{"id":"https://openalex.org/W1998204503","doi":"https://doi.org/10.3109/07420528.2010.514631","title":"CIRCADIAN PROFILES IN THE EMBRYONIC CHICK HEART: L-TYPE VOLTAGE-GATED CALCIUM CHANNELS AND SIGNALING PATHWAYS","display_name":"CIRCADIAN PROFILES IN THE EMBRYONIC CHICK HEART: L-TYPE VOLTAGE-GATED CALCIUM CHANNELS AND SIGNALING PATHWAYS","publication_year":2010,"publication_date":"2010-10-25","ids":{"openalex":"https://openalex.org/W1998204503","doi":"https://doi.org/10.3109/07420528.2010.514631","mag":"1998204503","pmid":"https://pubmed.ncbi.nlm.nih.gov/20969517","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3155203"},"language":"en","primary_location":{"id":"doi:10.3109/07420528.2010.514631","doi":"https://doi.org/10.3109/07420528.2010.514631","is_oa":false,"landing_page_url":"https://doi.org/10.3109/07420528.2010.514631","pdf_url":null,"source":{"id":"https://openalex.org/S75142505","display_name":"Chronobiology International","issn_l":"0742-0528","issn":["0742-0528","1525-6073"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chronobiology International","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3155203","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043062769","display_name":"Michael Lee Ko","orcid":"https://orcid.org/0000-0002-2723-2464","observed_orcids":["https://orcid.org/0000-0002-2723-2464"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael L. Ko","raw_affiliation_strings":["Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103422929","display_name":"Liheng Shi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liheng Shi","raw_affiliation_strings":["Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016697831","display_name":"Kirill S. Grushin","orcid":"https://orcid.org/0000-0003-1475-9758","observed_orcids":["https://orcid.org/0000-0003-1475-9758"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kirill Grushin","raw_affiliation_strings":["Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032414774","display_name":"Fikru Nigussie","orcid":"https://orcid.org/0000-0001-6486-8624","observed_orcids":["https://orcid.org/0000-0001-6486-8624"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fikru Nigussie","raw_affiliation_strings":["Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076008495","display_name":"Gladys Y.\u2010P. Ko","orcid":"https://orcid.org/0000-0002-6854-777X","observed_orcids":["https://orcid.org/0000-0002-6854-777X"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gladys Y.-P. Ko","raw_affiliation_strings":["Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, Texas, USA","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5076008495"],"corresponding_institution_ids":["https://openalex.org/I91045830"],"apc_list":null,"apc_paid":null,"fwci":0.8671,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.6748747,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"27","issue":"9-10","first_page":"1673","last_page":"1696"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.9136000275611877,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.07840000092983246,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circadian-clock","display_name":"circadian clock","score":0.9079999923706055},{"id":"https://openalex.org/keywords/embryonic-chick-heart","display_name":"chick embryo heart","score":0.9440000057220459},{"id":"https://openalex.org/keywords/l-type-calcium-channels","display_name":"L-type calcium channels","score":0.984000027179718},{"id":"https://openalex.org/keywords/circadian-entrainment","display_name":"circadian entrainment","score":0.7580000162124634},{"id":"https://openalex.org/keywords/light-dark-cycle","display_name":"light-dark cycle","score":0.7580000162124634},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.8970000147819519},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.7540000081062317},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.9810000061988831},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.8100000023841858},{"id":"https://openalex.org/keywords/gsk-3beta","display_name":"GSK3\u03b2","score":0.8479999899864197},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.828000009059906},{"id":"https://openalex.org/keywords/insulin-signaling","display_name":"insulin signaling","score":0.8330000042915344},{"id":"https://openalex.org/keywords/myocardial-contractility","display_name":"cardiac contractility","score":0.7870000004768372},{"id":"https://openalex.org/keywords/circadian-gene-expression","display_name":"circadian gene expression","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.749039351940155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5881741046905518},{"id":"https://openalex.org/C18699975","wikidata":"https://www.wikidata.org/wiki/Q14905735","display_name":"Voltage-dependent