{"id":"https://openalex.org/W1998108986","doi":"https://doi.org/10.1002/1097-0142(19950801)76:3<406::aid-cncr2820760310>3.0.co;2-s","title":"Long term results of a phase I/II study of aggressive chemotherapy and sequential upper and lower hemibody radiation for patients with extensive stage small cell lung cancer","display_name":"Long term results of a phase I/II study of aggressive chemotherapy and sequential upper and lower hemibody radiation for patients with extensive stage small cell lung cancer","publication_year":1995,"publication_date":"1995-08-01","ids":{"openalex":"https://openalex.org/W1998108986","doi":"https://doi.org/10.1002/1097-0142(19950801)76:3<406::aid-cncr2820760310>3.0.co;2-s","mag":"1998108986","pmid":"https://pubmed.ncbi.nlm.nih.gov/8625121"},"language":"en","primary_location":{"id":"doi:10.1002/1097-0142(19950801)76:3<406::aid-cncr2820760310>3.0.co;2-s","doi":"https://doi.org/10.1002/1097-0142(19950801)76:3<406::aid-cncr2820760310>3.0.co;2-s","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19950801)76:3<406::aid-cncr2820760310>3.0.co;2-s","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819950801%2976%3A3%3C406%3A%3AAID-CNCR2820760310%3E3.0.CO%3B2-S","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819950801%2976%3A3%3C406%3A%3AAID-CNCR2820760310%3E3.0.CO%3B2-S","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013854802","display_name":"James A. Bonner","orcid":"https://orcid.org/0000-0002-8413-3788","observed_orcids":["https://orcid.org/0000-0002-8413-3788"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James A. Bonner","raw_affiliation_strings":["Department of Oncology, Mayo Clinic, Rochester, Minnesota 55905, USA","Mayo Clinic, 200 First Street SW, Rochester, MN 55905"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Mayo Clinic, Rochester, Minnesota 55905, USA","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic, 200 First Street SW, Rochester, MN 55905","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112131378","display_name":"Robert T. Eagan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert T. Eagan","raw_affiliation_strings":["Department of Oncology , Mayo Clinic","Department of Oncology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology , Mayo Clinic","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Oncology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030833244","display_name":"Vichaivood Liengswangwong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vichaivood Liengswangwong","raw_affiliation_strings":["Department of Oncology , Mayo Clinic","Department of Oncology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology , Mayo Clinic","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Oncology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074002894","display_name":"Stephen Frytak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Frytak","raw_affiliation_strings":["Department of Oncology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103415116","display_name":"Edward G. Shaw","orcid":"https://orcid.org/0009-0004-2914-0119","observed_orcids":["https://orcid.org/0009-0004-2914-0119"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward G. Shaw","raw_affiliation_strings":["Department of Oncology , Mayo Clinic","Department of Oncology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology , Mayo Clinic","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Oncology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103425457","display_name":"Richard G. Evans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard G. Evans","raw_affiliation_strings":["Department of Oncology , Mayo Clinic","Department of Oncology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology , Mayo Clinic","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Oncology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032917850","display_name":"Edward T. Creagan","orcid":"https://orcid.org/0000-0002-2976-7075","observed_orcids":["https://orcid.org/0000-0002-2976-7075"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edward T. Creagan","raw_affiliation_strings":["Department of Oncology , Mayo Clinic","Foundation , Rochester , Minnesota. First Street SW , Rochester , MN 55905 ","Department of Oncology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology , Mayo Clinic","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Foundation , Rochester , Minnesota. First Street SW , Rochester , MN 55905 ","institution_ids":[]},{"raw_affiliation_string":"Department of Oncology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109920377","display_name":"Ronald L. Richardson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronald L. Richardson","raw_affiliation_strings":["Department of Oncology , Mayo Clinic","Department of Oncology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology , Mayo Clinic","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Oncology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.1495,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.49775687,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"76","issue":"3","first_page":"406","last_page":"412"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.02889999933540821,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/extensive-stage-small-cell-lung-cancer","display_name":"extensive-stage small cell lung cancer","score":0.9539999961853027},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.8939999938011169},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.8240000009536743},{"id":"https://openalex.org/keywords/lomustine","display_name":"lomustine","score":0.8889999985694885},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":0.7789999842643738},{"id":"https://openalex.org/keywords/vincristine","display_name":"vincristine","score":0.8960000276565552},{"id":"https://openalex.org/keywords/prophylactic-cranial-irradiation","display_name":"prophylactic cranial irradiation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/hematological-toxicity","display_name":"hematologic toxicity","score":0.8130000233650208},{"id":"https://openalex.org/keywords/peripheral-neurotoxicity","display_name":"peripheral neurotoxicity","score":0.7429999709129333},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.7429999709129333},{"id":"https://openalex.org/keywords/long-term-survival","display_name":"long-term