{"id":"https://openalex.org/W1998196464","doi":"https://doi.org/10.1111/j.1749-6632.1990.tb16132.x","title":"Local Induction of Acute Synovitis by Transforming Growth Factor\u2010\u03b2","display_name":"Local Induction of Acute Synovitis by Transforming Growth Factor\u2010\u03b2","publication_year":1990,"publication_date":"1990-06-01","ids":{"openalex":"https://openalex.org/W1998196464","doi":"https://doi.org/10.1111/j.1749-6632.1990.tb16132.x","mag":"1998196464"},"language":"en","primary_location":{"id":"doi:10.1111/j.1749-6632.1990.tb16132.x","doi":"https://doi.org/10.1111/j.1749-6632.1990.tb16132.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1990.tb16132.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1749-6632.1990.tb16132.x","source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1749-6632.1990.tb16132.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109853875","display_name":"J B Allen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. B. ALLEN","raw_affiliation_strings":["Cellular Immunology Section, National Institute of Dental Research, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Immunology Section, National Institute of Dental Research, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029802130","display_name":"Carl L. Manthey","orcid":"https://orcid.org/0000-0002-9298-6430","observed_orcids":["https://orcid.org/0000-0002-9298-6430"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. MANTHEY","raw_affiliation_strings":["Cellular Immunology Section, National Institute of Dental Research, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Immunology Section, National Institute of Dental Research, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069692025","display_name":"Larry R. Ellingsworth","orcid":"https://orcid.org/0000-0003-3060-8984","observed_orcids":["https://orcid.org/0000-0003-3060-8984"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L. ELLINGSWORTH","raw_affiliation_strings":["Collagen Corporation Palo Alto, California 94303"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collagen Corporation Palo Alto, California 94303","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035673687","display_name":"Sharon M. Wahl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210088259","display_name":"National Institute of Dental and Craniofacial Research","ror":"https://ror.org/004a2wv92","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. M. WAHL","raw_affiliation_strings":["Cellular Immunology Section, National Institute of Dental Research, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Immunology Section, National Institute of Dental Research, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210088259"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.10852603,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"593","issue":"1","first_page":"323","last_page":"324"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.5996000170707703,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.5996000170707703,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.2816999852657318,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.05959999933838844,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9879999756813049},{"id":"https://openalex.org/keywords/synovitis","display_name":"synovitis","score":0.8610000014305115},{"id":"https://openalex.org/keywords/acute-synovitis","display_name":"acute synovitis","score":0.6299999952316284},{"id":"https://openalex.org/keywords/intra-articular-injection","display_name":"intra-articular injection","score":0.8619999885559082},{"id":"https://openalex.org/keywords/talonavicular-joint","display_name":"talonavicular joint","score":0.671999990940094},{"id":"https://openalex.org/keywords/joint-swelling","display_name":"joint swelling","score":0.5699999928474426},{"id":"https://openalex.org/keywords/erythema","display_name":"erythema","score":0.9129999876022339},{"id":"https://openalex.org/keywords/erosive-polyarthritis","display_name":"erosive polyarthritis","score":0.7689999938011169},{"id":"https://openalex.org/keywords/arthritis","display_name":"arthritis","score":0.4790000021457672},{"id":"https://openalex.org/keywords/immunomodulatory-cytokines","display_name":"immunomodulatory cytokines","score":0.7319999933242798},{"id":"https://openalex.org/keywords/lewis-rats","display_name":"Lewis rats","score":0.4620000123977661}],"concepts":[{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.6403093338012695},{"id":"https://openalex.org/C2780129039","wikidata":"https://www.wikidata.org/wiki/Q1931107","display_name":"Section (typography)","level":2,"score":0.5875881910324097},{"id":"https://openalex.org/C2994040737","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dental research","level":2,"score":0.4985032081604004},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41811466217041016},{"id":"https://openalex.org/C2778805511","wikidata":"https://www.wikidata.org/wiki/Q1713","display_name":"Citation","level":2,"score":0.41363513469696045},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.13706094026565552},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.11910948157310486},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1111/j.1749-6632.1990.tb16132.x","doi":"https://doi.org/10.1111/j.1749-6632.1990.tb16132.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1990.tb16132.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1749-6632.1990.tb16132.x","source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1111/j.1749-6632.1990.tb16132.x","doi":"https://doi.org/10.1111/j.1749-6632.1990.tb16132.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1990.tb16132.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1749-6632.1990.tb16132.x","source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1998196464.pdf","grobid_xml":"https://content.openalex.org/works/W1998196464.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W1495519011","https://openalex.org/W2013993175","https://openalex.org/W2062199188","https://openalex.org/W2082317371","https://openalex.org/W4211166816"],"related_works":["https://openalex.org/W2082317371","https://openalex.org/W7096048959","https://openalex.org/W2157724807","https://openalex.org/W7100775463","https://openalex.org/W1977823951","https://openalex.org/W2119512066","https://openalex.org/W2075391843","https://openalex.org/W2157002510","https://openalex.org/W7097233338","https://openalex.org/W2308897620"],"abstract_inverted_index":{"Transforming":[0],"growth":[1],"factor-fl":[2],"(TGFP),":[3],"a":[4,13,19,33,83,156],"potent":[5],"immunomodulatory":[6],"cytokine":[7],"found":[8],"in":[9,36,43,74,88,97],"inflammatory":[10,67,89,99],"sites,":[11],"is":[12],"product":[14],"of":[15,22,66,71,77,95,123,127,136,146],"hemopoietic":[16],"cells.'TGFB":[17],"has":[18,26,49],"broad":[20],"spectrum":[21],"cellular":[23],"targets":[24],"and":[25,39,60,144],"multifunctional":[27],"actions":[28],"suggesting":[29],"that":[30],"it":[31],"plays":[32],"pivotal":[34],"role":[35,84,94],"many":[37],"physiological":[38],"pathological":[40],"processes?For":[41],"example,":[42],"v":[44],"i":[45],"m":[46],",":[47],"TGFP":[48,73,96],"been":[50],"shown":[51],"to":[52],"induce":[53],"human":[54,114],"monocyte":[55],"chemotaxis":[56],"at":[57],"femtomolar":[58],"concentrations,":[59],"picomolar":[61],"quantities":[62],"stimulate":[63],"the":[64,92,120,124,147],"production":[65],"mediators":[68],"by":[69],"monocytes?Identification":[70],"immunoreactive":[72],"inflamed":[75],"synovium":[76],"rodents":[78],"with":[79],"erosive":[80],"polyarthritis":[81],"suggested":[82],"for":[85],"this":[86],"polypeptide":[87],"lesions.To":[90],"define":[91],"potential":[93],"chronic":[98],"lesions":[100],"such":[101],"as":[102],"arthritis,":[103],"K":[104],"F":[105],"P":[106],"l":[107],"purified":[108],"from":[109],"bovine":[110],"bone":[111],"or":[112],"recombinant":[113],"TGFPl":[115],"was":[116],"injected":[117],"intra-articularly":[118],"through":[119],"extensor":[121],"surface":[122],"talarnavicular":[125],"joint":[126],"Lewis":[128],"rats":[129],"(Harlan":[130],"Sprague":[131],"Dawley,":[132],"Indianapolis,":[133],"IN)?Following":[134],"injection":[135],"1":[137],"pg":[138],"TGFB/25":[139],"pl":[140],"vehicle,":[141],"marked":[142],"swelling":[143],"erythema":[145],"treated":[148],"joints":[149],"were":[150],"apparent":[151],"within":[152],"12":[153],"h,":[154],"reaching":[155],"peak":[157]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}