{"id":"https://openalex.org/W1998129295","doi":"https://doi.org/10.1158/1538-7445.am2011-2487","title":"Abstract 2487: A multi-kinase inhibitor, XL228, enhanced human cancer cell radiosensitivity and suppressed cell invasion and migration","display_name":"Abstract 2487: A multi-kinase inhibitor, XL228, enhanced human cancer cell radiosensitivity and suppressed cell invasion and migration","publication_year":2011,"publication_date":"2011-04-01","ids":{"openalex":"https://openalex.org/W1998129295","doi":"https://doi.org/10.1158/1538-7445.am2011-2487","mag":"1998129295"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2011-2487","doi":"https://doi.org/10.1158/1538-7445.am2011-2487","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-2487","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007512249","display_name":"Fumihiko Matsumoto","orcid":"https://orcid.org/0000-0002-0802-8011","observed_orcids":["https://orcid.org/0000-0002-0802-8011"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fumihiko Matsumoto","raw_affiliation_strings":["1UT M.D. Anderson Cancer Ctr., Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT M.D. Anderson Cancer Ctr., Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083198568","display_name":"David P. Molkentine","orcid":"https://orcid.org/0000-0003-0505-6815","observed_orcids":["https://orcid.org/0000-0003-0505-6815"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Molkentine","raw_affiliation_strings":["1UT M.D. Anderson Cancer Ctr., Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT M.D. Anderson Cancer Ctr., Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110658666","display_name":"Douglas O. Clary","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I152988861","display_name":"Exelixis (United States)","ror":"https://ror.org/01e3jga91","country_code":"US","type":"company","lineage":["https://openalex.org/I152988861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas O. Clary","raw_affiliation_strings":["2Exelixis, Inc, South San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Exelixis, Inc, South San Francisco, CA","institution_ids":["https://openalex.org/I152988861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108796110","display_name":"Luka Milas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luka Milas","raw_affiliation_strings":["1UT M.D. Anderson Cancer Ctr., Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT M.D. Anderson Cancer Ctr., Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108338095","display_name":"Kian K Ang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kian K. Ang","raw_affiliation_strings":["1UT M.D. Anderson Cancer Ctr., Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT M.D. Anderson Cancer Ctr., Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109799014","display_name":"Uma Raju","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Uma Raju","raw_affiliation_strings":["1UT M.D. Anderson Cancer Ctr., Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1UT M.D. Anderson Cancer Ctr., Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"71","issue":"8_Supplement","first_page":"2487","last_page":"2487"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.33009999990463257,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.33009999990463257,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.10509999841451645,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.09350000321865082,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multikinase-inhibitor","display_name":"multikinase inhibitor","score":0.7929999828338623},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.9829999804496765},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.8920000195503235},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.5860000252723694},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9950000047683716},{"id":"https://openalex.org/keywords/igf-1-receptor","display_name":"IGF-1 receptor","score":0.7699999809265137},{"id":"https://openalex.org/keywords/src-kinase","display_name":"Src kinase","score":0.7139999866485596},{"id":"https://openalex.org/keywords/bcr-abl","display_name":"BCR-ABL","score":0.8489999771118164},{"id":"https://openalex.org/keywords/aurora-kinases","display_name":"Aurora kinases","score":0.9610000252723694},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7080000042915344},{"id":"https://openalex.org/keywords/clonogenic-survival","display_name":"clonogenic survival","score":0.8399999737739563},{"id":"https://openalex.org/keywords/radiosensitizers","display_name":"radiosensitizers","score":0.5960000157356262},{"id":"https://openalex.org/keywords/metastasis-inhibition","display_name":"metastasis suppression","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.8058932423591614},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6443188786506653},{"id":"https://openalex.org/C117262875","wikidata":"https://www.wikidata.org/wiki/Q5135057","display_name":"Clonogenic assay","level":3,"score":0.6345289349555969},{"id":"https://openalex.org/C81729549","wikidata":"https://www.wikidata.org/wiki/Q4649475","display_name":"A549 