{"id":"https://openalex.org/W1998153022","doi":"https://doi.org/10.1177/0333102413490351","title":"Occipital nerve stimulation in medically intractable, chronic cluster headache. The ICON study: Rationale and protocol of a randomised trial","display_name":"Occipital nerve stimulation in medically intractable, chronic cluster headache. The ICON study: Rationale and protocol of a randomised trial","publication_year":2013,"publication_date":"2013-05-29","ids":{"openalex":"https://openalex.org/W1998153022","doi":"https://doi.org/10.1177/0333102413490351","mag":"1998153022","pmid":"https://pubmed.ncbi.nlm.nih.gov/23720502"},"language":"en","primary_location":{"id":"doi:10.1177/0333102413490351","doi":"https://doi.org/10.1177/0333102413490351","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0333102413490351","pdf_url":null,"source":{"id":"https://openalex.org/S141866484","display_name":"Cephalalgia","issn_l":"0333-1024","issn":["0333-1024","1468-2982"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cephalalgia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074921337","display_name":"Leopoldine A. Wilbrink","orcid":"https://orcid.org/0000-0003-1226-1059","observed_orcids":["https://orcid.org/0000-0003-1226-1059"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]},{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800191616"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Leopoldine A Wilbrink","raw_affiliation_strings":["Department of Neurology, LUMC, the Netherlands","Department of Neurosurgery, MUMC+, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, LUMC, the Netherlands","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Department of Neurosurgery, MUMC+, the Netherlands","institution_ids":["https://openalex.org/I2800191616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006098774","display_name":"Onno Teernstra","orcid":"https://orcid.org/0009-0004-9416-5830","observed_orcids":["https://orcid.org/0009-0004-9416-5830"]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800191616"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Onno PM Teernstra","raw_affiliation_strings":["Department of Neurosurgery, MUMC+, the Netherlands","#N# 2Department of Neurosurgery, MUMC+, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, MUMC+, the Netherlands","institution_ids":["https://openalex.org/I2800191616"]},{"raw_affiliation_string":"#N# 2Department of Neurosurgery, MUMC+, the Netherlands","institution_ids":["https://openalex.org/I2800191616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109332440","display_name":"Joost Haan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]},{"id":"https://openalex.org/I4210156209","display_name":"Rijnland Ziekenhuis","ror":"https://ror.org/05vc4qy60","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210156209"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Joost Haan","raw_affiliation_strings":["Department of Neurology, LUMC, the Netherlands","Department of Neurology, Rijnland Hospital, the Netherlands","1Department of Neurology, LUMC, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, LUMC, the Netherlands","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"Department of Neurology, Rijnland Hospital, the Netherlands","institution_ids":["https://openalex.org/I4210156209"]},{"raw_affiliation_string":"1Department of Neurology, LUMC, the Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049851588","display_name":"Erik W. van Zwet","orcid":"https://orcid.org/0000-0001-5537-3179","observed_orcids":["https://orcid.org/0000-0001-5537-3179"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Erik W van Zwet","raw_affiliation_strings":["Department of Medical Statistics & BioInformatics, LUMC, the Netherlands","#N# 4Department of Medical Statistics & BioInformatics, LUMC, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Statistics & BioInformatics, LUMC, the Netherlands","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"#N# 4Department of Medical Statistics & BioInformatics, LUMC, the Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010411606","display_name":"Silvia Evers","orcid":"https://orcid.org/0000-0003-1026-570X","observed_orcids":["https://orcid.org/0000-0003-1026-570X"]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]},{"id":"https://openalex.org/I4405268545","display_name":"Care and Public Health Research Institute","ror":"https://ror.org/01930wn69","country_code":"NL","type":"facility","lineage":["https://openalex.org/I34352273","https://openalex.org/I4405268545"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Silvia MAA Evers","raw_affiliation_strings":["Faculty of Health, Medicine and Life Sciences, Maastricht University, Caphri School of Public Health and Primary Care, the Netherlands","5Faculty of Health, Medicine and Life