{"id":"https://openalex.org/W1998198750","doi":"https://doi.org/10.1038/nature08229","title":"XIAP discriminates between type I and type II FAS-induced apoptosis","display_name":"XIAP discriminates between type I and type II FAS-induced apoptosis","publication_year":2009,"publication_date":"2009-07-22","ids":{"openalex":"https://openalex.org/W1998198750","doi":"https://doi.org/10.1038/nature08229","mag":"1998198750","pmid":"https://pubmed.ncbi.nlm.nih.gov/19626005","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2956120"},"language":"en","primary_location":{"id":"doi:10.1038/nature08229","doi":"https://doi.org/10.1038/nature08229","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nature08229","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2956120","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090397464","display_name":"Philipp Jakob Jost","orcid":"https://orcid.org/0000-0003-2454-0362","observed_orcids":["https://orcid.org/0000-0003-2454-0362"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Philipp J. Jost","raw_affiliation_strings":["The Walter and Eliza Hall Institute of Medical Research, Melbourne University, Parkville, Victoria 3050, Australia","The Walter & Eliza Hall Institute of Medical Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Walter and Eliza Hall Institute of Medical Research, Melbourne University, Parkville, Victoria 3050, Australia","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I196021976"]},{"raw_affiliation_string":"The Walter & Eliza Hall Institute of Medical Research","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066686715","display_name":"Stephanie Grabow","orcid":"https://orcid.org/0000-0003-0467-7871","observed_orcids":["https://orcid.org/0000-0003-0467-7871"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Stephanie Grabow","raw_affiliation_strings":["Department of Medical Biology, Melbourne University, Parkville, Victoria 3050, Australia,","The Walter and Eliza Hall Institute of Medical Research,,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology, Melbourne University, Parkville, Victoria 3050, Australia,","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"The Walter and Eliza Hall Institute of Medical Research,,","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078006107","display_name":"Daniel H.D. Gray","orcid":"https://orcid.org/0000-0002-8457-8242","observed_orcids":["https://orcid.org/0000-0002-8457-8242"]},"institutions":[{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Daniel Gray","raw_affiliation_strings":["The Walter and Eliza Hall Institute of Medical Research,,","The Walter & Eliza Hall Institute of Medical Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Walter and Eliza Hall Institute of Medical Research,,","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"The Walter & Eliza Hall Institute of Medical Research","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109853276","display_name":"Mark D. McKenzie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I77826658","display_name":"St Vincents Institute of Medical Research","ror":"https://ror.org/02k3cxs74","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I77826658"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Mark D. McKenzie","raw_affiliation_strings":["Department of Medical Biology, Melbourne University, Parkville, Victoria 3050, Australia,","St Vincent\u2019s Institute of Medical Research, Fitzroy, Victoria 3065, Australia ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biology, Melbourne University, Parkville, Victoria 3050, Australia,","institution_ids":["https://openalex.org/I165779595"]},{"raw_affiliation_string":"St Vincent\u2019s Institute of Medical Research, Fitzroy, Victoria 3065, Australia ,","institution_ids":["https://openalex.org/I77826658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065424896","display_name":"Ueli Nachbur","orcid":"https://orcid.org/0000-0001-5968-2235","observed_orcids":["https://orcid.org/0000-0001-5968-2235"]},"institutions":[{"id":"https://openalex.org/I196829312","display_name":"La Trobe University","ror":"https://ror.org/01rxfrp27","country_code":"AU","type":"education","lineage":["https://openalex.org/I196829312"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ueli Nachbur","raw_affiliation_strings":["Institute of Biochemistry, LaTrobe University, Bundoora, Victoria 3086, Australia ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, LaTrobe University, Bundoora, Victoria 3086, Australia ,","institution_ids":["https://openalex.org/I196829312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040208750","display_name":"David C.S. Huang","orcid":"https://orcid.org/0000-0002-3101-4873","observed_orcids":["https://orcid.org/0000-0002-3101-4873"]},"institutions":[{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David C. S. Huang","raw_affiliation_strings":["The Walter and Eliza Hall Institute of Medical Research,,","The Walter & Eliza Hall Institute of Medical Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Walter and Eliza Hall