cell","level":3,"score":0.5693011283874512},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5080125331878662},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4989616870880127},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4905954897403717},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.4878223240375519},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45338523387908936},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4503324627876282},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4355708956718445},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.43217504024505615},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.431990385055542},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35603681206703186},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.25270211696624756},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2422010600566864},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.1889442801475525},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1749759316444397},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07098683714866638},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2011-2487","doi":"https://doi.org/10.1158/1538-7445.am2011-2487","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2011-2487","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2066390615","https://openalex.org/W1984696204","https://openalex.org/W4220870111","https://openalex.org/W2130230977","https://openalex.org/W1980925273","https://openalex.org/W2059001517","https://openalex.org/W2026579653","https://openalex.org/W4205938554","https://openalex.org/W3032570487","https://openalex.org/W2909243669"],"abstract_inverted_index":{"Abstract":[0],"Purpose:,":[1],"Targeting":[2],"signaling":[3],"pathways":[4],"that":[5,278,355],"are":[6,34,349],"implicated":[7],"in":[8,39,65,93,190,313,337,395],"cancer":[9,41,67],"cell":[10,48,54,68,130,141,185,288,295,332,389],"resistance":[11],"to":[12,17,70,101,154,170,208,228,310,384,403],"therapy":[13],"is":[14,21],"being":[15],"investigated":[16,60],"improve":[18],"outcome.":[19],"XL228":[20,64,111,120,162,218,234,282,319,356,374],"a":[22,191,358],"small":[23,53],"molecule":[24],"inhibitor":[25],"of":[26,63,107,110,119,157,183,202,222,239,253,255,263,281,286,318,322,330,339,345,368,429,434],"IGF-1R,":[27],"cSrc,":[28],"BCR/Abl":[29],"and":[30,45,51,73,79,81,87,129,136,148,193,197,200,211,215,225,242,258,298,334,366,377],"aurora":[31],"kinases,":[32],"which":[33],"frequently":[35],"overexpressed":[36],"or":[37,122,160,165],"hyperactive":[38],"many":[40],"types":[42],"including":[43,343],"head":[44],"neck":[46],"squamous":[47],"carcinomas":[49],"(HNSCCs)":[50],"non":[52],"lung":[55],"cancers":[56],"(NSCLCs).":[57],"This":[58,352],"study":[59,353],"the":[61,103,117,152,172,220,237,250,294,325,331,404,430,435],"potential":[62],"enhancing":[66],"sensitivity":[69],"radiation.":[71],"Materials":[72],"Methods:":[74],"Three":[75],"HNSCC":[76,376],"(HN-5,":[77],"FaDu":[78,210,226,243],"UMSCC-1)":[80],"three":[82,287],"NSCLC":[83,378],"lines":[84,186],"(H460,":[85],"A549":[86,147,224,241],"H1299)":[88],"were":[89,138],"used":[90,100,169],"for":[91,112,438],"this":[92],"vitro":[94],"study.":[95],"Cell":[96],"viability":[97],"assay":[98],"was":[99,168,408],"assess":[102],"single":[104,359],"agent":[105,360],"activity":[106],"5-100":[108,179],"nM":[109,217,233,270,280,317],"1-3":[113],"d.":[114],"In":[115,370],"addition,":[116],"effects":[118],"(10":[121],"100":[123,166,216,269,316],"nM)":[124,167],"on":[125,174,293],"apoptosis":[126,303,336],"(TUNEL":[127],"assay),":[128],"cycle":[131,296,333],"redistribution":[132],"(flow":[133],"cytometry),":[134],"migration":[135,199,365],"invasion":[137,201,367],"evaluated.":[139],"Clonogenic":[140],"survival":[142,182,251],"assayed":[143],"(in":[144],"HN-5,":[145],"FaDu,":[146],"H460)":[149],"after":[150,308],"exposing":[151],"cells":[153,227,244,265,315,323],"graded":[155],"doses":[156],"\u03b3-radiation,":[158],"with":[159,205,372],"without":[161],"(10,":[163],"50":[164,214],"quantify":[171],"effect":[173,292],"radiosensitivity.":[175,379],"Results:":[176],"XL228,":[177],"at":[178,249,268,305,324,399],"nM,":[180],"reduced":[181,361],"all":[184],"tested":[187,304],"by":[188,245,410,418],"10-70%":[189],"dose":[192],"time":[194],"dependent":[195],"manner":[196],"inhibited":[198,363],"two":[203],"tumors":[204],"high":[206],"propensity":[207],"metastasize,":[209],"H460.":[212],"At":[213,231],"abolished":[219],"ability":[221],"H460,":[223,240],"form":[229],"colony.":[230],"10":[232,279],"significantly":[235],"increased":[236],"radiosensitivity":[238,285,386],"enhancement":[246],"factors":[247],"(EF,":[248],"fraction":[252],"0.5)":[254],"1.52,":[256],"1.31":[257],"1.67":[259],"respectively.":[260],"But,":[261],"sensitization":[262],"HN-5":[264,314],"occurred":[266],"only":[267],"(EF":[271],"=":[272],"2.27).":[273],"Flow":[274],"cytometry":[275],"analysis":[276],"showed":[277],"(that":[283],"enhanced":[284,375,385],"lines)":[289],"had":[290],"no":[291],"distribution":[297],"it":[299],"did":[300],"not":[301],"induce":[302],"24":[306],"h":[307],"exposure":[309],"XL228.":[311],"However,":[312],"induced":[320,335],"accumulation":[321],"radiation":[326],"sensitive":[327],"G2/M":[328],"phase":[329],"32%":[338],"cells.":[340,369],"Mechanistic":[341],"studies":[342],"inhibition":[344],"DNA":[346],"repair":[347],"processes":[348,382],"ongoing.":[350],"Conclusions:":[351],"demonstrated":[354],"as":[357],"viability,":[362],"proliferation,":[364],"combination":[371],"radiation,":[373],"The":[380],"underlying":[381],"leading":[383],"may":[387],"be":[388],"type":[390],"specific.":[391],"These":[392],"data":[393],"warrant":[394],"vivo":[396],"investigations":[397],"aiming":[398],"taking":[400],"best":[401],"regimens":[402],"clinic":[405],"testing.":[406],"(XL228":[407],"provided":[409],"Exelixis,":[411],"Inc.":[412],"South":[413],"San":[414],"Francisco,":[415],"CA.":[416],"Supported":[417],"P0-1":[419],"CA-06294)":[420],"Citation":[421],"Format:":[422],"{Authors}.":[423],"{Abstract":[424],"title}":[425],"[abstract].":[426],"In:":[427],"Proceedings":[428],"102nd":[431],"Annual":[432],"Meeting":[433],"American":[436],"Association":[437],"Cancer":[439,449],"Research;":[440],"2011":[441],"Apr":[442],"2-6;":[443],"Orlando,":[444],"FL.":[445],"Philadelphia":[446],"(PA):":[447],"AACR;":[448],"Res":[450],"2011;71(8":[451],"Suppl):Abstract":[452],"nr":[453],"2487.":[454],"doi:10.1158/1538-7445.AM2011-2487":[455]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}