{"id":"https://openalex.org/W1998289697","doi":"https://doi.org/10.1021/bi0612723","title":"Structural Properties of Prion Protein Protofibrils and Fibrils: An Experimental Assessment of Atomic Models","display_name":"Structural Properties of Prion Protein Protofibrils and Fibrils: An Experimental Assessment of Atomic Models","publication_year":2006,"publication_date":"2006-12-01","ids":{"openalex":"https://openalex.org/W1998289697","doi":"https://doi.org/10.1021/bi0612723","mag":"1998289697","pmid":"https://pubmed.ncbi.nlm.nih.gov/17176078"},"language":"en","primary_location":{"id":"doi:10.1021/bi0612723","doi":"https://doi.org/10.1021/bi0612723","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi0612723","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086536084","display_name":"Mari L. DeMarco","orcid":"https://orcid.org/0000-0001-9281-9547","observed_orcids":["https://orcid.org/0000-0001-9281-9547"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4405287673","display_name":"Rocky Mountain Laboratories","ror":"https://ror.org/05v7g7w67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mari L. DeMarco","raw_affiliation_strings":["Department of Medicinal Chemistry, Biomolecular Structure and Design Program, University of Washington, Seattle, Washington 98195-7610, and Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Biomolecular Structure and Design Program, University of Washington, Seattle, Washington 98195-7610, and Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I201448701","https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109150076","display_name":"Jay R. Silveira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4405287673","display_name":"Rocky Mountain Laboratories","ror":"https://ror.org/05v7g7w67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay Silveira","raw_affiliation_strings":["Department of Medicinal Chemistry, Biomolecular Structure and Design Program, University of Washington, Seattle, Washington 98195-7610, and Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Biomolecular Structure and Design Program, University of Washington, Seattle, Washington 98195-7610, and Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I201448701","https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015110041","display_name":"Byron W. Caughey","orcid":"https://orcid.org/0000-0002-3928-6101","observed_orcids":["https://orcid.org/0000-0002-3928-6101"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4405287673","display_name":"Rocky Mountain Laboratories","ror":"https://ror.org/05v7g7w67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Byron Caughey","raw_affiliation_strings":["Department of Medicinal Chemistry, Biomolecular Structure and Design Program, University of Washington, Seattle, Washington 98195-7610, and Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Biomolecular Structure and Design Program, University of Washington, Seattle, Washington 98195-7610, and Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I201448701","https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021239442","display_name":"Valerie Daggett","orcid":"https://orcid.org/0000-0002-5116-6102","observed_orcids":["https://orcid.org/0000-0002-5116-6102"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]},{"id":"https://openalex.org/I4405287673","display_name":"Rocky Mountain Laboratories","ror":"https://ror.org/05v7g7w67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Valerie Daggett","raw_affiliation_strings":["Department of Medicinal Chemistry, Biomolecular Structure and Design Program, University of Washington, Seattle, Washington 98195-7610, and Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, Biomolecular Structure and Design Program, University of Washington, Seattle, Washington 98195-7610, and Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana 59840","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I201448701","https://openalex.org/I4210134534","https://openalex.org/I4405287673"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5021239442"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I201448701","https://openalex.org/I4210134534","https://openalex.org/I4405287673"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":2.2456,"has_fulltext":false,"cited_by_count":72,"citation_normalized_percentile":{"value":0.87141526,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"45","issue":"51","first_page":"15573","last_page":"15582"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prion-protein","display_name":"prion protein","score":0.9990000128746033},{"id":"https://openalex.org/keywords/prion-fibrils","display_name":"prion fibrils","score":0.8050000071525574},{"id":"https://openalex.org/keywords/prion-disease","display_name":"prion disease","score":0.921999990940094},{"id":"https://openalex.org/keywords/spiral-model","display_name":"spiral model","score":0.8220000267028809},{"id":"https://openalex.org/keywords/atomic-models","display_name":"atomic models","score":0.5529999732971191},{"id":"https://openalex.org/keywords/amyloid-fibril-formation","display_name":"amyloid fibril formation","score":0.5699999928474426},{"id":"https://openalex.org/keywords/epitope-exposure","display_name":"epitope exposure","score":0.7879999876022339},{"id":"https://openalex.org/keywords/enzymatic-digestion","display_name":"enzymatic digestion","score":0.6830000281333923},{"id":"https://openalex.org/keywords/disaggregation","display_name":"disaggregation","score":0.5460000038146973},{"id":"https://openalex.org/keywords/protein-misfolding","display_name":"protein misfolding","score":0.7459999918937683},{"id":"https://openalex.org/keywords/prion-toxicity","display_name":"prion toxicity","score":0.5289999842643738}],"concepts":[{"id":"https://openalex.org/C3019804061","wikidata":"https://www.wikidata.org/wiki/Q14881255","display_name":"Prion protein","level":3,"score":0.6967010498046875},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5108813643455505},{"id":"https://openalex.org/C27523624","wikidata":"https://www.wikidata.org/wiki/Q14860849","display_name":"Fibril","level":2,"score":0.49907708168029785},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.47747111320495605},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4725337326526642},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4712570011615753},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4492010474205017},{"id":"https://openalex.org/C200307862","wikidata":"https://www.wikidata.org/wiki/Q7797175","display_name":"Threading (protein sequence)","level":3,"score":0.4468103349208832},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36372172832489014},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23552319407463074},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08042493462562561},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000686","descriptor_name":"Amyloidosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008647","descriptor_name":"Mesocricetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017434","descriptor_name":"Protein Structure, Tertiary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017510","descriptor_name":"Protein Folding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018620","descriptor_name":"PrPSc Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D018620","descriptor_name":"PrPSc Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D018621","descriptor_name":"PrPC Proteins","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D018621","descriptor_name":"PrPC Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020894","descriptor_name":"Microfibrils","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D021122","descriptor_name":"Protein Subunits","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057927","descriptor_name":"Hydrophobic and Hydrophilic Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bi0612723","doi":"https://doi.org/10.1021/bi0612723","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bi0612723","pdf_url":null,"source":{"id":"https://openalex.org/S104038378","display_name":"Biochemistry","issn_l":"0006-2960","issn":["0006-2960","1520-4995","1943-295X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"journal-article"},{"id":"pmid:17176078","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17176078","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1858193389","display_name":null,"funder_award_id":"GM-50789","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7443692255","display_name":"Drug Action, Metabolism and Kinetics Training Grant","funder_award_id":"T32GM007750","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1458688721","https://openalex.org/W1501494207","https://openalex.org/W1534728973","https://openalex.org/W1567267284","https://openalex.org/W1998326973","https://openalex.org/W1999030993","https://openalex.org/W2005609778","https://openalex.org/W2016415814","https://openalex.org/W2017447396","https://openalex.org/W2017998960","https://openalex.org/W2022013908","https://openalex.org/W2022118976","https://openalex.org/W2026130582","https://openalex.org/W2063553621","https://openalex.org/W2072886460","https://openalex.org/W2075482445","https://openalex.org/W2078290196","https://openalex.org/W2085899859","https://openalex.org/W2092809867","https://openalex.org/W2097965815","https://openalex.org/W2103226116","https://openalex.org/W2110946337","https://openalex.org/W2112895519","https://openalex.org/W2142524352","https://openalex.org/W2167503783","https://openalex.org/W4296154147"],"related_works":["https://openalex.org/W2960300103","https://openalex.org/W7010741554","https://openalex.org/W1507905236","https://openalex.org/W2153526379","https://openalex.org/W2106444099","https://openalex.org/W2564301079","https://openalex.org/W7074247189","https://openalex.org/W2032959523","https://openalex.org/W857421749","https://openalex.org/W2804598295"],"abstract_inverted_index":{"Decades":[0],"after":[1],"the":[2,11,36,67,74,87,95,111,138,147,155,167,171,175,185,199,206,220,224],"prion":[3,37,53,68,88,196,203,227],"protein":[4,69],"was":[5,80,134],"implicated":[6],"in":[7,42,182],"transmissible":[8],"spongiform":[9],"encephalopathies,":[10],"structure":[12,93,225],"of":[13,20,35,51,66,86,110,131,154,166,179,195,202,226],"its":[14,18,57],"toxic":[15],"isoform":[16],"and":[17,102,127,205,223],"mechanism":[19],"toxicity":[21],"remain":[22],"unknown.":[23],"By":[24],"gathering":[25],"available":[26,112,136],"experimental":[27,113,156,168,176],"data,":[28],"albeit":[29],"low":[30,180],"resolution,":[31,181],"a":[32,52,62,84,91,192],"few":[33],"pieces":[34],"puzzle":[38],"can":[39,210],"be":[40,211],"put":[41],"place.":[43],"Currently,":[44],"there":[45],"are":[46,178],"two":[47,139],"fundamentally":[48],"different":[49],"models":[50,105,140,209],"protofibril.":[54],"One":[55],"has":[56],"building":[58],"blocks":[59],"derived":[60],"from":[61,94],"molecular":[63],"dynamics":[64],"simulation":[65],"under":[70],"amyloidogenic":[71],"conditions,":[72],"termed":[73],"spiral":[75,148],"model.":[76,173],"The":[77],"other":[78],"model":[79,149],"constructed":[81],"by":[82],"threading":[83],"portion":[85],"sequence":[89],"through":[90],"beta-helical":[92],"Protein":[96],"Data":[97],"Bank.":[98],"Here":[99],"we":[100,144,189],"compare":[101],"contrast":[103],"these":[104],"with":[106,152,170],"respect":[107],"to":[108,163,213,217],"all":[109,153],"information,":[114],"including":[115],"electron":[116],"micrographs,":[117],"symmetries,":[118],"secondary":[119],"structure,":[120],"oligomerization":[121],"interfaces,":[122],"enzymatic":[123],"digestion,":[124],"epitope":[125],"exposure,":[126],"disaggregation":[128],"profiles.":[129],"Much":[130],"this":[132],"information":[133],"not":[135],"when":[137],"were":[141],"introduced.":[142],"Overall,":[143],"find":[145],"that":[146],"is":[150,161],"consistent":[151],"results.":[157],"In":[158],"contrast,":[159],"it":[160],"difficult":[162],"reconcile":[164],"several":[165],"observables":[169],"beta-helix":[172],"While":[174],"constraints":[177],"bringing":[183],"together":[184],"previously":[186],"disconnected":[187],"experiments,":[188],"have":[190],"developed":[191],"clearer":[193],"picture":[194],"aggregates.":[197],"Both":[198],"improved":[200],"characterization":[201],"aggregates":[204],"existing":[207],"atomic":[208],"used":[212],"devise":[214],"further":[215],"experiments":[216],"better":[218],"elucidate":[219],"misfolding":[221],"pathway":[222],"protofibrils.":[228]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
