{"id":"https://openalex.org/W1998175292","doi":"https://doi.org/10.2307/3579975","title":"DNA Fragmentation Induced by a Cytoplasmic Extract from Irradiated Cells","display_name":"DNA Fragmentation Induced by a Cytoplasmic Extract from Irradiated Cells","publication_year":1998,"publication_date":"1998-09-01","ids":{"openalex":"https://openalex.org/W1998175292","doi":"https://doi.org/10.2307/3579975","mag":"1998175292","pmid":"https://pubmed.ncbi.nlm.nih.gov/9728655"},"language":"en","primary_location":{"id":"doi:10.2307/3579975","doi":"https://doi.org/10.2307/3579975","is_oa":false,"landing_page_url":"https://doi.org/10.2307/3579975","pdf_url":null,"source":{"id":"https://openalex.org/S152208300","display_name":"Radiation Research","issn_l":"0033-7587","issn":["0033-7587","1938-5404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315745","host_organization_name":"Radiation Research Society","host_organization_lineage":["https://openalex.org/P4310315745"],"host_organization_lineage_names":["Radiation Research Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103903019","display_name":"Hiroaki Kurihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89630735","display_name":"Yokohama City University","ror":"https://ror.org/0135d1r83","country_code":"JP","type":"education","lineage":["https://openalex.org/I89630735"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroaki Kurihara","raw_affiliation_strings":["Department of Radiology, Yokohama City University School of Medicine, Yokohama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Yokohama City University School of Medicine, Yokohama, Japan","institution_ids":["https://openalex.org/I89630735"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032901550","display_name":"Soichiro Torigoe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Soichiro Torigoe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018356776","display_name":"Motoko Omura","orcid":"https://orcid.org/0000-0002-1344-0588","observed_orcids":["https://orcid.org/0000-0002-1344-0588"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Motoko Omura","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103719287","display_name":"Kimihiko Saito","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kimihiko Saito","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084513674","display_name":"Miki Kurihara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Miki Kurihara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5011828736","display_name":"Sho Matsubara","orcid":"https://orcid.org/0000-0002-4323-5470","observed_orcids":["https://orcid.org/0000-0002-4323-5470"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sho Matsubara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2907,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.46410416,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"150","issue":"3","first_page":"269","last_page":"269"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiation-induced-apoptosis","display_name":"radiation-induced apoptosis","score":0.9240000247955322},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.9700000286102295},{"id":"https://openalex.org/keywords/cytoplasmic-extracts","display_name":"cytoplasmic extracts","score":0.9480000138282776},{"id":"https://openalex.org/keywords/caspase-3-activation","display_name":"caspase-3 activation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.7120000123977661},{"id":"https://openalex.org/keywords/gamma-radiation","display_name":"gamma radiation","score":0.703000009059906},{"id":"https://openalex.org/keywords/hl-60-cells","display_name":"HL-60 cells","score":0.7950000166893005},{"id":"https://openalex.org/keywords/hela-s3-cells","display_name":"HeLa S3 cells","score":0.9079999923706055},{"id":"https://openalex.org/keywords/caspase-3-inhibitor","display_name":"caspase-3 inhibitor","score":0.8009999990463257},{"id":"https://openalex.org/keywords/ice-inhibitors","display_name":"ICE inhibitors","score":0.8650000095367432}],"concepts":[{"id":"https://openalex.org/C155878803","wikidata":"https://www.wikidata.org/wiki/Q5205755","display_name":"DNA laddering","level":5,"score":0.9072850942611694},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.8475872278213501},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8203022480010986},{"id":"https://openalex.org/C191015642","wikidata":"https://www.wikidata.org/wiki/Q1132459","display_name":"Fragmentation (computing)","level":2,"score":0.6462321877479553},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.6401766538619995},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6300535798072815},{"id":"https://openalex.org/C2777366897","wikidata":"https://www.wikidata.org/wiki/Q847482","display_name":"HeLa","level":3,"score":0.6175743341445923},{"id":"https://openalex.org/C2780723820","wikidata":"https://www.wikidata.org/wiki/Q1934178","display_name":"Nucleus","level":2,"score":0.5673536062240601},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5613580346107483},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5520761013031006},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5515626668930054},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5481187105178833},{"id":"https://openalex.org/C87439868","wikidata":"https://www.wikidata.org/wiki/Q4780527","display_name":"Apoptotic DNA