{"id":"https://openalex.org/W1998134244","doi":"https://doi.org/10.1089/omi.2010.0076","title":"Neoplastic Alterations Induced in Mammalian Skin Following Mancozeb Exposure Using In Vivo and In Vitro Models","display_name":"Neoplastic Alterations Induced in Mammalian Skin Following Mancozeb Exposure Using In Vivo and In Vitro Models","publication_year":2011,"publication_date":"2011-03-01","ids":{"openalex":"https://openalex.org/W1998134244","doi":"https://doi.org/10.1089/omi.2010.0076","mag":"1998134244","pmid":"https://pubmed.ncbi.nlm.nih.gov/21375462"},"language":"en","primary_location":{"id":"doi:10.1089/omi.2010.0076","doi":"https://doi.org/10.1089/omi.2010.0076","is_oa":false,"landing_page_url":"https://doi.org/10.1089/omi.2010.0076","pdf_url":null,"source":{"id":"https://openalex.org/S116972989","display_name":"OMICS A Journal of Integrative Biology","issn_l":"1536-2310","issn":["1536-2310","1557-8100"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OMICS: A Journal of Integrative Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Shilpa Tyagi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I85145500","display_name":"Indian Institute of Toxicology Research","ror":"https://ror.org/01e70mw69","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702","https://openalex.org/I85145500"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shilpa Tyagi","raw_affiliation_strings":["Indian Institute of Toxicology Research","Proteomics Laboratory, Indian Institute of Toxicology Research, Council of Scientific & Industrial Research (CSIR), Lucknow 226001 (U.P), India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indian Institute of Toxicology Research","institution_ids":["https://openalex.org/I85145500"]},{"raw_affiliation_string":"Proteomics Laboratory, Indian Institute of Toxicology Research, Council of Scientific & Industrial Research (CSIR), Lucknow 226001 (U.P), India","institution_ids":["https://openalex.org/I66760702","https://openalex.org/I85145500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081025440","display_name":"Jasmine George","orcid":"https://orcid.org/0000-0001-9674-0027","observed_orcids":["https://orcid.org/0000-0001-9674-0027"]},"institutions":[{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I85145500","display_name":"Indian Institute of Toxicology Research","ror":"https://ror.org/01e70mw69","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702","https://openalex.org/I85145500"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Jasmine George","raw_affiliation_strings":["Indian Institute of Toxicology Research","Proteomics Laboratory, Indian Institute of Toxicology Research, Council of Scientific & Industrial Research (CSIR), Lucknow 226001 (U.P), India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indian Institute of Toxicology Research","institution_ids":["https://openalex.org/I85145500"]},{"raw_affiliation_string":"Proteomics Laboratory, Indian Institute of Toxicology Research, Council of Scientific & Industrial Research (CSIR), Lucknow 226001 (U.P), India","institution_ids":["https://openalex.org/I66760702","https://openalex.org/I85145500"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Richa Singh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I85145500","display_name":"Indian Institute of Toxicology Research","ror":"https://ror.org/01e70mw69","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702","https://openalex.org/I85145500"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Richa Singh","raw_affiliation_strings":["Indian Institute of Toxicology Research","Proteomics Laboratory, Indian Institute of Toxicology Research, Council of Scientific & Industrial Research (CSIR), Lucknow 226001 (U.P), India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indian Institute of Toxicology Research","institution_ids":["https://openalex.org/I85145500"]},{"raw_affiliation_string":"Proteomics Laboratory, Indian Institute of Toxicology Research, Council of Scientific & Industrial Research (CSIR), Lucknow 226001 (U.P), India","institution_ids":["https://openalex.org/I66760702","https://openalex.org/I85145500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049056014","display_name":"Kulpreet Bhui","orcid":"https://orcid.org/0009-0004-9132-0911","observed_orcids":["https://orcid.org/0009-0004-9132-0911"]},"institutions":[{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I85145500","display_name":"Indian Institute of Toxicology Research","ror":"https://ror.org/01e70mw69","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702","https://openalex.org/I85145500"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kulpreet Bhui","raw_affiliation_strings":["Indian Institute of Toxicology Research","Proteomics Laboratory, Indian Institute of Toxicology Research, Council of Scientific & Industrial Research (CSIR), Lucknow 226001 (U.P), India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indian Institute of Toxicology Research","institution_ids":["https://openalex.org/I85145500"]},{"raw_affiliation_string":"Proteomics Laboratory, Indian Institute of Toxicology Research, Council of Scientific & Industrial Research (CSIR), Lucknow 226001 (U.P), India","institution_ids":["https://openalex.org/I66760702","https://openalex.org/I85145500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109279538","display_name":"Yogeshwer Shukla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I66760702","display_name":"Council of Scientific and Industrial Research","ror":"https://ror.org/021wm7p51","country_code":"IN","type":"government","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702"]},{"id":"https://openalex.org/I85145500","display_name":"Indian Institute of Toxicology Research","ror":"https://ror.org/01e70mw69","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210134808","https://openalex.org/I66760702","https://openalex.org/I85145500"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Yogeshwer Shukla","raw_affiliation_strings":["Indian Institute of Toxicology Research","Proteomics Laboratory, Indian Institute of Toxicology Research, Council of Scientific & Industrial Research (CSIR), Lucknow 226001 (U.P), India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indian Institute of Toxicology Research","institution_ids":["https://openalex.org/I85145500"]},{"raw_affiliation_string":"Proteomics Laboratory, Indian Institute of Toxicology Research, Council of Scientific & Industrial Research (CSIR), Lucknow 226001 (U.P), India","institution_ids":["https://openalex.org/I66760702","https://openalex.org/I85145500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6329,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.6800584,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"15","issue":"3","first_page":"155","last_page":"167"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10875","display_name":"Pesticide Exposure and Toxicity","score":0.0406000018119812,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mancozeb","display_name":"mancozeb","score":1.0},{"id":"https://openalex.org/keywords/dithiocarbamate-fungicides","display_name":"dithiocarbamate fungicides","score":0.8799999952316284},{"id":"https://openalex.org/keywords/skin-carcinogenesis","display_name":"skin carcinogenesis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/s100a6","display_name":"S100A6","score":0.9549999833106995},{"id":"https://openalex.org/keywords/s100a9","display_name":"S100A9","score":0.9990000128746033},{"id":"https://openalex.org/keywords/erk-signaling","display_name":"ERK signaling","score":0.8640000224113464},{"id":"https://openalex.org/keywords/hacat-cells","display_name":"HaCaT keratinocytes","score":0.8040000200271606},{"id":"https://openalex.org/keywords/keratinocyte-proliferation","display_name":"keratinocyte proliferation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.6060000061988831},{"id":"https://openalex.org/keywords/cyclin-d1","display_name":"cyclin D1","score":0.8240000009536743},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.984000027179718},{"id":"https://openalex.org/keywords/anchorage-independent-growth","display_name":"anchorage-independent growth","score":0.7549999952316284},{"id":"https://openalex.org/keywords/pd98059","display_name":"PD98059","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C2779743564","wikidata":"https://www.wikidata.org/wiki/Q409132","display_name":"Mancozeb","level":3,"score":0.8240018486976624},{"id":"https://openalex.org/C118995209","wikidata":"https://www.wikidata.org/wiki/Q5636366","display_name":"HaCaT","level":3,"score":0.7781378030776978},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5833384990692139},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5697007179260254},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5072795748710632},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.5053451657295227},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4824567437171936},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.43584150075912476},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.414180189371109},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3621387481689453},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.34801366925239563},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.30505627393722534},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3034771680831909},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.27415114641189575},{"id":"https://openalex.org/C74600772","wikidata":"https://www.wikidata.org/wiki/Q193237","display_name":"Fungicide","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000075383","descriptor_name":"S100 Calcium Binding Protein A6","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002471","descriptor_name":"Cell Transformation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005659","descriptor_name":"Fungicides, Industrial","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008344","descriptor_name":"Maneb","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D009418","descriptor_name":"S100 Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015038","descriptor_name":"Zineb","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040502","descriptor_name":"Calgranulin B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/omi.2010.0076","doi":"https://doi.org/10.1089/omi.2010.0076","is_oa":false,"landing_page_url":"https://doi.org/10.1089/omi.2010.0076","pdf_url":null,"source":{"id":"https://openalex.org/S116972989","display_name":"OMICS