{"id":"https://openalex.org/W1998019782","doi":"https://doi.org/10.1161/01.res.73.1.135","title":"Rat atrial myocyte plasmalemmal caveolae in situ. Reversible experimental increases in caveolar size and in surface density of caveolar necks.","display_name":"Rat atrial myocyte plasmalemmal caveolae in situ. Reversible experimental increases in caveolar size and in surface density of caveolar necks.","publication_year":1993,"publication_date":"1993-07-01","ids":{"openalex":"https://openalex.org/W1998019782","doi":"https://doi.org/10.1161/01.res.73.1.135","mag":"1998019782","pmid":"https://pubmed.ncbi.nlm.nih.gov/8508525"},"language":"en","primary_location":{"id":"doi:10.1161/01.res.73.1.135","doi":"https://doi.org/10.1161/01.res.73.1.135","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.res.73.1.135","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.RES.73.1.135","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.RES.73.1.135","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046238491","display_name":"Leszek Kordylewski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Kordylewski","raw_affiliation_strings":["University of Chicago, Department of Medicine, IL 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Department of Medicine, IL 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112159764","display_name":"Gwen E. Goings","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G E Goings","raw_affiliation_strings":["University of Chicago, Department of Medicine, IL 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Department of Medicine, IL 60637","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110082068","display_name":"Ernest W. Page","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E Page","raw_affiliation_strings":["University of Chicago, Department of Medicine, IL 60637"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chicago, Department of Medicine, IL 60637","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":null,"apc_paid":null,"fwci":0.6484,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.67363462,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"73","issue":"1","first_page":"135","last_page":"146"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/caveolae","display_name":"caveolae","score":0.9589999914169312},{"id":"https://openalex.org/keywords/atrial-myocytes","display_name":"atrial myocytes","score":0.8500000238418579},{"id":"https://openalex.org/keywords/plasma-membrane","display_name":"plasma membrane","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.6420000195503235},{"id":"https://openalex.org/keywords/hypertonicity","display_name":"hypertonicity","score":0.6949999928474426},{"id":"https://openalex.org/keywords/sucrose","display_name":"sucrose","score":0.4869999885559082},{"id":"https://openalex.org/keywords/mannitol","display_name":"mannitol","score":0.9980000257492065},{"id":"https://openalex.org/keywords/horseradish-peroxidase","display_name":"horseradish peroxidase","score":0.8379999995231628},{"id":"https://openalex.org/keywords/interstitial-space","display_name":"interstitial space","score":0.5849999785423279},{"id":"https://openalex.org/keywords/freeze-fracture","display_name":"freeze-fracture","score":0.4959999918937683},{"id":"https://openalex.org/keywords/rat-heart","display_name":"rat heart","score":0.3370000123977661}],"concepts":[{"id":"https://openalex.org/C49866891","wikidata":"https://www.wikidata.org/wiki/Q1051872","display_name":"Caveolae","level":3,"score":0.9685931205749512},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5268208980560303},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.47759079933166504},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.4441303610801697},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.38465502858161926},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3481740355491638},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.31282472610473633},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2125343382358551},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14072567224502563},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.13671761751174927}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005614","descriptor_name":"Freeze