{"id":"https://openalex.org/W1998269329","doi":"https://doi.org/10.1359/jbmr.1999.14.3.406","title":"The Parathyroid Hormone\u2013Related Protein (PTHrP) Gene: Use of Downstream TATA Promotor and PTHrP 1\u2013139 Coding Pathways in Primary Breast Cancers Vary with the Occurrence of Bone Metastasis","display_name":"The Parathyroid Hormone\u2013Related Protein (PTHrP) Gene: Use of Downstream TATA Promotor and PTHrP 1\u2013139 Coding Pathways in Primary Breast Cancers Vary with the Occurrence of Bone Metastasis","publication_year":1999,"publication_date":"1999-03-01","ids":{"openalex":"https://openalex.org/W1998269329","doi":"https://doi.org/10.1359/jbmr.1999.14.3.406","mag":"1998269329","pmid":"https://pubmed.ncbi.nlm.nih.gov/10027905"},"language":"en","primary_location":{"id":"doi:10.1359/jbmr.1999.14.3.406","doi":"https://doi.org/10.1359/jbmr.1999.14.3.406","is_oa":false,"landing_page_url":"https://doi.org/10.1359/jbmr.1999.14.3.406","pdf_url":null,"source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109205534","display_name":"Zhor Bouizar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210119095","display_name":"H\u00f4pital Lariboisi\u00e8re","ror":"https://ror.org/02mqtne57","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210119095"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Zhor Dr. Bouizar","raw_affiliation_strings":["INSERM U349, Center Viggo Petersen H\u00f4pital Lariboisi\u00e8re, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U349, Center Viggo Petersen H\u00f4pital Lariboisi\u00e8re, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210119095"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111463210","display_name":"Fr\u00e9d\u00e9rique Spyratos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116453","display_name":"H\u00f4pital Ren\u00e9 Huguenin","ror":"https://ror.org/0263jp665","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210116453"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Frederique Spyratos","raw_affiliation_strings":["Center de Lutte contre le Cancer Ren\u00e9 Huguenin, Saint Cloud, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center de Lutte contre le Cancer Ren\u00e9 Huguenin, Saint Cloud, France","institution_ids":["https://openalex.org/I4210116453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111923686","display_name":"Marie Christine de Vernejoul","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210119095","display_name":"H\u00f4pital Lariboisi\u00e8re","ror":"https://ror.org/02mqtne57","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210119095"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie-Christine De vernejoul","raw_affiliation_strings":["INSERM U349, Center Viggo Petersen H\u00f4pital Lariboisi\u00e8re, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM U349, Center Viggo Petersen H\u00f4pital Lariboisi\u00e8re, Paris, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210119095"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5109205534"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I4210119095"],"apc_list":{"value":3780,"currency":"USD","value_usd":3780},"apc_paid":null,"fwci":1.6362,"has_fulltext":false,"cited_by_count":54,"citation_normalized_percentile":{"value":0.82966102,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"14","issue":"3","first_page":"406","last_page":"414"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.4438000023365021,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.4438000023365021,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.17749999463558197,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.08760000020265579,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parathyroid-hormone-related-protein","display_name":"parathyroid hormone-related protein","score":0.9779999852180481},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.7490000128746033},{"id":"https://openalex.org/keywords/bone-metastases","display_name":"bone metastasis","score":0.9929999709129333},{"id":"https://openalex.org/keywords/alternative-promoter-usage","display_name":"alternative promoters","score":0.5220000147819519},{"id":"https://openalex.org/keywords/tata-box","display_name":"TATA box","score":0.6589999794960022},{"id":"https://openalex.org/keywords/5-untranslated-region","display_name":"5' untranslated region","score":0.7329999804496765},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.6880000233650208},{"id":"https://openalex.org/keywords/transcription-start-site","display_name":"transcription start sites","score":0.7839999794960022},{"id":"https://openalex.org/keywords/premenopausal-women","display_name":"premenopausal women","score":0.6970000267028809},{"id":"https://openalex.org/keywords/metastasis-prediction","display_name":"metastasis prediction","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C2778828131","wikidata":"https://www.wikidata.org/wiki/Q2007821","display_name":"Parathyroid hormone-related protein","level":4,"score":0.719976007938385},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5697913765907288},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.569426417350769},{"id":"https://openalex.org/C65888428","wikidata":"https://www.wikidata.org/wiki/Q1413955","display_name":"TATA box","level":5,"score":0.5364959836006165},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.5194230079650879},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46510252356529236},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.45363008975982666},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45289790630340576},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4500456750392914},{"id":"https://openalex.org/C2777783956","wikidata":"https://www.wikidata.org/wiki/Q848085","display_name":"Bone metastasis","level":4,"score":0.44058749079704285},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4028940200805664},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.36358267068862915},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3452454209327698},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.1950661540031433},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.16423103213310242},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.12290862202644348},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.10696908831596375}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010281","descriptor_name":"Parathyroid