{"id":"https://openalex.org/W1998148244","doi":"https://doi.org/10.1016/0014-5793(96)00114-7","title":"Existence of Na+\u2010translocating NADH\u2010quinone reductase in Haemophilus influenzae","display_name":"Existence of Na+\u2010translocating NADH\u2010quinone reductase in Haemophilus influenzae","publication_year":1996,"publication_date":"1996-03-04","ids":{"openalex":"https://openalex.org/W1998148244","doi":"https://doi.org/10.1016/0014-5793(96)00114-7","mag":"1998148244","pmid":"https://pubmed.ncbi.nlm.nih.gov/8601449"},"language":"en","primary_location":{"id":"doi:10.1016/0014-5793(96)00114-7","doi":"https://doi.org/10.1016/0014-5793(96)00114-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(96)00114-7","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2896%2900114-7","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2896%2900114-7","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065526802","display_name":"Maki Hayashi","orcid":"https://orcid.org/0000-0002-1704-8049","observed_orcids":["https://orcid.org/0000-0002-1704-8049"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Maki Hayashi","raw_affiliation_strings":["Laboratory of Membrane Biochemistry, Faculty of Pharmaceutical Sciences, Chiba University, Japan","Laboratory of Membrane Biochemistry, Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Membrane Biochemistry, Faculty of Pharmaceutical Sciences, Chiba University, Japan","institution_ids":["https://openalex.org/I159385669"]},{"raw_affiliation_string":"Laboratory of Membrane Biochemistry, Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058098685","display_name":"Yuji Nakayama","orcid":"https://orcid.org/0000-0001-7882-0066","observed_orcids":["https://orcid.org/0000-0001-7882-0066"]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yuji Nakayama","raw_affiliation_strings":["Laboratory of Membrane Biochemistry, Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Membrane Biochemistry, Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263, Japan","institution_ids":["https://openalex.org/I159385669"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112269766","display_name":"Tsutomu Unemoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159385669","display_name":"Chiba University","ror":"https://ror.org/01hjzeq58","country_code":"JP","type":"education","lineage":["https://openalex.org/I159385669"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tsutomu Unemoto","raw_affiliation_strings":["Laboratory of Membrane Biochemistry, Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Membrane Biochemistry, Faculty of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263, Japan","institution_ids":["https://openalex.org/I159385669"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112269766"],"corresponding_institution_ids":["https://openalex.org/I159385669"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":1.399,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.80617842,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"381","issue":"3","first_page":"174","last_page":"176"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/haemophilus-influenzae","display_name":"Haemophilus influenzae","score":0.906000018119812},{"id":"https://openalex.org/keywords/vibrio-alginolyticus","display_name":"Vibrio alginolyticus","score":0.8679999709129333},{"id":"https://openalex.org/keywords/electron-transport-chain","display_name":"electron transport chain","score":0.7689999938011169},{"id":"https://openalex.org/keywords/energy-coupling","display_name":"energy coupling","score":0.9769999980926514},{"id":"https://openalex.org/keywords/membrane-fraction","display_name":"membrane fraction","score":0.5479999780654907},{"id":"https://openalex.org/keywords/gene-clusters","display_name":"gene clusters","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C203075996","wikidata":"https://www.wikidata.org/wiki/Q139677","display_name":"Operon","level":4,"score":0.8908237218856812},{"id":"https://openalex.org/C2776925733","wikidata":"https://www.wikidata.org/wiki/Q1141979","display_name":"Haemophilus influenzae","level":3,"score":0.8362537622451782},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5772598385810852},{"id":"https://openalex.org/C134651460","wikidata":"https://www.wikidata.org/wiki/Q3100717","display_name":"Reductase","level":3,"score":0.5646424293518066},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46383461356163025},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.44570648670196533},{"id":"https://openalex.org/C2780643102","wikidata":"https://www.wikidata.org/wiki/Q412382","display_name":"Quinone","level":2,"score":0.43871521949768066},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43189841508865356},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3966176211833954},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.30527204275131226},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.28930699825286865},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.26777225732803345},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13608676195144653}],"mesh":[{"descriptor_ui":"D002258","descriptor_name":"Carbonyl Cyanide m-Chlorophenyl Hydrazone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006193","descriptor_name":"Haemophilus influenzae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D006193","descriptor_name":"Haemophilus influenzae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006193","descriptor_name":"Haemophilus influenzae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008985","descriptor_name":"Monensin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009876","descriptor_name":"Operon","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011808","descriptor_name":"Quinone Reductases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011808","descriptor_name":"Quinone Reductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012964","descriptor_name":"Sodium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/0014-5793(96)00114-7","doi":"https://doi.org/10.1016/0014-5793(96)00114-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(96)00114-7","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2896%2900114-7","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:8601449","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8601449","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1016/0014-5793(96)00114-7","doi":"https://doi.org/10.1016/0014-5793(96)00114-7","is_oa":true,"landing_page_url":"https://doi.org/10.1016/0014-5793(96)00114-7","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/0014-5793%2896%2900114-7","source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1998148244.pdf","grobid_xml":"https://content.openalex.org/works/W1998148244.grobid-xml"},"referenced_works_count":14,"referenced_works":["https://openalex.org/W1934135863","https://openalex.org/W1971403296","https://openalex.org/W1982468096","https://openalex.org/W1983334395","https://openalex.org/W1988770551","https://openalex.org/W1993899301","https://openalex.org/W1997940536","https://openalex.org/W2008775871","https://openalex.org/W2022011099","https://openalex.org/W2041525640","https://openalex.org/W2045998842","https://openalex.org/W2107645256","https://openalex.org/W2165113273","https://openalex.org/W2893069646"],"related_works":["https://openalex.org/W2059411573","https://openalex.org/W2050770360","https://openalex.org/W2022011099","https://openalex.org/W2083746159","https://openalex.org/W1966481305","https://openalex.org/W1490205589","https://openalex.org/W1972538837","https://openalex.org/W2008775871","https://openalex.org/W2494101061","https://openalex.org/W2770134697"],"abstract_inverted_index":{"We":[0,38],"previously":[1],"cloned":[2],"and":[3,46,92],"sequenced":[4],"nqr":[5,25],"operon":[6,26],"encoding":[7],"the":[8,14,32,40,47,68,79,83],"Na+-translocating":[9],"NADH-quinone":[10],"reductase":[11],"(NQR)":[12],"from":[13,43],"marine":[15,69,81],"bacterium":[16],"Vibrio":[17],"alginolyticus.":[18,71],"A":[19],"gene":[20],"cluster":[21],"very":[22],"similar":[23,77],"to":[24,29,55,64,78],"was":[27,53],"found":[28,54,66],"exist":[30],"in":[31,67],"genome":[33],"of":[34,50],"Haemophilus":[35],"influenzae":[36,52,86],"Rd.":[37],"examined":[39],"membrane":[41],"fraction":[42],"H.":[44,51,85],"influenzae,":[45],"respiratory":[48],"chain":[49],"contain":[56],"a":[57,88],"Na+-dependent":[58],"NQR":[59],"that":[60,75],"is":[61],"essentially":[62],"identical":[63],"those":[65],"V.":[70],"These":[72],"results":[73],"indicate":[74],"quite":[76],"salt-loving":[80],"bacteria,":[82],"blood-loving":[84],"has":[87],"redox-driven":[89],"Na+":[90,94],"pump":[91],"utilizes":[93],"circulation":[95],"for":[96],"energy":[97],"coupling.":[98]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}