{"id":"https://openalex.org/W1997970568","doi":"https://doi.org/10.1038/oby.2009.184","title":"Enhanced Weight Loss With Pramlintide/Metreleptin: An Integrated Neurohormonal Approach to Obesity Pharmacotherapy","display_name":"Enhanced Weight Loss With Pramlintide/Metreleptin: An Integrated Neurohormonal Approach to Obesity Pharmacotherapy","publication_year":2009,"publication_date":"2009-06-11","ids":{"openalex":"https://openalex.org/W1997970568","doi":"https://doi.org/10.1038/oby.2009.184","mag":"1997970568","pmid":"https://pubmed.ncbi.nlm.nih.gov/19521351","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2754219"},"language":"en","primary_location":{"id":"doi:10.1038/oby.2009.184","doi":"https://doi.org/10.1038/oby.2009.184","is_oa":true,"landing_page_url":"https://doi.org/10.1038/oby.2009.184","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/oby.2009.184","source":{"id":"https://openalex.org/S29918858","display_name":"Obesity","issn_l":"1930-7381","issn":["1930-7381","1930-739X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W1997970568"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/oby.2009.184","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069618649","display_name":"\u00c9ric Ravussin","orcid":"https://orcid.org/0000-0003-2129-547X","observed_orcids":["https://orcid.org/0000-0003-2129-547X"]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Ravussin","raw_affiliation_strings":["Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA","institution_ids":["https://openalex.org/I103990859"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058441976","display_name":"Steven R. Smith","orcid":"https://orcid.org/0000-0002-5098-8147","observed_orcids":["https://orcid.org/0000-0002-5098-8147"]},"institutions":[{"id":"https://openalex.org/I103990859","display_name":"Pennington Biomedical Research Center","ror":"https://ror.org/040cnym54","country_code":"US","type":"facility","lineage":["https://openalex.org/I103990859","https://openalex.org/I121820613"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven R. Smith","raw_affiliation_strings":["Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA","institution_ids":["https://openalex.org/I103990859"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100831068","display_name":"Julie A. Mitchell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie A. Mitchell","raw_affiliation_strings":["Amylin Pharmaceuticals, Inc., San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amylin Pharmaceuticals, Inc., San Diego, California, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024034724","display_name":"Reshma Shringarpure","orcid":"https://orcid.org/0000-0001-5936-0447","observed_orcids":["https://orcid.org/0000-0001-5936-0447"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reshma Shringarpure","raw_affiliation_strings":["Amylin Pharmaceuticals, Inc., San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amylin Pharmaceuticals, Inc., San Diego, California, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085014208","display_name":"Kevin Shan","orcid":"https://orcid.org/0000-0003-1829-0387","observed_orcids":["https://orcid.org/0000-0003-1829-0387"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin Shan","raw_affiliation_strings":["Amylin Pharmaceuticals, Inc., San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amylin Pharmaceuticals, Inc., San Diego, California, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030866969","display_name":"Holly Maier","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Holly Maier","raw_affiliation_strings":["Amylin Pharmaceuticals, Inc., San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amylin Pharmaceuticals, Inc., San Diego, California, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077081402","display_name":"Joy E. Koda","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joy E. Koda","raw_affiliation_strings":["Amylin Pharmaceuticals, Inc., San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amylin Pharmaceuticals, Inc., San Diego, California, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109131952","display_name":"Christian Weyer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Christian Weyer","raw_affiliation_strings":["Amylin Pharmaceuticals, Inc., San Diego, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amylin Pharmaceuticals, Inc., San Diego, California, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109131952"],"corresponding_institution_ids":[],"apc_list":{"value":4980,"currency":"USD","value_usd":4980},"apc_paid":null,"fwci":24.7304,"has_fulltext":true,"cited_by_count":341,"citation_normalized_percentile":{"value":0.99848047,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"17","issue":"9","first_page":"1736","last_page":"1743"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.8384000062942505,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.8384000062942505,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.15970000624656677,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pramlintide","display_name":"pramlintide","score":0.9829999804496765},{"id":"https://openalex.org/keywords/metreleptin","display_name":"metreleptin","score":1.0},{"id":"https://openalex.org/keywords/obesity-pharmacotherapy","display_name":"obesity