{"id":"https://openalex.org/W1998247295","doi":"https://doi.org/10.1073/pnas.1402261111","title":"Role of cysteinyl leukotriene signaling in a mouse model of noise-induced cochlear injury","display_name":"Role of cysteinyl leukotriene signaling in a mouse model of noise-induced cochlear injury","publication_year":2014,"publication_date":"2014-06-23","ids":{"openalex":"https://openalex.org/W1998247295","doi":"https://doi.org/10.1073/pnas.1402261111","mag":"1998247295","pmid":"https://pubmed.ncbi.nlm.nih.gov/24958862","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4103370"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1402261111","doi":"https://doi.org/10.1073/pnas.1402261111","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1402261111","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4103370","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000231224","display_name":"Jung\u2010Sub Park","orcid":"https://orcid.org/0000-0002-7887-1557","observed_orcids":["https://orcid.org/0000-0002-7887-1557"]},"institutions":[{"id":"https://openalex.org/I4210129690","display_name":"Department of Biological Sciences","ror":"https://ror.org/038rjvd86","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210158638","display_name":"Department of Biological Sciences","ror":"https://ror.org/05dte6685","country_code":"BY","type":"facility","lineage":["https://openalex.org/I151823869","https://openalex.org/I4210158638"]},{"id":"https://openalex.org/I4403928205","display_name":"Research Center for Chronic Inflammatory Diseases","ror":"https://ror.org/00gdrb321","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4403928205","https://openalex.org/I70640408"]}],"countries":["BY","IR","RU"],"is_corresponding":false,"raw_author_name":"Jung-Sub Park","raw_affiliation_strings":["Chronic Inflammatory Disease Research Center, and","Department of Otolaryngology,","Department of Pharmacology,","Neuroscience Graduate Program, Department of Biological Sciences,","Department of Pharmacology,Department of Otolaryngology,Neuroscience Graduate Program, Department of Biological Sciences,Chronic Inflammatory Disease Research Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chronic Inflammatory Disease Research Center, and","institution_ids":["https://openalex.org/I4403928205"]},{"raw_affiliation_string":"Department of Otolaryngology,","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacology,","institution_ids":[]},{"raw_affiliation_string":"Neuroscience Graduate Program, Department of Biological Sciences,","institution_ids":["https://openalex.org/I4210129690","https://openalex.org/I4210158638"]},{"raw_affiliation_string":"Department of Pharmacology,Department of Otolaryngology,Neuroscience Graduate Program, Department of Biological Sciences,Chronic Inflammatory Disease Research Center, and","institution_ids":["https://openalex.org/I4210129690","https://openalex.org/I4210158638","https://openalex.org/I4403928205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029013592","display_name":"Seo\u2010Jun Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129690","display_name":"Department of Biological Sciences","ror":"https://ror.org/038rjvd86","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210158638","display_name":"Department of Biological Sciences","ror":"https://ror.org/05dte6685","country_code":"BY","type":"facility","lineage":["https://openalex.org/I151823869","https://openalex.org/I4210158638"]},{"id":"https://openalex.org/I4403928205","display_name":"Research Center for Chronic Inflammatory Diseases","ror":"https://ror.org/00gdrb321","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4403928205","https://openalex.org/I70640408"]}],"countries":["BY","IR","RU"],"is_corresponding":false,"raw_author_name":"Seo-Jun Kang","raw_affiliation_strings":["Chronic Inflammatory Disease Research Center, and","Department of Pharmacology,","Neuroscience Graduate Program, Department of Biological Sciences,","Department of Pharmacology,Neuroscience Graduate Program, Department of Biological Sciences,Chronic Inflammatory Disease Research Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chronic Inflammatory Disease Research Center, and","institution_ids":["https://openalex.org/I4403928205"]},{"raw_affiliation_string":"Department of Pharmacology,","institution_ids":[]},{"raw_affiliation_string":"Neuroscience Graduate