A Journal of Integrative Biology","issn_l":"1536-2310","issn":["1536-2310","1557-8100"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OMICS: A Journal of Integrative Biology","raw_type":"journal-article"},{"id":"pmid:21375462","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21375462","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Omics : a journal of integrative biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320720","display_name":"Indian Council of Medical Research","ror":"https://ror.org/0492wrx28"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W598858547","https://openalex.org/W1775749144","https://openalex.org/W1863889172","https://openalex.org/W1897193595","https://openalex.org/W1969992154","https://openalex.org/W1971755558","https://openalex.org/W1974684728","https://openalex.org/W1976672998","https://openalex.org/W1994883913","https://openalex.org/W2023407266","https://openalex.org/W2038899461","https://openalex.org/W2041278117","https://openalex.org/W2046670820","https://openalex.org/W2049433363","https://openalex.org/W2055072807","https://openalex.org/W2055569826","https://openalex.org/W2056492980","https://openalex.org/W2060093889","https://openalex.org/W2062219923","https://openalex.org/W2062657417","https://openalex.org/W2073022424","https://openalex.org/W2073205505","https://openalex.org/W2088686339","https://openalex.org/W2101108802","https://openalex.org/W2101254765","https://openalex.org/W2101454929","https://openalex.org/W2105145945","https://openalex.org/W2105515073","https://openalex.org/W2129771435","https://openalex.org/W2145400898","https://openalex.org/W2147935687","https://openalex.org/W2149235661","https://openalex.org/W2152987051","https://openalex.org/W2153812847","https://openalex.org/W2166650531","https://openalex.org/W4252911815"],"related_works":["https://openalex.org/W7096328577","https://openalex.org/W1972551779","https://openalex.org/W2023407266","https://openalex.org/W1969411650","https://openalex.org/W2166650531","https://openalex.org/W7214044792","https://openalex.org/W4213438614","https://openalex.org/W2329729210","https://openalex.org/W2033644136","https://openalex.org/W1449885776"],"abstract_inverted_index":{"Mancozeb,":[0],"ethylene(bis)dithiocarbamate":[1],"fungicides,":[2],"has":[3,22],"been":[4,23],"well":[5],"documented":[6],"in":[7,25,38,96,105,115,133,140,150,154,233],"the":[8,15,29,33,106,205,214,219,229],"literature":[9],"as":[10,113],"a":[11,50],"multipotent":[12],"carcinogen,":[13],"but":[14],"underlying":[16],"mechanism":[17,35,220],"remains":[18],"unrevealed.":[19],"Thus,":[20],"mancozeb":[21,57,129],"selected":[24],"this":[26],"study":[27],"with":[28],"objective":[30],"to":[31,48],"decipher":[32],"molecular":[34],"that":[36,218],"culminates":[37],"carcinogenesis.":[39,122],"We":[40],"employed":[41],"two-dimensional":[42],"gel":[43],"electrophoresis":[44],"and":[45,56,81,90,157,178,185,188,223],"mass":[46],"spectrometry":[47],"generate":[49],"comparative":[51],"proteome":[52],"profile":[53],"of":[54,87,124,152,162,167,207],"control":[55],"(200":[58],"mg/kg":[59],"body":[60],"weight)":[61],"exposed":[62],"mouse":[63],"skin.":[64,235],"Although":[65],"many":[66],"differentially":[67],"expressed":[68],"proteins":[69,127],"were":[70],"found,":[71],"among":[72],"them,":[73],"two":[74,126],"significantly":[75],"upregulated":[76],"proteins,":[77],"namely,":[78],"S100A6":[79,222],"(Calcyclin)":[80],"S100A9":[82,224],"(Calgranulin-B),":[83],"are":[84],"known":[85],"markers":[86],"keratinocyte":[88,121],"differentiation":[89],"proliferation,":[91],"which":[92],"suggested":[93],"their":[94],"role":[95],"mancozeb-induced":[97,230],"neoplastic":[98,138,231],"alterations.":[99],"Therefore,":[100],"we":[101,211],"verified":[102],"these":[103,125],"alterations":[104],"human":[107,119,141,234],"system":[108],"by":[109,148,202],"using":[110],"HaCaT":[111,134],"cells":[112,135],"an":[114],"vitro":[116],"model":[117],"for":[118],"skin":[120,142],"Upregulation":[123],"upon":[128],"(0.5":[130],"\u03bcg/mL)":[131],"exposure":[132],"indicated":[136],"its":[137],"potential":[139,145,232],"also.":[143],"This":[144],"was":[146,191],"confirmed":[147],"increase":[149],"number":[151],"colonies":[153],"colony":[155],"formation":[156],"anchorage-independent":[158],"growth":[159],"assays.":[160],"Modulation":[161],"S100A6/S100A9":[163],"targets,":[164],"elevated":[165],"phosphorylation":[166],"extracellular":[168],"signal":[169],"regulated":[170,225],"kinase":[171],"(ERK1/2),":[172],"Elk1,":[173],"nuclear":[174],"factor-":[175],"kappa":[176],"B":[177],"cell":[179,199],"division":[180],"cycle":[181],"25":[182],"C":[183],"phosphatase,":[184],"cyclin":[186],"D1":[187],"cyclooxygenase-2":[189],"upregulation":[190],"seen.":[192],"In":[193],"addition,":[194],"PD98059":[195],"(ERK1/2":[196],"inhibitor)":[197],"reduced":[198],"proliferation":[200],"induced":[201],"mancozeb,":[203],"confirming":[204],"involvement":[206],"ERK1/2":[208,226],"signaling.":[209],"Conclusively,":[210],"herein":[212],"present":[213],"first":[215],"report":[216],"asserting":[217],"involving":[221],"signaling":[227],"underlies":[228]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}