pharmacotherapy","score":0.8399999737739563},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.7979999780654907},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6990000009536743},{"id":"https://openalex.org/keywords/satiety-signals","display_name":"satiety signals","score":0.640999972820282},{"id":"https://openalex.org/keywords/diet-induced-obesity","display_name":"diet-induced obesity","score":0.7440000176429749},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.5479999780654907}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7528125047683716},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7476740479469299},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.6437989473342896},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6262547969818115},{"id":"https://openalex.org/C2780705028","wikidata":"https://www.wikidata.org/wiki/Q424643","display_name":"Amylin","level":4,"score":0.5565485954284668},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.5102179050445557},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.369381308555603},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.25520750880241394},{"id":"https://openalex.org/C165220095","wikidata":"https://www.wikidata.org/wiki/Q207524","display_name":"Islet","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000682","descriptor_name":"Amyloid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002149","descriptor_name":"Energy Intake","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005247","descriptor_name":"Feeding Behavior","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012527","descriptor_name":"Satiation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015992","descriptor_name":"Body Mass Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018000","descriptor_name":"Receptors, Peptide","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018000","descriptor_name":"Receptors, Peptide","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D019440","descriptor_name":"Anti-Obesity Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019440","descriptor_name":"Anti-Obesity Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D019440","descriptor_name":"Anti-Obesity Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D050154","descriptor_name":"Adiposity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000178","qualifier_name":"diet therapy","is_major_topic":false},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D050177","descriptor_name":"Overweight","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054411","descriptor_name":"Receptors, Leptin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054411","descriptor_name":"Receptors, Leptin","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D058228","descriptor_name":"Islet Amyloid Polypeptide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058287","descriptor_name":"Receptors, Islet Amyloid Polypeptide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/oby.2009.184","doi":"https://doi.org/10.1038/oby.2009.184","is_oa":true,"landing_page_url":"https://doi.org/10.1038/oby.2009.184","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/oby.2009.184","source":{"id":"https://openalex.org/S29918858","display_name":"Obesity","issn_l":"1930-7381","issn":["1930-7381","1930-739X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity","raw_type":"journal-article"},{"id":"pmid:19521351","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19521351","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity (Silver Spring, Md.)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2754219","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2754219/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Obesity (Silver Spring)","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/oby.2009.184","doi":"https://doi.org/10.1038/oby.2009.184","is_oa":true,"landing_page_url":"https://doi.org/10.1038/oby.2009.184","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1038/oby.2009.184","source":{"id":"https://openalex.org/S29918858","display_name":"Obesity","issn_l":"1930-7381","issn":["1930-7381","1930-739X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Obesity","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[{"id":"https://openalex.org/G9000905746","display_name":"Pennington/Louisiana NORC","funder_award_id":"P30DK072476","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320307768","display_name":"Amylin Pharmaceuticals","ror":"https://ror.org/043cec594"},{"id":"https://openalex.org/F4320317076","display_name":"Zafgen","ror":"https://ror.org/05035d657"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1997970568.pdf","grobid_xml":"https://content.openalex.org/works/W1997970568.