{"id":"https://openalex.org/W1998213240","doi":"https://doi.org/10.1016/s0167-4781(00)00132-9","title":"Molecular cloning of the murine cMOAT ATPase","display_name":"Molecular cloning of the murine cMOAT ATPase","publication_year":2000,"publication_date":"2000-07-01","ids":{"openalex":"https://openalex.org/W1998213240","doi":"https://doi.org/10.1016/s0167-4781(00)00132-9","mag":"1998213240","pmid":"https://pubmed.ncbi.nlm.nih.gov/11004524"},"language":"en","primary_location":{"id":"doi:10.1016/s0167-4781(00)00132-9","doi":"https://doi.org/10.1016/s0167-4781(00)00132-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0167-4781(00)00132-9","pdf_url":null,"source":{"id":"https://openalex.org/S4210212269","display_name":"Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression","issn_l":"0167-4781","issn":["0167-4781","1879-2634"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0167-4781(00)00132-9","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110053366","display_name":"Friederike Fritz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Friederike Fritz","raw_affiliation_strings":["Laboratory for Molecular Therapeutics, Program of Molecular Pharmacology and Experimental Therapeutics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA","Laboratory for Molecular Therapeutics, Program of Molecular Pharmacology and Experimental Therapeutics, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Molecular Therapeutics, Program of Molecular Pharmacology and Experimental Therapeutics, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Laboratory for Molecular Therapeutics, Program of Molecular Pharmacology and Experimental Therapeutics, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100394804","display_name":"Jing Chen","orcid":"https://orcid.org/0000-0001-5637-1829","observed_orcids":["https://orcid.org/0000-0001-5637-1829","https://orcid.org/0000-0001-8568-8390"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Chen","raw_affiliation_strings":["Laboratory for Molecular Therapeutics, Program of Molecular Pharmacology and Experimental Therapeutics, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Molecular Therapeutics, Program of Molecular Pharmacology and Experimental Therapeutics, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037276032","display_name":"Paula Hayes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paula Hayes","raw_affiliation_strings":["Laboratory for Molecular Therapeutics, Program of Molecular Pharmacology and Experimental Therapeutics, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Molecular Therapeutics, Program of Molecular Pharmacology and Experimental Therapeutics, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113546804","display_name":"F. M. Sirotnak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"F.M. Sirotnak","raw_affiliation_strings":["Graduate School of Medical Sciences, Cornell University, New York, NY 10021, USA","Laboratory for Molecular Therapeutics, Program of Molecular Pharmacology and Experimental Therapeutics, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY 10021, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate School of Medical Sciences, Cornell University, New York, NY 10021, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Laboratory for Molecular Therapeutics, Program of Molecular Pharmacology and Experimental Therapeutics, Memorial Sloan-Kettering Cancer Center, 1275 York Ave., New York, NY 10021, USA","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5113546804"],"corresponding_institution_ids":["https://openalex.org/I1334819555","https://openalex.org/I205783295"],"apc_list":null,"apc_paid":null,"fwci":0.842,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.72039358,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"1492","issue":"2-3","first_page":"531","last_page":"536"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mrp2","display_name":"MRP2","score":0.9789999723434448},{"id":"https://openalex.org/keywords/atpase","display_name":"ATPase","score":0.5609999895095825},{"id":"https://openalex.org/keywords/cdna-cloning","display_name":"cDNA cloning","score":0.7739999890327454},{"id":"https://openalex.org/keywords/mouse-liver","display_name":"mouse liver","score":0.7310000061988831},{"id":"https://openalex.org/keywords/mrna-variants","display_name":"mRNA variants","score":0.5899999737739563},{"id":"https://openalex.org/keywords/hepatocyte-canalicular-membrane","display_name":"hepatocyte canalicular membrane","score":0.8019999861717224},{"id":"https://openalex.org/keywords/sequence-homology","display_name":"sequence homology","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C187882448","wikidata":"https://www.wikidata.org/wiki/Q283478","display_name":"Complementary DNA","level":3,"score":0.7604455351829529},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.7222729921340942},{"id":"https://openalex.org/C47289529","wikidata":"https://www.wikidata.org/wiki/Q908550","display_name":"Open reading frame","level":4,"score":0.6922012567520142},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6443182229995728},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5650073885917664},{"id":"https://openalex.org/C177707886","wikidata":"https://www.wikidata.org/wiki/Q48520","display_name":"Northern