{"id":"https://openalex.org/W1998265298","doi":"https://doi.org/10.1083/jcb.78.3.663","title":"Heterogeneous nuclear RNA-protein fibers in chromatin-depleted nuclei.","display_name":"Heterogeneous nuclear RNA-protein fibers in chromatin-depleted nuclei.","publication_year":1978,"publication_date":"1978-09-01","ids":{"openalex":"https://openalex.org/W1998265298","doi":"https://doi.org/10.1083/jcb.78.3.663","mag":"1998265298","pmid":"https://pubmed.ncbi.nlm.nih.gov/701354","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2110193"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.78.3.663","doi":"https://doi.org/10.1083/jcb.78.3.663","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.78.3.663","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2110193","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022823833","display_name":"Ronald C. Herman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Herman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001914395","display_name":"Lisa A. Weymouth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Weymouth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5110114490","display_name":"Sheldon Penman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S Penman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.0758,"has_fulltext":false,"cited_by_count":237,"citation_normalized_percentile":{"value":0.98952823,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"78","issue":"3","first_page":"663","last_page":"674"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.913100004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.913100004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11841","display_name":"Nuclear Structure and Function","score":0.08540000021457672,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hnrnp","display_name":"heterogeneous nuclear ribonucleoproteins","score":0.8569999933242798},{"id":"https://openalex.org/keywords/heterogeneous-nuclear-rna","display_name":"heterogeneous nuclear RNA","score":0.7879999876022339},{"id":"https://openalex.org/keywords/nuclear-lamina","display_name":"nuclear lamina","score":0.9810000061988831},{"id":"https://openalex.org/keywords/poly-a-rna","display_name":"polyadenylated RNA","score":0.6129999756813049},{"id":"https://openalex.org/keywords/protein-rna-interactions","display_name":"RNA-protein interactions","score":0.5360000133514404},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.7749999761581421}],"concepts":[{"id":"https://openalex.org/C102063271","wikidata":"https://www.wikidata.org/wiki/Q7243183","display_name":"Precursor mRNA","level":5,"score":0.8407809138298035},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.7468321919441223},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.7406914234161377},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.6852260828018188},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6816876530647278},{"id":"https://openalex.org/C2909472194","wikidata":"https://www.wikidata.org/wiki/Q417662","display_name":"Heterogeneous nuclear ribonucleoprotein","level":5,"score":0.6133410334587097},{"id":"https://openalex.org/C10879258","wikidata":"https://www.wikidata.org/wiki/Q76826611","display_name":"RNase P","level":4,"score":0.6040582060813904},{"id":"https://openalex.org/C75934600","wikidata":"https://www.wikidata.org/wiki/Q419245","display_name":"Ribonucleoprotein","level":4,"score":0.5760676264762878},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.49698784947395325},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.42786332964897156},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35232147574424744},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.3274599313735962},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2885912358760834},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.17398884892463684},{"id":"https://openalex.org/C54458228","wikidata":"https://www.wikidata.org/wiki/Q237218","display_name":"RNA splicing","level":4,"score":0.15318384766578674},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002466","descriptor_name":"Cell Nucleolus","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009685","descriptor_name":"Nuclear Envelope","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009698","descriptor_name":"Nucleoproteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012260","descriptor_name":"Ribonucleases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012261","descriptor_name":"Ribonucleoproteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012261","descriptor_name":"Ribonucleoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012332","descriptor_name":"RNA, Heterogeneous Nuclear","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D012332","descriptor_name":"RNA, Heterogeneous Nuclear","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1083/jcb.78.3.663","doi":"https://doi.org/10.1083/jcb.78.3.663","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.78.3.663","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2110193","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2110193","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:701354","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/701354","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.280.3557","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.280.3557","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/56/77/J_Cell_Biol_1978_Sep_1_78(3)_663-674.