{"id":"https://openalex.org/W1998296446","doi":"https://doi.org/10.1073/pnas.87.1.123","title":"Pasteurella multocida toxin: potent mitogen for cultured fibroblasts.","display_name":"Pasteurella multocida toxin: potent mitogen for cultured fibroblasts.","publication_year":1990,"publication_date":"1990-01-01","ids":{"openalex":"https://openalex.org/W1998296446","doi":"https://doi.org/10.1073/pnas.87.1.123","mag":"1998296446","pmid":"https://pubmed.ncbi.nlm.nih.gov/2153282","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/53212"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.87.1.123","doi":"https://doi.org/10.1073/pnas.87.1.123","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.87.1.123","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC53212","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077935609","display_name":"Enrique Rozengurt","orcid":"https://orcid.org/0000-0002-7838-9170","observed_orcids":["https://orcid.org/0000-0002-7838-9170"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Rozengurt","raw_affiliation_strings":["Imperial Cancer Research Fund, Lincoln's Inn Fields, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial Cancer Research Fund, Lincoln's Inn Fields, London, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039215706","display_name":"Theresa Higgins","orcid":"https://orcid.org/0009-0003-6843-3611","observed_orcids":["https://orcid.org/0009-0003-6843-3611"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Higgins","raw_affiliation_strings":["Imperial Cancer Research Fund, Lincoln's Inn Fields, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial Cancer Research Fund, Lincoln's Inn Fields, London, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006189505","display_name":"N. Chanter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Chanter","raw_affiliation_strings":["Imperial Cancer Research Fund, Lincoln's Inn Fields, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial Cancer Research Fund, Lincoln's Inn Fields, London, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005941734","display_name":"Alistair J. Lax","orcid":"https://orcid.org/0000-0002-1424-5071","observed_orcids":["https://orcid.org/0000-0002-1424-5071"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A J Lax","raw_affiliation_strings":["Imperial Cancer Research Fund, Lincoln's Inn Fields, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial Cancer Research Fund, Lincoln's Inn Fields, London, United Kingdom","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013632436","display_name":"James M. Staddon","orcid":"https://orcid.org/0000-0003-2422-3674","observed_orcids":["https://orcid.org/0000-0003-2422-3674"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J M Staddon","raw_affiliation_strings":["Imperial Cancer Research Fund, Lincoln's Inn Fields, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Imperial Cancer Research Fund, Lincoln's Inn Fields, London, United Kingdom","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.1381,"has_fulltext":false,"cited_by_count":129,"citation_normalized_percentile":{"value":0.8801584,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"87","issue":"1","first_page":"123","last_page":"127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.4839000105857849,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.4839000105857849,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11688","display_name":"Microbial infections and disease research","score":0.22360000014305115,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.08640000224113464,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pasteurella-multocida-toxin","display_name":"Pasteurella multocida toxin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mitogens","display_name":"mitogens","score":0.6710000038146973},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.8479999899864197},{"id":"https://openalex.org/keywords/dna-synthesis","display_name":"DNA synthesis","score":0.8199999928474426},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/heat-labile-toxin","display_name":"heat-labile toxin","score":0.7360000014305115},{"id":"https://openalex.org/keywords/antiserum-inhibition","display_name":"antiserum inhibition","score":0.6759999990463257},{"id":"https://openalex.org/keywords/methylamine","display_name":"methylamine","score":0.8029999732971191},{"id":"https://openalex.org/keywords/temperature-dependence","display_name":"temperature dependence","score":0.5989999771118164},{"id":"https://openalex.org/keywords/acidic-compartments","display_name":"acidic compartments","score":0.5170000195503235},{"id":"https://openalex.org/keywords/inositol-phosphates","display_name":"inositol phosphates","score":0.9670000076293945},{"id":"https://openalex.org/keywords/camp","display_name":"cyclic AMP","score":0.984000027179718},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.6110000014305115},{"id":"https://openalex.org/keywords/toxin-internalization","display_name":"toxin internalization","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C64241487","wikidata":"https://www.wikidata.org/wiki/Q5205774","display_name":"DNA synthesis","level":3,"score":0.7430716753005981},{"id":"https://openalex.org/C2776796551","wikidata":"https://www.wikidata.org/wiki/Q310656","display_name":"Pasteurella multocida","level":3,"score":0.6576951742172241},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.569463849067688},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5462247729301453},{"id":"https://openalex.org/C2776746612","wikidata":"https://www.wikidata.org/wiki/Q68153243","display_name":"3T3 