{"id":"https://openalex.org/W1998128870","doi":"https://doi.org/10.1038/nbt1196-1574","title":"Targeted gene delivery by tropism-modified adenoviral vectors","display_name":"Targeted gene delivery by tropism-modified adenoviral vectors","publication_year":1996,"publication_date":"1996-11-01","ids":{"openalex":"https://openalex.org/W1998128870","doi":"https://doi.org/10.1038/nbt1196-1574","mag":"1998128870","pmid":"https://pubmed.ncbi.nlm.nih.gov/9634824"},"language":"en","primary_location":{"id":"doi:10.1038/nbt1196-1574","doi":"https://doi.org/10.1038/nbt1196-1574","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nbt1196-1574","pdf_url":null,"source":{"id":"https://openalex.org/S106963461","display_name":"Nature Biotechnology","issn_l":"0733-222X","issn":["0733-222X","1087-0156","1546-1696","2331-3684"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016393533","display_name":"Joanne T. Douglas","orcid":"https://orcid.org/0000-0002-8117-9828","observed_orcids":["https://orcid.org/0000-0002-8117-9828"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joanne T. Douglas","raw_affiliation_strings":["Gene Therapy Program, University of Alabama at Birmingham 35294, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Therapy Program, University of Alabama at Birmingham 35294, USA","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038121785","display_name":"Buck E. Rogers","orcid":"https://orcid.org/0000-0001-8189-1797","observed_orcids":["https://orcid.org/0000-0001-8189-1797"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Buck E. Rogers","raw_affiliation_strings":["Gene Therapy Program, University of Alabama at Birmingham, 1824 Sixth Avenue South, WTI 620, Birmingham, AL, 35294","Gene Therapy Program, University of Alabama at Birmingham, Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Therapy Program, University of Alabama at Birmingham, 1824 Sixth Avenue South, WTI 620, Birmingham, AL, 35294","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Gene Therapy Program, University of Alabama at Birmingham, Birmingham","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102091427","display_name":"Maryland E. Rosenfeld","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maryland E. Rosenfeld","raw_affiliation_strings":["Gene Therapy Program, University of Alabama at Birmingham, 1824 Sixth Avenue South, WTI 620, Birmingham, AL, 35294","Gene Therapy Program, University of Alabama at Birmingham, Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Therapy Program, University of Alabama at Birmingham, 1824 Sixth Avenue South, WTI 620, Birmingham, AL, 35294","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Gene Therapy Program, University of Alabama at Birmingham, Birmingham","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071143763","display_name":"S I Michael","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon I. Michael","raw_affiliation_strings":["Gene Therapy Program, University of Alabama at Birmingham, 1824 Sixth Avenue South, WTI 620, Birmingham, AL, 35294","Gene Therapy Program, University of Alabama at Birmingham, Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Therapy Program, University of Alabama at Birmingham, 1824 Sixth Avenue South, WTI 620, Birmingham, AL, 35294","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Gene Therapy Program, University of Alabama at Birmingham, Birmingham","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111427749","display_name":"Meizhen Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meizhen Feng","raw_affiliation_strings":["Gene Therapy Program, University of Alabama at Birmingham, 1824 Sixth Avenue South, WTI 620, Birmingham, AL, 35294","Gene Therapy Program, University of Alabama at Birmingham, Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Therapy Program, University of Alabama at Birmingham, 1824 Sixth Avenue South, WTI 620, Birmingham, AL, 35294","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Gene Therapy Program, University of Alabama at Birmingham, Birmingham","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022987623","display_name":"David T. Curiel","orcid":"https://orcid.org/0000-0003-3802-6014","observed_orcids":["https://orcid.org/0000-0003-3802-6014"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T. Curiel","raw_affiliation_strings":["Gene Therapy Program, University of Alabama at Birmingham, 1824 Sixth Avenue South, WTI 620, Birmingham, AL, 35294","Gene Therapy Program, University of Alabama at Birmingham, Birmingham"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Therapy Program, University of Alabama at Birmingham, 1824 Sixth Avenue South, WTI 620, Birmingham, AL, 35294","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Gene Therapy Program, University of Alabama at Birmingham, Birmingham","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32389192"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":16.0589,"has_fulltext":false,"cited_by_count":427,"citation_normalized_percentile":{"value":0.99469265,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"14","issue":"11","first_page":"1574","last_page":"1578"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenovirus-vectors","display_name":"adenoviral vector","score":0.9679999947547913},{"id":"https://openalex.org/keywords/targeted-gene-delivery","display_name":"targeted gene delivery","score":0.7960000038146973},{"id":"https://openalex.org/keywords/viral-tropism","display_name":"viral tropism","score":0.7870000004768372},{"id":"https://openalex.org/keywords/folate-receptor","display_name":"folate receptor","score":0.7829999923706055},{"id":"https://openalex.org/keywords/antibody-conjugates","display_name":"antibody conjugates","score":0.5040000081062317},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.6549999713897705},{"id":"https://openalex.org/keywords/herpes-simplex-virus-thymidine-kinase","display_name":"herpes