{"id":"https://openalex.org/W1998188987","doi":"https://doi.org/10.1002/(sici)1098-2825(1998)12:5<285::aid-jcla6>3.0.co;2-5","title":"Biochemical assay for AD7C-NTP in urine as an Alzheimer's disease marker","display_name":"Biochemical assay for AD7C-NTP in urine as an Alzheimer's disease marker","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W1998188987","doi":"https://doi.org/10.1002/(sici)1098-2825(1998)12:5<285::aid-jcla6>3.0.co;2-5","mag":"1998188987","pmid":"https://pubmed.ncbi.nlm.nih.gov/9773959","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6808140"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1098-2825(1998)12:5<285::aid-jcla6>3.0.co;2-5","doi":"https://doi.org/10.1002/(sici)1098-2825(1998)12:5<285::aid-jcla6>3.0.co;2-5","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1098-2825(1998)12:5<285::aid-jcla6>3.0.co;2-5","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291098-2825%281998%2912%3A5%3C285%3A%3AAID-JCLA6%3E3.0.CO%3B2-5","source":{"id":"https://openalex.org/S28295008","display_name":"Journal of Clinical Laboratory Analysis","issn_l":"0887-8013","issn":["0887-8013","1098-2825"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Laboratory Analysis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291098-2825%281998%2912%3A5%3C285%3A%3AAID-JCLA6%3E3.0.CO%3B2-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hossein Ghanbari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hossein Ghanbari","raw_affiliation_strings":["Nymox Corporation, Rockville, Maryland 20895, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nymox Corporation, Rockville, Maryland 20895, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046723368","display_name":"Kasra Ghanbari","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kasra Ghanbari","raw_affiliation_strings":["Nymox Corporation, Rockville, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nymox Corporation, Rockville, Maryland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052108317","display_name":"Iraj Beheshti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iraj Beheshti","raw_affiliation_strings":["Nymox Corporation, Rockville, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nymox Corporation, Rockville, Maryland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011257392","display_name":"Michael Munzar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Munzar","raw_affiliation_strings":["Nymox Corporation, Rockville, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nymox Corporation, Rockville, Maryland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026345808","display_name":"Audrey A. Vasauskas","orcid":"https://orcid.org/0000-0002-1724-5923","observed_orcids":["https://orcid.org/0000-0002-1724-5923"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Audrey Vasauskas","raw_affiliation_strings":["Nymox Corporation, Rockville, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nymox Corporation, Rockville, Maryland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033168021","display_name":"Paul Averback","orcid":"https://orcid.org/0000-0001-7144-255X","observed_orcids":["https://orcid.org/0000-0001-7144-255X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Averback","raw_affiliation_strings":["Nymox Corporation, Rockville, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nymox Corporation, Rockville, Maryland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3120,"currency":"USD","value_usd":3120},"apc_paid":null,"fwci":1.0601,"has_fulltext":true,"cited_by_count":76,"citation_normalized_percentile":{"value":0.73458977,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"12","issue":"5","first_page":"285","last_page":"288"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.027699999511241913,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11314","display_name":"Clinical Laboratory Practices and Quality Control","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3607","display_name":"Medical Laboratory Technology"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8130000233650208},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.9290000200271606},{"id":"https://openalex.org/keywords/immunoassay","display_name":"immunoassay","score":0.8700000047683716},{"id":"https://openalex.org/keywords/sandwich-elisa","display_name":"sandwich ELISA","score":0.9139999747276306},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.9190000295639038},{"id":"https://openalex.org/keywords/polyclonal-antibodies","display_name":"polyclonal antibodies","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.8130000233650208},{"id":"https://openalex.org/keywords/ultrafiltration","display_name":"ultrafiltration","score":0.609000027179718},{"id":"https://openalex.org/keywords/sensitivity-and-specificity","display_name":"sensitivity and specificity","score":0.5120000243186951}],"concepts":[{"id":"https://openalex.org/C2780420688","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Immunoassay","level":3,"score":0.7965860962867737},{"id":"https://openalex.org/C956191","wikidata":"https://www.wikidata.org/wiki/Q930144","display_name":"Polyclonal antibodies","level":3,"score":0.7713530659675598},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.7233039140701294},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6371584534645081},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6134588718414307},{"id":"https://openalex.org/C2778810118","wikidata":"https://www.wikidata.org/wiki/Q534260","display_name":"Microtiter