Institute of Medical Research,,","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"The Walter & Eliza Hall Institute of Medical Research","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066769237","display_name":"Philippe Bouillet","orcid":"https://orcid.org/0000-0002-9012-6058","observed_orcids":["https://orcid.org/0000-0002-9012-6058"]},"institutions":[{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Philippe Bouillet","raw_affiliation_strings":["The Walter and Eliza Hall Institute of Medical Research,,","The Walter & Eliza Hall Institute of Medical Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Walter and Eliza Hall Institute of Medical Research,,","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"The Walter & Eliza Hall Institute of Medical Research","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009874783","display_name":"Helen E. Thomas","orcid":"https://orcid.org/0000-0001-6604-6640","observed_orcids":["https://orcid.org/0000-0001-6604-6640"]},"institutions":[{"id":"https://openalex.org/I77826658","display_name":"St Vincents Institute of Medical Research","ror":"https://ror.org/02k3cxs74","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I77826658"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Helen E. Thomas","raw_affiliation_strings":["\u00b6St. Vincent's Institute of Medical Research, Fitzroy, Victoria 3065, Australia,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"\u00b6St. Vincent's Institute of Medical Research, Fitzroy, Victoria 3065, Australia,","institution_ids":["https://openalex.org/I77826658"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090130012","display_name":"Christoph Borner","orcid":"https://orcid.org/0000-0001-5127-7630","observed_orcids":["https://orcid.org/0000-0001-5127-7630"]},"institutions":[{"id":"https://openalex.org/I161046081","display_name":"University of Freiburg","ror":"https://ror.org/0245cg223","country_code":"DE","type":"education","lineage":["https://openalex.org/I161046081"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Borner","raw_affiliation_strings":["Institute of Molecular Medicine and Cell Research, Centre for Biochemistry and Molecular Cell Research, Freiburg, D79104, Germany ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Medicine and Cell Research, Centre for Biochemistry and Molecular Cell Research, Freiburg, D79104, Germany ,","institution_ids":["https://openalex.org/I161046081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087888938","display_name":"John Silke","orcid":"https://orcid.org/0000-0002-7611-5774","observed_orcids":["https://orcid.org/0000-0002-7611-5774"]},"institutions":[{"id":"https://openalex.org/I196829312","display_name":"La Trobe University","ror":"https://ror.org/01rxfrp27","country_code":"AU","type":"education","lineage":["https://openalex.org/I196829312"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"John Silke","raw_affiliation_strings":["Institute of Biochemistry, LaTrobe University, Bundoora, Victoria 3086, Australia ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry, LaTrobe University, Bundoora, Victoria 3086, Australia ,","institution_ids":["https://openalex.org/I196829312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046532595","display_name":"Andreas Strasser","orcid":"https://orcid.org/0000-0002-5020-4891","observed_orcids":["https://orcid.org/0000-0002-5020-4891"]},"institutions":[{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Andreas Strasser","raw_affiliation_strings":["The Walter and Eliza Hall Institute of Medical Research,,","The Walter & Eliza Hall Institute of Medical Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Walter and Eliza Hall Institute of Medical Research,,","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"The Walter & Eliza Hall Institute of Medical Research","institution_ids":["https://openalex.org/I196021976"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046291484","display_name":"Thomas Kaufmann","orcid":"https://orcid.org/0000-0001-9906-874X","observed_orcids":["https://orcid.org/0000-0001-9906-874X","https://orcid.org/0000-0002-5003-8731","https://orcid.org/0000-0002-3706-0459"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I196021976","display_name":"Walter and Eliza Hall Institute of Medical Research","ror":"https://ror.org/01b6kha49","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I196021976"]}],"countries":["AU","CH"],"is_corresponding":true,"raw_author_name":"Thomas Kaufmann","raw_affiliation_strings":["The Walter and Eliza Hall Institute of Medical Research,,","Present address: Institute of Pharmacology, University of Bern, Bern, CH-3010, Switzerland.,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Walter and Eliza Hall Institute of Medical Research,,","institution_ids":["https://openalex.org/I196021976"]},{"raw_affiliation_string":"Present address: Institute of Pharmacology, University of