simplex virus thymidine kinase","score":0.9490000009536743},{"id":"https://openalex.org/keywords/luciferase-reporter","display_name":"luciferase reporter","score":0.6869999766349792},{"id":"https://openalex.org/keywords/tumor-cell-targeting","display_name":"tumor cell targeting","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C35693153","wikidata":"https://www.wikidata.org/wiki/Q239762","display_name":"Tropism","level":3,"score":0.8150368928909302},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.6762138605117798},{"id":"https://openalex.org/C2780306303","wikidata":"https://www.wikidata.org/wiki/Q24784504","display_name":"Folate receptor","level":4,"score":0.6467441320419312},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.6127949357032776},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5818591117858887},{"id":"https://openalex.org/C33602714","wikidata":"https://www.wikidata.org/wiki/Q7809666","display_name":"Tissue tropism","level":4,"score":0.5747409462928772},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.563676118850708},{"id":"https://openalex.org/C2776954459","wikidata":"https://www.wikidata.org/wiki/Q193447","display_name":"Adenoviridae","level":4,"score":0.5476535558700562},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.5150830149650574},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4956916570663452},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.48242196440696716},{"id":"https://openalex.org/C15152581","wikidata":"https://www.wikidata.org/wiki/Q7833966","display_name":"Transduction (biophysics)","level":2,"score":0.43765029311180115},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.43681958317756653},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.4341239035129547},{"id":"https://openalex.org/C39060996","wikidata":"https://www.wikidata.org/wiki/Q7302706","display_name":"Recombinant virus","level":4,"score":0.4235781729221344},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.3881031274795532},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.272408127784729},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19001072645187378},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.14021524786949158},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.1169126033782959},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08717745542526245},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0729537308216095},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D000256","descriptor_name":"Adenoviridae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007140","descriptor_name":"Immunoglobulin Fab Fragments","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007140","descriptor_name":"Immunoglobulin Fab Fragments","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013937","descriptor_name":"Thymidine Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015967","descriptor_name":"Gene Expression Regulation, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018139","descriptor_name":"Simplexvirus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018523","descriptor_name":"Tropism","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058973","descriptor_name":"Folate Receptors, GPI-Anchored","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1038/nbt1196-1574","doi":"https://doi.org/10.1038/nbt1196-1574","is_oa":false,"landing_page_url":"https://doi.org/10.1038/nbt1196-1574","pdf_url":null,"source":{"id":"https://openalex.org/S106963461","display_name":"Nature Biotechnology","issn_l":"0733-222X","issn":["0733-222X","1087-0156","1546-1696","2331-3684"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Biotechnology","raw_type":"journal-article"},{"id":"pmid:9634824","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9634824","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature biotechnology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8721603539","display_name":null,"funder_award_id":"R01 5025505","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W120480743","https://openalex.org/W140890592","https://openalex.org/W1488798457","https://openalex.org/W1504640316","https://openalex.org/W1515543767","https://openalex.org/W1563488686","https://openalex.org/W1594700207","https://openalex.org/W1616735705","https://openalex.org/W1791027840","https://openalex.org/W1857650329","https://openalex.org/W1918960237","https://openalex.org/W1930355415","https://openalex.org/W1980773456","https://openalex.org/W2004742967","https://openalex.org/W2027980197","https://openalex.org/W2042493999","https://openalex.org/W2044275765","https://openalex.org/W2044296969","https://openalex.org/W2065337815","https://openalex.org/W2075227748","https://openalex.org/W2082032640","https://openalex.org/W2082650965","https://openalex.org/W2082652927","https://openalex.org/W2105678378","https://openalex.org/W2105812558","https://openalex.org/W2116071714","https://openalex.org/W2122280772","https://openalex.org/W2131720300","https://openalex.org/W2136159343","https://openalex.org/W2153450253","https://openalex.org/W2159913430","https://openalex.org/W2172238481","https://openalex.org/W2237804924","https://openalex.org/W2405055429","https://openalex.org/W2464754689","https://openalex.org/W4206302388"],"related_works":["https://openalex.org/W2026757769","https://openalex.org/W2084263686","https://openalex.org/W1996633642","https://openalex.org/W2468758822","https://openalex.org/W2119498791","https://openalex.org/W2114713912","https://openalex.org/W4233298146","https://openalex.org/W2029758849","https://openalex.org/W1969914406","https://openalex.org/W2080303092"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":6},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}