Hormone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012334","descriptor_name":"RNA, Neoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016385","descriptor_name":"TATA Box","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044162","descriptor_name":"Parathyroid Hormone-Related Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1359/jbmr.1999.14.3.406","doi":"https://doi.org/10.1359/jbmr.1999.14.3.406","is_oa":false,"landing_page_url":"https://doi.org/10.1359/jbmr.1999.14.3.406","pdf_url":null,"source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},{"id":"pmid:10027905","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10027905","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320309749","display_name":"Association pour la Recherche sur le Cancer","ror":"https://ror.org/0489qz649"},{"id":"https://openalex.org/F4320328670","display_name":"Groupement des Entreprises Fran\u00e7aises dans la lutte contre le Cancer","ror":"https://ror.org/00n7q1156"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W267005183","https://openalex.org/W1512392500","https://openalex.org/W1531559622","https://openalex.org/W1543126301","https://openalex.org/W1595268720","https://openalex.org/W1797037641","https://openalex.org/W1929693340","https://openalex.org/W1965434694","https://openalex.org/W1968109929","https://openalex.org/W1968905365","https://openalex.org/W1974058132","https://openalex.org/W1977031433","https://openalex.org/W1980822214","https://openalex.org/W1982705253","https://openalex.org/W1987933233","https://openalex.org/W2007091379","https://openalex.org/W2014224172","https://openalex.org/W2017382556","https://openalex.org/W2030415413","https://openalex.org/W2047707350","https://openalex.org/W2054351138","https://openalex.org/W2056356586","https://openalex.org/W2057993678","https://openalex.org/W2058121180","https://openalex.org/W2063699543","https://openalex.org/W2080532845","https://openalex.org/W2083847629","https://openalex.org/W2095426443","https://openalex.org/W2097681691","https://openalex.org/W2097686989","https://openalex.org/W2100991702","https://openalex.org/W2141393790","https://openalex.org/W2150045940","https://openalex.org/W2264211064","https://openalex.org/W2417657174","https://openalex.org/W2801690730"],"related_works":["https://openalex.org/W2097681691","https://openalex.org/W1965434694","https://openalex.org/W2008698773","https://openalex.org/W2150045940","https://openalex.org/W2157745853","https://openalex.org/W2045163244","https://openalex.org/W2337094326","https://openalex.org/W7200380776","https://openalex.org/W4285039951","https://openalex.org/W2028455879"],"abstract_inverted_index":{"We":[0,302],"analyzed":[1],"the":[2,8,12,53,87,95,164,167,185,237,256,276,280,289,295,309,316,326],"use":[3,281],"of":[4,11,20,35,55,68,78,86,97,110,146,166,175,187,193,214,249,258,282,291,311,318,328,338],"different":[5],"promoters":[6],"and":[7,16,76,218,315,325],"splicing":[9],"patterns":[10],"exons":[13],"encoding":[14],"5'-":[15],"3'-untranslated":[17],"sequence":[18],"amounts":[19,165],"parathyroid":[21],"hormone-related":[22],"protein":[23],"(PTHrP)":[24],"gene":[25,313],"products":[26],"in":[27,72,94,108,130,144,151,171,184,191,226,236],"breast":[28,37,131,296,319],"cancers.":[29],"Tumor":[30],"samples":[31],"from":[32,43,133,207,294],"74":[33],"cases":[34],"primary":[36],"cancer":[38],"that":[39],"had":[40],"been":[41],"followed":[42],"1":[44],"to":[45,52],"14":[46],"years":[47],"were":[48,177,223],"selected":[49],"retrospectively":[50],"according":[51],"occurrence":[54],"metastasis:":[56],"18":[57],"patients":[58,98,111,134,147,227,335],"developed":[59,64,70,80,101,113,136,149,229],"no":[60,114],"metastasis":[61,259],"(NM),":[62],"56":[63],"metastases":[65,71,82,102,115,138,150,230],"(M),":[66],"22":[67],"whom":[69,79],"soft":[73,152],"tissues":[74,153],"(MB-)":[75],"34":[77],"bone":[81,137],"(MB+).":[83],"The":[84,220,247,270,321],"amount":[85,248],"1-139":[88],"isoform":[89,124,169],"mRNA":[90,125,170,331],"was":[91,126,182,273,285],"much":[92],"higher":[93,183],"tumors":[96,132,176,186,239,297],"who":[99,112,135,148,228],"later":[100],"(M:":[103],"0.29":[104],"+/-":[105,118,141,156,233,242,262,267],"0.03)":[106,234],"than":[107,143,190,235],"those":[109,145,192],"(NM,":[116,240],"0.13":[117,241],"0.03;":[119,157,243],"p":[120,158,244],"<":[121,159,197,245,299],"0.01).":[122,246],"This":[123],"also":[127],"more":[128,224],"abundant":[129,225],"(MB+,":[139],"0.39":[140],"0.04)":[142],"(MB-,":[154],"0.15":[155],"0.":[160,265,300],"0001).":[161],"By":[162],"contrast,":[163],"1-141":[168],"these":[172],"three":[173,209],"groups":[174],"similar,":[178],"but":[179],"its":[180],"concentration":[181],"premenopausal":[188],"women":[189,195],"postmenopausal":[194],"(p":[196,298],"0.05).":[198],"Analysis":[199],"with":[200,255,288],"5'":[201],"untranslated":[202],"regions-specific":[203],"primers":[204],"showed":[205],"transcription":[206,211],"all":[208],"putative":[210],"start":[212,323],"sites":[213],"PTHrP":[215,312,329],"(P1,":[216],"P2,":[217],"P3).":[219],"P3-initiated":[221,322],"transcripts":[222],"(M,":[231],"0.31":[232],"nonmetastatic":[238],"P3":[250],"element":[251],"did":[252],"not":[253],"differ":[254],"site":[257,324],"(BM+,":[260],"0.32":[261],"0.05;":[263,268],"BM-,":[264],"28":[266],"NS).":[269],"same":[271],"trend":[272],"observed":[274],"for":[275],"P2":[277],"element.":[278],"However,":[279],"P2-initiated":[283],"messages":[284],"strongly":[286],"associated":[287],"absence":[290],"estrogen":[292],"receptors":[293],"01).":[301],"thus":[303],"find":[304],"a":[305],"close":[306],"association":[307],"between":[308],"pattern":[310],"expression":[314],"outcome":[317],"cancer.":[320],"presence":[327],"139":[330],"could":[332],"help":[333],"identify":[334],"at":[336],"risk":[337],"developing":[339],"metastases.":[340]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}