{"id":"https://openalex.org/W1998301733","doi":"https://doi.org/10.1074/jbc.270.38.22329","title":"Vma22p Is a Novel Endoplasmic Reticulum-associated Protein Required for Assembly of the Yeast Vacuolar H+-ATPase Complex","display_name":"Vma22p Is a Novel Endoplasmic Reticulum-associated Protein Required for Assembly of the Yeast Vacuolar H+-ATPase Complex","publication_year":1995,"publication_date":"1995-09-01","ids":{"openalex":"https://openalex.org/W1998301733","doi":"https://doi.org/10.1074/jbc.270.38.22329","mag":"1998301733","pmid":"https://pubmed.ncbi.nlm.nih.gov/7673216"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.270.38.22329","doi":"https://doi.org/10.1074/jbc.270.38.22329","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.270.38.22329","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.270.38.22329","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038663511","display_name":"Kathryn J. Hill","orcid":"https://orcid.org/0000-0002-6061-6208","observed_orcids":["https://orcid.org/0000-0002-6061-6208"]},"institutions":[{"id":"https://openalex.org/I181233156","display_name":"University of Oregon","ror":"https://ror.org/0293rh119","country_code":"US","type":"education","lineage":["https://openalex.org/I181233156"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn J. Hill","raw_affiliation_strings":["Institute of Molecular Biology, University of Oregon, Eugene 97403-1229, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, University of Oregon, Eugene 97403-1229, USA","institution_ids":["https://openalex.org/I181233156"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026009753","display_name":"Tom H. Stevens","orcid":"https://orcid.org/0000-0001-6427-6848","observed_orcids":["https://orcid.org/0000-0001-6427-6848"]},"institutions":[{"id":"https://openalex.org/I181233156","display_name":"University of Oregon","ror":"https://ror.org/0293rh119","country_code":"US","type":"education","lineage":["https://openalex.org/I181233156"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Tom H. Stevens","raw_affiliation_strings":["Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403-1229","From the Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403-1229"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403-1229","institution_ids":["https://openalex.org/I181233156"]},{"raw_affiliation_string":"From the Institute of Molecular Biology, University of Oregon, Eugene, Oregon 97403-1229","institution_ids":["https://openalex.org/I181233156"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026009753"],"corresponding_institution_ids":["https://openalex.org/I181233156"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.5562,"has_fulltext":false,"cited_by_count":63,"citation_normalized_percentile":{"value":0.82940315,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"270","issue":"38","first_page":"22329","last_page":"22336"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vacuolar-h-atpase","display_name":"vacuolar H+-ATPase","score":0.9279999732971191},{"id":"https://openalex.org/keywords/v-atpase-assembly","display_name":"V-ATPase assembly","score":0.9559999704360962},{"id":"https://openalex.org/keywords/endoplasmic-reticulum","display_name":"endoplasmic reticulum","score":0.875},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.6209999918937683},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.8949999809265137},{"id":"https://openalex.org/keywords/er-membrane-proteins","display_name":"ER membrane proteins","score":0.5830000042915344},{"id":"https://openalex.org/keywords/protein-complex-assembly","display_name":"protein complex formation","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.7910072803497314},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.7556669116020203},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.7009633779525757},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.645847499370575},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.6150078773498535},{"id":"https://openalex.org/C191678065","wikidata":"https://www.wikidata.org/wiki/Q7905656","display_name":"V-ATPase","level":4,"score":0.5979052782058716},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.5268065929412842},{"id":"https://openalex.org/C686708","wikidata":"https://www.wikidata.org/wiki/Q5423609","display_name":"F-ATPase","level":5,"score":0.5011157989501953},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4991006851196289},{"id":"https://openalex.org/C161200384","wikidata":"https://www.wikidata.org/wiki/Q1757382","display_name":"Integral membrane protein","level":4,"score":0.49698594212532043},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.490548312664032},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47487160563468933},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.368130624294281},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.30318695306777954},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.29478228092193604},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.29013359546661377},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2561265826225281},{"id":"https://openalex.org/C101692577","wikidata":"https://www.wikidata.org/wiki/Q337889","display_name":"Thylakoid","level":4,"score":0.0},{"id":"https://openalex.org/C69305403","wikidata":"https://www.wikidata.org/wiki/Q47263","display_name":"Chloroplast","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005656","descriptor_name":"Fungal Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006180","descriptor_name":"Proton-Translocating