{"id":"https://openalex.org/W1998008148","doi":"https://doi.org/10.1016/j.tig.2011.06.002","title":"The molecular origins of evolutionary innovations","display_name":"The molecular origins of evolutionary innovations","publication_year":2011,"publication_date":"2011-08-29","ids":{"openalex":"https://openalex.org/W1998008148","doi":"https://doi.org/10.1016/j.tig.2011.06.002","mag":"1998008148","pmid":"https://pubmed.ncbi.nlm.nih.gov/21872964"},"language":"en","primary_location":{"id":"doi:10.1016/j.tig.2011.06.002","doi":"https://doi.org/10.1016/j.tig.2011.06.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tig.2011.06.002","pdf_url":null,"source":{"id":"https://openalex.org/S139283865","display_name":"Trends in Genetics","issn_l":"0168-9525","issn":["0168-9525","1362-4555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Genetics","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5167/uzh-59819","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079730045","display_name":"Andreas Wagner","orcid":"https://orcid.org/0000-0003-4299-3840","observed_orcids":["https://orcid.org/0000-0003-4299-3840"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Andreas Wagner","raw_affiliation_strings":["University of Zurich Institute of Evolutionary Biology and Environmental Studies, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland. andreas.wagner@ieu.uzh.ch","University of Zurich, Institute of Evolutionary Biology and Environmental Studies, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Zurich Institute of Evolutionary Biology and Environmental Studies, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland. andreas.wagner@ieu.uzh.ch","institution_ids":["https://openalex.org/I202697423"]},{"raw_affiliation_string":"University of Zurich, Institute of Evolutionary Biology and Environmental Studies, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5079730045"],"corresponding_institution_ids":["https://openalex.org/I202697423"],"apc_list":{"value":7030,"currency":"USD","value_usd":7030},"apc_paid":null,"fwci":0.7793,"has_fulltext":false,"cited_by_count":124,"citation_normalized_percentile":{"value":0.61279127,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"27","issue":"10","first_page":"397","last_page":"410"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10778","display_name":"Philosophy and History of Science","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T12090","display_name":"Language and cultural evolution","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3316","display_name":"Cultural Studies"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/evolutionary-novelty","display_name":"evolutionary innovation","score":0.8730000257492065},{"id":"https://openalex.org/keywords/phenotypic-variation","display_name":"phenotypic variability","score":0.7900000214576721},{"id":"https://openalex.org/keywords/genotype-networks","display_name":"genotype networks","score":0.8360000252723694},{"id":"https://openalex.org/keywords/genotype-space","display_name":"genotype space","score":0.8679999709129333},{"id":"https://openalex.org/keywords/phenotypic-robustness","display_name":"phenotypic robustness","score":0.8320000171661377},{"id":"https://openalex.org/keywords/metabolic-networks","display_name":"metabolic networks","score":0.8349999785423279},{"id":"https://openalex.org/keywords/regulatory-circuits","display_name":"regulatory circuits","score":0.878000020980835},{"id":"https://openalex.org/keywords/macromolecules","display_name":"macromolecules","score":0.9390000104904175},{"id":"https://openalex.org/keywords/environmental-change","display_name":"environmental change","score":0.3919999897480011}],"concepts":[{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.7819949984550476},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7785888314247131},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5108044147491455},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.5086244344711304},{"id":"https://openalex.org/C124980797","wikidata":"https://www.wikidata.org/wiki/Q333018","display_name":"Common descent","level":4,"score":0.48837655782699585},{"id":"https://openalex.org/C130073038","wikidata":"https://www.wikidata.org/wiki/Q1211967","display_name":"Phenotypic trait","level":4,"score":0.48489052057266235},{"id":"https://openalex.org/C75268714","wikidata":"https://www.wikidata.org/wiki/Q43478","display_name":"Natural selection","level":3,"score":0.466231107711792},{"id":"https://openalex.org/C200844832","wikidata":"https://www.wikidata.org/wiki/Q5533517","display_name":"Genotype-phenotype distinction","level":4,"score":0.42149555683135986},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38953813910484314},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3487430214881897},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2863847613334656},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.18091443181037903},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.1588205099105835},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.11822649836540222},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.11607182025909424}],"mesh":[{"descriptor_ui":"D000220","descriptor_name":"Adaptation, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004777","descriptor_name":"Environment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010944","descriptor_name":"Plants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025461","descriptor_name":"Feedback, Physiological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.tig.2011.06.002","doi":"https://doi.org/10.1016/j.tig.2011.06.002","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.tig.2011.06.002","pdf_url":null,"source":{"id":"https://openalex.org/S139283865","display_name":"Trends in Genetics","issn_l":"0168-9525","issn":["0168-9525","1362-4555"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in Genetics","raw_type":"journal-article"},{"id":"pmid:21872964","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21872964","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trends in genetics : TIG","raw_type":"Journal