{"id":"https://openalex.org/W1998125703","doi":"https://doi.org/10.1021/jm800839j","title":"Discovery of Orally Bioavailable Cathepsin S Inhibitors for the Reversal of Neuropathic Pain","display_name":"Discovery of Orally Bioavailable Cathepsin S Inhibitors for the Reversal of Neuropathic Pain","publication_year":2008,"publication_date":"2008-08-29","ids":{"openalex":"https://openalex.org/W1998125703","doi":"https://doi.org/10.1021/jm800839j","mag":"1998125703","pmid":"https://pubmed.ncbi.nlm.nih.gov/18754655"},"language":"en","primary_location":{"id":"doi:10.1021/jm800839j","doi":"https://doi.org/10.1021/jm800839j","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm800839j","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055004549","display_name":"Osamu Irie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Osamu Irie","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080051748","display_name":"Takatoshi Kosaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Takatoshi Kosaka","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074805538","display_name":"Takeru Ehara","orcid":"https://orcid.org/0000-0002-4889-204X","observed_orcids":["https://orcid.org/0000-0002-4889-204X"]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Takeru Ehara","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026845080","display_name":"Fumiaki Yokokawa","orcid":"https://orcid.org/0000-0002-2861-9281","observed_orcids":["https://orcid.org/0000-0002-2861-9281"]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Fumiaki Yokokawa","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015048930","display_name":"Takanori Kanazawa","orcid":"https://orcid.org/0000-0002-0763-1564","observed_orcids":["https://orcid.org/0000-0002-0763-1564","https://orcid.org/0000-0002-3253-7182"]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Takanori Kanazawa","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050543425","display_name":"Hajime Hirao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Hajime Hirao","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068549218","display_name":"Astuko Iwasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Astuko Iwasaki","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021403973","display_name":"Junichi R. Sakaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Junichi Sakaki","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034188197","display_name":"Naoki Teno","orcid":"https://orcid.org/0000-0002-3940-5473","observed_orcids":["https://orcid.org/0000-0002-3940-5473"]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Naoki Teno","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055428133","display_name":"Yuko Hitomi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Yuko Hitomi","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043760692","display_name":"Genji Iwasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Genji Iwasaki","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008918607","display_name":"Hiroaki Fukaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Hiroaki Fukaya","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kazuhiko Nonomura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Kazuhiko Nonomura","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026638620","display_name":"Keiko Tanabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Keiko Tanabe","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058052018","display_name":"Shinichi Koizumi","orcid":"https://orcid.org/0000-0003-3827-6443","observed_orcids":["https://orcid.org/0000-0003-3827-6443"]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Shinichi Koizumi","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029180206","display_name":"Noriko Uchiyama","orcid":"https://orcid.org/0000-0003-4042-1574","observed_orcids":["https://orcid.org/0000-0003-4042-1574"]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Noriko Uchiyama","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018567435","display_name":"Stuart Bevan","orcid":"https://orcid.org/0000-0002-8977-1797","observed_orcids":["https://orcid.org/0000-0002-8977-1797"]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Stuart J. Bevan","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069049157","display_name":"Marzia Malcangio","orcid":"https://orcid.org/0000-0003-4296-5727","observed_orcids":["https://orcid.org/0000-0003-4296-5727"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marzia Malcangio","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076941904","display_name":"Clive Gentry","orcid":"https://orcid.org/0000-0002-1148-8203","observed_orcids":["https://orcid.org/0000-0002-1148-8203"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clive Gentry","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109187446","display_name":"Alyson J. Fox","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alyson J. Fox","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108687044","display_name":"Mohammed Yaqoob","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammed Yaqoob","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040971287","display_name":"Andrew J. Culshaw","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew J. Culshaw","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103481897","display_name":"Allan Hallett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Allan Hallett","raw_affiliation_strings":["Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for BioMedical Research, Ohkubo 8, Tsukuba, Ibaraki 300-2611, Japan, 5 Gower Place, London WC1E 6BS, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH","institution_ids":["https://openalex.org/I4400600974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5055004549"],"corresponding_institution_ids":["https://openalex.org/I4400600974"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":5.5776,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.96150171,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"51","issue":"18","first_page":"5502","last_page":"5505"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9901999831199646,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.006800000090152025,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cathepsin-s-inhibitors","display_name":"cathepsin S inhibitors","score":0.9950000047683716},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.996999979019165},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.8899999856948853},{"id":"https://openalex.org/keywords/selective-enzyme-inhibitors","display_name":"selective enzyme inhibitors","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.8898175954818726},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.620259165763855},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6127433180809021},{"id":"https://openalex.org/C167844969","wikidata":"https://www.wikidata.org/wiki/Q426245","display_name":"Cathepsin","level":3,"score":0.5770221948623657},{"id":"https://openalex.org/C151701858","wikidata":"https://www.wikidata.org/wiki/Q14902024","display_name":"Cathepsin S","level":4,"score":0.5495204329490662},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.45997074246406555},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.21962818503379822},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21430528163909912},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1329810619354248}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002403","descriptor_name":"Cathepsins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D015853","descriptor_name":"Cysteine Proteinase Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/jm800839j","doi":"https://doi.org/10.1021/jm800839j","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm800839j","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:18754655","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18754655","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1968519275","https://openalex.org/W1977471163","https://openalex.org/W1985834096","https://openalex.org/W1992462978","https://openalex.org/W2008896502","https://openalex.org/W2011580716","https://openalex.org/W2025358565","https://openalex.org/W2034218987","https://openalex.org/W2056688527","https://openalex.org/W2065020204","https://openalex.org/W2070562519","https://openalex.org/W2087765358","https://openalex.org/W2095557905","https://openalex.org/W2143700974","https://openalex.org/W2163502829"],"related_works":["https://openalex.org/W7099634765","https://openalex.org/W2118448291","https://openalex.org/W3021435438","https://openalex.org/W2008896502","https://openalex.org/W2056688527","https://openalex.org/W2782427457","https://openalex.org/W2289176740","https://openalex.org/W2468871454","https://openalex.org/W2080431216","https://openalex.org/W2034218987"],"abstract_inverted_index":{"Cathepsin":[0],"S":[1,22,39],"inhibitors":[2,23,40],"are":[3],"well-known":[4],"to":[5],"be":[6,26],"an":[7],"attractive":[8],"target":[9],"as":[10,41],"immunological":[11],"therapeutic":[12],"agents.":[13],"Recently,":[14],"our":[15],"gene":[16],"expression":[17],"analysis":[18],"identified":[19],"that":[20],"cathepsin":[21,38],"could":[24],"also":[25],"effective":[27],"for":[28],"neuropathic":[29,47],"pain.":[30],"Herein,":[31],"we":[32],"describe":[33],"the":[34],"efficacy":[35],"of":[36,46],"selective":[37],"antihyperalgesics":[42],"in":[43,49],"a":[44],"model":[45],"pain":[48],"rats":[50],"after":[51],"oral":[52],"administration.":[53]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