Fracturing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":true},{"descriptor_ui":"D012996","descriptor_name":"Solutions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013395","descriptor_name":"Sucrose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015388","descriptor_name":"Organelles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015388","descriptor_name":"Organelles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1161/01.res.73.1.135","doi":"https://doi.org/10.1161/01.res.73.1.135","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.res.73.1.135","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.RES.73.1.135","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},{"id":"pmid:8508525","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8508525","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation research","raw_type":"Journal Article"},{"id":"mag:3141387383","doi":null,"is_oa":false,"landing_page_url":"https://www.ahajournals.org/doi/abs/10.1161/res.73.1.8508525?legid=circresaha%3B73%2F1%2F135&cited-by=yes","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Circulation Research","raw_type":null}],"best_oa_location":{"id":"doi:10.1161/01.res.73.1.135","doi":"https://doi.org/10.1161/01.res.73.1.135","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.res.73.1.135","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.RES.73.1.135","source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1392648815","display_name":null,"funder_award_id":"HL 10503","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5754078603","display_name":null,"funder_award_id":"HL 20592","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6392258800","display_name":"CELL BIOLOGY OF CARDIAC AND SKELETAL MUSCLE","funder_award_id":"P01HL020592","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1998019782.pdf","grobid_xml":"https://content.openalex.org/works/W1998019782.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4415456739","https://openalex.org/W2083465797","https://openalex.org/W2739459547","https://openalex.org/W2051893643","https://openalex.org/W2611316003","https://openalex.org/W2610169826","https://openalex.org/W2011634087","https://openalex.org/W2011395933","https://openalex.org/W4319917316","https://openalex.org/W2066093462"],"abstract_inverted_index":{"The":[0],"structure,":[1],"size,":[2],"and":[3,47,68,86,108,197,229,247],"surface":[4],"density":[5],"of":[6,20,79,116,122,149,170,179,182,193,201,208],"the":[7,17,49,60,111,183,232,250],"conspicuous":[8],"flask-shaped":[9],"structures":[10,221],"called":[11],"caveolae":[12,39,80,98,218,243],"that":[13,97,120,215],"are":[14,43,219],"located":[15],"under":[16],"plasma":[18],"membrane":[19],"cardiac":[21],"myocytes":[22],"in":[23,66,145,190,198,241],"intact":[24],"rat":[25],"atria":[26,123,171],"were":[27],"studied":[28],"by":[29,137],"electron":[30,180],"microscopy":[31,115],"after":[32],"physiological":[33,132],"perturbations":[34],"designed":[35],"to":[36,110,131,154,164,173,239,249],"examine":[37],"whether":[38,48],"and/or":[40,99],"their":[41,100],"necks":[42,101,196,203,223],"fixed":[44],"or":[45,55,75,127,142],"mobile":[46],"caveolar":[50,150,195,202],"lumen":[51],"is":[52],"always":[53],"open":[54,109,246],"can":[56,102],"close":[57],"off":[58],"from":[59,231],"interstitial":[61,112,251],"space.":[62,113],"We":[63],"showed":[64],"that,":[65],"stretched":[67],"unstretched":[69],"atria,":[70],"horseradish":[71],"peroxidase":[72],"could":[73],"enter":[74],"be":[76,225],"washed":[77],"out":[78,96],"at":[81,124],"37":[82,125],"degrees,":[83,85],"18":[84,128],"4":[87],"degrees":[88,126,129],"C,":[89],"but":[90],"this":[91],"finding":[92],"does":[93],"not":[94,236],"rule":[95],"cycle":[103],"rapidly":[104,160],"between":[105],"states":[106,240],"closed":[107,248],"Electron":[114],"thin":[117],"sections":[118],"revealed":[119,186],"exposure":[121],"C":[130],"salt":[133],"solutions":[134],"made":[135],"hypertonic":[136,175],"adding":[138],"150":[139],"mM":[140],"sucrose":[141],"mannitol":[143],"resulted":[144],"a":[146],"striking":[147],"enlargement":[148,158],"profiles":[151],"within":[152],"1":[153],"5":[155],"minutes.":[156],"Caveolar":[157],"was":[159],"reversible":[161],"on":[162],"return":[163],"control":[165],"saline.":[166],"After":[167],"freeze":[168],"fracture":[169,184,210],"exposed":[172],"these":[174],"solutions,":[176],"quantitative":[177],"analysis":[178],"micrographs":[181],"faces":[185],"statistically":[187],"significant":[188],"increases":[189],"cross-sectional":[191],"diameter":[192],"cross-fractured":[194],"mean":[199],"number":[200],"penetrating":[204],"per":[205],"unit":[206],"area":[207],"plasmalemmal":[209],"face.":[211],"These":[212],"results":[213],"suggest":[214],"atrial":[216],"myocyte":[217],"dynamic":[220],"whose":[222],"may":[224],"reversibly":[226],"inserted":[227],"into":[228],"withdrawn":[230],"plasmalemma,":[233],"possibly":[234],"(but":[235],"necessarily)":[237],"corresponding":[238],"which":[242],"are,":[244],"respectively,":[245],"spaces.":[252]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
