{"id":"https://openalex.org/W1998107315","doi":"https://doi.org/10.1021/ac062309s","title":"Simple Method for Identification of Metallothionein Isoforms in Cultured Human Prostate Cells by MALDI-TOF/TOF Mass Spectrometry","display_name":"Simple Method for Identification of Metallothionein Isoforms in Cultured Human Prostate Cells by MALDI-TOF/TOF Mass Spectrometry","publication_year":2007,"publication_date":"2007-05-12","ids":{"openalex":"https://openalex.org/W1998107315","doi":"https://doi.org/10.1021/ac062309s","mag":"1998107315","pmid":"https://pubmed.ncbi.nlm.nih.gov/17497826","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4276256"},"language":"en","primary_location":{"id":"doi:10.1021/ac062309s","doi":"https://doi.org/10.1021/ac062309s","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac062309s","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4276256","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024182431","display_name":"Rongying Wang","orcid":"https://orcid.org/0000-0003-2645-912X","observed_orcids":["https://orcid.org/0000-0003-2645-912X","https://orcid.org/0009-0008-3307-2621"]},"institutions":[{"id":"https://openalex.org/I24571045","display_name":"University of North Dakota","ror":"https://ror.org/04a5szx83","country_code":"US","type":"education","lineage":["https://openalex.org/I24571045"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rongying Wang","raw_affiliation_strings":["Department of Pathology, and Proteomics Core Facility, School of Medicine and Health Science, University of North Dakota, Grand Forks, North Dakota 58202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, and Proteomics Core Facility, School of Medicine and Health Science, University of North Dakota, Grand Forks, North Dakota 58202","institution_ids":["https://openalex.org/I24571045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081166985","display_name":"Donald A. Sens","orcid":"https://orcid.org/0000-0002-7163-5236","observed_orcids":["https://orcid.org/0000-0002-7163-5236"]},"institutions":[{"id":"https://openalex.org/I24571045","display_name":"University of North Dakota","ror":"https://ror.org/04a5szx83","country_code":"US","type":"education","lineage":["https://openalex.org/I24571045"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald A. Sens","raw_affiliation_strings":["Department of Pathology, and Proteomics Core Facility, School of Medicine and Health Science, University of North Dakota, Grand Forks, North Dakota 58202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, and Proteomics Core Facility, School of Medicine and Health Science, University of North Dakota, Grand Forks, North Dakota 58202","institution_ids":["https://openalex.org/I24571045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032013340","display_name":"Amy Albrecht","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24571045","display_name":"University of North Dakota","ror":"https://ror.org/04a5szx83","country_code":"US","type":"education","lineage":["https://openalex.org/I24571045"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amy Albrecht","raw_affiliation_strings":["Department of Pathology, and Proteomics Core Facility, School of Medicine and Health Science, University of North Dakota, Grand Forks, North Dakota 58202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, and Proteomics Core Facility, School of Medicine and Health Science, University of North Dakota, Grand Forks, North Dakota 58202","institution_ids":["https://openalex.org/I24571045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068566357","display_name":"Scott H. Garrett","orcid":"https://orcid.org/0000-0002-4398-9213","observed_orcids":["https://orcid.org/0000-0002-4398-9213"]},"institutions":[{"id":"https://openalex.org/I24571045","display_name":"University of North Dakota","ror":"https://ror.org/04a5szx83","country_code":"US","type":"education","lineage":["https://openalex.org/I24571045"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott Garrett","raw_affiliation_strings":["Department of Pathology, and Proteomics Core Facility, School of Medicine and Health Science, University of North Dakota, Grand Forks, North Dakota 58202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, and Proteomics Core Facility, School of Medicine and Health Science, University of North Dakota, Grand Forks, North Dakota 58202","institution_ids":["https://openalex.org/I24571045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009658338","display_name":"Seema