{"id":"https://openalex.org/W1998016256","doi":"https://doi.org/10.1016/j.aquatox.2007.08.012","title":"Associations between altered vitellogenin concentrations and adverse health effects in fathead minnow (Pimephales promelas)","display_name":"Associations between altered vitellogenin concentrations and adverse health effects in fathead minnow (Pimephales promelas)","publication_year":2007,"publication_date":"2007-09-18","ids":{"openalex":"https://openalex.org/W1998016256","doi":"https://doi.org/10.1016/j.aquatox.2007.08.012","mag":"1998016256","pmid":"https://pubmed.ncbi.nlm.nih.gov/17942165"},"language":"en","primary_location":{"id":"doi:10.1016/j.aquatox.2007.08.012","doi":"https://doi.org/10.1016/j.aquatox.2007.08.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.aquatox.2007.08.012","pdf_url":null,"source":{"id":"https://openalex.org/S183233548","display_name":"Aquatic Toxicology","issn_l":"0166-445X","issn":["0166-445X","1879-1514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aquatic Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062055742","display_name":"Karen L. Thorpe","orcid":"https://orcid.org/0000-0002-7548-7189","observed_orcids":["https://orcid.org/0000-0002-7548-7189"]},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Karen L. Thorpe","raw_affiliation_strings":["School of Biosciences, Hatherley Laboratories, University of Exeter, Prince of Wales Road, Exeter, Devon EX4 4PS, UK. karen.thorpe@unibas.ch","School of Biosciences, Hatherley Laboratories, University of Exeter, Prince of Wales Road, Exeter, Devon EX4 4PS, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biosciences, Hatherley Laboratories, University of Exeter, Prince of Wales Road, Exeter, Devon EX4 4PS, UK. karen.thorpe@unibas.ch","institution_ids":["https://openalex.org/I23923803"]},{"raw_affiliation_string":"School of Biosciences, Hatherley Laboratories, University of Exeter, Prince of Wales Road, Exeter, Devon EX4 4PS, UK","institution_ids":["https://openalex.org/I23923803"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002123336","display_name":"Rachel Benstead","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184903800","display_name":"Environment Agency","ror":"https://ror.org/01zewfb16","country_code":"GB","type":"government","lineage":["https://openalex.org/I1326803253","https://openalex.org/I184903800","https://openalex.org/I2802373619"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rachel Benstead","raw_affiliation_strings":["The Environment Agency, National Centre for Ecotoxicology and Hazardous Substances, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Environment Agency, National Centre for Ecotoxicology and Hazardous Substances, UK","institution_ids":["https://openalex.org/I184903800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084388944","display_name":"Thomas H. Hutchinson","orcid":"https://orcid.org/0000-0001-8823-5442","observed_orcids":["https://orcid.org/0000-0001-8823-5442"]},"institutions":[{"id":"https://openalex.org/I105036370","display_name":"AstraZeneca (United Kingdom)","ror":"https://ror.org/04r9x1a08","country_code":"GB","type":"company","lineage":["https://openalex.org/I105036370"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Thomas H. Hutchinson","raw_affiliation_strings":["Brixham Environmental Laboratory, AstraZeneca UK Limited, Freshwater Quarry, Brixham, Devon, TQ5 8BA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brixham Environmental Laboratory, AstraZeneca UK Limited, Freshwater Quarry, Brixham, Devon, TQ5 8BA, UK","institution_ids":["https://openalex.org/I105036370"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002493080","display_name":"Charles R. Tyler","orcid":"https://orcid.org/0000-0003-2353-5748","observed_orcids":["https://orcid.org/0000-0003-2353-5748"]},"institutions":[{"id":"https://openalex.org/I23923803","display_name":"University of Exeter","ror":"https://ror.org/03yghzc09","country_code":"GB","type":"education","lineage":["https://openalex.org/I23923803"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Charles R. Tyler","raw_affiliation_strings":["School of Biosciences, Hatherley Laboratories, University of Exeter, Prince of Wales Road, Exeter, Devon EX4 4PS, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biosciences, Hatherley Laboratories, University of Exeter, Prince of Wales Road, Exeter, Devon EX4 4PS, UK","institution_ids":["https://openalex.org/I23923803"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5062055742"],"corresponding_institution_ids":["https://openalex.org/I23923803"],"apc_list":{"value":3320,"currency":"USD","value_usd":3320},"apc_paid":null,"fwci":3.6785,"has_fulltext":false,"cited_by_count":80,"citation_normalized_percentile":{"value":0.94843146,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"85","issue":"3","first_page":"176","last_page":"183"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.8022000193595886,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species","score":0.8022000193595886,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10447","display_name":"Environmental Toxicology and Ecotoxicology","score":0.10499999672174454,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.08370000123977661,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitellogenin","display_name":"vitellogenin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/fathead-minnow","display_name":"fathead minnow","score":0.9990000128746033},{"id":"https://openalex.org/keywords/estrogen-receptor-agonists","display_name":"estrogen receptor agonists","score":0.7089999914169312},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9679999947547913},{"id":"https://openalex.org/keywords/estrone","display_name":"estrone","score":0.9929999709129333},{"id":"https://openalex.org/keywords/aromatase-inhibition","display_name":"aromatase inhibition","score":0.7210000157356262},{"id":"https://openalex.org/keywords/fenarimol","display_name":"fenarimol","score":0.9980000257492065},{"id":"https://openalex.org/keywords/reproductive-fitness","display_name":"reproductive