{"id":"https://openalex.org/W1998092883","doi":"https://doi.org/10.1007/s12032-011-0152-1","title":"High expression of CXCR2 is associated with tumorigenesis, progression, and prognosis of laryngeal squamous cell carcinoma","display_name":"High expression of CXCR2 is associated with tumorigenesis, progression, and prognosis of laryngeal squamous cell carcinoma","publication_year":2012,"publication_date":"2012-01-24","ids":{"openalex":"https://openalex.org/W1998092883","doi":"https://doi.org/10.1007/s12032-011-0152-1","mag":"1998092883","pmid":"https://pubmed.ncbi.nlm.nih.gov/22274915"},"language":"en","primary_location":{"id":"doi:10.1007/s12032-011-0152-1","doi":"https://doi.org/10.1007/s12032-011-0152-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12032-011-0152-1","pdf_url":null,"source":{"id":"https://openalex.org/S204953464","display_name":"Medical Oncology","issn_l":"1357-0560","issn":["1357-0560","1559-131X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100613349","display_name":"Liang Han","orcid":"https://orcid.org/0000-0003-2563-7182","observed_orcids":["https://orcid.org/0000-0003-2563-7182"]},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]},{"id":"https://openalex.org/I4210105390","display_name":"Nantong Tumor Hospital","ror":"https://ror.org/01egmr022","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Han","raw_affiliation_strings":["Department of Head and Neck Surgery, Nantong Tuomor Hospital, Nantong, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head and Neck Surgery, Nantong Tuomor Hospital, Nantong, Jiangsu, China","institution_ids":["https://openalex.org/I199305430","https://openalex.org/I4210105390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101744791","display_name":"Bin Jiang","orcid":"https://orcid.org/0000-0002-4622-9703","observed_orcids":["https://orcid.org/0000-0002-4622-9703"]},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]},{"id":"https://openalex.org/I4210105390","display_name":"Nantong Tumor Hospital","ror":"https://ror.org/01egmr022","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105390"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Jiang","raw_affiliation_strings":["Department of Head and Neck Surgery, Nantong Tuomor Hospital, Nantong, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head and Neck Surgery, Nantong Tuomor Hospital, Nantong, Jiangsu, China","institution_ids":["https://openalex.org/I199305430","https://openalex.org/I4210105390"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101542218","display_name":"Hao Wu","orcid":"https://orcid.org/0000-0003-0324-8215","observed_orcids":["https://orcid.org/0000-0003-0324-8215"]},"institutions":[{"id":"https://openalex.org/I4210086801","display_name":"Affiliated Hospital of Nantong University","ror":"https://ror.org/001rahr89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086801"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Wu","raw_affiliation_strings":["Department of Otorhinolaryngology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Otorhinolaryngology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China","institution_ids":["https://openalex.org/I4210086801"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100757915","display_name":"Xudong Wang","orcid":"https://orcid.org/0000-0001-8323-2402","observed_orcids":["https://orcid.org/0000-0001-8323-2402"]},"institutions":[{"id":"https://openalex.org/I4210086801","display_name":"Affiliated Hospital of Nantong University","ror":"https://ror.org/001rahr89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086801"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xudong Wang","raw_affiliation_strings":["Surgical Comprehensive Laboratory, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Comprehensive Laboratory, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China","institution_ids":["https://openalex.org/I4210086801"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063344415","display_name":"Xiaojun Tang","orcid":"https://orcid.org/0000-0001-8757-0927","observed_orcids":["https://orcid.org/0000-0001-8757-0927"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaojun Tang","raw_affiliation_strings":["Key Laboratory of Antibody Technique of Ministry of Health, Department of Pathology, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Antibody Technique of Ministry of Health, Department of Pathology, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091700292","display_name":"Jianfei Huang","orcid":"https://orcid.org/0000-0002-1276-5962","observed_orcids":["https://orcid.org/0000-0002-1276-5962"]},"institutions":[{"id":"https://openalex.org/I199305430","display_name":"Nantong University","ror":"https://ror.org/02afcvw97","country_code":"CN","type":"education","lineage":["https://openalex.org/I199305430"]},{"id":"https://openalex.org/I4210086801","display_name":"Affiliated Hospital of Nantong University","ror":"https://ror.org/001rahr89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086801"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianfei Huang","raw_affiliation_strings":["Department of Clinical Pathology, Nantong University Affiliated Hospital, Nantong, China","No. 20 Xisi Road, Nantong, 226001, Jiangsu, China","Surgical Comprehensive Laboratory, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathology, Nantong University Affiliated Hospital, Nantong, China","institution_ids":["https://openalex.org/I199305430","https://openalex.org/I4210086801"]},{"raw_affiliation_string":"No. 20 Xisi Road, Nantong, 226001, Jiangsu, China","institution_ids":[]},{"raw_affiliation_string":"Surgical Comprehensive Laboratory, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China","institution_ids":["https://openalex.org/I4210086801"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111491081","display_name":"Jin Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387152453","display_name":"Huadong Medical Institute of Biotechniques","ror":"https://ror.org/00vzyt138","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4387152453"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jin Zhu","raw_affiliation_strings":["Huadong Medical Institute of Biotechniques, Nanjing, Jiangsu, China","Key Laboratory of Antibody Technique of Ministry of Health, Department of Pathology, Nanjing