Program, Department of Biological Sciences,","institution_ids":["https://openalex.org/I4210129690","https://openalex.org/I4210158638"]},{"raw_affiliation_string":"Department of Pharmacology,Neuroscience Graduate Program, Department of Biological Sciences,Chronic Inflammatory Disease Research Center, and","institution_ids":["https://openalex.org/I4210129690","https://openalex.org/I4403928205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023766676","display_name":"Mi-Kyoung Seo","orcid":"https://orcid.org/0000-0002-9372-9313","observed_orcids":["https://orcid.org/0000-0002-9372-9313"]},"institutions":[{"id":"https://openalex.org/I4403928205","display_name":"Research Center for Chronic Inflammatory Diseases","ror":"https://ror.org/00gdrb321","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4403928205","https://openalex.org/I70640408"]},{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["IR","KR"],"is_corresponding":false,"raw_author_name":"Mi-kyoung Seo","raw_affiliation_strings":["Chronic Inflammatory Disease Research Center, and","Department of Physiology, Ajou University School of Medicine, Yeongtong-gu, Suwon 443-380, Korea","Chronic Inflammatory Disease Research Center, andDepartment of Physiology, Ajou University School of Medicine, Yeongtong-gu, Suwon 443-380, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chronic Inflammatory Disease Research Center, and","institution_ids":["https://openalex.org/I4403928205"]},{"raw_affiliation_string":"Department of Physiology, Ajou University School of Medicine, Yeongtong-gu, Suwon 443-380, Korea","institution_ids":["https://openalex.org/I57664883"]},{"raw_affiliation_string":"Chronic Inflammatory Disease Research Center, andDepartment of Physiology, Ajou University School of Medicine, Yeongtong-gu, Suwon 443-380, Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060680796","display_name":"Ilo Jou","orcid":"https://orcid.org/0000-0002-1354-1223","observed_orcids":["https://orcid.org/0000-0002-1354-1223"]},"institutions":[{"id":"https://openalex.org/I4210129690","display_name":"Department of Biological Sciences","ror":"https://ror.org/038rjvd86","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210158638","display_name":"Department of Biological Sciences","ror":"https://ror.org/05dte6685","country_code":"BY","type":"facility","lineage":["https://openalex.org/I151823869","https://openalex.org/I4210158638"]},{"id":"https://openalex.org/I4403928205","display_name":"Research Center for Chronic Inflammatory Diseases","ror":"https://ror.org/00gdrb321","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4403928205","https://openalex.org/I70640408"]}],"countries":["BY","IR","RU"],"is_corresponding":false,"raw_author_name":"Ilo Jou","raw_affiliation_strings":["Chronic Inflammatory Disease Research Center, and","Department of Pharmacology,","Neuroscience Graduate Program, Department of Biological Sciences,","aDepartment of Pharmacology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chronic Inflammatory Disease Research Center, and","institution_ids":["https://openalex.org/I4403928205"]},{"raw_affiliation_string":"Department of Pharmacology,","institution_ids":[]},{"raw_affiliation_string":"Neuroscience Graduate Program, Department of Biological Sciences,","institution_ids":["https://openalex.org/I4210129690","https://openalex.org/I4210158638"]},{"raw_affiliation_string":"aDepartment of Pharmacology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070772179","display_name":"Hyun Goo Woo","orcid":"https://orcid.org/0000-0002-0916-893X","observed_orcids":["https://orcid.org/0000-0002-0916-893X"]},"institutions":[{"id":"https://openalex.org/I4403928205","display_name":"Research Center for Chronic Inflammatory Diseases","ror":"https://ror.org/00gdrb321","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4403928205","https://openalex.org/I70640408"]},{"id":"https://openalex.org/I57664883","display_name":"Ajou University","ror":"https://ror.org/03tzb2h73","country_code":"KR","type":"education","lineage":["https://openalex.org/I57664883"]}],"countries":["IR","KR"],"is_corresponding":false,"raw_author_name":"Hyun Goo Woo","raw_affiliation_strings":["Chronic Inflammatory Disease Research Center, and","Department of Physiology, Ajou University School of Medicine, Yeongtong-gu, Suwon 443-380, Korea","eDepartment of Physiology, Ajou University School