{"id":"https://openalex.org/W1998093640","doi":"https://doi.org/10.1016/s0022-2836(65)80285-6","title":"On the nature of allosteric transitions: A plausible model","display_name":"On the nature of allosteric transitions: A plausible model","publication_year":1965,"publication_date":"1965-05-01","ids":{"openalex":"https://openalex.org/W1998093640","doi":"https://doi.org/10.1016/s0022-2836(65)80285-6","mag":"1998093640","pmid":"https://pubmed.ncbi.nlm.nih.gov/14343300"},"language":"en","primary_location":{"id":"doi:10.1016/s0022-2836(65)80285-6","doi":"https://doi.org/10.1016/s0022-2836(65)80285-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-2836(65)80285-6","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1998093640"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057454601","display_name":"Jacques Monod","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["FR","IT"],"is_corresponding":false,"raw_author_name":"Jacque Monod","raw_affiliation_strings":["Istituto Regina Elena per lo Studio e la Cura dei Tumori, Rome, Italy","Servic le Biochimie Cellulaire, Institut Pasteur, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Regina Elena per lo Studio e la Cura dei Tumori, Rome, Italy","institution_ids":["https://openalex.org/I4387152244"]},{"raw_affiliation_string":"Servic le Biochimie Cellulaire, Institut Pasteur, Paris, France","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111606091","display_name":"Jeffries Wyman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["FR","IT"],"is_corresponding":false,"raw_author_name":"Jeffries Wyman","raw_affiliation_strings":["Istituto Regina Elena per lo Studio e la Cura dei Tumori, Rome, Italy","Servic le Biochimie Cellulaire, Institut Pasteur, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Regina Elena per lo Studio e la Cura dei Tumori, Rome, Italy","institution_ids":["https://openalex.org/I4387152244"]},{"raw_affiliation_string":"Servic le Biochimie Cellulaire, Institut Pasteur, Paris, France","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056074308","display_name":"Jean\u2010Pierre Changeux","orcid":"https://orcid.org/0000-0003-0297-1583","observed_orcids":["https://orcid.org/0000-0003-0297-1583"]},"institutions":[{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I4387152244","display_name":"Instituto Nazionale Tumori Regina Elena","ror":"https://ror.org/04mgfev69","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210153126","https://openalex.org/I4387152244"]}],"countries":["FR","IT"],"is_corresponding":false,"raw_author_name":"Jean-Pierre Changeux","raw_affiliation_strings":["Istituto Regina Elena per lo Studio e la Cura dei Tumori, Rome, Italy","Servic le Biochimie Cellulaire, Institut Pasteur, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Istituto Regina Elena per lo Studio e la Cura dei Tumori, Rome, Italy","institution_ids":["https://openalex.org/I4387152244"]},{"raw_affiliation_string":"Servic le Biochimie Cellulaire, Institut Pasteur, Paris, France","institution_ids":["https://openalex.org/I157536573"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4730,"currency":"USD","value_usd":4730},"apc_paid":null,"fwci":78.064,"has_fulltext":false,"cited_by_count":8905,"citation_normalized_percentile":{"value":1.0,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"12","issue":"1","first_page":"88","last_page":"118"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.8026999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.8026999831199646,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.09470000118017197,"subfield":{"id":"https://openalex.org/subfields/1315","display_name":"Structural Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.0502999983727932,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allosteric-transition","display_name":"allosteric transition","score":0.9779999852180481},{"id":"https://openalex.org/keywords/oligomeric-enzymes","display_name":"oligomeric enzymes","score":0.8159999847412109},{"id":"https://openalex.org/keywords/lactate-dehydrogenase","display_name":"lactate dehydrogenase","score":0.8880000114440918},{"id":"https://openalex.org/keywords/pyruvate-reduction","display_name":"pyruvate reduction","score":0.8360000252723694},{"id":"https://openalex.org/keywords/nadh","display_name":"NADH","score":0.722000002861023},{"id":"https://openalex.org/keywords/pre-steady-state-kinetics","display_name":"pre-steady-state kinetics","score":0.9309999942779541},{"id":"https://openalex.org/keywords/subunit-heterogeneity","display_name":"subunit heterogeneity","score":0.5249999761581421},{"id":"https://openalex.org/keywords/multiple-active-sites","display_name":"multiple active sites","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.8288657665252686},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6811771392822266},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.655102014541626},{"id":"https://openalex.org/C104292427","wikidata":"https://www.wikidata.org/wiki/Q899781","display_name":"Protein