plate","level":2,"score":0.5211639404296875},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4696744382381439},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.45205917954444885},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.43033671379089355},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3406286835670471},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1836097538471222},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16001155972480774},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.156520813703537},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14647316932678223}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000652","qualifier_name":"urine","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/(sici)1098-2825(1998)12:5<285::aid-jcla6>3.0.co;2-5","doi":"https://doi.org/10.1002/(sici)1098-2825(1998)12:5<285::aid-jcla6>3.0.co;2-5","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1098-2825(1998)12:5<285::aid-jcla6>3.0.co;2-5","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291098-2825%281998%2912%3A5%3C285%3A%3AAID-JCLA6%3E3.0.CO%3B2-5","source":{"id":"https://openalex.org/S28295008","display_name":"Journal of Clinical Laboratory Analysis","issn_l":"0887-8013","issn":["0887-8013","1098-2825"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Laboratory Analysis","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5806069","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6808140","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:9773959","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9773959","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical laboratory analysis","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:6808140","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC6808140/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Lab Anal","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/(sici)1098-2825(1998)12:5<285::aid-jcla6>3.0.co;2-5","doi":"https://doi.org/10.1002/(sici)1098-2825(1998)12:5<285::aid-jcla6>3.0.co;2-5","is_oa":true,"landing_page_url":"https://doi.org/10.1002/(sici)1098-2825(1998)12:5<285::aid-jcla6>3.0.co;2-5","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/%28SICI%291098-2825%281998%2912%3A5%3C285%3A%3AAID-JCLA6%3E3.0.CO%3B2-5","source":{"id":"https://openalex.org/S28295008","display_name":"Journal of Clinical Laboratory Analysis","issn_l":"0887-8013","issn":["0887-8013","1098-2825"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","medline","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Laboratory Analysis","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308349","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1998188987.pdf","grobid_xml":"https://content.openalex.org/works/W1998188987.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1802685009","https://openalex.org/W1982341565","https://openalex.org/W1992760273","https://openalex.org/W2000548634","https://openalex.org/W2008075718","https://openalex.org/W2013764865","https://openalex.org/W2022423664","https://openalex.org/W2029267814","https://openalex.org/W2031767797","https://openalex.org/W2049054180","https://openalex.org/W2062767658","https://openalex.org/W2078172920","https://openalex.org/W2083163204","https://openalex.org/W2156220037","https://openalex.org/W2171405125"],"related_works":["https://openalex.org/W2008075718","https://openalex.org/W2377626432","https://openalex.org/W2378705810","https://openalex.org/W2116532638","https://openalex.org/W2357869196","https://openalex.org/W2081336013","https://openalex.org/W1517756135","https://openalex.org/W4213051861","https://openalex.org/W2120564388","https://openalex.org/W1929619733"],"abstract_inverted_index":{"A":[0],"reliable":[1],"and":[2,10,29,33,46,63,100,135,167],"specific":[3],"immunoassay":[4,78],"has":[5,38,54,96,124],"been":[6,125],"developed":[7,66],"to":[8,31,60,174],"detect":[9],"measure":[11],"AD7C-NTP,":[12,103],"a":[13,91,97,115],"biochemical":[14],"marker":[15],"for":[16,102],"Alzheimer's":[17,131],"disease,":[18],"in":[19,44,139,162],"urine.":[20],"The":[21,36,85,110,119],"urine":[22,128],"samples":[23],"are":[24],"first":[25],"processed":[26],"by":[27,49],"centrifugation":[28],"ultrafiltration":[30],"fractionate":[32],"concentrate":[34],"AD7C-NTP.":[35,70],"urinaryAD7C-NTP":[37],"the":[39,57,61,108,122,140,150],"same":[40],"molecular":[41],"weight":[42],"asAD7C-NTP":[43],"brain":[45],"cerebrospinal":[47],"fluid":[48],"size":[50],"exclusion":[51],"chromatography.":[52],"It":[53],"also":[55],"retained":[56],"binding":[58],"properties":[59],"monoclonal":[62,92],"polyclonal":[64,116],"antibodies":[65],"against":[67],"recombinantly":[68],"produced":[69],"This":[71],"assay":[72,123],"is":[73,88],"an":[74],"enzyme":[75],"linked":[76],"sandwich":[77],"(ELSIA)":[79],"using":[80,114,127],"96":[81],"well":[82],"microtiter":[83],"plates.":[84],"plate":[86],"surface":[87],"coated":[89],"with":[90],"antibody":[93,117],"(N314)":[94],"which":[95],"high":[98],"affinity":[99],"specificity":[101,166],"capturing":[104],"it":[105],"effectively":[106],"from":[107,130],"samples.":[109],"detection":[111],"was":[112,146],"achieved":[113],"(ADRI).":[118],"utility":[120],"of":[121,169],"demonstrated":[126],"specimens":[129],"disease":[132],"(AD)":[133],"patients":[134],"non-Alzheimer's":[136],"controls.":[137],"UrinaryAD7C-NTP":[138],"AD":[141],"group":[142,152],"(2.5":[143],"ng/mL,":[144,154],"n=66)":[145],"significantly":[147],"higher":[148],"than":[149],"non-AD":[151],"(0.8":[153],"n=134).":[155],"Using":[156],"1.5":[157],"ng/mL":[158],"as":[159],"cut":[160],"off,":[161],"this":[163],"patient":[164],"population,":[165],"sensitivity":[168],"urinary":[170],"AD7C-NTP":[171],"were":[172],"comparable":[173],"CSFAD7C-NTP.":[175]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}