Somji","orcid":"https://orcid.org/0000-0001-8044-5234","observed_orcids":["https://orcid.org/0000-0001-8044-5234"]},"institutions":[{"id":"https://openalex.org/I24571045","display_name":"University of North Dakota","ror":"https://ror.org/04a5szx83","country_code":"US","type":"education","lineage":["https://openalex.org/I24571045"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seema Somji","raw_affiliation_strings":["Department of Pathology, and Proteomics Core Facility, School of Medicine and Health Science, University of North Dakota, Grand Forks, North Dakota 58202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, and Proteomics Core Facility, School of Medicine and Health Science, University of North Dakota, Grand Forks, North Dakota 58202","institution_ids":["https://openalex.org/I24571045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033798889","display_name":"Mary Ann Sens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24571045","display_name":"University of North Dakota","ror":"https://ror.org/04a5szx83","country_code":"US","type":"education","lineage":["https://openalex.org/I24571045"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Ann Sens","raw_affiliation_strings":["Department of Pathology, and Proteomics Core Facility, School of Medicine and Health Science, University of North Dakota, Grand Forks, North Dakota 58202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, and Proteomics Core Facility, School of Medicine and Health Science, University of North Dakota, Grand Forks, North Dakota 58202","institution_ids":["https://openalex.org/I24571045"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011925403","display_name":"Xiaoning Lu","orcid":"https://orcid.org/0000-0001-8012-8458","observed_orcids":["https://orcid.org/0000-0001-8012-8458"]},"institutions":[{"id":"https://openalex.org/I24571045","display_name":"University of North Dakota","ror":"https://ror.org/04a5szx83","country_code":"US","type":"education","lineage":["https://openalex.org/I24571045"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiaoning Lu","raw_affiliation_strings":["Department of Pathology, and Proteomics Core Facility, School of Medicine and Health Science, University of North Dakota, Grand Forks, North Dakota 58202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, and Proteomics Core Facility, School of Medicine and Health Science, University of North Dakota, Grand Forks, North Dakota 58202","institution_ids":["https://openalex.org/I24571045"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5011925403"],"corresponding_institution_ids":["https://openalex.org/I24571045"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.2315,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.74303886,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"79","issue":"12","first_page":"4433","last_page":"4441"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.6133000254631042,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10683","display_name":"Mass Spectrometry Techniques and Applications","score":0.6133000254631042,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.3345000147819519,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.021700000390410423,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metallothionein-isoforms","display_name":"metallothionein isoforms","score":0.9660000205039978},{"id":"https://openalex.org/keywords/rwpe-1-cells","display_name":"RWPE-1 cells","score":0.9819999933242798},{"id":"https://openalex.org/keywords/protein-identification","display_name":"protein identification","score":0.5109999775886536},{"id":"https://openalex.org/keywords/tryptic-digestion","display_name":"trypsin digestion","score":0.765999972820282},{"id":"https://openalex.org/keywords/size-exclusion-chromatography","display_name":"size exclusion chromatography","score":0.5139999985694885},{"id":"https://openalex.org/keywords/n-terminal-acetylation","display_name":"N-terminal acetylation","score":0.8460000157356262},{"id":"https://openalex.org/keywords/metal-ion-binding","display_name":"metal ion binding","score":0.3479999899864197},{"id":"https://openalex.org/keywords/maldi-tof-tof-mass-spectrometry","display_name":"MALDI-TOF/TOF mass