{"id":"https://openalex.org/W1997994432","doi":"https://doi.org/10.1177/0960327111405863","title":"Monoamine concentrations changes in the PTU-induced hypothyroid rat brain and the ameliorating role of folic acid","display_name":"Monoamine concentrations changes in the PTU-induced hypothyroid rat brain and the ameliorating role of folic acid","publication_year":2011,"publication_date":"2011-04-08","ids":{"openalex":"https://openalex.org/W1997994432","doi":"https://doi.org/10.1177/0960327111405863","mag":"1997994432","pmid":"https://pubmed.ncbi.nlm.nih.gov/21478293"},"language":"en","primary_location":{"id":"doi:10.1177/0960327111405863","doi":"https://doi.org/10.1177/0960327111405863","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0960327111405863","pdf_url":null,"source":{"id":"https://openalex.org/S147701277","display_name":"Human & Experimental Toxicology","issn_l":"0960-3271","issn":["0960-3271","1477-0903"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human &amp; Experimental Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013239647","display_name":"Ehab Tousson","orcid":"https://orcid.org/0000-0001-9722-3603","observed_orcids":["https://orcid.org/0000-0001-9722-3603"]},"institutions":[{"id":"https://openalex.org/I21376657","display_name":"Tanta University","ror":"https://ror.org/016jp5b92","country_code":"EG","type":"education","lineage":["https://openalex.org/I21376657"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"E Tousson","raw_affiliation_strings":["Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt","institution_ids":["https://openalex.org/I21376657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069664483","display_name":"Wafaa Ibrahim","orcid":"https://orcid.org/0000-0001-7858-7057","observed_orcids":["https://orcid.org/0000-0001-7858-7057"]},"institutions":[{"id":"https://openalex.org/I21376657","display_name":"Tanta University","ror":"https://ror.org/016jp5b92","country_code":"EG","type":"education","lineage":["https://openalex.org/I21376657"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"W Ibrahim","raw_affiliation_strings":["Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Tanta, Egypt","2 Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Tanta, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Tanta, Egypt","institution_ids":["https://openalex.org/I21376657"]},{"raw_affiliation_string":"2 Department of Medical Biochemistry, Faculty of Medicine, Tanta University, Tanta, Egypt","institution_ids":["https://openalex.org/I21376657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077297808","display_name":"Nadia M. S. Arafa","orcid":"https://orcid.org/0000-0002-2115-7950","observed_orcids":["https://orcid.org/0000-0002-2115-7950"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Arafa","raw_affiliation_strings":["National Authority for Control and Pharmaceutical Research, Giza, Egypt","3 National Authority for Control and Pharmaceutical Research, Giza, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Authority for Control and Pharmaceutical Research, Giza, Egypt","institution_ids":[]},{"raw_affiliation_string":"3 National Authority for Control and Pharmaceutical Research, Giza, Egypt","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037306807","display_name":"Mohamed Ahmed Akela","orcid":"https://orcid.org/0000-0002-5620-1907","observed_orcids":["https://orcid.org/0000-0002-5620-1907"]},"institutions":[{"id":"https://openalex.org/I21376657","display_name":"Tanta University","ror":"https://ror.org/016jp5b92","country_code":"EG","type":"education","lineage":["https://openalex.org/I21376657"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"MA Akela","raw_affiliation_strings":["Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt","1 Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt","institution_ids":["https://openalex.org/I21376657"]},{"raw_affiliation_string":"1 Department of Zoology, Faculty of Science, Tanta University, Tanta, Egypt","institution_ids":["https://openalex.org/I21376657"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5013239647"],"corresponding_institution_ids":["https://openalex.org/I21376657"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":null,"fwci":3.929,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.93359788,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"31","issue":"3","first_page":"282","last_page":"289"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10293","display_name":"Thyroid Disorders and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12229","display_name":"Pharmacological Effects and Toxicity Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/folic-acid","display_name":"folic acid","score":0.753000020980835},{"id":"https://openalex.org/keywords/brain-monoamines","display_name":"brain monoamines","score":0.8849999904632568},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":1.0},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.9039999842643738},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.8119999766349792},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.9829999804496765},{"id":"https://openalex.org/keywords/thyroid-hormones","display_name":"thyroid hormones","score":0.8600000143051147},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.6019999980926514},{"id":"https://openalex.org/keywords/adjuvant-therapy","display_name":"adjuvant therapy","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.856677234172821},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.8504247069358826},{"id":"https://openalex.org/C187714386","wikidata":"https://www.wikidata.org/wiki/Q420225","display_name":"Monoamine