Sciences, Maastricht University, Caphri School of Public Health and Primary Care, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Health, Medicine and Life Sciences, Maastricht University, Caphri School of Public Health and Primary Care, the Netherlands","institution_ids":["https://openalex.org/I34352273"]},{"raw_affiliation_string":"5Faculty of Health, Medicine and Life Sciences, Maastricht University, Caphri School of Public Health and Primary Care, the Netherlands","institution_ids":["https://openalex.org/I34352273","https://openalex.org/I4405268545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090480150","display_name":"Geert H.J.J. Spincemaille","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800191616","display_name":"Maastricht University Medical Centre","ror":"https://ror.org/02d9ce178","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800191616"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Geert H Spincemaille","raw_affiliation_strings":["Department of Neurosurgery, MUMC+, the Netherlands","#N# 2Department of Neurosurgery, MUMC+, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, MUMC+, the Netherlands","institution_ids":["https://openalex.org/I2800191616"]},{"raw_affiliation_string":"#N# 2Department of Neurosurgery, MUMC+, the Netherlands","institution_ids":["https://openalex.org/I2800191616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080611863","display_name":"Petrus H. Veltink","orcid":"https://orcid.org/0000-0002-1796-9999","observed_orcids":["https://orcid.org/0000-0002-1796-9999"]},"institutions":[{"id":"https://openalex.org/I94624287","display_name":"University of Twente","ror":"https://ror.org/006hf6230","country_code":"NL","type":"education","lineage":["https://openalex.org/I94624287"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Peter H Veltink","raw_affiliation_strings":["Department of Biomedical Signals and Systems University of Twente, the Netherlands","6Department of Biomedical Signals and Systems University of Twente, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Signals and Systems University of Twente, the Netherlands","institution_ids":["https://openalex.org/I94624287"]},{"raw_affiliation_string":"6Department of Biomedical Signals and Systems University of Twente, the Netherlands","institution_ids":["https://openalex.org/I94624287"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016685655","display_name":"Wim M. Mulleners","orcid":"https://orcid.org/0000-0002-8039-2491","observed_orcids":["https://orcid.org/0000-0002-8039-2491"]},"institutions":[{"id":"https://openalex.org/I4210113935","display_name":"Canisius-Wilhelmina Ziekenhuis","ror":"https://ror.org/027vts844","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210113935"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Wim Mulleners","raw_affiliation_strings":["Department of Neurology, Canisius-Wilhelmina Hospital, the Netherlands","#N# 7Department of Neurology, Canisius-Wilhelmina Hospital, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Canisius-Wilhelmina Hospital, the Netherlands","institution_ids":["https://openalex.org/I4210113935"]},{"raw_affiliation_string":"#N# 7Department of Neurology, Canisius-Wilhelmina Hospital, the Netherlands","institution_ids":["https://openalex.org/I4210113935"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110182683","display_name":"Ronald Brand","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ronald Brand","raw_affiliation_strings":["Department of Medical Statistics & BioInformatics, LUMC, the Netherlands","#N# 4Department of Medical Statistics & BioInformatics, LUMC, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Statistics & BioInformatics, LUMC, the Netherlands","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"#N# 4Department of Medical Statistics & BioInformatics, LUMC, the Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010222570","display_name":"Frank J.P.M. Huygen","orcid":"https://orcid.org/0000-0002-2852-4880","observed_orcids":["https://orcid.org/0000-0002-2852-4880"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Frank JPM Huygen","raw_affiliation_strings":["Department of Anaesthesiology, Erasmus MC, the Netherlands","8Department of Anaesthesiology, Erasmus MC, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anaesthesiology, Erasmus MC, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]},{"raw_affiliation_string":"8Department of Anaesthesiology, Erasmus MC, the Netherlands","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018165002","display_name":"Rigmor Jensen","orcid":"https://orcid.org/0000-0001-6433-5887","observed_orcids":["https://orcid.org/0000-0001-6433-5887"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802086085","display_name":"Glostrup