ATPases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018832","descriptor_name":"Molecular Chaperones","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046911","descriptor_name":"Macromolecular Substances","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.270.38.22329","doi":"https://doi.org/10.1074/jbc.270.38.22329","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.270.38.22329","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:7673216","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7673216","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.270.38.22329","doi":"https://doi.org/10.1074/jbc.270.38.22329","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.270.38.22329","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2752659093","display_name":"Sorting and Transport of Yeast Membrane Proteins","funder_award_id":"R01GM038006","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W160422442","https://openalex.org/W1481801182","https://openalex.org/W1494174270","https://openalex.org/W1497077766","https://openalex.org/W1497289365","https://openalex.org/W1509504914","https://openalex.org/W1521277810","https://openalex.org/W1526043578","https://openalex.org/W1535147323","https://openalex.org/W1535401962","https://openalex.org/W1537141010","https://openalex.org/W1556265505","https://openalex.org/W1559639924","https://openalex.org/W1573088096","https://openalex.org/W1578803116","https://openalex.org/W1580000922","https://openalex.org/W1581013366","https://openalex.org/W1582076669","https://openalex.org/W1592537807","https://openalex.org/W1600651336","https://openalex.org/W1631725776","https://openalex.org/W1643128520","https://openalex.org/W1687563194","https://openalex.org/W1747506719","https://openalex.org/W1851054717","https://openalex.org/W1854614617","https://openalex.org/W1873059855","https://openalex.org/W1914964702","https://openalex.org/W1940939086","https://openalex.org/W1981862236","https://openalex.org/W1989324307","https://openalex.org/W1989526931","https://openalex.org/W2020141062","https://openalex.org/W2027662766","https://openalex.org/W2052562460","https://openalex.org/W2055043387","https://openalex.org/W2056037336","https://openalex.org/W2062872843","https://openalex.org/W2064773838","https://openalex.org/W2081118837","https://openalex.org/W2082402874","https://openalex.org/W2110522042","https://openalex.org/W2118562402","https://openalex.org/W2124006800","https://openalex.org/W2138270253","https://openalex.org/W2151585536","https://openalex.org/W2158561703","https://openalex.org/W2167837958","https://openalex.org/W2169333620","https://openalex.org/W2170055655","https://openalex.org/W2174160083","https://openalex.org/W2416123939","https://openalex.org/W2888511473"],"related_works":["https://openalex.org/W2098135462","https://openalex.org/W2039440442","https://openalex.org/W2158561703","https://openalex.org/W2139465069","https://openalex.org/W2257692174","https://openalex.org/W2048105144","https://openalex.org/W4318765538","https://openalex.org/W176006312","https://openalex.org/W1537141010","https://openalex.org/W2091181826"],"abstract_inverted_index":{"The":[0,25,89,116],"Saccharomyces":[1],"cerevisiae":[2],"vacuolar":[3],"H(+)-ATPase":[4],"(V-ATPase)":[5],"is":[6,66,96,102,111,139],"a":[7,31,48,97,104,129,156],"multi-subunit":[8],"complex":[9],"that":[10,101,131,138,148],"can":[11],"be":[12],"structurally":[13],"and":[14,20,61,153],"functionally":[15],"divided":[16],"into":[17],"peripheral":[18],"(V1)":[19],"integral":[21,73],"membrane":[22,74,135],"(V0)":[23],"sectors.":[24],"vma22-1":[26],"mutation":[27],"was":[28,76,123],"isolated":[29],"in":[30,36,58,80,127],"screen":[32],"for":[33,142,162],"mutants":[34],"defective":[35],"V-ATPase":[37,44,108,143,163],"function":[38],"vma22":[39,86],"delta":[40,87],"cells":[41],"contain":[42],"no":[43],"activity":[45],"due":[46],"to":[47,50,78],"failure":[49],"assemble":[51],"the":[52,59,62,71,81,92,107],"enzyme":[53],"complex;":[54],"V1":[55],"subunits":[56],"accumulate":[57],"cytosol,":[60],"V0":[63],"100-kDa":[64,72],"subunit":[65,105],"rapidly":[67],"degraded.":[68],"Turnover":[69],"of":[70,85,91,106,118,158],"protein":[75,100,136],"found":[77],"occur":[79],"endoplasmic":[82],"reticulum":[83],"(ER)":[84],"cells.":[88],"product":[90],"VMA22":[93],"gene,":[94],"Vma22p,":[95,149],"21-kDa":[98],"hydrophilic":[99],"not":[103],"but":[109],"rather":[110],"associated":[112],"with":[113,120,151],"ER":[114,121,134,159],"membranes.":[115],"association":[117],"Vma22p":[119],"membranes":[122],"perturbed":[124],"by":[125],"mutations":[126],"VMA12,":[128],"gene":[130],"encodes":[132],"an":[133],"(Vma12p)":[137],"also":[140],"required":[141,161],"assembly.":[144,164],"These":[145],"results":[146],"indicate":[147],"along":[150],"Vma21p":[152],"Vma12p,":[154],"form":[155],"set":[157],"proteins":[160]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}