{"id":"https://openalex.org/W1998212880","doi":"https://doi.org/10.1007/bf01701825","title":"Evaluation of pollutant toxicity in aquatic environment by assay of enzymes released from lysosomes","display_name":"Evaluation of pollutant toxicity in aquatic environment by assay of enzymes released from lysosomes","publication_year":1990,"publication_date":"1990-07-01","ids":{"openalex":"https://openalex.org/W1998212880","doi":"https://doi.org/10.1007/bf01701825","mag":"1998212880","pmid":"https://pubmed.ncbi.nlm.nih.gov/2383680"},"language":"en","primary_location":{"id":"doi:10.1007/bf01701825","doi":"https://doi.org/10.1007/bf01701825","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01701825","pdf_url":null,"source":{"id":"https://openalex.org/S106502101","display_name":"Bulletin of Environmental Contamination and Toxicology","issn_l":"0007-4861","issn":["0007-4861","1432-0800"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin of Environmental Contamination and Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080420073","display_name":"Masako Tabata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masako Tabata","raw_affiliation_strings":["Faculty of Pharmaceutical Science, Science University of Tokyo, Japan","\u2020Faculty of Pharmaceutical Science, Science University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Science, Science University of Tokyo, Japan","institution_ids":["https://openalex.org/I161296585"]},{"raw_affiliation_string":"\u2020Faculty of Pharmaceutical Science, Science University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I161296585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009487036","display_name":"Yoshikazu Kobayashi","orcid":"https://orcid.org/0000-0003-1416-7066","observed_orcids":["https://orcid.org/0000-0003-1416-7066"]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshikazu Kobayashi","raw_affiliation_strings":["Faculty of Pharmaceutical Science, Science University of Tokyo, 12 Funaqawara-machi, Ichigaya Shinjukuku, 162, Tokyo, Japan","\u2020Faculty of Pharmaceutical Science, Science University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Science, Science University of Tokyo, 12 Funaqawara-machi, Ichigaya Shinjukuku, 162, Tokyo, Japan","institution_ids":["https://openalex.org/I161296585"]},{"raw_affiliation_string":"\u2020Faculty of Pharmaceutical Science, Science University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I161296585"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Atsushi Nakajima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Nakajima","raw_affiliation_strings":["Faculty of Pharmaceutical Science, Science University of Tokyo, 12 Funaqawara-machi, Ichigaya Shinjukuku, 162, Tokyo, Japan","\u2020Faculty of Pharmaceutical Science, Science University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Science, Science University of Tokyo, 12 Funaqawara-machi, Ichigaya Shinjukuku, 162, Tokyo, Japan","institution_ids":["https://openalex.org/I161296585"]},{"raw_affiliation_string":"\u2020Faculty of Pharmaceutical Science, Science University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I161296585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112642996","display_name":"Shizuo Suzuki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161296585","display_name":"Tokyo University of Science","ror":"https://ror.org/05sj3n476","country_code":"JP","type":"education","lineage":["https://openalex.org/I161296585"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shizuo Suzuki","raw_affiliation_strings":["Faculty of Pharmaceutical Science, Science University of Tokyo, 12 Funaqawara-machi, Ichigaya Shinjukuku, 162, Tokyo, Japan","\u2020Faculty of Pharmaceutical Science, Science University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Science, Science University of Tokyo, 12 Funaqawara-machi, Ichigaya Shinjukuku, 162, Tokyo, Japan","institution_ids":["https://openalex.org/I161296585"]},{"raw_affiliation_string":"\u2020Faculty of Pharmaceutical Science, Science University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I161296585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I161296585"],"apc_list":{"value":3990,"currency":"USD","value_usd":3990},"apc_paid":null,"fwci":0.4442,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.53235083,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"45","issue":"1","first_page":"31","last_page":"38"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pollutant-toxicity","display_name":"pollutant toxicity","score":0.9549999833106995},{"id":"https://openalex.org/keywords/aquatic-organisms","display_name":"aquatic organisms","score":0.75},{"id":"https://openalex.org/keywords/lysosomal-enzymes","display_name":"lysosomal enzymes","score":0.9169999957084656},{"id":"https://openalex.org/keywords/enzyme-release","display_name":"enzyme release","score":0.8349999785423279},{"id":"https://openalex.org/keywords/toxicity-assays","display_name":"toxicity assays","score":0.4580000042915344},{"id":"https://openalex.org/keywords/water-pollution","display_name":"water pollution","score":0.32499998807907104}],"concepts":[{"id":"https://openalex.org/C82685317","wikidata":"https://www.wikidata.org/wiki/Q19829510","display_name":"Pollutant","level":2,"score":0.7809739112854004},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.7447823286056519},{"id":"https://openalex.org/C115346097","wikidata":"https://www.wikidata.org/wiki/Q1412144","display_name":"Ecotoxicology","level":2,"score":0.709576427936554},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.6134774088859558},{"id":"https://openalex.org/C107872376","wikidata":"https://www.wikidata.org/wiki/Q321355","display_name":"Environmental chemistry","level":1,"score":0.547433614730835},{"id":"https://openalex.org/C2991714712","wikidata":"https://www.wikidata.org/wiki/Q3289906","display_name":"Aquatic environment","level":2,"score":0.521660327911377},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4797212481498718},{"id":"https://openalex.org/C90195498","wikidata":"https://www.wikidata.org/wiki/Q183129","display_name":"Water pollution","level":2,"score":0.4356834590435028},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34468793869018555},{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.32874470949172974},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2572488784790039},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.17552176117897034},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06469452381134033}],"mesh":[{"descriptor_ui":"D000135","descriptor_name":"Acid Phosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004784","descriptor_name":"Environmental Monitoring","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D007425","descriptor_name":"Intracellular Membranes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008247","descriptor_name":"Lysosomes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011919","descriptor_name":"Rats, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014873","descriptor_name":"Water Pollutants","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D014874","descriptor_name":"Water Pollutants, Chemical","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf01701825","doi":"https://doi.org/10.1007/bf01701825","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf01701825","pdf_url":null,"source":{"id":"https://openalex.org/S106502101","display_name":"Bulletin of Environmental Contamination and Toxicology","issn_l":"0007-4861","issn":["0007-4861","1432-0800"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin of Environmental Contamination and Toxicology","raw_type":"journal-article"},{"id":"pmid:2383680","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2383680","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bulletin of environmental contamination and toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.7778000235557556,"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":9,"referenced_works":["https://openalex.org/W1775749144","https://openalex.org/W1982835766","https://openalex.org/W2030684769","https://openalex.org/W2031644975","https://openalex.org/W2036185357","https://openalex.org/W2050018275","https://openalex.org/W2057919845","https://openalex.org/W2398609140","https://openalex.org/W2443099238"],"related_works":["https://openalex.org/W2072116693","https://openalex.org/W2075106479","https://openalex.org/W999443792","https://openalex.org/W1982148693","https://openalex.org/W2057284602","https://openalex.org/W7220105537","https://openalex.org/W6981520246","https://openalex.org/W2078125616","https://openalex.org/W1973345322","https://openalex.org/W2008494647"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}