{"id":"https://openalex.org/W1998096813","doi":"https://doi.org/10.1002/mrm.1910010106","title":"Natural abundance 13C NMR spectra of human muscle, normal and diseased","display_name":"Natural abundance 13C NMR spectra of human muscle, normal and diseased","publication_year":1984,"publication_date":"1984-03-01","ids":{"openalex":"https://openalex.org/W1998096813","doi":"https://doi.org/10.1002/mrm.1910010106","mag":"1998096813","pmid":"https://pubmed.ncbi.nlm.nih.gov/6571435"},"language":"en","primary_location":{"id":"doi:10.1002/mrm.1910010106","doi":"https://doi.org/10.1002/mrm.1910010106","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mrm.1910010106","pdf_url":null,"source":{"id":"https://openalex.org/S111160002","display_name":"Magnetic Resonance in Medicine","issn_l":"0740-3194","issn":["0740-3194","1522-2594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic Resonance in Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000040836","display_name":"Michael B\u00e1r\u00e1ny","orcid":"https://orcid.org/0000-0002-4067-5112","observed_orcids":["https://orcid.org/0000-0002-4067-5112"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael B\u00e1r\u00e1ny","raw_affiliation_strings":["Department of Biological Chemistry, University of Illinois, Health Sciences Center, Chicago, Illinois 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, University of Illinois, Health Sciences Center, Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110036447","display_name":"Donald D. Doyle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald D. Doyle","raw_affiliation_strings":["Department of Biological Chemistry, University of Illinois, Health Sciences Center, Chicago, Illinois 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, University of Illinois, Health Sciences Center, Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111907147","display_name":"Gustav Graff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gustav Graff","raw_affiliation_strings":["Department of Biological Chemistry, University of Illinois, Health Sciences Center, Chicago, Illinois 60612"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, University of Illinois, Health Sciences Center, Chicago, Illinois 60612","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073545620","display_name":"William M. Westler","orcid":"https://orcid.org/0000-0003-2799-671X","observed_orcids":["https://orcid.org/0000-0003-2799-671X"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William M. Westler","raw_affiliation_strings":["Department of Chemistry, Purdue University, West Lafayette, Indiana 47907"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Purdue University, West Lafayette, Indiana 47907","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001861589","display_name":"John L. Markley","orcid":"https://orcid.org/0000-0003-1799-6134","observed_orcids":["https://orcid.org/0000-0003-1799-6134"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John L. Markley","raw_affiliation_strings":["Department of Chemistry, Purdue University, West Lafayette, Indiana 47907"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Purdue University, West Lafayette, Indiana 47907","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000040836"],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":{"value":3680,"currency":"USD","value_usd":3680},"apc_paid":null,"fwci":3.3154,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.92502836,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"1","issue":"1","first_page":"30","last_page":"43"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.5957000255584717,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11809","display_name":"Advanced NMR Techniques and Applications","score":0.5957000255584717,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.24449999630451202,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.06930000334978104,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/13c-nmr-spectroscopy","display_name":"13C NMR","score":0.7670000195503235},{"id":"https://openalex.org/keywords/human-skeletal-muscle","display_name":"human skeletal muscle","score":0.8130000233650208},{"id":"https://openalex.org/keywords/myopathy","display_name":"myopathy","score":0.6970000267028809},{"id":"https://openalex.org/keywords/neurogenic-disease","display_name":"neurogenic disease","score":0.9900000095367432},{"id":"https://openalex.org/keywords/fatty-acyl-chains","display_name":"fatty acyl chains","score":0.7009999752044678},{"id":"https://openalex.org/keywords/phospholipids","display_name":"phospholipids","score":0.7730000019073486},{"id":"https://openalex.org/keywords/creatine","display_name":"creatine","score":0.7080000042915344},{"id":"https://openalex.org/keywords/lactic-acid","display_name":"lactic acid","score":0.9769999980926514},{"id":"https://openalex.org/keywords/disease-severity-classification","display_name":"disease severity classification","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C2777949474","wikidata":"https://www.wikidata.org/wiki/Q422703","display_name":"Isopentane","level":3,"score":0.9591882228851318},{"id":"https://openalex.org/C2779896295","wikidata":"https://www.wikidata.org/wiki/Q223600","display_name":"Creatine","level":2,"score":0.7447986602783203},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6905219554901123},{"id":"https://openalex.org/C67787023","wikidata":"https://www.wikidata.org/wiki/Q6954755","display_name":"NMR