fitness","score":0.6060000061988831},{"id":"https://openalex.org/keywords/egg-production","display_name":"egg production","score":0.7689999938011169},{"id":"https://openalex.org/keywords/male-mortality","display_name":"male mortality","score":0.7860000133514404},{"id":"https://openalex.org/keywords/health-biomarkers","display_name":"health biomarkers","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C2993305272","wikidata":"https://www.wikidata.org/wiki/Q2700010","display_name":"Pimephales promelas","level":4,"score":0.9262176752090454},{"id":"https://openalex.org/C2779078696","wikidata":"https://www.wikidata.org/wiki/Q83134957","display_name":"Vitellogenin","level":3,"score":0.9032823443412781},{"id":"https://openalex.org/C2776451064","wikidata":"https://www.wikidata.org/wiki/Q3333234","display_name":"Minnow","level":3,"score":0.8674277067184448},{"id":"https://openalex.org/C2776166826","wikidata":"https://www.wikidata.org/wiki/Q415287","display_name":"Aromatase","level":4,"score":0.7546223402023315},{"id":"https://openalex.org/C2779272402","wikidata":"https://www.wikidata.org/wiki/Q423964","display_name":"Xenoestrogen","level":5,"score":0.6430480480194092},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6398817300796509},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6218064427375793},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5586056709289551},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5567460060119629},{"id":"https://openalex.org/C115346097","wikidata":"https://www.wikidata.org/wiki/Q1412144","display_name":"Ecotoxicology","level":2,"score":0.5380091071128845},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4131402373313904},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3264322578907013},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.31904536485671997},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.29465678334236145},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17138731479644775},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.10988679528236389},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003530","descriptor_name":"Cyprinidae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004970","descriptor_name":"Estrone","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005298","descriptor_name":"Fertility","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005298","descriptor_name":"Fertility","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005659","descriptor_name":"Fungicides, Industrial","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009026","descriptor_name":"Mortality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D012098","descriptor_name":"Reproduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012098","descriptor_name":"Reproduction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012733","descriptor_name":"Sex Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014819","descriptor_name":"Vitellogenins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014874","descriptor_name":"Water Pollutants, Chemical","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D047072","descriptor_name":"Aromatase Inhibitors","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.aquatox.2007.08.012","doi":"https://doi.org/10.1016/j.aquatox.2007.08.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.aquatox.2007.08.012","pdf_url":null,"source":{"id":"https://openalex.org/S183233548","display_name":"Aquatic Toxicology","issn_l":"0166-445X","issn":["0166-445X","1879-1514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aquatic Toxicology","raw_type":"journal-article"},{"id":"pmid:17942165","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17942165","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Aquatic toxicology (Amsterdam, Netherlands)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8199999928474426}],"study_designs":[],"awards":[{"id":"https://openalex.org/G518731467","display_name":null,"funder_award_id":"pml010001","funder_id":"https://openalex.org/F4320334631","funder_display_name":"Natural Environment Research Council"}],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"},{"id":"https://openalex.org/F4320334631","display_name":"Natural Environment Research Council","ror":"https://ror.org/02b5d8509"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1968766422","https://openalex.org/W1969110187","https://openalex.org/W1970522623","https://openalex.org/W1974926081","https://openalex.org/W1982993939","https://openalex.org/W1993512615","https://openalex.org/W1996495020","https://openalex.org/W1999637204","https://openalex.org/W2000849916","https://openalex.org/W2002481914","https://openalex.org/W2037024562","https://openalex.org/W2048122753","https://openalex.org/W2052137006","https://openalex.org/W2058355606","https://openalex.org/W2073657931","https://openalex.org/W2080093229","https://openalex.org/W2083081530","https://openalex.org/W2083213003","https://openalex.org/W2090778700","https://openalex.org/W2093738509","https://openalex.org/W2098239925","https://openalex.org/W2101362986","https://openalex.org/W2103621695","https://openalex.org/W2109331320","https://openalex.org/W2110573732","https://openalex.org/W2123484230","https://openalex.org/W2136188844","https://openalex.org/W2139272239","https://openalex.org/W2143853738","https://openalex.org/W2151486223","https://openalex.org/W2157414721","https://openalex.org/W6680630316"],"related_works":["https://openalex.org/W2000849916","https://openalex.org/W7096865211","https://openalex.org/W2131660346","https://openalex.org/W7100454506","https://openalex.org/W2087041814","https://openalex.org/W2518806583","https://openalex.org/W2041322846","https://openalex.org/W7098205393","https://openalex.org/W2041522835","https://openalex.org/W4388983201"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":9},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