fragmentation","level":5,"score":0.4589240849018097},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.457057923078537},{"id":"https://openalex.org/C2778271344","wikidata":"https://www.wikidata.org/wiki/Q903395","display_name":"Agarose gel electrophoresis","level":3,"score":0.43175452947616577},{"id":"https://openalex.org/C2780114586","wikidata":"https://www.wikidata.org/wiki/Q40260","display_name":"Cell nucleus","level":3,"score":0.42217332124710083},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.41822415590286255},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2784665822982788},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25104743242263794},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002457","descriptor_name":"Cell Extracts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002474","descriptor_name":"Cell-Free System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002588","descriptor_name":"Cesium Radioisotopes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005720","descriptor_name":"Gamma Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D018922","descriptor_name":"HL-60 Cells","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053938","descriptor_name":"DNA Fragmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2307/3579975","doi":"https://doi.org/10.2307/3579975","is_oa":false,"landing_page_url":"https://doi.org/10.2307/3579975","pdf_url":null,"source":{"id":"https://openalex.org/S152208300","display_name":"Radiation Research","issn_l":"0033-7587","issn":["0033-7587","1938-5404"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315745","host_organization_name":"Radiation Research Society","host_organization_lineage":["https://openalex.org/P4310315745"],"host_organization_lineage_names":["Radiation Research Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation Research","raw_type":"journal-article"},{"id":"pmid:9728655","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9728655","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Radiation research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.46810001134872437}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W996402337","https://openalex.org/W1485476587","https://openalex.org/W1660472675","https://openalex.org/W1832527043","https://openalex.org/W1916777863","https://openalex.org/W1917341586","https://openalex.org/W1962843014","https://openalex.org/W1979995768","https://openalex.org/W1981106016","https://openalex.org/W1982789641","https://openalex.org/W1987785848","https://openalex.org/W1990917512","https://openalex.org/W1991605327","https://openalex.org/W2007861801","https://openalex.org/W2014988811","https://openalex.org/W2017729786","https://openalex.org/W2049108649","https://openalex.org/W2052853635","https://openalex.org/W2057257609","https://openalex.org/W2064508977","https://openalex.org/W2081145901","https://openalex.org/W2081948388","https://openalex.org/W2082259697","https://openalex.org/W2083560313","https://openalex.org/W2093875241","https://openalex.org/W2131274358","https://openalex.org/W2142301272","https://openalex.org/W2149967205","https://openalex.org/W2292126774"],"related_works":["https://openalex.org/W229225355","https://openalex.org/W2003173723","https://openalex.org/W2102611193","https://openalex.org/W2058324380","https://openalex.org/W2165177373","https://openalex.org/W2124716791","https://openalex.org/W2148016257","https://openalex.org/W2047840444","https://openalex.org/W2259493378","https://openalex.org/W2017971377"],"abstract_inverted_index":{"Apoptosis":[0],"is":[1,89],"a":[2,29,72,103,132,142,155],"mode":[3],"of":[4,63,96,117,127,163,169],"cell":[5],"death":[6],"characterized":[7],"by":[8,141,147],"distinct":[9],"morphological":[10],"features":[11],"and":[12,28,86,121],"DNA":[13,84,134],"fragmentation.":[14],"The":[15],"program":[16],"that":[17,71,87,154],"leads":[18],"to":[19,24,33,82,102],"apoptosis":[20],"has":[21,79],"been":[22,112],"considered":[23],"be":[25],"predominantly":[26],"extranuclear,":[27],"signal":[30,51,156],"transduction":[31,52,157],"pathway":[32,53,158],"the":[34,44,50,57,60,80,128],"nucleus":[35],"exists":[36],"during":[37,171],"apoptosis,":[38,49],"while":[39],"characteristic":[40,133],"events":[41],"occur":[42],"in":[43,91],"nucleus.":[45],"As":[46],"for":[47],"radiation-induced":[48,172],"remains":[54],"unclear,":[55],"especially":[56],"sites":[58],"where":[59],"primary":[61],"effect":[62],"radiation":[64,165],"occurs.":[65],"In":[66],"this":[67,92],"study,":[68],"we":[69],"demonstrate":[70],"cytoplasmic":[73,104],"extract":[74,105],"prepared":[75],"from":[76,107,159],"irradiated":[77,113],"cells":[78,99,109],"ability":[81],"cause":[83],"fragmentation":[85],"caspase-3":[88,143,170],"activated":[90],"extract.":[93],"Normal":[94],"nuclei":[95,130],"HeLa":[97],"S3":[98],"were":[100,122],"added":[101,129],"made":[106],"HL60":[108],"which":[110],"had":[111],"with":[114],"30":[115],"Gy":[116],"137Cs":[118],"gamma":[119,164],"rays":[120],"incubated.":[123],"Agarose":[124],"gel":[125],"electrophoresis":[126],"showed":[131],"laddering":[135],"pattern.":[136],"This":[137],"reaction":[138],"was":[139],"blocked":[140],"inhibitor":[144],"but":[145],"not":[146],"an":[148,160],"ICE":[149],"inhibitor.":[150],"These":[151],"observations":[152],"suggest":[153],"unknown":[161],"target":[162],"may":[166],"exist":[167],"upstream":[168],"apoptosis.":[173]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
