{"id":"https://openalex.org/W1998048742","doi":"https://doi.org/10.1097/00024382-199409000-00008","title":"CARDIODYNAMIC RESPONSE TO ESCHERICHIA COLI ENDOTOXEMIA","display_name":"CARDIODYNAMIC RESPONSE TO ESCHERICHIA COLI ENDOTOXEMIA","publication_year":1994,"publication_date":"1994-09-01","ids":{"openalex":"https://openalex.org/W1998048742","doi":"https://doi.org/10.1097/00024382-199409000-00008","mag":"1998048742","pmid":"https://pubmed.ncbi.nlm.nih.gov/7743351"},"language":"en","primary_location":{"id":"doi:10.1097/00024382-199409000-00008","doi":"https://doi.org/10.1097/00024382-199409000-00008","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00024382-199409000-00008","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SHOCK","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072354211","display_name":"Juming Zhong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Juming Zhong","raw_affiliation_strings":["Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia 65211, USA","Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, Columbia, Missouri 65211"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, University of Missouri, Columbia 65211, USA","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, Columbia, Missouri 65211","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110263834","display_name":"Leona J. Rubin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leona J. Rubin","raw_affiliation_strings":["Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri 65211","Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, Columbia, Missouri 65211"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri 65211","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, Columbia, Missouri 65211","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110098839","display_name":"Janet L. Parker","orcid":"https://orcid.org/0009-0005-1080-1041","observed_orcids":["https://orcid.org/0009-0005-1080-1041"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet L. Parker","raw_affiliation_strings":["Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri 65211","The Department of Physiology, School of Medicine, University of Missouri, Columbia, Missouri 65211"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri 65211","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"The Department of Physiology, School of Medicine, University of Missouri, Columbia, Missouri 65211","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110915304","display_name":"H. Richard Adams","orcid":"https://orcid.org/0009-0005-2392-9888","observed_orcids":["https://orcid.org/0009-0005-2392-9888"]},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"H. Richard Adams","raw_affiliation_strings":["Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri 65211","Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, Columbia, Missouri 65211"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dalton Cardiovascular Research Center, University of Missouri, Columbia, Missouri 65211","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Department of Veterinary Biomedical Sciences, College of Veterinary Medicine, Columbia, Missouri 65211","institution_ids":["https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5072354211","https://openalex.org/A5110263834","https://openalex.org/A5110915304"],"corresponding_institution_ids":["https://openalex.org/I76835614"],"apc_list":null,"apc_paid":null,"fwci":0.3423,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.58509698,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"2","issue":"3","first_page":"203","last_page":"209"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/escherichia-coli-endotoxin","display_name":"Escherichia coli endotoxin","score":0.9129999876022339},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.8450000286102295},{"id":"https://openalex.org/keywords/endotoxemia","display_name":"endotoxemia","score":0.8519999980926514},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/fluid-resuscitation","display_name":"fluid resuscitation","score":0.8420000076293945},{"id":"https://openalex.org/keywords/left-ventricular-contractility","display_name":"left ventricular contractility","score":0.781000018119812},{"id":"https://openalex.org/keywords/diastolic-compliance","display_name":"diastolic compliance","score":0.8830000162124634},{"id":"https://openalex.org/keywords/systolic-function","display_name":"systolic function","score":0.8679999709129333},{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C39078644","wikidata":"https://www.wikidata.org/wiki/Q17092725","display_name":"Isovolumetric contraction","level":4,"score":0.805902361869812},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6920677423477173},{"id":"https://openalex.org/C2778165595","wikidata":"https://www.wikidata.org/wiki/Q5491454","display_name":"Resuscitation","level":2,"score":0.6873953938484192},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.6189005374908447},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5838078260421753},{"id":"https://openalex.org/C80461066","wikidata":"https://www.wikidata.org/wiki/Q1698533","display_name":"Stroke volume","level":4,"score":0.5815690755844116},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.565802276134491},{"id":"https://openalex.org/C2781460075","wikidata":"https://www.wikidata.org/wiki/Q1399332","display_name":"Compliance (psychology)","level":2,"score":0.536470353603363},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.5132615566253662},{"id":"https://openalex.org/C17140001","wikidata":"https://www.wikidata.org/wiki/Q1759415","display_name":"Pulse pressure","level":3,"score":0.49282553791999817},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.46285712718963623},{"id":"https://openalex.org/C195646399","wikidata":"https://www.wikidata.org/wiki/Q6058580","display_name":"Intravascular volume status","level":3,"score":0.4305129945278168},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.321158230304718},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.25740161538124084},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.0},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001831","descriptor_name":"Body Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002302","descriptor_name":"Cardiac Output","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003326","descriptor_name":"Coronary Circulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004731","descriptor_name":"Endotoxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005440","descriptor_name":"Fluid Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006168","descriptor_name":"Guinea Pigs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012151","descriptor_name":"Resuscitation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012772","descriptor_name":"Shock, Septic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D013318","descriptor_name":"Stroke Volume","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00024382-199409000-00008","doi":"https://doi.org/10.1097/00024382-199409000-00008","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00024382-199409000-00008","pdf_url":null,"source":{"id":"https://openalex.org/S174819509","display_name":"Shock","issn_l":"1073-2322","issn":["1073-2322","1540-0514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SHOCK","raw_type":"journal-article"},{"id":"pmid:7743351","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7743351","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Shock (Augusta, Ga.)","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8600000143051147,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1254577648","display_name":"LIPOPOLYSACCHARIDE AND CARDIAC MYOCYTE DYSFUNCTION","funder_award_id":"1r15hl050082-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2055764912","display_name":"MYCOCARDIAL DYSFUNCTION AND CA++ FLUXES IN SHOCK","funder_award_id":"5r01hl036079-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5484452398","display_name":null,"funder_award_id":"HL-47812","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6161731356","display_name":null,"funder_award_id":"HL 36079","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7893261188","display_name":null,"funder_award_id":"HL50082","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G8557957025","display_name":"CORONARY OCCLUSION--COLLATERAL ARTERY FUNCTION","funder_award_id":"5r01hl047812-03","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2048614712","https://openalex.org/W1987190501","https://openalex.org/W2107805895","https://openalex.org/W2045956771","https://openalex.org/W2406002177","https://openalex.org/W156008035","https://openalex.org/W2076849320","https://openalex.org/W1829997719","https://openalex.org/W2418308556","https://openalex.org/W2285416551"],"abstract_inverted_index":{"We":[0],"tested":[1],"the":[2],"influence":[3],"of":[4,13,18,78,111,127],"in":[5,105],"vivo":[6],"volume":[7,120],"resuscitation":[8,35,90],"on":[9],"intrinsic":[10],"contractile":[11],"properties":[12],"left":[14],"ventricular":[15],"(LV)":[16],"preparations":[17,54,66],"endotoxemic":[19],"guinea":[20],"pigs.":[21],"Escherichia":[22],"coli":[23],"endotoxin":[24],"(LPS)-injected":[25],"animals":[26],"were":[27,91],"divided":[28],"into":[29],"nonresuscitated":[30],"and":[31,39,45,48,84,141,147],"resuscitated":[32],"groups.":[33],"Volume":[34],"improved":[36,123],"cardiac":[37],"output":[38],"stroke":[40],"volume,":[41],"increased":[42],"arterial":[43],"pH":[44],"body":[46],"temperature,":[47],"decreased":[49,104],"mortality.":[50],"In":[51],"isovolumetric":[52],"LV":[53,61,73,100,109,124,132,139],"isolated":[55,67],"4":[56,68],"h":[57,69],"after":[58,70],"LPS":[59,71,79,128],"injection,":[60,72],"systolic":[62,74,133,140],"pressures":[63,75],"(in":[64,76],"mmHg)":[65,77],"with":[80,145],"(42":[81,86],"+/-":[82,87,98],"3)":[83],"without":[85,130],"2)":[88],"fluid":[89],"consistently":[92],"less":[93],"than":[94],"control":[95],"values":[96],"(70":[97],"3).":[99],"end-diastolic":[101],"pressure-volume":[102],"(compliance)":[103],"LPS-nonresuscitated":[106],"hearts,":[107],"while":[108],"compliance":[110,126],"LPS-resuscitated":[112],"hearts":[113,129],"was":[114],"similar":[115],"to":[116],"control.":[117],"Thus,":[118],"intravascular":[119],"expansion":[121],"selectively":[122],"diastolic":[125,142],"affecting":[131],"function.":[134],"These":[135],"findings":[136],"suggest":[137],"that":[138],"dysfunctions":[143],"associated":[144],"endotoxemia":[146],"Gram-negative":[148],"sepsis":[149],"may":[150],"involve":[151],"separate":[152],"pathogenic":[153],"mechanisms.":[154]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}