{"id":"https://openalex.org/W1998182007","doi":"https://doi.org/10.1200/jco.2007.15.3767","title":"Oxaliplatin-Related Neurotoxicity: Interest of Calcium-Magnesium Infusion and No Impact on Its Efficacy","display_name":"Oxaliplatin-Related Neurotoxicity: Interest of Calcium-Magnesium Infusion and No Impact on Its Efficacy","publication_year":2008,"publication_date":"2008-02-28","ids":{"openalex":"https://openalex.org/W1998182007","doi":"https://doi.org/10.1200/jco.2007.15.3767","mag":"1998182007","pmid":"https://pubmed.ncbi.nlm.nih.gov/18309961"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2007.15.3767","doi":"https://doi.org/10.1200/jco.2007.15.3767","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2007.15.3767","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2007.15.3767?role=tab","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1998182007"],"child_works_count":0,"type":"letter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2007.15.3767?role=tab","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033165264","display_name":"Laurence Gamelin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Laurence Gamelin","raw_affiliation_strings":["Clinical Pharmacology Department, Cancer Center Paul Papin, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Angers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Department, Cancer Center Paul Papin, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Angers, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081664619","display_name":"Mich\u00e8le Boisdron\u2010Celle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mich\u00e8le Boisdron-Celle","raw_affiliation_strings":["Clinical Pharmacology Department, Cancer Center Paul Papin, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Angers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Department, Cancer Center Paul Papin, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Angers, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010952073","display_name":"Alain Morel","orcid":"https://orcid.org/0000-0003-0125-1883","observed_orcids":["https://orcid.org/0000-0003-0125-1883"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Alain Morel","raw_affiliation_strings":["Clinical Pharmacology Department, Cancer Center Paul Papin, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Angers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology Department, Cancer Center Paul Papin, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Angers, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Anne Lise Poirier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Anne Lise Poirier","raw_affiliation_strings":["Statistics Department, Cancer Center Paul Papin, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Angers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Statistics Department, Cancer Center Paul Papin, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Angers, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111417134","display_name":"Virginie Berger","orcid":"https://orcid.org/0000-0003-4561-5984","observed_orcids":["https://orcid.org/0000-0003-4561-5984"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Virginie Berger","raw_affiliation_strings":["Clinical Trial Department, Cancer Center Paul Papin, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Angers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trial Department, Cancer Center Paul Papin, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Angers, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056083434","display_name":"Erick C. Gamelin","orcid":"https://orcid.org/0009-0007-8408-2523","observed_orcids":["https://orcid.org/0009-0007-8408-2523"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Erick Gamelin","raw_affiliation_strings":["Medical Oncology and Clinical Pharmacology Departments, Cancer Center Paul Papin, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Angers, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology and Clinical Pharmacology Departments, Cancer Center Paul Papin, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Angers, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020893157","display_name":"Christophe Tournigand","orcid":"https://orcid.org/0000-0002-6232-4815","observed_orcids":["https://orcid.org/0000-0002-6232-4815"]},"institutions":[{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christophe Tournigand","raw_affiliation_strings":["Medical Oncology, Saint Antoine Hospital, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology, Saint Antoine Hospital, Paris, France","institution_ids":["https://openalex.org/I4210102928"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054670872","display_name":"Aimery de Gramont","orcid":"https://orcid.org/0000-0001-7940-9877","observed_orcids":["https://orcid.org/0000-0001-7940-9877"]},"institutions":[{"id":"https://openalex.org/I4210102928","display_name":"H\u00f4pital Saint-Antoine","ror":"https://ror.org/01875pg84","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210102928"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Aimery de Gramont","raw_affiliation_strings":["Medical Oncology, Saint Antoine Hospital, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology, Saint Antoine Hospital, Paris, France","institution_ids":["https://openalex.org/I4210102928"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":100,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"26","issue":"7","first_page":"1188","last_page":"1189"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oxaliplatin","display_name":"oxaliplatin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.9819999933242798},{"id":"https://openalex.org/keywords/chemotherapy-induced-peripheral-neuropathy","display_name":"chemotherapy-induced peripheral neuropathy","score":0.6399999856948853},{"id":"https://openalex.org/keywords/drug-efficacy","display_name":"drug efficacy","score":0.42100000381469727},{"id":"https://openalex.org/keywords/supportive-care","display_name":"supportive care","score":0.3499999940395355}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8811715841293335},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.7962212562561035},{"id":"https://openalex.org/C2780962732","wikidata":"https://www.wikidata.org/wiki/Q422327","display_name":"Oxaliplatin","level":4,"score":0.7676532864570618},{"id":"https://openalex.org/C543218039","wikidata":"https://www.wikidata.org/wiki/Q660","display_name":"Magnesium","level":2,"score":0.5767247080802917},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5005087852478027},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.43737661838531494},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.3431450128555298},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31068193912506104},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.27473676204681396},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.1395794153213501},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.0},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077150","descriptor_name":"Oxaliplatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008274","descriptor_name":"Magnesium","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D009944","descriptor_name":"Organoplatinum Compounds","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D015337","descriptor_name":"Multicenter Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016032","descriptor_name":"Randomized Controlled Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020258","descriptor_name":"Neurotoxicity Syndromes","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1200/jco.2007.15.3767","doi":"https://doi.org/10.1200/jco.2007.15.3767","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2007.15.3767","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2007.15.3767?role=tab","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:18309961","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18309961","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical oncology : official journal of the American Society of Clinical Oncology","raw_type":"Letter"}],"best_oa_location":{"id":"doi:10.1200/jco.2007.15.3767","doi":"https://doi.org/10.1200/jco.2007.15.3767","is_oa":true,"landing_page_url":"https://doi.org/10.1200/jco.2007.15.3767","pdf_url":"https://ascopubs.org/doi/pdfdirect/10.1200/JCO.2007.15.3767?role=tab","source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319918","display_name":"York University","ror":"https://ror.org/05fq50484"},{"id":"https://openalex.org/F4320332230","display_name":"School of Medicine, New York University","ror":"https://ror.org/0190ak572"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1998182007.pdf","grobid_xml":"https://content.openalex.org/works/W1998182007.grobid-xml"},"referenced_works_count":3,"referenced_works":["https://openalex.org/W2122169848","https://openalex.org/W2148622949","https://openalex.org/W2175773713"],"related_works":["https://openalex.org/W1980899499","https://openalex.org/W2396254463","https://openalex.org/W2122169848","https://openalex.org/W4247005296","https://openalex.org/W4230618524","https://openalex.org/W2103128889","https://openalex.org/W2367806705","https://openalex.org/W2750725778","https://openalex.org/W2903640684","https://openalex.org/W2591239359"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}