Hospital","ror":"https://ror.org/05p1frt18","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802086085","https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Rigmor H Jensen","raw_affiliation_strings":["Danish Headache Centre, Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark","9Danish Headache Centre, Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Danish Headache Centre, Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802086085"]},{"raw_affiliation_string":"9Danish Headache Centre, Department of Neurology, Glostrup Hospital, University of Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802086085"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039556087","display_name":"Koen Paemeleire","orcid":"https://orcid.org/0000-0001-8103-3899","observed_orcids":["https://orcid.org/0000-0001-8103-3899"]},"institutions":[{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Koen Paemeleire","raw_affiliation_strings":["Department of Neurology, Ghent University Hospital, Belgium","10Department of Neurology, Ghent University Hospital, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Ghent University Hospital, Belgium","institution_ids":["https://openalex.org/I2801227569"]},{"raw_affiliation_string":"10Department of Neurology, Ghent University Hospital, Belgium","institution_ids":["https://openalex.org/I2801227569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004525209","display_name":"Peter James Goadsby","orcid":"https://orcid.org/0000-0003-3260-5904","observed_orcids":["https://orcid.org/0000-0003-3260-5904"]},"institutions":[{"id":"https://openalex.org/I2803209242","display_name":"University of California System","ror":"https://ror.org/00pjdza24","country_code":"US","type":"education","lineage":["https://openalex.org/I2803209242"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter J Goadsby","raw_affiliation_strings":["Headache Group, Department of Neurology, University of California, CA, USA","#N# 11Headache Group, Department of Neurology, University of California, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Headache Group, Department of Neurology, University of California, CA, USA","institution_ids":["https://openalex.org/I2803209242"]},{"raw_affiliation_string":"#N# 11Headache Group, Department of Neurology, University of California, CA, USA","institution_ids":["https://openalex.org/I2803209242"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005468329","display_name":"Veerle E. R. M. Visser-Vandewalle","orcid":"https://orcid.org/0000-0002-5274-7929","observed_orcids":["https://orcid.org/0000-0002-5274-7929"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Veerle Visser-Vandewalle","raw_affiliation_strings":["Department of Stereotactic and Functional Neurosurgery, University of Cologne, Germany","#N# 12Department of Stereotactic and Functional Neurosurgery, University of Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Stereotactic and Functional Neurosurgery, University of Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"#N# 12Department of Stereotactic and Functional Neurosurgery, University of Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039941295","display_name":"Michel Dominique Ferrari","orcid":"https://orcid.org/0000-0001-9691-9449","observed_orcids":["https://orcid.org/0000-0001-9691-9449"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Michel D Ferrari","raw_affiliation_strings":["Department of Neurology, LUMC, the Netherlands","1Department of Neurology, LUMC, the Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, LUMC, the Netherlands","institution_ids":["https://openalex.org/I2800006345"]},{"raw_affiliation_string":"1Department of Neurology, LUMC, the Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":13,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":5.4244,"has_fulltext":false,"cited_by_count":79,"citation_normalized_percentile":{"value":0.96000196,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"33","issue":"15","first_page":"1238","last_page":"1247"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10852","display_name":"Temporomandibular Joint Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3603","display_name":"Complementary and Manual Therapy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/occipital-nerve-stimulation","display_name":"occipital nerve stimulation","score":0.9860000014305115},{"id":"https://openalex.org/keywords/chronic-cluster-headache","display_name":"chronic cluster headache","score":0.9980000257492065},{"id":"https://openalex.org/keywords/headache-prevention","display_name":"headache prevention","score":0.7429999709129333},{"id":"https://openalex.org/keywords/neuromodulation","display_name":"neuromodulation","score":0.9639999866485596},{"id":"https://openalex.org/keywords/double-blind-design","display_name":"double-blind