spectrometry","score":0.8949999809265137}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8800313472747803},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.721961259841919},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.7101825475692749},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.7034851908683777},{"id":"https://openalex.org/C20719415","wikidata":"https://www.wikidata.org/wiki/Q416896","display_name":"Metallothionein","level":3,"score":0.5621473789215088},{"id":"https://openalex.org/C202157981","wikidata":"https://www.wikidata.org/wiki/Q7251488","display_name":"Protein mass spectrometry","level":4,"score":0.5486541390419006},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5421704649925232},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.5229079127311707},{"id":"https://openalex.org/C75280812","wikidata":"https://www.wikidata.org/wiki/Q190382","display_name":"Matrix-assisted laser desorption/ionization","level":4,"score":0.5076867341995239},{"id":"https://openalex.org/C7623868","wikidata":"https://www.wikidata.org/wiki/Q1967135","display_name":"Centrifugation","level":2,"score":0.43064630031585693},{"id":"https://openalex.org/C2778576202","wikidata":"https://www.wikidata.org/wiki/Q2540164","display_name":"Sample preparation","level":2,"score":0.42868998646736145},{"id":"https://openalex.org/C27420735","wikidata":"https://www.wikidata.org/wiki/Q5968721","display_name":"Peptide mass fingerprinting","level":4,"score":0.42087897658348083},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4198005795478821},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.3562469482421875},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3304764926433563},{"id":"https://openalex.org/C40684141","wikidata":"https://www.wikidata.org/wiki/Q902061","display_name":"Electrospray ionization","level":3,"score":0.3274156153202057},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.18168166279792786},{"id":"https://openalex.org/C162711632","wikidata":"https://www.wikidata.org/wiki/Q905514","display_name":"Desorption","level":3,"score":0.14822274446487427},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09453088045120239},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06932574510574341},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002850","descriptor_name":"Chromatography, Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004492","descriptor_name":"Edetic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008668","descriptor_name":"Metallothionein","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008668","descriptor_name":"Metallothionein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008668","descriptor_name":"Metallothionein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014357","descriptor_name":"Trypsin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019032","descriptor_name":"Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019216","descriptor_name":"Metals, Heavy","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020033","descriptor_name":"Protein Isoforms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1021/ac062309s","doi":"https://doi.org/10.1021/ac062309s","is_oa":false,"landing_page_url":"https://doi.org/10.1021/ac062309s","pdf_url":null,"source":{"id":"https://openalex.org/S191963794","display_name":"Analytical Chemistry","issn_l":"0003-2700","issn":["0003-2700","1520-6882"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical Chemistry","raw_type":"journal-article"},{"id":"pmid:17497826","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17497826","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Analytical chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3241387","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4276256","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4276256","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4276256","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Anal Chem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3241387","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4276256","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2077246550","display_name":null,"funder_award_id":"P20RR016741","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G2339510952","display_name":"Cadmium, Metallothionein and Breast Cancer Progression","funder_award_id":"R01CA098832","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5253910379","display_name":"North Dakota INBRE:  Health and the Environment","funder_award_id":"P20RR016471","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G915594056","display_name":"Metallothionein