cells","level":4,"score":0.5042318105697632},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5040794610977173},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5003409385681152},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.50002121925354},{"id":"https://openalex.org/C2779404806","wikidata":"https://www.wikidata.org/wiki/Q488614","display_name":"Fetal bovine serum","level":3,"score":0.4684206247329712},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4403592646121979},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.41530150175094604},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3448973298072815},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.329010546207428},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2725646495819092},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.12054586410522461},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.10168871283531189},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.09820553660392761},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004261","descriptor_name":"DNA Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004355","descriptor_name":"Drug Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006133","descriptor_name":"Growth Substances","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006358","descriptor_name":"Hot Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007295","descriptor_name":"Inositol Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008744","descriptor_name":"Methylamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008934","descriptor_name":"Mitogens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1073/pnas.87.1.123","doi":"https://doi.org/10.1073/pnas.87.1.123","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.87.1.123","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:47283","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC53212","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:53212","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/53212","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:2153282","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2153282","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:47283","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC53212","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.4000000059604645}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W71372952","https://openalex.org/W1507197838","https://openalex.org/W1565712124","https://openalex.org/W1865495976","https://openalex.org/W1982186695","https://openalex.org/W1992472345","https://openalex.org/W2023838194","https://openalex.org/W2047453707","https://openalex.org/W2071335049","https://openalex.org/W2095234199","https://openalex.org/W2106449644","https://openalex.org/W2119491400","https://openalex.org/W2122965320","https://openalex.org/W2136189765","https://openalex.org/W2138352514","https://openalex.org/W2138466097","https://openalex.org/W2144239810","https://openalex.org/W2148704930","https://openalex.org/W2238363303","https://openalex.org/W4407201290"],"related_works":["https://openalex.org/W1581634192","https://openalex.org/W2159350304","https://openalex.org/W2036450918","https://openalex.org/W2292943466","https://openalex.org/W1971954477","https://openalex.org/W1581692215","https://openalex.org/W2004522910","https://openalex.org/W2048396934","https://openalex.org/W2080535706","https://openalex.org/W1488612260"],"abstract_inverted_index":{"Native":[0],"Pasteurella":[1],"multocida":[2],"toxin":[3,73,159],"(PMT)":[4],"is":[5],"shown":[6],"to":[7,46,104,139],"be":[8],"an":[9,168],"extremely":[10],"potent":[11,77],"mitogen":[12,78],"for":[13,31,79],"Swiss":[14,119,199],"3T3":[15,83,120,200],"fibroblasts.":[16,93],"Half-maximal":[17],"stimulation":[18,154],"of":[19,26,40,62,97,117,128,136,155,183,195,204,220],"DNA":[20,42,107,156],"synthesis":[21,43,108],"was":[22,44,56,67,74,99,130],"obtained":[23],"at":[24,141,147,173],"concentrations":[25],"1":[27],"and":[28,35,81,87,165],"2":[29],"pM":[30],"recombinant":[32],"PMT":[33,105],"(rPMT)":[34],"PMT,":[36],"respectively.":[37],"The":[38,72,94,171,202],"degree":[39],"rPMT-induced":[41],"comparable":[45],"that":[47],"elicited":[48],"by":[49,70],"10%":[50],"fetal":[51],"bovine":[52],"serum":[53],"and,":[54],"moreover,":[55],"observed":[57],"in":[58,152,180,198,217],"the":[59,118,137,181,192,218],"complete":[60],"absence":[61],"other":[63],"factors.":[64],"Cell":[65],"proliferation":[66],"also":[68,75,131],"enhanced":[69],"rPMT.":[71,123],"a":[76,153,177,209],"BALB/c":[80],"NIH":[82],"cells,":[84,86],"3T6":[85],"tertiary":[88],"mouse":[89],"embryo":[90],"or":[91],"human":[92],"mitogenic":[95,174],"activity":[96],"rPMT":[98,140,188,205],"heat-labile.":[100],"A":[101,124],"polyclonal":[102],"antiserum":[103],"inhibited":[106],"when":[109],"added":[110],"early,":[111],"but":[112,145],"not":[113,146,190],"late,":[114],"during":[115],"treatment":[116],"cells":[121,138],"with":[122],"similar":[125],"time-dependent":[126],"action":[127,160,206],"methylamine":[129],"observed.":[132],"Furthermore,":[133],"transient":[134],"exposure":[135],"37":[142],"degrees":[143,149],"C,":[144,150],"4":[148],"resulted":[151],"synthesis.":[157],"Thus,":[158],"may":[161,207],"require":[162],"cell":[163,221],"entry":[164],"processing":[166],"via":[167],"acidic":[169],"compartment.":[170],"toxin,":[172],"concentrations,":[175],"caused":[176],"large":[178],"increase":[179,191],"production":[182],"inositol":[184],"phosphates.":[185],"In":[186],"contrast,":[187],"did":[189],"intracellular":[193],"concentration":[194],"cyclic":[196],"AMP":[197],"cells.":[201],"basis":[203],"afford":[208],"unique":[210],"insight":[211],"into":[212],"molecular":[213],"signaling":[214],"events":[215],"involved":[216],"control":[219],"proliferation.":[222]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}