{"id":"https://openalex.org/W1998204850","doi":"https://doi.org/10.1158/1535-7163.targ-11-a203","title":"Abstract A203: Identification of FoxM1/Bub1b signaling pathway as a molecular target in rhabdomyosarcoma.","display_name":"Abstract A203: Identification of FoxM1/Bub1b signaling pathway as a molecular target in rhabdomyosarcoma.","publication_year":2011,"publication_date":"2011-11-01","ids":{"openalex":"https://openalex.org/W1998204850","doi":"https://doi.org/10.1158/1535-7163.targ-11-a203","mag":"1998204850"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.targ-11-a203","doi":"https://doi.org/10.1158/1535-7163.targ-11-a203","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.targ-11-a203","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063240531","display_name":"Xiaolin Wan","orcid":"https://orcid.org/0000-0001-6179-253X","observed_orcids":["https://orcid.org/0000-0001-6179-253X"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaolin Wan","raw_affiliation_strings":["1NCI, NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NCI, NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082248977","display_name":"Choh L. Yeung","orcid":"https://orcid.org/0009-0002-6643-4904","observed_orcids":["https://orcid.org/0009-0002-6643-4904"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Choh Yeung","raw_affiliation_strings":["1NCI, NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NCI, NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100645032","display_name":"Su Young Kim","orcid":"https://orcid.org/0000-0002-6486-8445","observed_orcids":["https://orcid.org/0000-0002-6486-8445","https://orcid.org/0000-0001-7190-0362"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Su Young Kim","raw_affiliation_strings":["1NCI, NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NCI, NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064457454","display_name":"Louis M. Asaudt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louis M. Asaudt","raw_affiliation_strings":["1NCI, NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NCI, NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026629100","display_name":"Helman J. Helman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helman J. Helman","raw_affiliation_strings":["1NCI, NIH, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1NCI, NIH, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"11_Supplement","first_page":"A203","last_page":"A203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.04500000178813934,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.013700000010430813,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rhabdomyosarcoma","display_name":"rhabdomyosarcoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/foxm1","display_name":"FOXM1","score":0.9670000076293945},{"id":"https://openalex.org/keywords/bub1b","display_name":"BUB1B","score":0.9980000257492065},{"id":"https://openalex.org/keywords/spindle-assembly-checkpoint","display_name":"spindle assembly checkpoint","score":0.6890000104904175},{"id":"https://openalex.org/keywords/endoreduplication","display_name":"endoreduplication","score":0.9819999933242798},{"id":"https://openalex.org/keywords/mitotic-catastrophe","display_name":"mitotic catastrophe","score":0.9929999709129333},{"id":"https://openalex.org/keywords/promoter-binding","display_name":"promoter binding","score":0.4950000047683716},{"id":"https://openalex.org/keywords/shrna-screen","display_name":"shRNA screen","score":0.5550000071525574},{"id":"https://openalex.org/keywords/xenograft-tumor-growth","display_name":"xenograft tumor growth","score":0.8169999718666077},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.640999972820282},{"id":"https://openalex.org/keywords/pediatric-soft-tissue-sarcoma","display_name":"pediatric soft tissue sarcoma","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.7928471565246582},{"id":"https://openalex.org/C170240278","wikidata":"https://www.wikidata.org/wiki/Q17928773","display_name":"FOXM1","level":4,"score":0.7592679262161255},{"id":"https://openalex.org/C2780844630","wikidata":"https://www.wikidata.org/wiki/Q1898141","display_name":"Rhabdomyosarcoma","level":3,"score":0.7130281925201416},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5243958830833435},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4888105094432831},{"id":"https://openalex.org/C190232843","wikidata":"https://www.wikidata.org/wiki/Q1950808","display_name":"Small hairpin