neurotransmitter","level":4,"score":0.7188462018966675},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.6860728859901428},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6526812314987183},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5317049622535706},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5170601010322571},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.5082287788391113},{"id":"https://openalex.org/C2777195454","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Euthyroid","level":3,"score":0.49801182746887207},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.4711659848690033},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.42559894919395447},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4035276174545288},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001923","descriptor_name":"Brain Chemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007031","descriptor_name":"Hypothalamus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007037","descriptor_name":"Hypothyroidism","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011441","descriptor_name":"Propylthiouracil","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013972","descriptor_name":"Thyrotropin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014284","descriptor_name":"Triiodothyronine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014803","descriptor_name":"Vitamin B Complex","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/0960327111405863","doi":"https://doi.org/10.1177/0960327111405863","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0960327111405863","pdf_url":null,"source":{"id":"https://openalex.org/S147701277","display_name":"Human & Experimental Toxicology","issn_l":"0960-3271","issn":["0960-3271","1477-0903"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","norway-1","poland-70","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human &amp; Experimental Toxicology","raw_type":"journal-article"},{"id":"pmid:21478293","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21478293","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human & experimental toxicology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W290541521","https://openalex.org/W1498505275","https://openalex.org/W1508825618","https://openalex.org/W1536447024","https://openalex.org/W1849676453","https://openalex.org/W1972605809","https://openalex.org/W1985254292","https://openalex.org/W1988208439","https://openalex.org/W1989004477","https://openalex.org/W1993775827","https://openalex.org/W1994512857","https://openalex.org/W1995544207","https://openalex.org/W2000568043","https://openalex.org/W2024116370","https://openalex.org/W2029802256","https://openalex.org/W2030725177","https://openalex.org/W2033638549","https://openalex.org/W2035063750","https://openalex.org/W2041329238","https://openalex.org/W2045883797","https://openalex.org/W2050742296","https://openalex.org/W2059664047","https://openalex.org/W2066023103","https://openalex.org/W2067305678","https://openalex.org/W2071436714","https://openalex.org/W2072620003","https://openalex.org/W2090214570","https://openalex.org/W2090874043","https://openalex.org/W2092400104","https://openalex.org/W2099739994","https://openalex.org/W2100900899","https://openalex.org/W2125170809","https://openalex.org/W2126038578","https://openalex.org/W2127115382","https://openalex.org/W2144017680","https://openalex.org/W2152482512","https://openalex.org/W2157186750","https://openalex.org/W2164097626","https://openalex.org/W2323212802","https://openalex.org/W4249219792"],"related_works":["https://openalex.org/W2071484175","https://openalex.org/W2061966417","https://openalex.org/W1969676412","https://openalex.org/W2090214570","https://openalex.org/W2200462073","https://openalex.org/W3123198603","https://openalex.org/W1986051195","https://openalex.org/W2198487036","https://openalex.org/W2020517037","https://openalex.org/W1988412622"],"abstract_inverted_index":{"Thyroid":[0],"hormones":[1,8],"are":[2],"recognized":[3],"as":[4,238],"the":[5,15,31,46,68,76,80,85,123,132,163,171,176,189,221,244,251],"key":[6],"metabolic":[7],"that":[9,114],"play":[10],"a":[11],"critical":[12],"role":[13,48],"in":[14,33,37,43,83,89,122,131,148,152,170,195,210],"development":[16],"of":[17,49,134,165,175],"central":[18],"nervous":[19],"system":[20],"(CNS)":[21],"throughout":[22],"life.":[23],"The":[24,95],"present":[25],"study":[26],"was":[27,79,192,232],"designed":[28],"to":[29,45,243],"determine":[30],"changes":[32],"brain":[34],"monoamine":[35],"concentrations":[36,118,145],"6-n-propyl":[38],"thiouracil":[39],"(PTU)-induced":[40],"hypothyroid":[41,81,108,135,160,177,185,196,204,216],"rats,":[42,109,161,205],"addition":[44],"ameliorating":[47],"folic":[50,71,104,156,181,200,212,229],"acid":[51,72,105,157,182,201,213,230],"treatment.":[52],"Fifty":[53],"male":[54],"albino":[55],"rats":[56,86,136,178,197,217],"were":[57,67,100,119,146,167],"equally":[58],"divided":[59],"into":[60],"five":[61],"groups;":[62],"first":[63],"and":[64,70,97,102,116,125,143,150,154,173,179,198],"second":[65],"groups":[66,99,106,158],"control":[69,140,222],"groups,":[73],"respectively,":[74],"while":[75,127,162,206],"third":[77],"group":[78,82,183,202,214],"which":[84],"received":[87],"PTU":[88,249],"drinking":[90,252],"water":[91],"for":[92],"6":[93],"weeks.":[94],"fourth":[96],"fifth":[98],"co-":[101,153],"post-treated":[103,155,199],"with":[107,139,159,184,203,215,220],"respectively.":[110],"Our":[111],"results":[112,226],"revealed":[113,227],"serotonin":[115],"norepinephrine":[117,144],"significantly":[120,129,168,193,208],"decreased":[121,147,209],"hypothalamus":[124,149,172],"cortex,":[126,188],"it":[128,207,235],"increased":[130,169,194],"hippocampus":[133,174],"when":[137,218],"compared":[138,219],"group.":[141,223],"Serotonin":[142],"cortex":[151],"concentration":[164,191],"dopamine":[166,190],"co-treated":[180,211],"rats.":[186],"In":[187],"Also,":[224],"our":[225],"that,":[228],"treatment":[231],"better":[233],"if":[234],"is":[236],"administered":[237],"an":[239],"adjuvant":[240],"after":[241],"returning":[242],"euthyroid":[245],"state":[246],"by":[247],"withdrawing":[248],"from":[250],"water.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
