{"id":"https://openalex.org/W1998068806","doi":"https://doi.org/10.1615/forumimmundisther.2012006334","title":"Thiol Modification By Pharmacologically Active Agents of the Diazeniumdiolate Class","display_name":"Thiol Modification By Pharmacologically Active Agents of the Diazeniumdiolate Class","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W1998068806","doi":"https://doi.org/10.1615/forumimmundisther.2012006334","mag":"1998068806","pmid":"https://pubmed.ncbi.nlm.nih.gov/23585982","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3622254"},"language":"en","primary_location":{"id":"doi:10.1615/forumimmundisther.2012006334","doi":"https://doi.org/10.1615/forumimmundisther.2012006334","is_oa":false,"landing_page_url":"https://doi.org/10.1615/forumimmundisther.2012006334","pdf_url":null,"source":{"id":"https://openalex.org/S20825486","display_name":"Forum on Immunopathological Diseases and Therapeutics","issn_l":"2151-8017","issn":["2151-8017","2151-8025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310315730","host_organization_name":"Begell House","host_organization_lineage":["https://openalex.org/P4310315730"],"host_organization_lineage_names":["Begell House"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Forum on Immunopathological Diseases and Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/articles/PMC3622254","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000314948","display_name":"Anna E. Maciag","orcid":"https://orcid.org/0000-0001-6562-5640","observed_orcids":["https://orcid.org/0000-0001-6562-5640"]},"institutions":[{"id":"https://openalex.org/I880747138","display_name":"Science Applications International Corporation (United States)","ror":"https://ror.org/00zv91802","country_code":"US","type":"company","lineage":["https://openalex.org/I880747138"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna E. Maciag","raw_affiliation_strings":["Basic Science Program, SAIC-Frederick, Inc., Frederick, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Science Program, SAIC-Frederick, Inc., Frederick, Maryland","institution_ids":["https://openalex.org/I880747138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103517233","display_name":"Ryan J. Holland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan J. Holland","raw_affiliation_strings":["Chemical Biology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Biology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland","institution_ids":["https://openalex.org/I4210130649"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076715400","display_name":"Joseph E. Saavedra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I880747138","display_name":"Science Applications International Corporation (United States)","ror":"https://ror.org/00zv91802","country_code":"US","type":"company","lineage":["https://openalex.org/I880747138"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph E. Saavedra","raw_affiliation_strings":["Basic Science Program, SAIC-Frederick, Inc., Frederick, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Basic Science Program, SAIC-Frederick, Inc., Frederick, Maryland","institution_ids":["https://openalex.org/I880747138"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036424513","display_name":"Harinath Chakrapani","orcid":"https://orcid.org/0000-0002-7267-0906","observed_orcids":["https://orcid.org/0000-0002-7267-0906"]},"institutions":[{"id":"https://openalex.org/I181996519","display_name":"Indian Institute of Science Education and Research Pune","ror":"https://ror.org/028qa3n13","country_code":"IN","type":"education","lineage":["https://openalex.org/I181996519"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Harinath Chakrapani","raw_affiliation_strings":["Indian Institute of Science Education and Research, Pune, India","Indian Institute of Science Education & Research Pune (India)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indian Institute of Science Education and Research, Pune, India","institution_ids":["https://openalex.org/I181996519"]},{"raw_affiliation_string":"Indian Institute of Science Education & Research Pune (India)","institution_ids":["https://openalex.org/I181996519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103426984","display_name":"Paul J. Shami","orcid":"https://orcid.org/0000-0002-5696-6512","observed_orcids":["https://orcid.org/0000-0002-5696-6512"]},"institutions":[{"id":"https://openalex.org/I223532165","display_name":"University of Utah","ror":"https://ror.org/03r0ha626","country_code":"US","type":"education","lineage":["https://openalex.org/I223532165"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul J. Shami","raw_affiliation_strings":["Division of Hematology and Hematologic Malignancies, University of Utah, Salt Lake City, Utah"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology and Hematologic Malignancies, University of Utah, Salt Lake City, Utah","institution_ids":["https://openalex.org/I223532165"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069348197","display_name":"Larry K. Keefer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210130649","display_name":"Frederick National Laboratory for Cancer Research","ror":"https://ror.org/03v6m3209","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210130649","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Larry K. Keefer","raw_affiliation_strings":["Chemical Biology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chemical Biology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, Maryland","institution_ids":["https://openalex.org/I4210130649"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5069348197"],"corresponding_institution_ids":["https://openalex.org/I4210130649"],"apc_list":null,"apc_paid":null,"fwci":0.1203,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.43393908,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"3","issue":"2","first_page":"91","last_page":"95"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.7788000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.7788000106811523,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.11140000075101852,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0738999992609024,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diazeniumdiolates","display_name":"diazeniumdiolates","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nonoates","display_name":"NONOates","score":0.9480000138282776},{"id":"https://openalex.org/keywords/thiol-modification","display_name":"thiol