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2110193","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2110193","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1966968662","https://openalex.org/W1970266617","https://openalex.org/W1978281353","https://openalex.org/W1979321980","https://openalex.org/W1995567382","https://openalex.org/W2006216882","https://openalex.org/W2014615353","https://openalex.org/W2016381728","https://openalex.org/W2018491753","https://openalex.org/W2027393724","https://openalex.org/W2038019779","https://openalex.org/W2039008851","https://openalex.org/W2040158270","https://openalex.org/W2041682515","https://openalex.org/W2046110818","https://openalex.org/W2051114240","https://openalex.org/W2057778658","https://openalex.org/W2073250430","https://openalex.org/W2074905874","https://openalex.org/W2077615999","https://openalex.org/W2091357535","https://openalex.org/W2092892114","https://openalex.org/W2121012559","https://openalex.org/W2142344604","https://openalex.org/W2162929205"],"related_works":["https://openalex.org/W7101044704","https://openalex.org/W2060832808","https://openalex.org/W1965338973","https://openalex.org/W2108184942","https://openalex.org/W1031598470","https://openalex.org/W2070356374","https://openalex.org/W7097090061","https://openalex.org/W2093842915","https://openalex.org/W2041682515","https://openalex.org/W2039789117"],"abstract_inverted_index":{"The":[0,130,148],"heterogeneous":[1],"nuclear":[2,14,44,98,157,182,253,278],"RNA-protein":[3],"(hnRNP)":[4],"fibers":[5,105],"in":[6,23,29,82,134,145,161,265],"HeLa":[7],"cell":[8],"nuclei":[9,62,137],"are":[10,57],"visualized":[11,133],"by":[12,163,228],"a":[13,24,30,107,125,266],"subfractionation":[15],"technique":[16],"which":[17],"removes":[18],"96%":[19],"of":[20,37,78,88,95,127,170,202,213,247,249],"the":[21,35,38,42,60,65,76,103,111,118,128,156,171,181,185,200,214,223,229,250,277],"chromatin":[22,79,91],"single":[25],"step":[26],"and":[27,50,80,174,191,222,242],"99%":[28],"two-step":[31],"elution":[32,192],"but":[33,217,270],"leaves":[34],"bulk":[36],"hnRNA":[39,56,99,123,149,165,176,221,251,259],"complexed":[40],"with":[41,59,90,155,180,189,193,211],"remnant":[43,61,136],"structure":[45],"or":[46,184],"lamina.":[47],"Both":[48],"steady-state":[49],"newly":[51],"synthesized":[52],"(approximately":[53],"15-s":[54],"label)":[55],"associated":[58,154,179],"to":[63,73,84,141,152,238,252,276],"about":[64],"same":[66],"extent.":[67],"This":[68],"association":[69,87],"does":[70,261],"not":[71,226,262],"appear":[72,151,237],"depend":[74],"on":[75,117,271],"presence":[77],"exists":[81],"addition":[83],"any":[85],"possible":[86],"hnRNP":[89,104,224],"itself.":[92],"Electron":[93],"microscopy":[94],"partially":[96,215],"purified":[97],"complexes":[100],"shows":[101],"that":[102,122,258],"form":[106],"ribonucleoprotein":[108],"network":[109,132],"throughout":[110],"nucleus,":[112],"whose":[113],"integrity":[114],"is":[115,124,208,256],"dependent":[116],"RNA.":[119],"Autoradiography":[120],"confirms":[121],"constituent":[126],"fibers.":[129],"RNA":[131,142,235],"these":[135],"may":[138,243],"be":[139,153,239],"similar":[140],"networks":[143],"seen":[144],"intact":[146],"cells.":[147],"molecules":[150],"lamina,":[158],"at":[159],"least":[160],"part,":[162],"unusual":[164],"sequences.":[166],"More":[167],"than":[168],"half":[169],"recovered":[172],"poly(A)":[173],"double-stranded":[175],"regions":[177,236],"remains":[178],"structures":[183,273],"laminae":[186],"after":[187],"digestion":[188],"RNase":[190],"0.4":[194],"M":[195],"ammonium":[196,230],"sulfate.":[197],"In":[198],"contrast,":[199],"majority":[201],"oligo(A),":[203],"another":[204],"ribonuclease":[205],"resistant":[206],"segment,":[207],"released":[209],"together":[210],"most":[212],"digested":[216],"still":[218],"acid-precipitable":[219],"single-stranded":[220],"proteins":[225],"eluted":[227],"sulfate":[231],"alone.":[232],"These":[233],"special":[234],"tightly":[240],"bound":[241,275],"serve":[244],"as":[245],"points":[246],"attachment":[248],"substructures.":[254],"It":[255],"suggested":[257],"metabolism":[260],"take":[263],"place":[264],"soluble":[267],"nucleoplasmic":[268],"compartment":[269],"organized":[272],"firmly":[274],"structure.":[279]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