subunit","level":3,"score":0.6159461736679077},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5829652547836304},{"id":"https://openalex.org/C56856141","wikidata":"https://www.wikidata.org/wiki/Q883112","display_name":"Enzyme kinetics","level":4,"score":0.4773281216621399},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.46735289692878723},{"id":"https://openalex.org/C166940927","wikidata":"https://www.wikidata.org/wiki/Q178827","display_name":"Monomer","level":3,"score":0.45850828289985657},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.42646878957748413},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42620521783828735},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.38475096225738525},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.2663671672344208},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1636228859424591},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.07776549458503723},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002627","descriptor_name":"Chemistry, Physical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004798","descriptor_name":"Enzymes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012106","descriptor_name":"Research","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014461","descriptor_name":"Ultracentrifugation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0022-2836(65)80285-6","doi":"https://doi.org/10.1016/s0022-2836(65)80285-6","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0022-2836(65)80285-6","pdf_url":null,"source":{"id":"https://openalex.org/S46058472","display_name":"Journal of Molecular Biology","issn_l":"0022-2836","issn":["0022-2836","1089-8638"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Molecular Biology","raw_type":"journal-article"},{"id":"pmid:14343300","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14343300","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of molecular biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W3971878","https://openalex.org/W7820940","https://openalex.org/W18986559","https://openalex.org/W23156506","https://openalex.org/W26059681","https://openalex.org/W101455241","https://openalex.org/W104836998","https://openalex.org/W123729535","https://openalex.org/W1519790750","https://openalex.org/W1520815476","https://openalex.org/W1526010060","https://openalex.org/W1560037002","https://openalex.org/W1568502048","https://openalex.org/W1592356287","https://openalex.org/W1675915938","https://openalex.org/W1965093856","https://openalex.org/W1966408224","https://openalex.org/W1967217187","https://openalex.org/W1982121444","https://openalex.org/W1984587464","https://openalex.org/W1985375575","https://openalex.org/W1991852495","https://openalex.org/W1996225323","https://openalex.org/W2002865060","https://openalex.org/W2006731860","https://openalex.org/W2008617374","https://openalex.org/W2008812906","https://openalex.org/W2010473140","https://openalex.org/W2014638127","https://openalex.org/W2024122825","https://openalex.org/W2032088556","https://openalex.org/W2032939910","https://openalex.org/W2035276544","https://openalex.org/W2040881232","https://openalex.org/W2050643839","https://openalex.org/W2071173626","https://openalex.org/W2076249828","https://openalex.org/W2088437224","https://openalex.org/W2091508479","https://openalex.org/W2091673587","https://openalex.org/W2102489535","https://openalex.org/W2170404539","https://openalex.org/W2255916647","https://openalex.org/W2318211712","https://openalex.org/W2320796935","https://openalex.org/W2325701134","https://openalex.org/W2327883350","https://openalex.org/W2330268139","https://openalex.org/W2398388055","https://openalex.org/W2411202773","https://openalex.org/W2423085559","https://openalex.org/W2433995207","https://openalex.org/W3118508829","https://openalex.org/W4211189179","https://openalex.org/W4237303696","https://openalex.org/W7098458818","https://openalex.org/W7098531535","https://openalex.org/W7099342467"],"related_works":["https://openalex.org/W4388821813","https://openalex.org/W2003044536","https://openalex.org/W2017200168","https://openalex.org/W2460748189","https://openalex.org/W2005710377","https://openalex.org/W2002913620","https://openalex.org/W1998487685","https://openalex.org/W1568085756","https://openalex.org/W2414598548","https://openalex.org/W1984883228"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":169},{"year":2025,"cited_by_count":137},{"year":2024,"cited_by_count":154},{"year":2023,"cited_by_count":169},{"year":2022,"cited_by_count":151},{"year":2021,"cited_by_count":203},{"year":2020,"cited_by_count":169},{"year":2019,"cited_by_count":168},{"year":2018,"cited_by_count":178},{"year":2017,"cited_by_count":181},{"year":2016,"cited_by_count":208},{"year":2015,"cited_by_count":207},{"year":2014,"cited_by_count":210},{"year":2013,"cited_by_count":251},{"year":2012,"cited_by_count":195}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