Medical University, Nanjing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huadong Medical Institute of Biotechniques, Nanjing, Jiangsu, China","institution_ids":["https://openalex.org/I4387152453"]},{"raw_affiliation_string":"Key Laboratory of Antibody Technique of Ministry of Health, Department of Pathology, Nanjing Medical University, Nanjing, China","institution_ids":["https://openalex.org/I83519826"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5091700292","https://openalex.org/A5111491081"],"corresponding_institution_ids":["https://openalex.org/I199305430","https://openalex.org/I4210086801","https://openalex.org/I4387152453","https://openalex.org/I83519826"],"apc_list":{"value":4290,"currency":"USD","value_usd":4290},"apc_paid":null,"fwci":6.2103,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.96796947,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"29","issue":"4","first_page":"2466","last_page":"2472"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.7188000082969666,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.7188000082969666,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.2782999873161316,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cxcr2","display_name":"CXCR2","score":0.9240000247955322},{"id":"https://openalex.org/keywords/laryngeal-squamous-cell-carcinoma","display_name":"laryngeal squamous cell carcinoma","score":0.9679999947547913},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8799999952316284},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.8820000290870667},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.878000020980835},{"id":"https://openalex.org/keywords/histopathological-grade","display_name":"histopathological grade","score":0.7960000038146973},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.6610000133514404},{"id":"https://openalex.org/keywords/tnm-classification","display_name":"TNM classification","score":0.7540000081062317},{"id":"https://openalex.org/keywords/chemokine-receptor-expression","display_name":"chemokine receptor expression","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C84913492","wikidata":"https://www.wikidata.org/wiki/Q5014892","display_name":"CXC chemokine receptors","level":5,"score":0.7654935121536255},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.6695469617843628},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5835078954696655},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5733641982078552},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.5017459392547607},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.47646641731262207},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4701908826828003},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.466418594121933},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4171212315559387},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4143245816230774},{"id":"https://openalex.org/C2778740770","wikidata":"https://www.wikidata.org/wiki/Q6708283","display_name":"Lymphovascular invasion","level":4,"score":0.41346049308776855},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.40346816182136536},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.36819759011268616},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.2674870491027832},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.23880252242088318}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002294","descriptor_name":"Carcinoma, Squamous Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D007822","descriptor_name":"Laryngeal Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008207","descriptor_name":"Lymphatic Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023063","descriptor_name":"Receptors, Interleukin-8B","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D023063","descriptor_name":"Receptors, Interleukin-8B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023063","descriptor_name":"Receptors, Interleukin-8B","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/s12032-011-0152-1","doi":"https://doi.org/10.1007/s12032-011-0152-1","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s12032-011-0152-1","pdf_url":null,"source":{"id":"https://openalex.org/S204953464","display_name":"Medical Oncology","issn_l":"1357-0560","issn":["1357-0560","1559-131X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical Oncology","raw_type":"journal-article"},{"id":"pmid:22274915","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22274915","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medical oncology (Northwood, London, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W97158386","https://openalex.org/W121421619","https://openalex.org/W1483257978","https://openalex.org/W1495127214","https://openalex.org/W1498223456","https://openalex.org/W1501778305","https://openalex.org/W1976586742","https://openalex.org/W1992321269","https://openalex.org/W2001356286","https://openalex.org/W2005576626","https://openalex.org/W2010239869","https://openalex.org/W2015483851","https://openalex.org/W2058902088","https://openalex.org/W2061631515","https://openalex.org/W2062275568","https://openalex.org/W2063804511","https://openalex.org/W2065483162","https://openalex.org/W2073955698","https://openalex.org/W2087129977","https://openalex.org/W2087233597","https://openalex.org/W2092021793","https://openalex.org/W2101995865","https://openalex.org/W2115567169","https://openalex.org/W2121479816","https://openalex.org/W2123116698","https://openalex.org/W2127638445","https://openalex.org/W2130801530","https://openalex.org/W2136546686","https://openalex.org/W2138749386","https://openalex.org/W2140847299","https://openalex.org/W2150799704","https://openalex.org/W2153372998","https://openalex.org/W2166946831","https://openalex.org/W2170037266","https://openalex.org/W2172874896","https://openalex.org/W2181647431","https://openalex.org/W2323027157"],"related_works":["https://openalex.org/W2004396122","https://openalex.org/W2385259463","https://openalex.org/W2352121741","https://openalex.org/W2381417931","https://openalex.org/W2074919994","https://openalex.org/W3151901495","https://openalex.org/W2053900433","https://openalex.org/W2332606083","https://openalex.org/W7019987168","https://openalex.org/W2737310512"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}