{"id":"https://openalex.org/W1998024558","doi":"https://doi.org/10.1242/dev.00905","title":"XenopusMeis3 protein forms a hindbrain-inducing center by activating FGF/MAP kinase and PCP pathways","display_name":"XenopusMeis3 protein forms a hindbrain-inducing center by activating FGF/MAP kinase and PCP pathways","publication_year":2003,"publication_date":"2003-12-09","ids":{"openalex":"https://openalex.org/W1998024558","doi":"https://doi.org/10.1242/dev.00905","mag":"1998024558","pmid":"https://pubmed.ncbi.nlm.nih.gov/14660437"},"language":"en","primary_location":{"id":"doi:10.1242/dev.00905","doi":"https://doi.org/10.1242/dev.00905","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.00905","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000474496","display_name":"Emil Aamar","orcid":"https://orcid.org/0000-0001-7924-4021","observed_orcids":["https://orcid.org/0000-0001-7924-4021"]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]},{"id":"https://openalex.org/I4210117163","display_name":"Rappaport Family Institute for Research in the Medical Sciences","ror":"https://ror.org/029hzjx43","country_code":"IL","type":"facility","lineage":["https://openalex.org/I4210117163"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Emil Aamar","raw_affiliation_strings":["Department of Biochemistry, The Rappaport Family Institute for Research in the Medical Sciences, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, The Rappaport Family Institute for Research in the Medical Sciences, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel","institution_ids":["https://openalex.org/I174306211","https://openalex.org/I4210117163"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102897738","display_name":"Dale Frank","orcid":"https://orcid.org/0000-0002-1857-6820","observed_orcids":["https://orcid.org/0000-0002-1857-6820"]},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]},{"id":"https://openalex.org/I4210117163","display_name":"Rappaport Family Institute for Research in the Medical Sciences","ror":"https://ror.org/029hzjx43","country_code":"IL","type":"facility","lineage":["https://openalex.org/I4210117163"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Dale Frank","raw_affiliation_strings":["Department of Biochemistry, The Rappaport Family Institute for Research in the Medical Sciences, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, The Rappaport Family Institute for Research in the Medical Sciences, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa 31096, Israel","institution_ids":["https://openalex.org/I174306211","https://openalex.org/I4210117163"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4597,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.5765756,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"131","issue":"1","first_page":"153","last_page":"163"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnt-pcp-pathway","display_name":"Wnt/PCP pathway","score":0.8489999771118164},{"id":"https://openalex.org/keywords/convergent-extension","display_name":"convergent extension","score":0.8820000290870667},{"id":"https://openalex.org/keywords/anteroposterior-patterning","display_name":"anterior-posterior patterning","score":0.9160000085830688},{"id":"https://openalex.org/keywords/neural-induction","display_name":"neural induction","score":0.45500001311302185},{"id":"https://openalex.org/keywords/bmp-signaling","display_name":"BMP signaling","score":0.5770000219345093},{"id":"https://openalex.org/keywords/xenopus-embryo","display_name":"Xenopus embryo","score":0.6010000109672546}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9201964139938354},{"id":"https://openalex.org/C2777075493","wikidata":"https://www.wikidata.org/wiki/Q1137072","display_name":"Hindbrain","level":3,"score":0.9136415123939514},{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.755933403968811},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6391907930374146},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.6214002370834351},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4398547410964966},{"id":"https://openalex.org/C66332042","wikidata":"https://www.wikidata.org/wiki/Q5425488","display_name":"FGF and mesoderm formation","level":5,"score":0.4212193191051483},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3736329674720764},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3530181646347046},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21655955910682678},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.18402528762817383},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1826852560043335},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.10369139909744263},{"id":"https://openalex.org/C129536746","wikidata":"https://www.wikidata.org/wiki/Q1141026","display_name":"Gastrulation","level":4,"score":0.09937834739685059}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005307","descriptor_name":"Fertilization in