{"id":"https://openalex.org/W1998275392","doi":"https://doi.org/10.1158/1538-7445.am10-1375","title":"Abstract 1375: Amlexanox inhibits FGF-mediated paracrine and autocrine activity of tumor-derived melanoma cell lines and cell strains","display_name":"Abstract 1375: Amlexanox inhibits FGF-mediated paracrine and autocrine activity of tumor-derived melanoma cell lines and cell strains","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W1998275392","doi":"https://doi.org/10.1158/1538-7445.am10-1375","mag":"1998275392"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am10-1375","doi":"https://doi.org/10.1158/1538-7445.am10-1375","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-1375","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033900609","display_name":"Ruea-Yea Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruea-Yea Huang","raw_affiliation_strings":["1Roswell Park Cancer Inst., Buffalo, NY","1Roswell Park Cancer Institute, Buffalo, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Roswell Park Cancer Inst., Buffalo, NY","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"1Roswell Park Cancer Institute, Buffalo, NY;","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Dawn Bowers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dawn Bowers","raw_affiliation_strings":["1Roswell Park Cancer Inst., Buffalo, NY","1Roswell Park Cancer Institute, Buffalo, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Roswell Park Cancer Inst., Buffalo, NY","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"1Roswell Park Cancer Institute, Buffalo, NY;","institution_ids":["https://openalex.org/I1292894508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101645219","display_name":"Michael K.K. Wong","orcid":"https://orcid.org/0000-0002-6694-4624","observed_orcids":["https://orcid.org/0000-0002-6694-4624"]},"institutions":[{"id":"https://openalex.org/I1292894508","display_name":"Roswell Park Comprehensive Cancer Center","ror":"https://ror.org/0499dwk57","country_code":"US","type":"facility","lineage":["https://openalex.org/I1292894508"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael K. Wong","raw_affiliation_strings":["1Roswell Park Cancer Inst., Buffalo, NY","1Roswell Park Cancer Institute, Buffalo, NY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Roswell Park Cancer Inst., Buffalo, NY","institution_ids":["https://openalex.org/I1292894508"]},{"raw_affiliation_string":"1Roswell Park Cancer Institute, Buffalo, NY;","institution_ids":["https://openalex.org/I1292894508"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1292894508"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"70","issue":"8_Supplement","first_page":"1375","last_page":"1375"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.7416999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.7416999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.24899999797344208,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amlexanox","display_name":"amlexanox","score":0.9729999899864197},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9580000042915344},{"id":"https://openalex.org/keywords/fgf1","display_name":"FGF1","score":0.8799999952316284},{"id":"https://openalex.org/keywords/fgf2","display_name":"FGF2","score":0.996999979019165},{"id":"https://openalex.org/keywords/paracrine-signaling","display_name":"paracrine signaling","score":0.7749999761581421},{"id":"https://openalex.org/keywords/autocrine-signaling","display_name":"autocrine signaling","score":0.9649999737739563},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.8009999990463257},{"id":"https://openalex.org/keywords/s100a13","display_name":"S100A13","score":0.9169999957084656},{"id":"https://openalex.org/keywords/conditioned-medium","display_name":"conditioned medium","score":0.6290000081062317},{"id":"https://openalex.org/keywords/endothelial-cell-proliferation","display_name":"endothelial cell proliferation","score":0.8180000185966492},{"id":"https://openalex.org/keywords/endothelial-cell-migration","display_name":"endothelial cell migration","score":0.8529999852180481}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.780266523361206},{"id":"https://openalex.org/C7876069","wikidata":"https://www.wikidata.org/wiki/Q14873666","display_name":"Paracrine signalling","level":3,"score":0.7605087757110596},{"id":"https://openalex.org/C128240485","wikidata":"https://www.wikidata.org/wiki/Q786998","display_name":"Autocrine