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1512875938","https://openalex.org/W1845447069","https://openalex.org/W1965321234","https://openalex.org/W1965851116","https://openalex.org/W1986299003","https://openalex.org/W1999851917","https://openalex.org/W2021699445","https://openalex.org/W2044939881","https://openalex.org/W2054705005","https://openalex.org/W2057919982","https://openalex.org/W2064611710","https://openalex.org/W2075691591","https://openalex.org/W2081436606","https://openalex.org/W2082113374","https://openalex.org/W2084310603","https://openalex.org/W2091419870","https://openalex.org/W2092893248","https://openalex.org/W2098025594","https://openalex.org/W2100364658","https://openalex.org/W2102695417","https://openalex.org/W2109742508","https://openalex.org/W2116843182","https://openalex.org/W2124093429","https://openalex.org/W2159205789","https://openalex.org/W2166281097","https://openalex.org/W2166947492","https://openalex.org/W2169216660","https://openalex.org/W2170571946","https://openalex.org/W2315517171","https://openalex.org/W2316534927","https://openalex.org/W2319361543","https://openalex.org/W2494628130","https://openalex.org/W4238663920"],"related_works":["https://openalex.org/W2039778454","https://openalex.org/W1999851917","https://openalex.org/W20018587","https://openalex.org/W2095283910","https://openalex.org/W2163848442","https://openalex.org/W2075691591","https://openalex.org/W1986379253","https://openalex.org/W2019131037","https://openalex.org/W4234817869","https://openalex.org/W2102695417"],"abstract_inverted_index":{"The":[0,182,207],"neurohormonal":[1,241],"control":[2],"of":[3,42,119,204,235],"body":[4,186],"weight":[5,35,111,144,187,196],"involves":[6],"a":[7,51,87,205,238],"complex":[8],"interplay":[9],"between":[10],"long-term":[11],"adiposity":[12],"signals":[13,19],"(e.g.,":[14,20],"leptin),":[15],"and":[16,103,195,218,226],"short-term":[17],"satiation":[18],"amylin).":[21],"In":[22],"diet-induced":[23],"obese":[24,61],"(DIO)":[25],"rodents,":[26],"amylin/leptin":[27,44],"combination":[28],"treatment":[29,120,137,160],"led":[30,140],"to":[31,116,141,148,224,243],"marked,":[32],"synergistic,":[33],"fat-specific":[34],"loss.":[36],"To":[37],"evaluate":[38],"the":[39,200],"weight-lowering":[40],"effect":[41],"combined":[43],"agonism":[45],"(with":[46],"pramlintide/metreleptin)":[47],"in":[48,60,185],"human":[49],"obesity,":[50],"24-week,":[52],"randomized,":[53],"double-blind,":[54],"active-drug-controlled,":[55],"proof-of-concept":[56],"study":[57],"was":[58,188],"conducted":[59],"or":[62,130,169],"overweight":[63],"subjects":[64,108],"(N":[65],"=":[66,180],"177;":[67],"63%":[68],"female;":[69],"39":[70],"+/-":[71,76,80,84,152,157,164,172],"8":[72],"years;":[73],"BMI":[74],"32.0":[75],"2.1":[77],"kg/m(2);":[78],"93.3":[79],"13.2":[81],"kg;":[82],"mean":[83,156],"s.d.).":[85],"After":[86],"4-week":[88],"lead-in":[89],"period":[90],"with":[91,121,138,161,212],"pramlintide":[92,126,162],"(180":[93],"microg":[94,100,128],"b.i.d.":[95,101],"for":[96],"2":[97],"weeks,":[98],"360":[99],"thereafter)":[102],"diet":[104],"(40%":[105],"calorie":[106],"deficit),":[107],"achieving":[109],"2-8%":[110],"loss":[112,145,197],"were":[113,214,221],"randomized":[114],"1:2:2":[115],"20":[117,150],"weeks":[118],"metreleptin":[122,170],"(5":[123],"mg":[124,134],"b.i.d.),":[125,129],"(360":[127,132],"pramlintide/metreleptin":[131,139,213,236],"microg/5":[133],"b.i.d.).":[135],"Combination":[136],"significantly":[142],"greater":[143,183],"from":[146],"enrollment":[147],"week":[149,193],"(-12.7":[151],"0.9%;":[153,165],"least":[154],"squares":[155],"s.e.)":[158],"than":[159],"(-8.4":[163],"P":[166,174],"<":[167,175],"0.001)":[168],"(-8.2":[171],"1.3%;":[173],"0.01)":[176],"alone":[177],"(evaluable,":[178],"N":[179],"93).":[181],"reduction":[184],"significant":[189],"as":[190,192,237],"early":[191],"4,":[194],"continued":[198],"throughout":[199],"study,":[201],"without":[202],"evidence":[203],"plateau.":[206],"most":[208],"common":[209],"adverse":[210],"events":[211,217],"injection":[215],"site":[216],"nausea,":[219],"which":[220],"mostly":[222],"mild":[223],"moderate":[225],"decreased":[227],"over":[228],"time.":[229],"These":[230],"results":[231],"support":[232],"further":[233],"development":[234],"novel,":[239],"integrated":[240],"approach":[242],"obesity":[244],"pharmacotherapy.":[245]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":18},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":15},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":25},{"year":2014,"cited_by_count":33},{"year":2013,"cited_by_count":29},{"year":2012,"cited_by_count":36}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}