{"id":"https://openalex.org/W1998106736","doi":"https://doi.org/10.1016/s1262-3636(12)71024-8","title":"O46 Les fluctuations du glucose induisent une activation de la fibrose r\u00e9nale par des voies de signalisation P38-MAP kinase et Rho/Rock","display_name":"O46 Les fluctuations du glucose induisent une activation de la fibrose r\u00e9nale par des voies de signalisation P38-MAP kinase et Rho/Rock","publication_year":2012,"publication_date":"2012-03-01","ids":{"openalex":"https://openalex.org/W1998106736","doi":"https://doi.org/10.1016/s1262-3636(12)71024-8","mag":"1998106736"},"language":"fr","primary_location":{"id":"doi:10.1016/s1262-3636(12)71024-8","doi":"https://doi.org/10.1016/s1262-3636(12)71024-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1262-3636(12)71024-8","pdf_url":null,"source":{"id":"https://openalex.org/S49871393","display_name":"Diabetes & Metabolism","issn_l":"1262-3636","issn":["1262-3636","1878-1780"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes & Metabolism","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045280775","display_name":"Thomas Harnois","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T. Harnois","raw_affiliation_strings":["IPBC UMR 6187, Poitiers"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IPBC UMR 6187, Poitiers","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017943574","display_name":"Sonia Brishoual","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S. Brishoual","raw_affiliation_strings":["INSERM CIC 0802, Poitiers"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM CIC 0802, Poitiers","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058302251","display_name":"E. Vincent-Tassin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111187","display_name":"Centre Hospitalier Universitaire de Poitiers","ror":"https://ror.org/029s6hd13","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210111187"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"E. Vincent-Tassin","raw_affiliation_strings":["CHU, Poitiers"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CHU, Poitiers","institution_ids":["https://openalex.org/I4210111187"]}]},{"author_position":"middle","author":{"id":null,"display_name":"I. Paris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"I. Paris","raw_affiliation_strings":["INSERM ERM324, Poitiers"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM ERM324, Poitiers","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069789309","display_name":"Nicolas Bourmeyster","orcid":"https://orcid.org/0000-0002-9563-5142","observed_orcids":["https://orcid.org/0000-0002-9563-5142"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N. Bourmeyster","raw_affiliation_strings":["IPBC UMR 6187, Poitiers"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IPBC UMR 6187, Poitiers","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039339457","display_name":"Samy Hadjadj","orcid":"https://orcid.org/0000-0001-7110-6994","observed_orcids":["https://orcid.org/0000-0001-7110-6994"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S. Hadjadj","raw_affiliation_strings":["INSERM CIC 0802, Poitiers"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INSERM CIC 0802, Poitiers","institution_ids":["https://openalex.org/I154526488"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4490,"currency":"USD","value_usd":4490},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"38","issue":null,"first_page":"A12","last_page":"A12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.736299991607666,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.736299991607666,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.2337999939918518,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycemic-fluctuation","display_name":"glucose fluctuations","score":0.7480000257492065},{"id":"https://openalex.org/keywords/renal-fibrosis","display_name":"renal fibrosis","score":0.9269999861717224},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.8109999895095825},{"id":"https://openalex.org/keywords/rhoa-rock-signaling-pathway","display_name":"RhoA/ROCK signaling","score":0.8600000143051147},{"id":"https://openalex.org/keywords/diabetic-nephropathy","display_name":"diabetic nephropathy","score":0.9179999828338623},{"id":"https://openalex.org/keywords/mesangial-cells","display_name":"mesangial cells","score":0.8339999914169312},{"id":"https://openalex.org/keywords/dermal-fibroblasts","display_name":"dermal fibroblasts","score":0.8619999885559082},{"id":"https://openalex.org/keywords/fibronectin","display_name":"fibronectin","score":0.9649999737739563},{"id":"https://openalex.org/keywords/type-i-collagen","display_name":"type I collagen","score":0.9679999947547913},{"id":"https://openalex.org/keywords/high-glucose","display_name":"high glucose","score":0.8299999833106995},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.4519999921321869},{"id":"https://openalex.org/keywords/profibrotic-factors","display_name":"profibrotic factors","score":0.6729999780654907},{"id":"https://openalex.org/keywords/mannitol","display_name":"mannitol","score":0.5450000166893005},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.49300000071525574},{"id":"https://openalex.org/keywords/nf-kappab","display_name":"NF-\u03baB","score":0.925000011920929},{"id":"https://openalex.org/keywords/rho-kinase-inhibitor","display_name":"ROCK inhibitor","score":0.4320000112056732},{"id":"https://openalex.org/keywords/p38-inhibitor","display_name":"p38 inhibitor","score":0.8169999718666077}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.7003591060638428},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6556006669998169},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15274471044540405}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/s1262-3636(12)71024-8","doi":"https://doi.org/10.1016/s1262-3636(12)71024-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s1262-3636(12)71024-8","pdf_url":null,"source":{"id":"https://openalex.org/S49871393","display_name":"Diabetes & Metabolism","issn_l":"1262-3636","issn":["1262-3636","1878-1780"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Diabetes & Metabolism","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7044705090","https://openalex.org/W7095850763","https://openalex.org/W1993473474","https://openalex.org/W2587392559","https://openalex.org/W2362174078","https://openalex.org/W2062361442","https://openalex.org/W2388918605","https://openalex.org/W2028940749","https://openalex.org/W7016727239","https://openalex.org/W2371729218"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}