Vitro","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009479","descriptor_name":"Neuropeptides","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010060","descriptor_name":"Ovulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012249","descriptor_name":"Rhombencephalon","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D014981","descriptor_name":"Xenopus","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018398","descriptor_name":"Homeodomain Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019485","descriptor_name":"Bone Morphogenetic Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019521","descriptor_name":"Body Patterning","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D029867","descriptor_name":"Xenopus Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1242/dev.00905","doi":"https://doi.org/10.1242/dev.00905","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.00905","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"pmid:14660437","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14660437","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W154439523","https://openalex.org/W1769901379","https://openalex.org/W1926770385","https://openalex.org/W1965927965","https://openalex.org/W1966518930","https://openalex.org/W1970147973","https://openalex.org/W1973921994","https://openalex.org/W1974712344","https://openalex.org/W1978186065","https://openalex.org/W1981177192","https://openalex.org/W1982579649","https://openalex.org/W1984371544","https://openalex.org/W1989441067","https://openalex.org/W1990202320","https://openalex.org/W1998020029","https://openalex.org/W1998106871","https://openalex.org/W1998625209","https://openalex.org/W2000551120","https://openalex.org/W2006671195","https://openalex.org/W2007123200","https://openalex.org/W2012542569","https://openalex.org/W2016871070","https://openalex.org/W2017087879","https://openalex.org/W2025670420","https://openalex.org/W2037397876","https://openalex.org/W2038073573","https://openalex.org/W2038158007","https://openalex.org/W2040306164","https://openalex.org/W2042534572","https://openalex.org/W2043377295","https://openalex.org/W2044695696","https://openalex.org/W2046813157","https://openalex.org/W2047035364","https://openalex.org/W2060148681","https://openalex.org/W2063503670","https://openalex.org/W2069598734","https://openalex.org/W2070849620","https://openalex.org/W2071507443","https://openalex.org/W2082759522","https://openalex.org/W2100151931","https://openalex.org/W2100555636","https://openalex.org/W2102735467","https://openalex.org/W2111181435","https://openalex.org/W2112406299","https://openalex.org/W2113786860","https://openalex.org/W2113812441","https://openalex.org/W2115686163","https://openalex.org/W2116259205","https://openalex.org/W2119710343","https://openalex.org/W2125423296","https://openalex.org/W2134485689","https://openalex.org/W2136317649","https://openalex.org/W2141791819","https://openalex.org/W2142931826","https://openalex.org/W2147073510","https://openalex.org/W2147751805","https://openalex.org/W2150589615","https://openalex.org/W2153593562","https://openalex.org/W2154882012","https://openalex.org/W2156659930","https://openalex.org/W2157679927","https://openalex.org/W2159549191","https://openalex.org/W2166901010","https://openalex.org/W2168050076","https://openalex.org/W2183822742","https://openalex.org/W2184401420","https://openalex.org/W2213529608","https://openalex.org/W2327424061","https://openalex.org/W2328269288","https://openalex.org/W2409871700","https://openalex.org/W2470905000","https://openalex.org/W6701979062","https://openalex.org/W7073689161"],"related_works":["https://openalex.org/W2154882012","https://openalex.org/W2110643566","https://openalex.org/W1971883588","https://openalex.org/W2071507443","https://openalex.org/W2327424061","https://openalex.org/W4248324722","https://openalex.org/W2132521696","https://openalex.org/W2188543190","https://openalex.org/W1985368135","https://openalex.org/W2025265318"],"abstract_inverted_index":{"Knockdown":[0],"studies":[1],"in":[2,54,105],"Xenopus":[3],"demonstrated":[4],"that":[5,101],"the":[6,42,89,106],"XMeis3":[7,28,35,82,95],"gene":[8],"is":[9],"required":[10],"for":[11],"proper":[12],"hindbrain":[13,61],"formation.":[14],"An":[15],"explant":[16],"assay":[17],"was":[18,71,75],"developed":[19],"to":[20],"distinguish":[21],"between":[22],"autonomous":[23],"and":[24,62,66,79],"inductive":[25],"activities":[26],"of":[27],"protein.":[29,46],"Animal":[30],"cap":[31],"explants":[32,39,59],"caudalized":[33],"by":[34,41],"were":[36],"recombined":[37],"with":[38],"neuralized":[40,56],"BMP":[43],"dominant-negative":[44],"receptor":[45],"XMeis3-expressing":[47],"cells":[48],"induced":[49],"convergent":[50],"extension":[51],"cell":[52],"elongations":[53],"juxtaposed":[55],"explants.":[57],"Elongated":[58],"expressed":[60],"primary":[63],"neuron":[64],"markers,":[65],"anterior":[67],"neural":[68],"marker":[69],"expression":[70],"extinguished.":[72],"Cell":[73],"elongation":[74],"dependent":[76],"on":[77],"FGF/MAP-kinase":[78,84],"Wnt-PCP":[80],"activities.":[81],"activates":[83],"signaling,":[85],"which":[86],"then":[87],"modulates":[88],"PCP":[90],"pathway.":[91],"In":[92],"this":[93],"manner,":[94],"protein":[96],"establishes":[97],"a":[98],"hindbrain-inducing":[99],"center":[100],"determines":[102],"anteroposterior":[103],"patterning":[104],"brain.":[107]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}