{"id":"https://openalex.org/W1998112160","doi":"https://doi.org/10.1289/ehp.99107s5701","title":"Neuroendocrine Host Factors and Inflammatory Disease Susceptibility","display_name":"Neuroendocrine Host Factors and Inflammatory Disease Susceptibility","publication_year":1999,"publication_date":"1999-10-01","ids":{"openalex":"https://openalex.org/W1998112160","doi":"https://doi.org/10.1289/ehp.99107s5701","mag":"1998112160","pmid":"https://pubmed.ncbi.nlm.nih.gov/10502534","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1566252"},"language":"en","primary_location":{"id":"doi:10.1289/ehp.99107s5701","doi":"https://doi.org/10.1289/ehp.99107s5701","is_oa":true,"landing_page_url":"https://doi.org/10.1289/ehp.99107s5701","pdf_url":null,"source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1289/ehp.99107s5701","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043040832","display_name":"Sophie Ligier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S Ligier","raw_affiliation_strings":["Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1284, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1284, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110109780","display_name":"Esther M. Sternberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E M Sternberg","raw_affiliation_strings":["Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1284, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892-1284, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.6115,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.58137255,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"107","issue":"suppl 5","first_page":"701","last_page":"701"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12626","display_name":"Cancer, Stress, Anesthesia, and Immune Response","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroendocrine-system","display_name":"neuroendocrine system","score":0.8939999938011169},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.9039999842643738},{"id":"https://openalex.org/keywords/sympathetic-nervous-system","display_name":"sympathetic nervous system","score":0.8640000224113464},{"id":"https://openalex.org/keywords/stress-response","display_name":"stress response","score":0.8830000162124634},{"id":"https://openalex.org/keywords/immune-dysregulation","display_name":"immune dysregulation","score":0.7179999947547913},{"id":"https://openalex.org/keywords/self-tolerance","display_name":"self-tolerance","score":0.9520000219345093},{"id":"https://openalex.org/keywords/environmental-exposure","display_name":"environmental exposure","score":0.9210000038146973},{"id":"https://openalex.org/keywords/toxic-compounds","display_name":"toxic compounds","score":0.5920000076293945},{"id":"https://openalex.org/keywords/animal-models-of-autoimmunity","display_name":"animal models of autoimmunity","score":0.8600000143051147},{"id":"https://openalex.org/keywords/host-factors","display_name":"host factors","score":0.47999998927116394}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.781658411026001},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.7265362739562988},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6649343371391296},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.5723721981048584},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.527299165725708},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.48205623030662537},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.47814854979515076},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3998837471008301},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38468074798583984},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.32904887199401855},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.09490025043487549},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.08788561820983887}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001172","descriptor_name":"Arthritis, Rheumatoid","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D001327","descriptor_name":"Autoimmune Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009490","descriptor_name":"Neurosecretory Systems","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012859","descriptor_name":"Sjogren's Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D013312","descriptor_name":"Stress, Physiological","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1289/ehp.99107s5701","doi":"https://doi.org/10.1289/ehp.99107s5701","is_oa":true,"landing_page_url":"https://doi.org/10.1289/ehp.99107s5701","pdf_url":null,"source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},{"id":"doi:10.2307/3434330","doi":"https://doi.org/10.2307/3434330","is_oa":true,"landing_page_url":"https://doi.org/10.2307/3434330","pdf_url":null,"source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:351709","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1566252","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:10502534","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10502534","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental health perspectives","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1289/ehp.99107s5701","doi":"https://doi.org/10.1289/ehp.99107s5701","is_oa":true,"landing_page_url":"https://doi.org/10.1289/ehp.99107s5701","pdf_url":null,"source":{"id":"https://openalex.org/S10446503","display_name":"Environmental Health Perspectives","issn_l":"0091-6765","issn":["0091-6765","1552-9924"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319799","host_organization_name":"National Institute of Environmental Health Sciences","host_organization_lineage":["https://openalex.org/P4310319799","https://openalex.org/P4310316754"],"host_organization_lineage_names":["National Institute of Environmental Health Sciences","National Institutes of Health"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Health