RNA","level":4,"score":0.43899890780448914},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4117050766944885},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3622535467147827},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.32452428340911865},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30037569999694824},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.2996264696121216},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.22421032190322876},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1924152970314026},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.16546180844306946},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06566810607910156}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.targ-11-a203","doi":"https://doi.org/10.1158/1535-7163.targ-11-a203","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.targ-11-a203","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6200000047683716,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2002435345","https://openalex.org/W2155285468","https://openalex.org/W2487368057","https://openalex.org/W2601700710","https://openalex.org/W6886152291","https://openalex.org/W3132761859","https://openalex.org/W2524677612","https://openalex.org/W3101126143","https://openalex.org/W3127796123","https://openalex.org/W2589507345"],"abstract_inverted_index":{"Abstract":[0],"Rhabdomyosarcoma":[1],"(RMS)":[2],"is":[3,48,177,219],"the":[4,20,34,51,167,180,183,193,216,222,238,249],"most":[5],"common":[6],"pediatric":[7],"soft":[8],"tissue":[9],"sarcoma.":[10],"Intensive":[11],"multi-modal":[12],"therapeutic":[13],"regimens":[14],"have":[15],"increased":[16],"overall":[17],"survival":[18,54,209,225],"in":[19,104,111,124,210,237],"last":[21],"25":[22],"years,":[23],"but":[24],"25%":[25],"of":[26,36,55,64,100,107,117,137,182,187,200,205,226,248],"patients":[27],"still":[28],"succumb":[29],"to":[30,78,87,91,166,198],"disease,":[31],"thus":[32],"necessitating":[33],"identification":[35],"novel":[37],"targets":[38],"for":[39,50,158,179,221,234],"therapy.":[40],"In":[41],"this":[42],"study,":[43],"we":[44,75],"identified":[45],"that":[46,80,135,149,174,215],"Bub1b":[47,72,88,101,119,138,168,184,201],"necessary":[49],"growth":[52,110,207,223],"and":[53,58,161,203,208,224,229,255],"both":[56],"ARMS":[57],"ERMS":[59],"cells":[60,83,120,228],"using":[61],"a":[62,232],"loss":[63],"function":[65],"high-throughput":[66],"shRNA":[67,73,191],"screen.":[68],"Using":[69],"many":[70],"additional":[71],"sequences,":[74],"were":[76,84],"able":[77],"confirm":[79],"human":[81,92,95],"RMS":[82,108,227,235],"more":[85],"sensitive":[86],"knockdown":[89,118,136],"compared":[90],"fibroblasts":[93],"or":[94,192],"ovarian":[96],"cancer":[97],"cells.":[98],"Knockdown":[99],"also":[102],"resulted":[103],"significant":[105],"suppression":[106],"xenografts":[109],"vivo.":[112],"Mechanistically,":[113],"flow":[114],"cytometry":[115],"analysis":[116],"had":[121],"an":[122,154],"increase":[123],">4N":[125],"DNA":[126],"content.":[127],"Live-cell":[128],"time-lapse":[129],"microscopy":[130],"studies":[131],"provided":[132],"direct":[133],"evidence":[134],"promotes":[139],"endoreduplication,":[140],"eventually":[141],"causing":[142],"mitotic":[143,162],"catastrophe.":[144],"Further,":[145],"ChIP":[146],"assay":[147,172],"demonstrated":[148],"Forkhead":[150],"Box":[151],"M1":[152],"(FoxM1),":[153],"essential":[155],"transcriptional":[156],"factor":[157],"G1/S":[159],"transition":[160],"progression,":[163],"directly":[164],"binds":[165],"promoter.":[169,185],"Luciferase":[170],"reporter":[171],"showed":[173],"FoxM1-binding":[175],"region":[176],"critical":[178],"activation":[181],"Suppression":[186],"FoxM1,":[188],"either":[189],"by":[190],"inhibitor":[194],"siomycin":[195],"A,":[196],"led":[197],"reduction":[199],"expression":[202],"inhibition":[204],"cell":[206],"vitro.":[211],"These":[212],"findings":[213],"indicate":[214],"FoxM1-Bub1b":[217],"axis":[218],"important":[220],"may":[230],"be":[231],"target":[233],"therapy":[236],"future.":[239],"Citation":[240],"Format:":[241],"{Authors}.":[242],"{Abstract":[243],"title}":[244],"[abstract].":[245],"In:":[246],"Proceedings":[247],"AACR-NCI-EORTC":[250],"International":[251],"Conference:":[252],"Molecular":[253],"Targets":[254],"Cancer":[256,268],"Therapeutics;":[257],"2011":[258],"Nov":[259],"12-16;":[260],"San":[261],"Francisco,":[262],"CA.":[263],"Philadelphia":[264],"(PA):":[265],"AACR;":[266],"Mol":[267],"Ther":[269],"2011;10(11":[270],"Suppl):Abstract":[271],"nr":[272],"A203.":[273]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2016-06-24T00:00:00"}