design","score":0.6150000095367432},{"id":"https://openalex.org/keywords/economic-evaluation","display_name":"economic evaluation","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9095776081085205},{"id":"https://openalex.org/C2777942821","wikidata":"https://www.wikidata.org/wiki/Q166907","display_name":"Cluster headache","level":3,"score":0.7592637538909912},{"id":"https://openalex.org/C2776911203","wikidata":"https://www.wikidata.org/wiki/Q3614","display_name":"Occipital nerve stimulation","level":3,"score":0.7022557258605957},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.46811074018478394},{"id":"https://openalex.org/C2778447006","wikidata":"https://www.wikidata.org/wiki/Q1156474","display_name":"Icon","level":2,"score":0.4453775882720947},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.429703950881958},{"id":"https://openalex.org/C99508421","wikidata":"https://www.wikidata.org/wiki/Q2678675","display_name":"Physical medicine and rehabilitation","level":1,"score":0.36383605003356934},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.12507888674736023},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10753646492958069},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07029440999031067},{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D002985","descriptor_name":"Clinical Protocols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003027","descriptor_name":"Cluster Headache","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004567","descriptor_name":"Electrodes, Implanted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004599","descriptor_name":"Electric Stimulation Therapy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012107","descriptor_name":"Research Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false}],"locations_count":15,"locations":[{"id":"doi:10.1177/0333102413490351","doi":"https://doi.org/10.1177/0333102413490351","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0333102413490351","pdf_url":null,"source":{"id":"https://openalex.org/S141866484","display_name":"Cephalalgia","issn_l":"0333-1024","issn":["0333-1024","1468-2982"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cephalalgia","raw_type":"journal-article"},{"id":"pmid:23720502","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23720502","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cephalalgia : an international journal of headache","raw_type":"Journal Article"},{"id":"pmh:oai:USBKOELN.ub.uni-koeln.de:47334","doi":null,"is_oa":false,"landing_page_url":"https://kups.ub.uni-koeln.de/47334/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400371","display_name":"K\u00f6lner Universit\u00e4ts PublikationsServer (Universit\u00e4t zu K\u00f6ln)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115942","host_organization_name":"Rhenish Institute for Environmental Research","host_organization_lineage":["https://openalex.org/I4210115942"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"doc-type:article"},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire_cris_publications/21a3ba83-0a65-4745-b6f7-ca07e01fd4a0","doi":null,"is_oa":false,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/21a3ba83-0a65-4745-b6f7-ca07e01fd4a0","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wilbrink, L A, Teernstra, O P M, Haan, J, van Zwet, E W, Evers, S M A A, Spincemaille, G H, Veltink, P H, Mulleners, W, Brand, R, Huygen, F J P M, Jensen, R H, Paemeleire, K, Goadsby, P J, Visser-Vandewalle, V & Ferrari, M D 2013, 'Occipital nerve stimulation in medically intractable, chronic cluster headache. The ICON study: Rationale and protocol of a randomised trial', Cephalalgia, vol. 33, no. 15, pp. 1238-1247. https://doi.org/10.1177/0333102413490351","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:pure.eur.nl:openaire_cris_publications/48c880d4-eb31-412d-9326-bb7107a06fce","doi":null,"is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/48c880d4-eb31-412d-9326-bb7107a06fce","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wilbrink, LA, Teernstra, OPM, de Haan, J, van Zwet, EW, Evers, SMAA, Spincemaille, GH, Veltink, PH, Mulleners, W, Brand, R, Huygen, F, Jensen, RH, Paemeleire, K, Goadsby, PJ, Visser-Vandewalle, V & Ferrari, MD 2013, 'Occipital nerve stimulation in medically intractable, chronic cluster headache. The ICON study: Rationale and protocol of a randomised trial', Cephalalgia, vol. 33, no. 15, pp. 1238-1247. https://doi.org/10.1177/0333102413490351","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:ris.utwente.nl:openaire_cris_publications/d4ed4993-4e49-4647-8690-05ae5c94df8d","doi":null,"is_oa":false,"landing_page_url":"https://research.utwente.nl/en/publications/d4ed4993-4e49-4647-8690-05ae5c94df8d","pdf_url":null,"source":{"id":"https://openalex.org/S4406922991","display_name":"University of