Perspectives","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":98,"referenced_works":["https://openalex.org/W111804031","https://openalex.org/W157397294","https://openalex.org/W1248884518","https://openalex.org/W1263158759","https://openalex.org/W1272328312","https://openalex.org/W1499904716","https://openalex.org/W1679390840","https://openalex.org/W1718876362","https://openalex.org/W1965229834","https://openalex.org/W1966066588","https://openalex.org/W1968663617","https://openalex.org/W1970131172","https://openalex.org/W1972922050","https://openalex.org/W1980900917","https://openalex.org/W1982686484","https://openalex.org/W1988964034","https://openalex.org/W1990121258","https://openalex.org/W1992854442","https://openalex.org/W1993826689","https://openalex.org/W1998374950","https://openalex.org/W1998405496","https://openalex.org/W2001005368","https://openalex.org/W2002739906","https://openalex.org/W2003066587","https://openalex.org/W2004796862","https://openalex.org/W2005443587","https://openalex.org/W2006387906","https://openalex.org/W2006551603","https://openalex.org/W2007041596","https://openalex.org/W2007341044","https://openalex.org/W2009393272","https://openalex.org/W2011783734","https://openalex.org/W2012305198","https://openalex.org/W2013667866","https://openalex.org/W2015113923","https://openalex.org/W2015611430","https://openalex.org/W2015638788","https://openalex.org/W2017710616","https://openalex.org/W2018934334","https://openalex.org/W2019340779","https://openalex.org/W2020788976","https://openalex.org/W2021430553","https://openalex.org/W2021462259","https://openalex.org/W2022873017","https://openalex.org/W2034965533","https://openalex.org/W2035236079","https://openalex.org/W2036065289","https://openalex.org/W2038200340","https://openalex.org/W2041596843","https://openalex.org/W2042491566","https://openalex.org/W2046141884","https://openalex.org/W2047755464","https://openalex.org/W2049736152","https://openalex.org/W2050517674","https://openalex.org/W2056763517","https://openalex.org/W2056795324","https://openalex.org/W2064069399","https://openalex.org/W2064627701","https://openalex.org/W2066872946","https://openalex.org/W2067547922","https://openalex.org/W2072424877","https://openalex.org/W2077439270","https://openalex.org/W2079762367","https://openalex.org/W2082062343","https://openalex.org/W2082195400","https://openalex.org/W2084909553","https://openalex.org/W2088355439","https://openalex.org/W2092358120","https://openalex.org/W2093102863","https://openalex.org/W2093774437","https://openalex.org/W2094628847","https://openalex.org/W2098755321","https://openalex.org/W2103261141","https://openalex.org/W2106493420","https://openalex.org/W2110963030","https://openalex.org/W2114506500","https://openalex.org/W2118022144","https://openalex.org/W2119337467","https://openalex.org/W2120930246","https://openalex.org/W2136135254","https://openalex.org/W2140298451","https://openalex.org/W2141381018","https://openalex.org/W2152151195","https://openalex.org/W2159370098","https://openalex.org/W2281049980","https://openalex.org/W2320349682","https://openalex.org/W2322809662","https://openalex.org/W2323601729","https://openalex.org/W2401902918","https://openalex.org/W2406162057","https://openalex.org/W2406686038","https://openalex.org/W2409528478","https://openalex.org/W2441871659","https://openalex.org/W2468534450","https://openalex.org/W2906953680","https://openalex.org/W4233170815","https://openalex.org/W4255304519","https://openalex.org/W4294184534"],"related_works":["https://openalex.org/W2117197980","https://openalex.org/W4255429695","https://openalex.org/W1965945661","https://openalex.org/W2236825824","https://openalex.org/W2049708791","https://openalex.org/W336745349","https://openalex.org/W7133208474","https://openalex.org/W193703443","https://openalex.org/W2085148725","https://openalex.org/W2049861686"],"abstract_inverted_index":{"The":[0,39,114],"etiology":[1],"of":[2,11,35,50,57,82,94,110,117,150,179,191],"autoimmune":[3,22,83,126,167],"diseases":[4,84,127,168],"is":[5,128,185],"multifactorial,":[6],"resulting":[7],"from":[8],"a":[9,71,92,134,181,189],"combination":[10],"genetically":[12],"predetermined":[13],"host":[14],"characteristics":[15],"and":[16,26,41,61,96,99,125,169,173,177],"environmental":[17,123,156,192],"exposures.":[18,193],"As":[19,64],"the":[20,33,51,55,108,118,147,151,164,170,175],"term":[21],"implies,":[23],"immune":[24,52,112,152],"dysfunction":[25],"dysregulated":[27],"self-tolerance":[28],"are":[29,45],"key":[30],"elements":[31],"in":[32,67,88,107,121,146],"pathophysiology":[34],"all":[36],"these":[37],"diseases.":[38],"neuroendocrine":[40,89,119,171],"sympathetic":[42],"nervous":[43],"systems":[44],"increasingly":[46],"recognized":[47],"as":[48],"modulators":[49],"response":[53,69,149,183],"at":[54],"levels":[56],"both":[58,97],"early":[59],"inflammation":[60],"specific":[62],"immunity.":[63],"such,":[65],"alterations":[66],"their":[68],"represent":[70,133],"potential":[72,115],"mechanism":[73],"by":[74],"which":[75],"pathologic":[76],"autoimmunity":[77],"may":[78,132,144],"develop.":[79],"Animal":[80],"models":[81],"show":[85],"pre-existing":[86],"changes":[87],"responses":[90,106],"to":[91,154,187],"variety":[93],"stimuli,":[95],"animal":[98],"human":[100],"studies":[101],"have":[102],"shown":[103],"altered":[104],"stress":[105],"setting":[109],"active":[111],"activation.":[113],"role":[116],"system":[120,153,172],"linking":[122],"exposures":[124],"2-fold.":[129],"First,":[130],"it":[131],"direct":[135],"target":[136],"for":[137],"toxic":[138],"compounds.":[139],"Second,":[140],"its":[141],"inadequate":[142],"function":[143],"result":[145],"inappropriate":[148],"an":[155],"agent":[157],"with":[158],"immunogenic":[159],"properties.":[160],"This":[161],"article":[162],"reviews":[163],"relationship":[165],"between":[166],"discusses":[174],"difficulties":[176],"pitfalls":[178],"investigating":[180],"physiologic":[182],"that":[184],"sensitive":[186],"such":[188],"multiplicity":[190]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}