survival","score":0.6600000262260437},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.6809999942779541},{"id":"https://openalex.org/keywords/complete-response","display_name":"complete response","score":0.6449999809265137}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8642618656158447},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6907436847686768},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5939513444900513},{"id":"https://openalex.org/C61797465","wikidata":"https://www.wikidata.org/wiki/Q1188986","display_name":"Term (time)","level":2,"score":0.5360669493675232},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.5215437412261963},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5088041424751282},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.457409143447876},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3887680470943451},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.33173954486846924},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017619","descriptor_name":"Hemibody Irradiation","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/1097-0142(19950801)76:3<406::aid-cncr2820760310>3.0.co;2-s","doi":"https://doi.org/10.1002/1097-0142(19950801)76:3<406::aid-cncr2820760310>3.0.co;2-s","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19950801)76:3<406::aid-cncr2820760310>3.0.co;2-s","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819950801%2976%3A3%3C406%3A%3AAID-CNCR2820760310%3E3.0.CO%3B2-S","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:8625121","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8625121","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Clinical Trial"}],"best_oa_location":{"id":"doi:10.1002/1097-0142(19950801)76:3<406::aid-cncr2820760310>3.0.co;2-s","doi":"https://doi.org/10.1002/1097-0142(19950801)76:3<406::aid-cncr2820760310>3.0.co;2-s","is_oa":true,"landing_page_url":"https://doi.org/10.1002/1097-0142(19950801)76:3<406::aid-cncr2820760310>3.0.co;2-s","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/1097-0142%2819950801%2976%3A3%3C406%3A%3AAID-CNCR2820760310%3E3.0.CO%3B2-S","source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1998108986.pdf","grobid_xml":"https://content.openalex.org/works/W1998108986.grobid-xml"},"referenced_works_count":17,"referenced_works":["https://openalex.org/W1839070320","https://openalex.org/W1883554783","https://openalex.org/W1894342532","https://openalex.org/W1945129735","https://openalex.org/W1979300931","https://openalex.org/W2027280653","https://openalex.org/W2050377134","https://openalex.org/W2051755740","https://openalex.org/W2065134107","https://openalex.org/W2075492696","https://openalex.org/W2084803292","https://openalex.org/W2093536022","https://openalex.org/W2123767004","https://openalex.org/W2242379377","https://openalex.org/W2258518953","https://openalex.org/W3041047318","https://openalex.org/W4367294795"],"related_works":["https://openalex.org/W2121983031","https://openalex.org/W2102835965","https://openalex.org/W2051755740","https://openalex.org/W2034773102","https://openalex.org/W2014986882","https://openalex.org/W2038042148","https://openalex.org/W2135676478","https://openalex.org/W2474970446","https://openalex.org/W2414808941","https://openalex.org/W2132003688"],"abstract_inverted_index":{"BACKGROUND:":[0],"A":[1],"Phase":[2],"I/II":[3],"study":[4],"of":[5,15,45,52,64,81,108,142,164,273,280],"an":[6],"aggressive":[7,242],"six-drug":[8],"chemotherapy":[9,82,109],"regimen":[10,63,243],"followed":[11,133],"by":[12,134],"the":[13,78,105,123,170,177,281],"use":[14],"sequential":[16,285],"hemibody":[17,131,138,191,260,275,286],"radiation":[18,70,97,132,261,287],"therapy":[19],"as":[20],"a":[21,62,74,101,219],"possible":[22],"non-cross-resistant":[23],"systemic":[24],"treatment":[25,157,288],"was":[26,71,98,176,224],"undertaken":[27],"for":[28,147,156,180,246],"patients":[29,41,126,144,168,184,194,247,282],"with":[30,67,248],"extensive":[31,249],"stage":[32,250],"small":[33,251],"cell":[34,252],"lung":[35,253],"cancer.":[36],"METHODS:":[37],"The":[38,48],"20":[39,143],"enrolled":[40],"received":[42,127],"7":[43,124,172],"cycles":[44,60,83,110],"cyclophosphamide-based":[46],"chemotherapy.":[47],"first":[49,79,106],"cycle":[50],"consisted":[51],"cyclophosphamide,":[53],"doxorubicin,":[54],"etoposide,":[55],"vincristine,":[56],"and":[57,85,112,149,208,231,237],"lomustine.":[58],"Subsequent":[59],"used":[61],"doxorubicin":[65],"alternating":[66],"cisplatin.":[68],"Thoracic":[69],"delivered":[72,99],"in":[73,89,100,116,162],"split-course":[75,102],"fashion":[76,103],"during":[77,92,104,119],"week":[80,107],"5":[84,117],"6":[86],"(2000":[87],"cGy":[88,115,129,136],"five":[90],"fractions":[91,118],"each":[93,120],"week).":[94,121],"Prophylactic":[95],"cranial":[96],"2":[111],"3":[113],"(1700":[114],"After":[122],"cycles,":[125],"600":[128],"upper":[130],"800":[135],"lower":[137,190,259,270,274],"radiation.":[139,192,276],"RESULTS:":[140],"Nineteen":[141],"were":[145,235],"evaluable":[146],"toxicity":[148,154],"response":[150],"to":[151],"treatment.":[152,182],"Hematologic":[153],"accounted":[155],"delays":[158],"or":[159,197],"decreased":[160],"doses":[161,272],"16":[163],"19":[165,215],"patients.":[166],"Thirteen":[167],"completed":[169],"initial":[171,271],"cycles;":[173],"progressive":[174],"disease":[175],"only":[178],"reason":[179],"discontinuing":[181],"Two":[183],"had":[185,195,203,210],"fatal":[186],"hematologic":[187],"complications":[188],"after":[189,258],"Three":[193],"severe":[196,204,211],"greater":[198],"peripheral":[199],"neurologic":[200,206],"toxicity,":[201,207],"two":[202],"central":[205],"one":[209],"cardiac":[212],"toxicity.":[213],"Of":[214],"patients,":[216],"9":[217],"achieved":[218],"complete":[220],"response;":[221],"median":[222],"survival":[223,230,234,279],"11.5":[225],"months.":[226],"Five-year":[227],"progression":[228],"free":[229],"5-year":[232],"overall":[233],"27%":[236],"16%,":[238],"respectively.":[239],"CONCLUSIONS:":[240],"This":[241],"is":[244],"feasible":[245],"cancer;":[254],"however,":[255],"hematologic-related":[256],"mortality":[257],"suggests":[262,283],"that":[263,284],"future":[264],"investigations":[265],"should":[266],"be":[267],"initiated":[268],"at":[269],"Long":[277],"term":[278],"warrants":[289],"further":[290],"investigation.":[291]},"counts_by_year":[{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}