spectra database","level":3,"score":0.5757072567939758},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.5165345072746277},{"id":"https://openalex.org/C163111631","wikidata":"https://www.wikidata.org/wiki/Q1952454","display_name":"Carbon-13 NMR","level":2,"score":0.45069581270217896},{"id":"https://openalex.org/C2993909470","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Human muscle","level":3,"score":0.42525485157966614},{"id":"https://openalex.org/C66974803","wikidata":"https://www.wikidata.org/wiki/Q10359898","display_name":"Nuclear magnetic resonance spectroscopy","level":2,"score":0.42480504512786865},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.42058658599853516},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3221491575241089},{"id":"https://openalex.org/C4839761","wikidata":"https://www.wikidata.org/wiki/Q212111","display_name":"Spectral line","level":2,"score":0.2640337347984314},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.2482304871082306},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2165219783782959},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.2094613015651703},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1742067039012909},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009135","descriptor_name":"Muscular Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/mrm.1910010106","doi":"https://doi.org/10.1002/mrm.1910010106","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mrm.1910010106","pdf_url":null,"source":{"id":"https://openalex.org/S111160002","display_name":"Magnetic Resonance in Medicine","issn_l":"0740-3194","issn":["0740-3194","1522-2594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-2","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic Resonance in Medicine","raw_type":"journal-article"},{"id":"pmid:6571435","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6571435","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Magnetic resonance in medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320313002","display_name":"Shriners Hospitals for Children","ror":"https://ror.org/03e8tm275"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W1474718299","https://openalex.org/W1556964350","https://openalex.org/W1594286063","https://openalex.org/W1972399550","https://openalex.org/W1991898785","https://openalex.org/W2001242302","https://openalex.org/W2021398334","https://openalex.org/W2025462601","https://openalex.org/W2046528345","https://openalex.org/W2059524469","https://openalex.org/W2060820863","https://openalex.org/W2070881094","https://openalex.org/W2073138531","https://openalex.org/W2119950431","https://openalex.org/W2322366903","https://openalex.org/W2417494850"],"related_works":["https://openalex.org/W2060820863","https://openalex.org/W2395040797","https://openalex.org/W1974749288","https://openalex.org/W59434353","https://openalex.org/W2085807133","https://openalex.org/W115396804","https://openalex.org/W2024292616","https://openalex.org/W2422110705","https://openalex.org/W2622875633","https://openalex.org/W1970726097"],"abstract_inverted_index":{"13C":[0,21,47,81,209],"NMR":[1,48,82,210],"spectra":[2,49,83],"of":[3,29,36,46,50,57,84,94,146,156,192,211,218,228,231],"human":[4],"surgical":[5],"muscle":[6,89,111,119,149,183,200,213,222],"samples":[7,90],"have":[8,23,43],"been":[9,24,44],"obtained":[10],"at":[11],"50":[12],"and":[13,32,39,52,67,87,108,117,129,136,164,181,201],"118":[14],"MHz.":[15],"Numerous":[16],"sharp":[17],"peaks":[18],"in":[19,105,109,115,132,171,189,198,206],"the":[20,92,95,157,169,175,190,199,229,232],"spectrum":[22],"assigned":[25],"to":[26,139,187,204,215],"carbon":[27,100],"atoms":[28],"soluble":[30],"metabolites":[31],"fatty":[33,195],"acyl":[34,196],"chains":[35,197],"neutral":[37,58],"fats":[38],"membrane-bound":[40],"phospholipids.":[41],"Comparisons":[42],"made":[45],"normal":[51,86,106,128,180,219],"diseased":[53,88,130,148,182,221,225],"muscles":[54,73,107,131],"after":[55],"removal":[56],"fat":[59],"by":[60,74],"extraction":[61],"with":[62],"isopentane.":[63,75],"Creatine,":[64],"lactic":[65,141],"acid,":[66],"phospholipids":[68,159],"are":[69,160,184],"not":[70,202],"removed":[71],"from":[72,220],"The":[76],"most":[77],"striking":[78],"difference":[79,188],"between":[80,127,179],"isopentane-extracted":[85,147,212],"was":[91],"size":[93],"residual":[96],"30.5":[97,176],"ppm":[98,177],"methylene":[99],"resonance,":[101],"that":[102,153,168],"is,":[103],"small":[104],"nonspecific":[110],"diseases,":[112],"but":[113],"large":[114],"myogenic":[116],"neurogenic":[118],"diseases.":[120],"In":[121],"addition,":[122],"differences":[123,170,205],"were":[124],"also":[125],"found":[126],"their":[133,137],"creatine":[134],"content":[135],"ability":[138],"produce":[140],"acid.":[142],"By":[143],"deoxycholate":[144],"treatment":[145],"it":[150],"is":[151],"estimated":[152],"about":[154],"one-fifth":[155],"total":[158],"highly":[161,193],"mobile.":[162],"T1":[163],"NOE":[165],"measurements":[166],"indicated":[167],"peak":[172],"height":[173],"for":[174],"resonance":[178],"due":[185,203],"only":[186],"amount":[191],"mobile":[194],"relaxation":[207],"parameters.":[208],"appears":[214],"permit":[216],"differentiation":[217],"and,":[223],"within":[224],"muscle,":[226],"grading":[227],"severity":[230],"disease.":[233]},"counts_by_year":[{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}