Twente Research Information","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wilbrink, L A, Teernstra, O P M, Haan, J, van Zwet, E W, Evers, S M A A, Spincemaille, G H, Veltink, P H, Mulleners, W, Brand, R, Huygen, F J P M, Jensen, R H, Paemeleire, K, Goadsby, P J, Visser-Vandewalle, V & Ferrari, M D 2013, 'Occipital nerve stimulation in medically intractable, chronic cluster headache. The ICON study: Rationale and protocol of a randomised trial', Cephalalgia, vol. 33, no. 15, pp. 1238-1247. https://doi.org/10.1177/0333102413490351","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:eur:oai:pure.eur.nl:publications/48c880d4-eb31-412d-9326-bb7107a06fce","doi":null,"is_oa":false,"landing_page_url":"https://pure.eur.nl/en/publications/48c880d4-eb31-412d-9326-bb7107a06fce","pdf_url":null,"source":{"id":"https://openalex.org/S4306401266","display_name":"EUR Research Repository (Erasmus University Rotterdam)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I913958620","host_organization_name":"Erasmus University Rotterdam","host_organization_lineage":["https://openalex.org/I913958620"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cephalalgia, 33(15), 1238 - 1247. SAGE Publications Ltd","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:lumc:oai:scholarlypublications.universiteitleiden.nl:item_2989318","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/100548","pdf_url":null,"source":{"id":"https://openalex.org/S4306401843","display_name":"Data Archiving and Networked Services (DANS)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1322597698","host_organization_name":"Royal Netherlands Academy of Arts and Sciences","host_organization_lineage":["https://openalex.org/I1322597698"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cephalalgia, 33(15), 1238 - 1247","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:alma.31UKB_LEU:9940753176002711","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1887/100548","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cephalalgia, Vol. 33, no. 15, p. 1238-1247","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:archive.ugent.be:4084237","doi":null,"is_oa":false,"landing_page_url":"https://biblio.ugent.be/publication/4084237","pdf_url":null,"source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0333-1024","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:openaccess.leidenuniv.nl:1887/100548","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1887/100548","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"33","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/5944fa45-49aa-49bc-92ab-df7e6cf05f43","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/5944fa45-49aa-49bc-92ab-df7e6cf05f43","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wilbrink, L A, Teernstra, O P, Haan, J, van Zwet, E W, Evers, S M, Spincemaille, G H, Veltink, P H, Mulleners, W, Brand, R, Huygen, F J, Jensen, R H, Paemeleire, K, Goadsby, P J, Visser-Vandewalle, V & Ferrari, M D 2013, 'Occipital nerve stimulation in medically intractable, chronic cluster headache. The ICON study : Rationale and protocol of a randomised trial', Cephalalgia. https://doi.org/10.1177/0333102413490351","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:scholarlypublications.universiteitleiden.nl:item_2989318","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/1887/100548","pdf_url":null,"source":{"id":"https://openalex.org/S4306400850","display_name":"Leiden Repository (Leiden University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I121797337","host_organization_name":"Leiden University","host_organization_lineage":["https://openalex.org/I121797337"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cephalalgia","raw_type":"Article / Letter to editor"},{"id":"pmh:um:oai:cris.maastrichtuniversity.nl:publications/21a3ba83-0a65-4745-b6f7-ca07e01fd4a0","doi":null,"is_oa":false,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/21a3ba83-0a65-4745-b6f7-ca07e01fd4a0","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cephalalgia, 33(15), 1238 - 1247. SAGE Publications Ltd","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:ut:oai:ris.utwente.nl:publications/d4ed4993-4e49-4647-8690-05ae5c94df8d","doi":null,"is_oa":false,"landing_page_url":"https://research.utwente.nl/en/publications/d4ed4993-4e49-4647-8690-05ae5c94df8d","pdf_url":null,"source":{"id":"https://openalex.org/S4406922991","display_name":"University of Twente Research Information","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cephalalgia, 33(15), 1238 - 1247. Sage","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Study Protocol","id":"https://openalex.org/study-designs/study-protocol"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307105","display_name":"Amgen","ror":"https://ror.org/03g03ge92"},{"id":"https://openalex.org/F4320307758","display_name":"Eli