blot","level":4,"score":0.525281548500061},{"id":"https://openalex.org/C121050878","wikidata":"https://www.wikidata.org/wiki/Q5135020","display_name":"Cloning (programming)","level":2,"score":0.4720902144908905},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.45678552985191345},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.43499213457107544},{"id":"https://openalex.org/C19924922","wikidata":"https://www.wikidata.org/wiki/Q408351","display_name":"Molecular cloning","level":4,"score":0.43175172805786133},{"id":"https://openalex.org/C23265538","wikidata":"https://www.wikidata.org/wiki/Q300033","display_name":"ATPase","level":3,"score":0.41401731967926025},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36134010553359985},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.32664239406585693},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28351399302482605},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1710716187953949},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000251","descriptor_name":"Adenosine Triphosphatases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D020121","descriptor_name":"5' Untranslated Regions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027321","descriptor_name":"Anion Transport Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0167-4781(00)00132-9","doi":"https://doi.org/10.1016/s0167-4781(00)00132-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0167-4781(00)00132-9","pdf_url":null,"source":{"id":"https://openalex.org/S4210212269","display_name":"Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression","issn_l":"0167-4781","issn":["0167-4781","1879-2634"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression","raw_type":"journal-article"},{"id":"pmid:11004524","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11004524","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0167-4781(00)00132-9","doi":"https://doi.org/10.1016/s0167-4781(00)00132-9","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0167-4781(00)00132-9","pdf_url":null,"source":{"id":"https://openalex.org/S4210212269","display_name":"Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression","issn_l":"0167-4781","issn":["0167-4781","1879-2634"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2103687263","display_name":"MECHANISM-BASED THERAPEUTICS EXPLOITING TUMOR BIOLOGY","funder_award_id":"R35CA056517","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G546047228","display_name":null,"funder_award_id":"CA08748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G872256609","display_name":null,"funder_award_id":"CA56517","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000856728","display_name":"Cancer Center Support Grant","funder_award_id":"P30CA008748","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W193327837","https://openalex.org/W1605102643","https://openalex.org/W1618268377","https://openalex.org/W1911655428","https://openalex.org/W1977842477","https://openalex.org/W1986071829","https://openalex.org/W2124335825","https://openalex.org/W2192996503","https://openalex.org/W2276147274"],"related_works":["https://openalex.org/W2164646248","https://openalex.org/W1982640074","https://openalex.org/W2063863692","https://openalex.org/W1497325243","https://openalex.org/W7096174288","https://openalex.org/W2134492379","https://openalex.org/W2059091288","https://openalex.org/W3101216973","https://openalex.org/W2159398732","https://openalex.org/W2038860254"],"abstract_inverted_index":{"cMOAT":[0,37,78,100],"encodes":[1],"an":[2,13],"ATPase":[3],"within":[4,19],"the":[5,20,32,63,75,86,123,133,136],"family":[6],"of":[7,23,34,47,77,88,97,135],"cMOAT/MRP":[8],"ATPases":[9],"that":[10,25,74],"functions":[11],"as":[12],"ATP":[14],"dependent,":[15],"multispecific":[16],"anion":[17],"transporter":[18],"canalicular":[21],"surface":[22],"hepatocytes":[24],"has":[26],"pharmacologic":[27],"significance.":[28],"We":[29],"describe":[30],"here":[31],"cloning":[33],"a":[35,109],"murine":[36,126],"cDNA":[38,49],"isolated":[39],"from":[40],"mouse":[41,83,106,118],"liver.":[42],"The":[43],"open":[44],"reading":[45],"frame":[46],"this":[48],"incorporates":[50],"4627":[51],"nucleotides":[52],"encoding":[53],"1309":[54],"amino":[55,68],"acids":[56],"with":[57,62,91],"77.5%":[58],"and":[59,65,94],"86.7%":[60],"identity":[61],"human":[64],"rat":[66],"encoded":[67],"acids,":[69],"respectively.":[70],"Northern":[71],"blotting":[72],"showed":[73],"expression":[76,129],"mRNA":[79,101,139],"occurs":[80],"primarily":[81],"in":[82,85,105,116,132],"liver":[84],"form":[87,134],"two":[89,138],"variants":[90],"approximately":[92],"5.6":[93],"7.8":[95],"kb":[96],"sequence":[98],"each.":[99],"was":[102,113,130],"also":[103,131],"detected":[104,115],"kidney":[107],"at":[108],"low":[110],"level":[111],"but":[112],"not":[114],"other":[117],"organs":[119],"or":[120],"tumors":[121],"except":[122],"Hep":[124],"1-6":[125],"hepatoma":[127],"where":[128],"same":[137],"variants.":[140]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}