modification","score":0.9860000014305115},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.8769999742507935},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.7409999966621399},{"id":"https://openalex.org/keywords/s-nitrosylation","display_name":"S-nitrosylation","score":0.9079999923706055},{"id":"https://openalex.org/keywords/s-glutathionylation","display_name":"S-glutathionylation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nitroxyl","display_name":"nitroxyl","score":0.984000027179718},{"id":"https://openalex.org/keywords/disulfide-bond-formation","display_name":"disulfide bond formation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/sulfinamides","display_name":"sulfinamides","score":0.9240000247955322},{"id":"https://openalex.org/keywords/protein-thiol-modification","display_name":"protein thiol modification","score":0.6069999933242798},{"id":"https://openalex.org/keywords/drug-mechanisms-of-action","display_name":"drug mechanisms of action","score":0.7250000238418579}],"concepts":[{"id":"https://openalex.org/C2781324293","wikidata":"https://www.wikidata.org/wiki/Q220410","display_name":"Thiol","level":2,"score":0.9222509264945984},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.8201068639755249},{"id":"https://openalex.org/C2776142628","wikidata":"https://www.wikidata.org/wiki/Q2919470","display_name":"Nitroxyl","level":2,"score":0.787445068359375},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.745685875415802},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7391283512115479},{"id":"https://openalex.org/C2777553025","wikidata":"https://www.wikidata.org/wiki/Q25323683","display_name":"S-Nitrosylation","level":4,"score":0.6379956603050232},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5165613889694214},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.417064905166626},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.3795962333679199},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.26257622241973877},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.20044639706611633},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.19426164031028748},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.07649797201156616}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1615/forumimmundisther.2012006334","doi":"https://doi.org/10.1615/forumimmundisther.2012006334","is_oa":false,"landing_page_url":"https://doi.org/10.1615/forumimmundisther.2012006334","pdf_url":null,"source":{"id":"https://openalex.org/S20825486","display_name":"Forum on Immunopathological Diseases and Therapeutics","issn_l":"2151-8017","issn":["2151-8017","2151-8025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310315730","host_organization_name":"Begell House","host_organization_lineage":["https://openalex.org/P4310315730"],"host_organization_lineage_names":["Begell House"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Forum on Immunopathological Diseases and Therapeutics","raw_type":"journal-article"},{"id":"pmid:23585982","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23585982","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Forum on immunopathological diseases and therapeutics","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2624216","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3622254","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3622254","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3622254","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"For Immunopathol Dis Therap","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2624216","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3622254","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G386607036","display_name":null,"funder_award_id":"HHSN261200800001E)","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5888954722","display_name":null,"funder_award_id":"HHSN261200800001C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1968913262","https://openalex.org/W2006172842","https://openalex.org/W2011083094","https://openalex.org/W2031027059","https://openalex.org/W2031082710","https://openalex.org/W2046504033","https://openalex.org/W2049462428","https://openalex.org/W2063266714","https://openalex.org/W2082822526","https://openalex.org/W2093903751","https://openalex.org/W2115569680","https://openalex.org/W2117949567","https://openalex.org/W2131953369","https://openalex.org/W2136838857","https://openalex.org/W2162337307"],"related_works":["https://openalex.org/W1976913510","https://openalex.org/W1987410803","https://openalex.org/W2080566655","https://openalex.org/W2080797373","https://openalex.org/W2065685888","https://openalex.org/W2949608401","https://openalex.org/W2233845087","https://openalex.org/W2076860008","https://openalex.org/W2004641607","https://openalex.org/W2038132880"],"abstract_inverted_index":{"Promising":[0],"drug":[1,55],"candidates":[2],"of":[3,12,18,34,53,60],"the":[4,31,38,47,54,57,75,82],"diazeniumdiolate":[5],"(NONOate)":[6],"chemical":[7],"family":[8],"include":[9],"several":[10],"types":[11],"thiol":[13,32,58,103],"modification":[14],"among":[15],"their":[16],"mechanisms":[17],"action:":[19],"1)":[20],"drugs":[21],"designed":[22],"to":[23,67,89,105],"release":[24],"nitric":[25],"oxide":[26],"(NO)":[27],"on":[28],"reaction":[29,52],"with":[30,56,102],"group":[33,59],"glutathione":[35],"(GSH)":[36],"arylate":[37],"GSH,":[39],"a":[40,50,61,79],"step":[41],"that":[42],"removes":[43],"reducing":[44],"equivalents":[45],"from":[46],"cell;":[48],"(2)":[49],"similar":[51],"protein":[62],"changes":[63],"its":[64],"structure,":[65],"leading":[66,88],"potentially":[68],"impaired":[69],"function":[70],"and":[71,91,93],"cell":[72],"death;":[73],"(3)":[74],"NO":[76],"generated":[77],"as":[78],"byproduct":[80],"in":[81],"above":[83],"reactions":[84],"can":[85,96],"undergo":[86],"oxidation,":[87],"S-nitrosylation":[90],"S-glutathionylation;":[92],"(4)":[94],"diazeniumdiolates":[95],"also":[97],"generate":[98],"nitroxyl,":[99],"which":[100],"reacts":[101],"groups":[104],"form":[106],"disulfides":[107],"or":[108],"sulfinamides.":[109]},"counts_by_year":[{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