calcium channel","level":3,"score":0.5565570592880249},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5419950485229492},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5075034499168396},{"id":"https://openalex.org/C201571599","wikidata":"https://www.wikidata.org/wiki/Q5018840","display_name":"Calcium signaling","level":3,"score":0.4954437017440796},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.492931604385376},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.43739187717437744},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4342253506183624},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.43297067284584045},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39054983854293823},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18813684582710266},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16338783502578735},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13984915614128113}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001683","descriptor_name":"Biological Clocks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002940","descriptor_name":"Circadian Rhythm","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020746","descriptor_name":"Calcium Channels, L-Type","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020746","descriptor_name":"Calcium Channels, L-Type","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020930","descriptor_name":"MAP Kinase Kinase Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.3109/07420528.2010.514631","doi":"https://doi.org/10.3109/07420528.2010.514631","is_oa":false,"landing_page_url":"https://doi.org/10.3109/07420528.2010.514631","pdf_url":null,"source":{"id":"https://openalex.org/S75142505","display_name":"Chronobiology International","issn_l":"0742-0528","issn":["0742-0528","1525-6073"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chronobiology International","raw_type":"journal-article"},{"id":"pmid:20969517","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20969517","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chronobiology international","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3155203","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3155203","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Chronobiol Int","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3155203","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3155203","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Chronobiol Int","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1955978931","display_name":"Circadian Rhythm in Cone Photoreceptors:  Cellular Mechanisms","funder_award_id":"R01EY017452","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":93,"referenced_works":["https://openalex.org/W123622833","https://openalex.org/W154737236","https://openalex.org/W1580066475","https://openalex.org/W1820592996","https://openalex.org/W1967956072","https://openalex.org/W1968078345","https://openalex.org/W1968602579","https://openalex.org/W1970684287","https://openalex.org/W1972454538","https://openalex.org/W1973472018","https://openalex.org/W1974392774","https://openalex.org/W1982815375","https://openalex.org/W1984670498","https://openalex.org/W1989193989","https://openalex.org/W1989325705","https://openalex.org/W1989365038","https://openalex.org/W1989950796","https://openalex.org/W1991105548","https://openalex.org/W1993757019","https://openalex.org/W1993807839","https://openalex.org/W1994912338","https://openalex.org/W1995230392","https://openalex.org/W1998672281","https://openalex.org/W2007337163","https://openalex.org/W2015162349","https://openalex.org/W2016375600","https://openalex.org/W2019028325","https://openalex.org/W2019047215","https://openalex.org/W2024493318","https://openalex.org/W2025907795","https://openalex.org/W2026095792","https://openalex.org/W2026220981","https://openalex.org/W2026304422","https://openalex.org/W2035809873","https://openalex.org/W2037896553","https://openalex.org/W2041618682","https://openalex.org/W2049705063","https://openalex.org/W2050653323","https://openalex.org/W2052610555","https://openalex.org/W2053493452","https://openalex.org/W2053855315","https://openalex.org/W2056659007","https://openalex.org/W2063220119","https://openalex.org/W2064123037","https://openalex.org/W2065511465","https://openalex.org/W2067395653","https://openalex.org/W2067837318","https://openalex.org/W2070352761","https://openalex.org/W2072621146","https://openalex.org/W2074102566","https://openalex.org/W2079131177","https://openalex.org/W2081515783","https://openalex.org/W2083118618","https://openalex.org/W2087133824","https://openalex.org/W2088262418","https://openalex.org/W2094516949","https://openalex.org/W2095836481","https://openalex.org/W2097067662","https://openalex.org/W2098488924","https://openalex.org/W2099546758","https://openalex.org/W2100078256","https://openalex.org/W2101652962","https://openalex.org/W2103466919","https://openalex.org/W2106686068","https://openalex.org/W2106876658","https://openalex.org/W2107594352","https://openalex.org/W2108962098","https://openalex.org/W2109229222","https://openalex.org/W2111374626","https://openalex.org/W2120556942","https://openalex.org/W2122453474","https://openalex.org/W2124642081","https://openalex.org/W2127020339","https://openalex.org/W2130892205","https://openalex.org/W2132222938","https://openalex.org/W2137229556","https://openalex.org/W2138162648","https://openalex.org/W2138773108","https://openalex.org/W2141283808","https://openalex.org/W2153701236","https://openalex.org/W2156407866","https://openalex.org/W2157380176","https://openalex.org/W2157431565","https://openalex.org/W2157691027","https://openalex.org/W2159346017","https://openalex.org/W2159729988","https://openalex.org/W2159825471","https://openalex.org/W2163118541","https://openalex.org/W2165168573","https://openalex.org/W2169597375","https://openalex.org/W2208164462","https://openalex.org/W2417354627","https://openalex.org/W2530879109"],"related_works":["https://openalex.org/W4390902286","https://openalex.org/W1990015610","https://openalex.org/W2046603933","https://openalex.org/W2347113216","https://openalex.org/W4283460250","https://openalex.org/W2026095792","https://openalex.org/W2163118541","https://openalex.org/W4241166918","https://openalex.org/W2037124960","https://openalex.org/W2504027901"],"abstract_inverted_index":{"Circadian":[0],"clocks":[1],"exist":[2],"in":[3,36,51,67,95,119,162,198,203,228,242],"the":[4,108,113,138,151,204,239,243,254],"heart":[5,215,244],"tissue":[6],"and":[7,18,23,63,126,131,137,165,181,193,202,214,221,249],"modulate":[8],"multiple":[9],"physiological":[10,233],"events,":[11],"from":[12],"cardiac":[13,116,166,200,212],"metabolism":[14],"to":[15,47,65,84,253],"contractile":[16],"function":[17],"expression":[19,128],"of":[20,74,81,102,115,129,158,206,237,257],"circadian":[21,34,58,100,135,189,240,255],"oscillator":[22],"metabolic-related":[24],"genes.":[25],"Ample":[26],"evidence":[27],"has":[28],"demonstrated":[29],"that":[30,78],"there":[31],"are":[32,60,79,133,148,186],"endogenous":[33],"oscillators":[35,241],"adult":[37],"mammalian":[38,41],"cardiomyocytes.":[39],"However,":[40],"embryos":[42,77],"cannot":[43],"be":[44,90],"entrained":[45,91],"independently":[46],"light-dark":[48],"(LD)":[49],"cycles":[50,94],"vivo":[52],"without":[53],"any":[54],"maternal":[55,82],"influence,":[56],"but":[57],"genes":[59],"well":[61],"expressed":[62],"able":[64],"oscillate":[66],"embryonic":[68,87,120],"stages.":[69],"The":[70,97,123,155],"authors":[71,98],"took":[72],"advantage":[73],"using":[75],"chick":[76,121],"independent":[80],"influences":[83],"investigate":[85],"whether":[86],"hearts":[88],"could":[89],"under":[92,134,188],"LD":[93],"ovo.":[96],"found":[99],"regulation":[101,256],"L-type":[103],"voltage-gated":[104],"calcium":[105],"channels":[106,110],"(L-VGCCs),":[107],"ion":[109],"responsible":[111],"for":[112],"production":[114],"muscle":[117],"contraction":[118],"hearts.":[122],"mRNA":[124],"levels":[125],"protein":[127,174,177],"VGCC\u03b11C":[130],"VGCC\u03b11D":[132],"control,":[136],"average":[139],"L-VGCC":[140],"current":[141],"density":[142],"is":[143],"significantly":[144],"larger":[145],"when":[146],"cardiomyocytes":[147],"recorded":[149],"during":[150],"night":[152],"than":[153],"day.":[154],"phosphorylation":[156],"states":[157,236],"several":[159],"kinases":[160],"involved":[161],"insulin":[163],"signaling":[164,225],"metabolism,":[167],"including":[168],"extracellular":[169],"signal-regulated":[170],"kinase":[171,175,178],"(Erk),":[172],"stress-activated":[173],"(p38),":[176],"B":[179],"(Akt),":[180],"glycogen":[182],"synthase":[183],"kinase-3\u03b2":[184],"(GSK-3\u03b2),":[185],"also":[187],"control.":[190],"Both":[191],"Erk":[192,220],"p38":[194],"have":[195],"been":[196],"implicated":[197],"regulating":[199],"contractility":[201],"development":[205],"various":[207],"pathological":[208,235],"states,":[209],"such":[210],"as":[211],"hypertrophy":[213],"failure.":[216],"Even":[217],"though":[218],"both":[219,250],"phosphoinositide":[222],"3-kinase":[223],"(PI3K)-Akt":[224],"pathways":[226,247,251],"participate":[227],"complex":[229],"cellular":[230],"processes":[231],"regarding":[232],"or":[234],"cardiomyocytes,":[238],"regulate":[245],"these":[246],"independently,":[248],"contribute":[252],"L-VGCCs.":[258]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}