Lilly and Company","ror":"https://ror.org/01qat3289"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320307773","display_name":"GlaxoSmithKline","ror":"https://ror.org/01xsqw823"},{"id":"https://openalex.org/F4320310567","display_name":"Boston Scientific Corporation","ror":"https://ror.org/0385es521"},{"id":"https://openalex.org/F4320313767","display_name":"Zogenix","ror":"https://ror.org/03ynh3q24"},{"id":"https://openalex.org/F4320321007","display_name":"ZonMw","ror":"https://ror.org/01yaj9a77"},{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"},{"id":"https://openalex.org/F4320322148","display_name":"Eisai","ror":"https://ror.org/04vvh7p27"},{"id":"https://openalex.org/F4320327918","display_name":"H. Lundbeck A/S","ror":"https://ror.org/0564cd633"},{"id":"https://openalex.org/F4320332585","display_name":"Allergan","ror":"https://ror.org/00wthd003"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1545409067","https://openalex.org/W1819925601","https://openalex.org/W1982387055","https://openalex.org/W1995564570","https://openalex.org/W2001845443","https://openalex.org/W2010034626","https://openalex.org/W2022305238","https://openalex.org/W2028106167","https://openalex.org/W2037377025","https://openalex.org/W2045291273","https://openalex.org/W2054345912","https://openalex.org/W2072601405","https://openalex.org/W2076704145","https://openalex.org/W2082774221","https://openalex.org/W2089857856","https://openalex.org/W2091823111","https://openalex.org/W2098472777","https://openalex.org/W2117753124","https://openalex.org/W2120148445","https://openalex.org/W2120706668","https://openalex.org/W2127751874","https://openalex.org/W2127983995","https://openalex.org/W2129136808","https://openalex.org/W2129627527","https://openalex.org/W2134784695","https://openalex.org/W2135310849","https://openalex.org/W2136901194","https://openalex.org/W2137566510","https://openalex.org/W2143532751","https://openalex.org/W2147905899","https://openalex.org/W2151875733","https://openalex.org/W2161630779","https://openalex.org/W2165467426","https://openalex.org/W2169186856","https://openalex.org/W4232280109","https://openalex.org/W4247292047","https://openalex.org/W4285719527","https://openalex.org/W4292806894"],"related_works":["https://openalex.org/W3168434812","https://openalex.org/W3163259183","https://openalex.org/W7134228831","https://openalex.org/W3170418016","https://openalex.org/W4387847884","https://openalex.org/W4411211293","https://openalex.org/W7210263666","https://openalex.org/W163988396","https://openalex.org/W2127983995","https://openalex.org/W2027918078"],"abstract_inverted_index":{"BACKGROUND:":[0],"About":[1],"10%":[2,13],"of":[3,14,91,103,114,123,171,181],"cluster":[4,88,155],"headache":[5,89,156],"patients":[6,90,150],"have":[7,49,56],"the":[8,100,106,127,172,176],"chronic":[9,16,87,154],"form.":[10],"At":[11],"least":[12],"this":[15,71],"group":[17],"is":[18,99,118,134,144,160],"intractable":[19,153],"to":[20],"or":[21],"cannot":[22],"tolerate":[23],"medical":[24],"treatment.":[25],"Open":[26],"pilot":[27],"studies":[28,44],"suggest":[29],"that":[30],"occipital":[31],"nerve":[32],"stimulation":[33],"(ONS)":[34],"might":[35],"offer":[36],"effective":[37,146],"prevention":[38],"in":[39,45,53,61,84,183],"these":[40],"patients.":[41],"Controlled":[42],"neuromodulation":[43,63],"treatments":[46],"inducing":[47],"paraesthesias":[48],"a":[50,58,76,111,161,184],"general":[51],"problem":[52],"blinding.":[54],"We":[55,74],"introduced":[57],"new":[59],"design":[60,170],"pain":[62],"by":[64],"which":[65],"we":[66,68],"think":[67],"can":[69],"overcome":[70],"problem.":[72],"METHODS/DESIGN:":[73],"propose":[75],"prospective,":[77],"randomised,":[78],"double-blind,":[79],"parallel-group":[80],"international":[81],"clinical":[82],"study":[83,112,133,139,173],"medically":[85,152],"intractable,":[86],"high-":[92,164],"versus":[93],"low-amplitude":[94,166],"ONS.":[95],"Primary":[96],"outcome":[97],"measure":[98],"mean":[101],"number":[102],"attacks":[104],"over":[105],"last":[107],"four":[108],"weeks.":[109],"After":[110],"period":[113],"six":[115,124],"months":[116],"there":[117,159],"an":[119,130,145],"open":[120],"extension":[121],"phase":[122],"months.":[125],"Alongside":[126],"randomised":[128],"trial":[129],"economic":[131],"evaluation":[132],"performed.":[135],"DISCUSSION:":[136],"The":[137,168],"ICON":[138],"will":[140],"show":[141],"if":[142,158],"ONS":[143,182],"preventive":[147],"therapy":[148],"for":[149,175],"suffering":[151],"and":[157,165],"difference":[162],"between":[163],"stimulation.":[167],"innovative":[169],"will,":[174],"first":[177],"time,":[178],"assess":[179],"efficacy":[180],"blinded":[185],"way.":[186]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