signalling","level":3,"score":0.7074931263923645},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5934028625488281},{"id":"https://openalex.org/C191709040","wikidata":"https://www.wikidata.org/wiki/Q14889334","display_name":"FGF1","level":5,"score":0.5184752345085144},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5062157511711121},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.48680612444877625},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.4649800956249237},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4558218717575073},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39403289556503296},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3889312148094177},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3505128026008606},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.213065505027771},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1122397780418396},{"id":"https://openalex.org/C82867764","wikidata":"https://www.wikidata.org/wiki/Q24780051","display_name":"Fibroblast growth factor receptor","level":4,"score":0.11060541868209839},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08469581604003906},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am10-1375","doi":"https://doi.org/10.1158/1538-7445.am10-1375","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am10-1375","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4310623722","https://openalex.org/W2023438835","https://openalex.org/W2101034782","https://openalex.org/W2170119446","https://openalex.org/W2059778390","https://openalex.org/W2137191111","https://openalex.org/W4398794211","https://openalex.org/W2144370960","https://openalex.org/W2514579254","https://openalex.org/W2410890520"],"abstract_inverted_index":{"Abstract":[0],"Melanoma":[1],"is":[2,16,35,142],"a":[3,197,223],"highly":[4],"invasive":[5],"disease":[6],"characterized":[7],"by":[8,40,127,138,227],"widespread":[9],"lymphatic":[10],"and":[11,59,72,78,92,111,125,129,132,219,235],"systemic":[12],"metastases.":[13],"Although":[14],"angiogenesis":[15],"critical":[17],"for":[18,255],"this":[19,33],"to":[20,36,107,115,212],"occur,":[21],"the":[22,68,98,116,121,133,153,213,216,247,252],"responsible":[23],"mechanisms":[24],"within":[25],"melanoma":[26,42,56,63,117,168,189,204],"cells":[27,43],"remain":[28],"unclear.":[29],"The":[30,102,206],"purpose":[31],"of":[32,76,88,104,123,136,152,161,200,208,215,229,246,251],"study":[34],"identify":[37],"factors":[38],"secreted":[39],"tumor-derived":[41],"which":[44],"can":[45],"mediate":[46],"these":[47,167,209],"processes.":[48],"Serum-free":[49],"conditioned":[50,99],"medium":[51,100],"(CM)":[52],"isolated":[53],"from":[54,166],"two":[55],"cell":[57,64,190],"lines":[58],"four":[60],"newly":[61],"derived":[62],"strains":[65],"promote":[66],"both":[67,89,233],"growth":[69],"in":[70,80,97,173,203],"culture":[71],"angiogenic":[73,134],"outgrowth":[74],"activity":[75,135],"HUVEC":[77,124,177],"HMEC1":[79,126,137],"3-dimensional":[81],"(3-D)":[82],"collagen":[83,184],"gel":[84,185],"culture.":[85],"Substantial":[86],"amounts":[87],"FGF1":[90,108],"(acidic)":[91],"FGF2":[93,112],"(basic)":[94],"are":[95],"found":[96],"(CM).":[101],"addition":[103],"neutralizing":[105],"antibodies":[106],"(5":[109],"\u03bcg/ml)":[110,114],"(3":[113],"CM":[118],"significantly":[119],"decreased":[120],"proliferation":[122],"(20%)":[128],"(40%),":[130],"respectively,":[131],"(20%).":[139],"Amlexanox":[140],"(AMX)":[141],"an":[143],"anti-inflammatory":[144],"agent":[145,226],"that":[146],"binds":[147],"intracellular":[148],"S100A13,":[149],"one":[150],"component":[151],"putative":[154],"FGF1-secretion":[155],"complexes.":[156],"AMX":[157,221],"suppresses":[158],"constitutive":[159],"release":[160],"FGF1,":[162],"but":[163],"not":[164],"FGF2,":[165],"cells.":[169,205],"AMX-treated":[170],"melanoma-CM":[171],"results":[172,210],"significant":[174,224],"reduction":[175],"of:":[176],"mitogenic":[178],"activity,":[179],"endothelial":[180],"migration":[181],"into":[182],"3-D":[183],"as":[186,188,222],"well":[187],"proliferation.":[191],"These":[192],"AMX-mediated":[193],"effects":[194],"correlate":[195],"with":[196],"concomitant":[198],"decrease":[199],"FGFR1":[201],"phosphorylation":[202],"sum":[207],"point":[211],"importance":[214],"FGF-1":[217],"pathway":[218],"nominate":[220],"anti-melanoma":[225],"virtue":[228],"its":[230],"impact":[231],"on":[232],"paracrine":[234],"autocrine":[236],"activity.":[237],"Citation":[238],"Format:":[239],"{Authors}.":[240],"{Abstract":[241],"title}":[242],"[abstract].":[243],"In:":[244],"Proceedings":[245],"101st":[248],"Annual":[249],"Meeting":[250],"American":[253],"Association":[254],"Cancer":[256,266],"Research;":[257],"2010":[258],"Apr":[259],"17-21;":[260],"Washington,":[261],"DC.":[262],"Philadelphia":[263],"(PA):":[264],"AACR;":[265],"Res":[267],"2010;70(8":[268],"Suppl):Abstract":[269],"nr":[270],"1375.":[271]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}