of Medicine, Yeongtong-gu, Suwon 443-380, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chronic Inflammatory Disease Research Center, and","institution_ids":["https://openalex.org/I4403928205"]},{"raw_affiliation_string":"Department of Physiology, Ajou University School of Medicine, Yeongtong-gu, Suwon 443-380, Korea","institution_ids":["https://openalex.org/I57664883"]},{"raw_affiliation_string":"eDepartment of Physiology, Ajou University School of Medicine, Yeongtong-gu, Suwon 443-380, Korea","institution_ids":["https://openalex.org/I57664883"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074674397","display_name":"Sang Myun Park","orcid":"https://orcid.org/0000-0002-1001-4743","observed_orcids":["https://orcid.org/0000-0002-1001-4743"]},"institutions":[{"id":"https://openalex.org/I4210129690","display_name":"Department of Biological Sciences","ror":"https://ror.org/038rjvd86","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690"]},{"id":"https://openalex.org/I4210158638","display_name":"Department of Biological Sciences","ror":"https://ror.org/05dte6685","country_code":"BY","type":"facility","lineage":["https://openalex.org/I151823869","https://openalex.org/I4210158638"]},{"id":"https://openalex.org/I4403928205","display_name":"Research Center for Chronic Inflammatory Diseases","ror":"https://ror.org/00gdrb321","country_code":"IR","type":"facility","lineage":["https://openalex.org/I4403928205","https://openalex.org/I70640408"]}],"countries":["BY","IR","RU"],"is_corresponding":false,"raw_author_name":"Sang Myun Park","raw_affiliation_strings":["Chronic Inflammatory Disease Research Center, and","Department of Pharmacology,","Neuroscience Graduate Program, Department of Biological Sciences,","Department of Pharmacology,Neuroscience Graduate Program, Department of Biological Sciences,Chronic Inflammatory Disease Research Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chronic Inflammatory Disease Research Center, and","institution_ids":["https://openalex.org/I4403928205"]},{"raw_affiliation_string":"Department of Pharmacology,","institution_ids":[]},{"raw_affiliation_string":"Neuroscience Graduate Program, Department of Biological Sciences,","institution_ids":["https://openalex.org/I4210129690","https://openalex.org/I4210158638"]},{"raw_affiliation_string":"Department of Pharmacology,Neuroscience Graduate Program, Department of Biological Sciences,Chronic Inflammatory Disease Research Center, and","institution_ids":["https://openalex.org/I4210129690","https://openalex.org/I4403928205"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4468,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.76535948,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"111","issue":"27","first_page":"9911","last_page":"9916"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10334","display_name":"Hearing, Cochlea, Tinnitus, Genetics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10283","display_name":"Hearing Loss and Rehabilitation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3616","display_name":"Speech and Hearing"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11692","display_name":"Noise Effects and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3102","display_name":"Acoustics and Ultrasonics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/noise-induced-hearing-loss","display_name":"noise-induced hearing loss","score":0.9079999923706055},{"id":"https://openalex.org/keywords/cysteinyl-leukotriene-receptor-1","display_name":"cysteinyl leukotriene receptor 1","score":0.8330000042915344},{"id":"https://openalex.org/keywords/leukotriene-receptor-antagonists","display_name":"leukotriene receptor antagonists","score":0.8960000276565552},{"id":"https://openalex.org/keywords/montelukast","display_name":"montelukast","score":0.9990000128746033},{"id":"https://openalex.org/keywords/5-lipoxygenase","display_name":"5-lipoxygenase","score":0.9829999804496765},{"id":"https://openalex.org/keywords/matrix-metalloproteinase-3","display_name":"matrix metalloproteinase-3","score":0.953000009059906},{"id":"https://openalex.org/keywords/hair-cell-death","display_name":"hair cell death","score":0.8379999995231628},{"id":"https://openalex.org/keywords/cochlear-damage","display_name":"cochlear damage","score":0.7400000095367432},{"id":"https://openalex.org/keywords/spiral-ligament","display_name":"spiral