"concepts":[{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6843653917312622},{"id":"https://openalex.org/C75563809","wikidata":"https://www.wikidata.org/wiki/Q2656896","display_name":"Missense mutation","level":4,"score":0.6208797693252563},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.617362380027771},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6113529801368713},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6058967113494873},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.5947250127792358},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5597655177116394},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5014262199401855},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.44312524795532227},{"id":"https://openalex.org/C3020813896","wikidata":"https://www.wikidata.org/wiki/Q283350","display_name":"P53 protein","level":3,"score":0.4309084117412567},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4233921468257904},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4196932315826416},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.2148982584476471}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016147","descriptor_name":"Genes, Tumor Suppressor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016158","descriptor_name":"Genes, p53","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018740","descriptor_name":"Genetic Heterogeneity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018740","descriptor_name":"Genetic Heterogeneity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018740","descriptor_name":"Genetic Heterogeneity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bbrc.2005.03.190","doi":"https://doi.org/10.1016/j.bbrc.2005.03.190","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bbrc.2005.03.190","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:15865939","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15865939","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8100000023841858}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":74,"referenced_works":["https://openalex.org/W1490290866","https://openalex.org/W1545495395","https://openalex.org/W1552426876","https://openalex.org/W1564956131","https://openalex.org/W1650797637","https://openalex.org/W1650984530","https://openalex.org/W1760393685","https://openalex.org/W1964178865","https://openalex.org/W1970378023","https://openalex.org/W1971274526","https://openalex.org/W1977617512","https://openalex.org/W1980810506","https://openalex.org/W1986233163","https://openalex.org/W1987783969","https://openalex.org/W1992760686","https://openalex.org/W1998008917","https://openalex.org/W1998543370","https://openalex.org/W1998559412","https://openalex.org/W2002292653","https://openalex.org/W2007978091","https://openalex.org/W2008220860","https://openalex.org/W2008257691","https://openalex.org/W2013743651","https://openalex.org/W2018552508","https://openalex.org/W2034882416","https://openalex.org/W2038619560","https://openalex.org/W2042042897","https://openalex.org/W2043912950","https://openalex.org/W2044079387","https://openalex.org/W2047596219","https://openalex.org/W2049137769","https://openalex.org/W2063669247","https://openalex.org/W2074222004","https://openalex.org/W2076149108","https://openalex.org/W2078109925","https://openalex.org/W2078242867","https://openalex.org/W2079852484","https://openalex.org/W2081540197","https://openalex.org/W2087732778","https://openalex.org/W2088740611","https://openalex.org/W2089623038","https://openalex.org/W2093865758","https://openalex.org/W2094117733","https://openalex.org/W2096276671","https://openalex.org/W2108966286","https://openalex.org/W2109328121","https://openalex.org/W2109825478","https://openalex.org/W2114980992","https://openalex.org/W2118530896","https://openalex.org/W2126679757","https://openalex.org/W2130521757","https://openalex.org/W2130721894","https://openalex.org/W2132440722","https://openalex.org/W2135360650","https://openalex.org/W2138068224","https://openalex.org/W2139986038","https://openalex.org/W2146642286","https://openalex.org/W2151085515","https://openalex.org/W2159021709","https://openalex.org/W2160345685","https://openalex.org/W2162320351","https://openalex.org/W2167184679","https://openalex.org/W2170645943","https://openalex.org/W2172142216","https://openalex.org/W2223661640","https://openalex.org/W2312641146","https://openalex.org/W2322456862","https://openalex.org/W2411092595","https://openalex.org/W2732727695","https://openalex.org/W6632976546","https://openalex.org/W6633850501","https://openalex.org/W6683516901","https://openalex.org/W6685183203","https://openalex.org/W6685253425"],"related_works":["https://openalex.org/W4247184542","https://openalex.org/W2017449972","https://openalex.org/W1588821132","https://openalex.org/W156957756","https://openalex.org/W2135918756","https://openalex.org/W2904049988","https://openalex.org/W4220746635","https://openalex.org/W1529921298","https://openalex.org/W2098536240","https://openalex.org/W2129099369"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":23}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