Isoform 3 as a Urinary Marker for Bladder Cancer","funder_award_id":"R01ES015100","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W279641908","https://openalex.org/W1507671215","https://openalex.org/W1512639331","https://openalex.org/W1615397418","https://openalex.org/W1885137129","https://openalex.org/W1972379271","https://openalex.org/W1974235044","https://openalex.org/W1989798855","https://openalex.org/W1995968305","https://openalex.org/W1996631183","https://openalex.org/W1999173548","https://openalex.org/W2004731363","https://openalex.org/W2006489082","https://openalex.org/W2008170207","https://openalex.org/W2017891214","https://openalex.org/W2027452172","https://openalex.org/W2043030760","https://openalex.org/W2045417839","https://openalex.org/W2055783409","https://openalex.org/W2059253421","https://openalex.org/W2062589674","https://openalex.org/W2072637379","https://openalex.org/W2074988198","https://openalex.org/W2082318378","https://openalex.org/W2112329971","https://openalex.org/W2112955251","https://openalex.org/W2143236746","https://openalex.org/W2143609309","https://openalex.org/W2145330633","https://openalex.org/W2147245798","https://openalex.org/W2153685597","https://openalex.org/W2403095893","https://openalex.org/W4250221563"],"related_works":["https://openalex.org/W2517086142","https://openalex.org/W2103505454","https://openalex.org/W2072989126","https://openalex.org/W300691993","https://openalex.org/W2560510143","https://openalex.org/W7135947950","https://openalex.org/W4298435090","https://openalex.org/W2055831520","https://openalex.org/W1990832290","https://openalex.org/W2340211771"],"abstract_inverted_index":{"The":[0,167,191],"present":[1],"paper":[2],"describes":[3],"a":[4],"rapid":[5],"method":[6,192],"for":[7,123,131,181],"identification":[8,183],"and":[9,44,99,137,160,211],"characterization":[10],"of":[11,36,52,61,75,110,152,176,184,230],"human":[12,202],"metallothionein":[13],"(MT)":[14],"isoforms":[15,186],"in":[16,187,225,233],"complex":[17],"cell":[18,53,82],"cultures":[19],"using":[20,69],"high-resolution":[21],"matrix-assisted":[22],"laser":[23],"desorption/ionization":[24],"time-of-flight/time-of-flight":[25],"mass":[26,127,170],"spectrometry":[27],"(MALDI-TOF/TOF).":[28],"In":[29,78,140],"the":[30,33,59,96,107,111,114,129,141,144,150,172,188,228],"proposed":[31],"method,":[32],"sample":[34,116],"preparation":[35],"MTs":[37,84,159],"from":[38,158,200],"cultured":[39],"cells":[40,198,235],"is":[41,47,117],"both":[42],"simple":[43],"fast.":[45],"It":[46],"accomplished":[48],"by":[49,66,95,102,135,149,237],"trypsin":[50],"cleavage":[51],"proteins":[54,146],"into":[55,119],"small":[56],"peptide":[57,174],"species,":[58],"majority":[60],"which":[62,154],"are":[63,147,224],"subsequently":[64],"removed":[65],"gel":[67,97],"filtration":[68],"beads":[70,98],"with":[71,91,171,227],"an":[72],"exclusion":[73],"limit":[74],"4000":[76],"Da.":[77],"contrast":[79],"to":[80,164,196],"most":[81],"proteins,":[83],"remain":[85],"intact":[86,124],"(undigested)":[87],"upon":[88],"being":[89,93,217],"treated":[90],"trypsin,":[92],"excluded":[94],"thus":[100],"recovered":[101],"low-speed":[103],"centrifugation.":[104],"To":[105],"identify":[106],"protein":[108,125],"constitutes":[109],"MT":[112,115,145,178,185,206,231],"preparation,":[113],"divided":[118],"two":[120],"parts,":[121],"one":[122],"accurate":[126,169],"measurement,":[128],"other":[130],"tryptic":[132,165],"digestion":[133],"followed":[134],"MS":[136],"MS/MS":[138],"analyses.":[139],"latter":[142],"case,":[143],"denatured":[148],"addition":[151],"EDTA":[153],"strips":[155],"heavy":[156],"metals":[157],"renders":[161],"them":[162],"susceptible":[163],"digestion.":[166],"obtained":[168],"unique":[173],"sequences":[175],"each":[177],"isoform":[179],"allows":[180],"unambiguous":[182],"prepared":[189],"mixture.":[190],"has":[193],"been":[194,214],"applied":[195],"RWPE-1":[197,234],"derived":[199],"normal":[201],"prostate":[203],"epithelium.":[204],"Four":[205],"isoforms,":[207],"1E,":[208],"1G,":[209],"1X,":[210],"2A,":[212],"have":[213],"confidently":[215],"identified,":[216],"primarily":[218],"acetylated":[219],"at":[220],"N-termini.":[221],"These":[222],"results":[223],"agreement":[226],"expression":[229],"mRNAs":[232],"determined":[236],"real-time":[238],"reverse-transcription":[239],"polymerase":[240],"chain":[241],"reaction":[242],"(RT-PCR).":[243]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