Bern, Bern, CH-3010, Switzerland.,","institution_ids":["https://openalex.org/I118564535"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5046291484","https://openalex.org/A5046532595"],"corresponding_institution_ids":["https://openalex.org/I118564535","https://openalex.org/I196021976"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":12.9653,"has_fulltext":false,"cited_by_count":501,"citation_normalized_percentile":{"value":0.99425805,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"460","issue":"7258","first_page":"1035","last_page":"1039"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/xiap","display_name":"XIAP","score":0.9879999756813049},{"id":"https://openalex.org/keywords/fas","display_name":"Fas","score":0.6690000295639038},{"id":"https://openalex.org/keywords/fas-ligand","display_name":"Fas ligand","score":0.8289999961853027},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.781000018119812},{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.9390000104904175},{"id":"https://openalex.org/keywords/caspase-9","display_name":"caspase-9","score":0.9369999766349792},{"id":"https://openalex.org/keywords/bid","display_name":"Bid","score":0.9620000123977661},{"id":"https://openalex.org/keywords/smac","display_name":"Smac/DIABLO","score":0.6299999952316284},{"id":"https://openalex.org/keywords/iap-inhibitors","display_name":"IAP inhibitors","score":0.5950000286102295},{"id":"https://openalex.org/keywords/hepatocytes","display_name":"hepatocytes","score":0.828000009059906},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.777999997138977},{"id":"https://openalex.org/keywords/lymphocytes","display_name":"lymphocytes","score":0.8870000243186951},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.3190000057220459},{"id":"https://openalex.org/keywords/liver-disease","display_name":"liver disease","score":0.43799999356269836},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.625},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.421999990940094},{"id":"https://openalex.org/keywords/cell-death-signaling","display_name":"cell death signaling","score":0.3889999985694885},{"id":"https://openalex.org/keywords/gene-targeting","display_name":"gene targeting","score":0.43700000643730164},{"id":"https://openalex.org/keywords/smac-mimetics","display_name":"IAP antagonists","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C33195913","wikidata":"https://www.wikidata.org/wiki/Q20970121","display_name":"XIAP","level":5,"score":0.8795961141586304},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7214933633804321},{"id":"https://openalex.org/C2777408456","wikidata":"https://www.wikidata.org/wiki/Q174299","display_name":"Inhibitor of apoptosis","level":4,"score":0.6879836320877075},{"id":"https://openalex.org/C66008609","wikidata":"https://www.wikidata.org/wiki/Q14866113","display_name":"Fas ligand","level":4,"score":0.6788556575775146},{"id":"https://openalex.org/C3031857","wikidata":"https://www.wikidata.org/wiki/Q1649375","display_name":"Fas receptor","level":4,"score":0.669114887714386},{"id":"https://openalex.org/C170301204","wikidata":"https://www.wikidata.org/wiki/Q24788681","display_name":"Inhibitor of apoptosis domain","level":5,"score":0.6648625135421753},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.6577177047729492},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5757245421409607},{"id":"https://openalex.org/C163421366","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Intrinsic apoptosis","level":5,"score":0.5131788849830627},{"id":"https://openalex.org/C176912530","wikidata":"https://www.wikidata.org/wiki/Q18036542","display_name":"NLRP1","level":5,"score":0.4991323947906494},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4796612560749054},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4760691523551941},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44586503505706787},{"id":"https://openalex.org/C2779004061","wikidata":"https://www.wikidata.org/wiki/Q5247322","display_name":"Death domain","level":4,"score":0.4158675968647003},{"id":"https://openalex.org/C2776055636","wikidata":"https://www.wikidata.org/wiki/Q14907137","display_name":"FADD","level":5,"score":0.41342371702194214},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3976094424724579},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3718540668487549},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1099075973033905}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006505","descriptor_name":"Hepatitis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006505","descriptor_name":"Hepatitis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D022781","descriptor_name":"Hepatocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D040761","descriptor_name":"Biomimetic Materials","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051023","descriptor_name":"BH3 Interacting Domain Death Agonist Protein","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D051023","descriptor_name":"BH3 Interacting Domain Death Agonist Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051636","descriptor_name":"X-Linked Inhibitor of Apoptosis Protein","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D051636","descriptor_name":"X-Linked