Article"},{"id":"pmh:oai:www.zora.uzh.ch:59819","doi":null,"is_oa":false,"landing_page_url":"https://www.zora.uzh.ch/id/eprint/59819/1/Wagner_TrendsinGenetics.pdf","pdf_url":"https://www.zora.uzh.ch/id/eprint/59819/1/Wagner_TrendsinGenetics.pdf","source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Wagner, A (2011). The molecular origins of evolutionary innovations. Trends in Genetics, 27(10):397-410.","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:www.zora.uzh.ch:20.500.14742/70261","doi":null,"is_oa":false,"landing_page_url":"https://www.zora.uzh.ch/handle/20.500.14742/70261","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Wagner, A. (2011). The molecular origins of evolutionary innovations. Trends in Genetics\u202f: Tig, 27, 397\u2013410. https://doi.org/10.1016/j.tig.2011.06.002","raw_type":"Journal Article"},{"id":"doi:10.5167/uzh-59819","doi":"https://doi.org/10.5167/uzh-59819","is_oa":true,"landing_page_url":"https://doi.org/10.5167/uzh-59819","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.5167/uzh-59819","doi":"https://doi.org/10.5167/uzh-59819","is_oa":true,"landing_page_url":"https://doi.org/10.5167/uzh-59819","pdf_url":null,"source":{"id":"https://openalex.org/S4306401281","display_name":"Zurich Open Repository and Archive (University of Zurich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I202697423","host_organization_name":"University of Zurich","host_organization_lineage":["https://openalex.org/I202697423"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":125,"referenced_works":["https://openalex.org/W8519953","https://openalex.org/W73742397","https://openalex.org/W234963275","https://openalex.org/W393299573","https://openalex.org/W1528121124","https://openalex.org/W1554180547","https://openalex.org/W1623155147","https://openalex.org/W1935467915","https://openalex.org/W1965016854","https://openalex.org/W1965857389","https://openalex.org/W1965879814","https://openalex.org/W1967681616","https://openalex.org/W1968814137","https://openalex.org/W1971013467","https://openalex.org/W1972216879","https://openalex.org/W1972517047","https://openalex.org/W1976127881","https://openalex.org/W1977940795","https://openalex.org/W1982583288","https://openalex.org/W1986122165","https://openalex.org/W1987220754","https://openalex.org/W1990383114","https://openalex.org/W1991138583","https://openalex.org/W1992613346","https://openalex.org/W1995862894","https://openalex.org/W1998238795","https://openalex.org/W1998460935","https://openalex.org/W2000118138","https://openalex.org/W2003160232","https://openalex.org/W2003489966","https://openalex.org/W2006413392","https://openalex.org/W2008341268","https://openalex.org/W2009216260","https://openalex.org/W2012457691","https://openalex.org/W2014921885","https://openalex.org/W2018466639","https://openalex.org/W2025663053","https://openalex.org/W2030719605","https://openalex.org/W2034265459","https://openalex.org/W2034536549","https://openalex.org/W2038864914","https://openalex.org/W2042206208","https://openalex.org/W2043440339","https://openalex.org/W2044350743","https://openalex.org/W2045391589","https://openalex.org/W2047544230","https://openalex.org/W2053575414","https://openalex.org/W2056375311","https://openalex.org/W2056857562","https://openalex.org/W2057048484","https://openalex.org/W2059557910","https://openalex.org/W2060399360","https://openalex.org/W2063166493","https://openalex.org/W2066704242","https://openalex.org/W2069614478","https://openalex.org/W2070004581","https://openalex.org/W2070316123","https://openalex.org/W2071153025","https://openalex.org/W2072133388","https://openalex.org/W2073103611","https://openalex.org/W2076814714","https://openalex.org/W2076935369","https://openalex.org/W2080249432","https://openalex.org/W2081050097","https://openalex.org/W2082738116","https://openalex.org/W2083034544","https://openalex.org/W2084516445","https://openalex.org/W2085563725","https://openalex.org/W2090760025","https://openalex.org/W2094399313","https://openalex.org/W2095864746","https://openalex.org/W2096245011","https://openalex.org/W2097324875","https://openalex.org/W2100380298","https://openalex.org/W2102164505","https://openalex.org/W2102744682","https://openalex.org/W2103328552","https://openalex.org/W2103736146","https://openalex.org/W2104856129","https://openalex.org/W2105557836","https://openalex.org/W2108350807","https://openalex.org/W2110146147","https://openalex.org/W2112364806","https://openalex.org/W2112840884","https://openalex.org/W2114518254","https://openalex.org/W2115010760","https://openalex.org/W2115595474","https://openalex.org/W2115826734","https://openalex.org/W2119668245","https://openalex.org/W2121105996","https://openalex.org/W2122789299","https://openalex.org/W2123370576","https://openalex.org/W2123598330","https://openalex.org/W2125395354","https://openalex.org/W2126074998","https://openalex.org/W2126796035","https://openalex.org/W2136692684","https://openalex.org/W2137266088","https://openalex.org/W2139412432","https://openalex.org/W2139553051","https://openalex.org/W2148801861","https://openalex.org/W2148902358","https://openalex.org/W2150360867","https://openalex.org/W2150700412","https://openalex.org/W2150961198","https://openalex.org/W2151233592","https://openalex.org/W2153373497","https://openalex.org/W2156368951","https://openalex.org/W2157109398","https://openalex.org/W2159482845","https://openalex.org/W2159993062","https://openalex.org/W2165330496","https://openalex.org/W2169336096","https://openalex.org/W2171193618","https://openalex.org/W2180500077","https://openalex.org/W2316508456","https://openalex.org/W2329156357","https://openalex.org/W2527757134","https://openalex.org/W2999074976","https://openalex.org/W4241088457","https://openalex.org/W4254837461","https://openalex.org/W4256010680","https://openalex.org/W4285719527","https://openalex.org/W4298266640","https://openalex.org/W4299328967"],"related_works":["https://openalex.org/W141572739","https://openalex.org/W4254837461","https://openalex.org/W2104989261","https://openalex.org/W4206710771","https://openalex.org/W4234783048","https://openalex.org/W581861726","https://openalex.org/W2951886612","https://openalex.org/W4233758394","https://openalex.org/W4252305647","https://openalex.org/W4239553162"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