ligament","score":0.7179999947547913},{"id":"https://openalex.org/keywords/organ-of-corti","display_name":"organ of Corti","score":0.9900000095367432},{"id":"https://openalex.org/keywords/threshold-shift","display_name":"threshold shift","score":0.6480000019073486},{"id":"https://openalex.org/keywords/sensorineural-hearing-loss","display_name":"sensorineural hearing loss","score":0.9020000100135803}],"concepts":[{"id":"https://openalex.org/C2776322731","wikidata":"https://www.wikidata.org/wiki/Q417767","display_name":"Montelukast","level":3,"score":0.8607885837554932},{"id":"https://openalex.org/C2779356876","wikidata":"https://www.wikidata.org/wiki/Q1475712","display_name":"Noise-induced hearing loss","level":4,"score":0.7320549488067627},{"id":"https://openalex.org/C2780493683","wikidata":"https://www.wikidata.org/wiki/Q16035842","display_name":"Hearing loss","level":2,"score":0.586899995803833},{"id":"https://openalex.org/C2778585322","wikidata":"https://www.wikidata.org/wiki/Q1566641","display_name":"Hair cell","level":3,"score":0.5797626972198486},{"id":"https://openalex.org/C2776452501","wikidata":"https://www.wikidata.org/wiki/Q424190","display_name":"Leukotriene","level":3,"score":0.5104962587356567},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.49055856466293335},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.46141374111175537},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.42483022809028625},{"id":"https://openalex.org/C2777242621","wikidata":"https://www.wikidata.org/wiki/Q647917","display_name":"Leukotriene D4","level":4,"score":0.42000940442085266},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.4164816737174988},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4117182493209839},{"id":"https://openalex.org/C2780130748","wikidata":"https://www.wikidata.org/wiki/Q317857","display_name":"Cochlea","level":2,"score":0.3016229569911957},{"id":"https://openalex.org/C3018332767","wikidata":"https://www.wikidata.org/wiki/Q4117845","display_name":"Noise exposure","level":3,"score":0.2807140052318573},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.2413696050643921},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18480244278907776},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.16294065117835999}],"mesh":[{"descriptor_ui":"D000085","descriptor_name":"Acetates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003051","descriptor_name":"Cochlea","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":true},{"descriptor_ui":"D003521","descriptor_name":"Cyclopropanes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009622","descriptor_name":"Noise","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011804","descriptor_name":"Quinolines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013440","descriptor_name":"Sulfides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014947","descriptor_name":"Wounds and Injuries","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014947","descriptor_name":"Wounds and Injuries","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D015289","descriptor_name":"Leukotrienes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018077","descriptor_name":"Receptors, Leukotriene","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019278","descriptor_name":"Matrix Metalloproteinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020024","descriptor_name":"Leukotriene Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1073/pnas.1402261111","doi":"https://doi.org/10.1073/pnas.1402261111","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1402261111","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3256051","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4103370","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:24958862","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24958862","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4103370","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4103370/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmh:oai:repository.ajou.ac.kr:201003/12018","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4103370","pdf_url":null,"source":{"id":"https://openalex.org/S4306401331","display_name":"AJOU Open Repository (Ajou University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I57664883","host_organization_name":"Ajou