{"id":"https://openalex.org/W1998049513","doi":"https://doi.org/10.1083/jcb.200402120","title":"Monitoring disulfide bond formation in the eukaryotic cytosol","display_name":"Monitoring disulfide bond formation in the eukaryotic cytosol","publication_year":2004,"publication_date":"2004-07-26","ids":{"openalex":"https://openalex.org/W1998049513","doi":"https://doi.org/10.1083/jcb.200402120","mag":"1998049513","pmid":"https://pubmed.ncbi.nlm.nih.gov/15277542","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2172265"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.200402120","doi":"https://doi.org/10.1083/jcb.200402120","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.200402120","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2172265","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Henrik \u00d8stergaard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800060819","display_name":"Carlsberg Laboratory","ror":"https://ror.org/055hfb865","country_code":"DK","type":"facility","lineage":["https://openalex.org/I2800060819"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Henrik \u00d8stergaard","raw_affiliation_strings":["1Department of Physiology, Carlsberg Laboratory, Gamle Carlsberg Vej 10, DK-2500 Copenhagen Valby, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Physiology, Carlsberg Laboratory, Gamle Carlsberg Vej 10, DK-2500 Copenhagen Valby, Denmark","institution_ids":["https://openalex.org/I2800060819"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108787855","display_name":"Christine Tachibana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I2800060819","display_name":"Carlsberg Laboratory","ror":"https://ror.org/055hfb865","country_code":"DK","type":"facility","lineage":["https://openalex.org/I2800060819"]}],"countries":["DK","US"],"is_corresponding":false,"raw_author_name":"Christine Tachibana","raw_affiliation_strings":["1Department of Physiology, Carlsberg Laboratory, Gamle Carlsberg Vej 10, DK-2500 Copenhagen Valby, Denmark","2Department of Biochemistry, University of Washington, Seattle, WA 98195"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Physiology, Carlsberg Laboratory, Gamle Carlsberg Vej 10, DK-2500 Copenhagen Valby, Denmark","institution_ids":["https://openalex.org/I2800060819"]},{"raw_affiliation_string":"2Department of Biochemistry, University of Washington, Seattle, WA 98195","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056900972","display_name":"Jakob Rahr Winther","orcid":"https://orcid.org/0000-0001-6995-9154","observed_orcids":["https://orcid.org/0000-0001-6995-9154"]},"institutions":[{"id":"https://openalex.org/I2800060819","display_name":"Carlsberg Laboratory","ror":"https://ror.org/055hfb865","country_code":"DK","type":"facility","lineage":["https://openalex.org/I2800060819"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Jakob R. Winther","raw_affiliation_strings":["1Department of Physiology, Carlsberg Laboratory, Gamle Carlsberg Vej 10, DK-2500 Copenhagen Valby, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Physiology, Carlsberg Laboratory, Gamle Carlsberg Vej 10, DK-2500 Copenhagen Valby, Denmark","institution_ids":["https://openalex.org/I2800060819"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.3183,"has_fulltext":false,"cited_by_count":343,"citation_normalized_percentile":{"value":0.93514168,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"166","issue":"3","first_page":"337","last_page":"345"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.9520999789237976,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11481","display_name":"Sulfur Compounds in Biology","score":0.04650000110268593,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/disulfide-bond-formation","display_name":"disulfide bond formation","score":0.902999997138977},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.8370000123977661},{"id":"https://openalex.org/keywords/glutathione-disulfide","display_name":"glutathione disulfide","score":0.9120000004768372},{"id":"https://openalex.org/keywords/glutaredoxin","display_name":"glutaredoxin","score":0.9869999885559082},{"id":"https://openalex.org/keywords/yeast","display_name":"yeast","score":0.5109999775886536},{"id":"https://openalex.org/keywords/thiol-redox-state","display_name":"thiol redox state","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.9221429824829102},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.8752197623252869},{"id":"https://openalex.org/C55904794","wikidata":"https://www.wikidata.org/wiki/Q82682","display_name":"Redox","level":2,"score":0.8027359247207642},{"id":"https://openalex.org/C125619963","wikidata":"https://www.wikidata.org/wiki/Q81984039","display_name":"Glutaredoxin","level":4,"score":0.7907209992408752},{"id":"https://openalex.org/C2779179908","wikidata":"https://www.wikidata.org/wiki/Q3324838","display_name":"Glutathione disulfide","level":4,"score":0.761427640914917},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6385505199432373},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6067517399787903},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5018236637115479},{"id":"https://openalex.org/C203635412","wikidata":"https://www.wikidata.org/wiki/Q17007432","display_name":"Compartment (ship)","level":2,"score":0.41130760312080383},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3924766778945923},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1990031898021698},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16707593202590942},{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.0},{"id":"https://openalex.org/C111368507","wikidata":"https://www.wikidata.org/wiki/Q43518","display_name":"Oceanography","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D003553","descriptor_name":"Cystine","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004220","descriptor_name":"Disulfides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054477","descriptor_name":"Glutaredoxins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1083/jcb.200402120","doi":"https://doi.org/10.1083/jcb.200402120","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.200402120","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2172265","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2172265","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:15277542","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15277542","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2172265","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2172265","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W569951484","https://openalex.org/W758260955","https://openalex.org/W1489279202","https://openalex.org/W1501659119","https://openalex.org/W1511013913","https://openalex.org/W1512686244","https://openalex.org/W1518284854","https://openalex.org/W1555938743","https://openalex.org/W1563504653","https://openalex.org/W1788190869","https://openalex.org/W1968071144","https://openalex.org/W1970477208","https://openalex.org/W1970749661","https://openalex.org/W1973996060","https://openalex.org/W1978598692","https://openalex.org/W1983482381","https://openalex.org/W1986372254","https://openalex.org/W1986740222","https://openalex.org/W1997161797","https://openalex.org/W1998591058","https://openalex.org/W2002794726","https://openalex.org/W2006370393","https://openalex.org/W2015562222","https://openalex.org/W2032152464","https://openalex.org/W2036273285","https://openalex.org/W2043640575","https://openalex.org/W2050994990","https://openalex.org/W2059586921","https://openalex.org/W2065158529","https://openalex.org/W2065741201","https://openalex.org/W2066533724","https://openalex.org/W2066878866","https://openalex.org/W2069271483","https://openalex.org/W2074073932","https://openalex.org/W2077106628","https://openalex.org/W2087795097","https://openalex.org/W2090883788","https://openalex.org/W2097135162","https://openalex.org/W2121023572","https://openalex.org/W2123130100","https://openalex.org/W2132878122","https://openalex.org/W2137564704","https://openalex.org/W2163029215","https://openalex.org/W2167450976","https://openalex.org/W2169333620","https://openalex.org/W2169357831","https://openalex.org/W3120389717","https://openalex.org/W4240065971"],"related_works":["https://openalex.org/W1980444360","https://openalex.org/W2048123996","https://openalex.org/W2035719618","https://openalex.org/W3003689711","https://openalex.org/W2133048919","https://openalex.org/W2080155389","https://openalex.org/W1984247046","https://openalex.org/W7166963706","https://openalex.org/W7143988408","https://openalex.org/W2093768752"],"abstract_inverted_index":{"Glutathione":[0],"is":[1,105,129,153],"the":[2,10,61,74,98,109,125,140],"most":[3],"abundant":[4],"low":[5,141],"molecular":[6],"weight":[7],"thiol":[8],"in":[9,67,70,139],"eukaryotic":[11],"cytosol.":[12],"The":[13],"compartment-specific":[14],"ratio":[15],"and":[16,21,25,69,81,132],"absolute":[17],"concentrations":[18],"of":[19,84,113,151],"reduced":[20],"oxidized":[22],"glutathione":[23,63,126],"(GSH":[24],"GSSG,":[26],"respectively)":[27],"are,":[28],"however,":[29],"not":[30],"easily":[31],"determined.":[32],"Here,":[33],"we":[34,55],"present":[35],"a":[36,91,101,135,148],"glutathione-specific":[37],"green":[38],"fluorescent":[39],"protein-based":[40],"redox":[41,44,64,110,127],"probe":[42,104],"termed":[43],"sensitive":[45],"YFP":[46],"(rxYFP).":[47],"Using":[48],"yeast":[49],"with":[50,60],"genetically":[51,102],"manipulated":[52],"GSSG":[53,87,137],"levels,":[54],"find":[56,117],"that":[57,82,124],"rxYFP":[58,152],"equilibrates":[59],"cytosolic":[62,114,136],"buffer.":[65],"Furthermore,":[66],"vivo":[68],"vitro":[71],"data":[72],"show":[73],"equilibration":[75],"to":[76,89,107,119,134],"be":[77,120],"catalyzed":[78],"by":[79],"glutaredoxins":[80],"conditions":[83,147],"high":[85],"intracellular":[86],"confer":[88],"these":[90,146],"new":[92],"role":[93],"as":[94],"dithiol":[95],"oxidases.":[96],"For":[97],"first":[99],"time":[100],"encoded":[103],"used":[106],"determine":[108],"potential":[111],"specifically":[112],"glutathione.":[115],"We":[116],"it":[118],"-289":[121],"mV,":[122],"indicating":[123],"status":[128],"highly":[130],"reducing":[131],"corresponds":[133],"level":[138],"micromolar":[142],"range.":[143],"Even":[144],"under":[145],"significant":[149],"fraction":[150],"oxidized.":[154]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":15},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":17},{"year":2014,"cited_by_count":22},{"year":2013,"cited_by_count":17},{"year":2012,"cited_by_count":22}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