Inhibitor of Apoptosis Protein","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D051636","descriptor_name":"X-Linked Inhibitor of Apoptosis Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051636","descriptor_name":"X-Linked Inhibitor of Apoptosis Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053222","descriptor_name":"Fas Ligand Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061945","descriptor_name":"Caspase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/nature08229","doi":"https://doi.org/10.1038/nature08229","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nature08229","pdf_url":null,"source":{"id":"https://openalex.org/S137773608","display_name":"Nature","issn_l":"0028-0836","issn":["0028-0836","1476-4687"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"journal-article"},{"id":"pmid:19626005","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19626005","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2956120","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2956120","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nature","raw_type":"Text"},{"id":"pmh:doi:10.48620/8330","doi":null,"is_oa":false,"landing_page_url":"https://boris-portal.unibe.ch/handle/20.500.12422/45943","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"pmh:oai:RePEc:nat:nature:v:460:y:2009:i:7258:d:10.1038_nature08229","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/nature08229","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:boris.unibe.ch:30679","doi":null,"is_oa":false,"landing_page_url":"https://boris.unibe.ch/30679/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401747","display_name":"BORIS (University Library Bern)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210103840","host_organization_name":"Nakuru County Council","host_organization_lineage":["https://openalex.org/I4210103840"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Jost, Philipp J; Grabow, Stephanie; Gray, Daniel; McKenzie, Mark D; Nachbur, Ueli; Huang, David C S; Bouillet, Philippe; Thomas, Helen E; Borner, Christoph; Silke, John; Strasser, Andreas; Kaufmann, Thomas (2009). XIAP discriminates between type I and type II FAS-induced apoptosis. Nature, 460(7258), pp. 1035-1039. London: Macmillan Journals Ltd. 10.1038/nature08229 <http://dx.doi.org/10.1038/nature08229>","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2956120","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2956120","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Nature","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3719052126","display_name":"ONCOGENE INDUCED LEUKEMOGENESIS IN TRANGENIC MICE","funder_award_id":"R01CA043540","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G842413471","display_name":"Mechanisms in the regulation of apoptosis","funder_award_id":"R01CA080188","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1536694140","https://openalex.org/W1593219141","https://openalex.org/W1642763135","https://openalex.org/W1845459216","https://openalex.org/W1973109581","https://openalex.org/W1973462203","https://openalex.org/W1979129905","https://openalex.org/W1996174406","https://openalex.org/W2005775622","https://openalex.org/W2009128649","https://openalex.org/W2010364403","https://openalex.org/W2012825099","https://openalex.org/W2016345107","https://openalex.org/W2040394091","https://openalex.org/W2042409437","https://openalex.org/W2058855556","https://openalex.org/W2064299413","https://openalex.org/W2067534266","https://openalex.org/W2069800916","https://openalex.org/W2080559728","https://openalex.org/W2082259697","https://openalex.org/W2089671344","https://openalex.org/W2093475144","https://openalex.org/W2093730092","https://openalex.org/W2098975407","https://openalex.org/W2105253445","https://openalex.org/W2116609506","https://openalex.org/W2120633856","https://openalex.org/W2128566344","https://openalex.org/W2133958296","https://openalex.org/W2136434413","https://openalex.org/W2145611701","https://openalex.org/W2145626047","https://openalex.org/W2159583680","https://openalex.org/W2162653594","https://openalex.org/W2170640668"],"related_works":["https://openalex.org/W2055756085","https://openalex.org/W2161583051","https://openalex.org/W7096085133","https://openalex.org/W2020547407","https://openalex.org/W3126928504","https://openalex.org/W2022135873","https://openalex.org/W2161892192","https://openalex.org/W1590814623","https://openalex.org/W2029595161","https://openalex.org/W2079630333"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":10},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":26},{"year":2022,"cited_by_count":31},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":31},{"year":2019,"cited_by_count":23},{"year":2018,"cited_by_count":29},{"year":2017,"cited_by_count":41},{"year":2016,"cited_by_count":33},{"year":2015,"cited_by_count":26},{"year":2014,"cited_by_count":39},{"year":2013,"cited_by_count":42},{"year":2012,"cited_by_count":41}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}