University","host_organization_lineage":["https://openalex.org/I57664883"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3256051","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4103370","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1505316130","https://openalex.org/W1529543999","https://openalex.org/W1606314433","https://openalex.org/W1969898277","https://openalex.org/W1972679022","https://openalex.org/W1985090920","https://openalex.org/W1988286804","https://openalex.org/W2005154068","https://openalex.org/W2010739314","https://openalex.org/W2013963477","https://openalex.org/W2017545512","https://openalex.org/W2019323276","https://openalex.org/W2021950845","https://openalex.org/W2029444903","https://openalex.org/W2031645960","https://openalex.org/W2038122030","https://openalex.org/W2041405746","https://openalex.org/W2044592983","https://openalex.org/W2046208572","https://openalex.org/W2049478302","https://openalex.org/W2050820296","https://openalex.org/W2054765077","https://openalex.org/W2056485984","https://openalex.org/W2060862679","https://openalex.org/W2062029090","https://openalex.org/W2062658512","https://openalex.org/W2069577821","https://openalex.org/W2071409404","https://openalex.org/W2079162573","https://openalex.org/W2088897605","https://openalex.org/W2102941077","https://openalex.org/W2105812451","https://openalex.org/W2108176270","https://openalex.org/W2115111224","https://openalex.org/W2131478576","https://openalex.org/W2131825199","https://openalex.org/W2139443444","https://openalex.org/W2146946820","https://openalex.org/W2153212953","https://openalex.org/W2160896745","https://openalex.org/W2167471691","https://openalex.org/W2168389777","https://openalex.org/W2412899635"],"related_works":["https://openalex.org/W3210246157","https://openalex.org/W2009291568","https://openalex.org/W2344245973","https://openalex.org/W2316483864","https://openalex.org/W2761498029","https://openalex.org/W2979202421","https://openalex.org/W7002126026","https://openalex.org/W4391855071","https://openalex.org/W4226071638","https://openalex.org/W3145714561"],"abstract_inverted_index":{"Noise-induced":[0],"hearing":[1,12,199],"loss":[2,200],"is":[3],"one":[4],"of":[5,10,23,42,71,74,81,89,129,183,194,205],"the":[6,19,31,40,65,69,108,115,120,127,152,157,171,192,202],"most":[7],"common":[8],"types":[9],"sensorineural":[11],"loss.":[13],"In":[14],"this":[15],"study,":[16],"we":[17,124],"examined":[18],"expression":[20,41,60,128],"and":[21,26,57,68,83,112,138,155,173,201],"localization":[22],"leukotriene":[24,44,94],"receptors":[25],"their":[27],"respective":[28],"changes":[29],"in":[30,64,119,170,197],"cochlea":[32,172],"after":[33,54,103,135],"hazardous":[34],"noise":[35,55,104,136],"exposure.":[36],"We":[37],"found":[38,125],"that":[39,80,126,164],"cysteinyl":[43],"type":[45],"1":[46],"receptor":[47,95],"(CysLTR1)":[48],"was":[49,61,76,85,133,140],"increased":[50,77],"until":[51],"3":[52],"d":[53],"exposure":[56,105],"enhanced":[58],"CysLTR1":[59],"mainly":[62],"observed":[63],"spiral":[66],"ligament":[67],"organ":[70],"Corti.":[72],"Expression":[73],"5-lipoxygenase":[75],"similar":[78],"to":[79],"CysLTR1,":[82],"there":[84],"an":[86],"accompanying":[87],"elevation":[88],"CysLT":[90,168],"concentration.":[91],"Posttreatment":[92,145],"with":[93,146],"antagonist":[96],"(LTRA),":[97],"montelukast,":[98],"for":[99],"4":[100],"consecutive":[101],"days":[102],"significantly":[106,141],"decreased":[107],"permanent":[109,158],"threshold":[110,159],"shift":[111],"also":[113,150],"reduced":[114,156],"hair":[116,153],"cell":[117],"death":[118],"cochlea.":[121],"Using":[122],"RNA-sequencing,":[123],"matrix":[130],"metalloproteinase-3":[131],"(MMP-3)":[132],"up-regulated":[134,167],"exposure,":[137],"it":[139],"inhibited":[142],"by":[143,179],"montelukast.":[144],"a":[147],"MMP-3":[148,184],"inhibitor":[149],"protected":[151],"cells":[154],"shift.":[160],"These":[161],"findings":[162],"suggest":[163],"acoustic":[165],"injury":[166,175],"signaling":[169,196],"cochlear":[174],"could":[176],"be":[177],"attenuated":[178],"LTRA":[180],"through":[181],"regulation":[182],"expression.":[185],"This":[186],"study":[187],"provides":[188],"mechanistic":[189],"insights":[190],"into":[191],"role":[193],"CysLTs":[195],"noise-induced":[198],"therapeutic":[203],"benefit":[204],"LTRA.":[206]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}