{"id":"https://openalex.org/W1997956794","doi":"https://doi.org/10.2174/1875043500801010014","title":"Retroviral-Based BMP-4 In Vivo Gene Transfer Strategy with Intramedullary Viral Delivery Optimizes Transgene Expression in Rat Femur Fractures","display_name":"Retroviral-Based BMP-4 In Vivo Gene Transfer Strategy with Intramedullary Viral Delivery Optimizes Transgene Expression in Rat Femur Fractures","publication_year":2008,"publication_date":"2008-11-17","ids":{"openalex":"https://openalex.org/W1997956794","doi":"https://doi.org/10.2174/1875043500801010014","mag":"1997956794"},"language":"en","primary_location":{"id":"doi:10.2174/1875043500801010014","doi":"https://doi.org/10.2174/1875043500801010014","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1875043500801010014","pdf_url":"http://benthamopen.com/contents/pdf/TOTERMJ/TOTERMJ-1-14.pdf","source":{"id":"https://openalex.org/S104431058","display_name":"The Open Tissue Engineering and Regenerative Medicine Journal","issn_l":"1875-0435","issn":["1875-0435"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Open Tissue Engineering and Regenerative Medicine Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://benthamopen.com/contents/pdf/TOTERMJ/TOTERMJ-1-14.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003851565","display_name":"Charles H. Rundle","orcid":"https://orcid.org/0000-0003-4691-8143","observed_orcids":["https://orcid.org/0000-0003-4691-8143"]},"institutions":[{"id":"https://openalex.org/I4210116750","display_name":"Jerry L. Pettis Memorial VA Medical Center","ror":"https://ror.org/02bqrry13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116750","https://openalex.org/I4210138663","https://openalex.org/I4210141570"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles H. Rundle","raw_affiliation_strings":["Department of Medicine,","Musculoskeletal Disease Center, Jerry L. Pettis Memorial Veterans Administration Medical Center, 11201 Benton Street, Loma Linda, California, 92357 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine,","institution_ids":[]},{"raw_affiliation_string":"Musculoskeletal Disease Center, Jerry L. Pettis Memorial Veterans Administration Medical Center, 11201 Benton Street, Loma Linda, California, 92357 and","institution_ids":["https://openalex.org/I4210116750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029231318","display_name":"Shin\u2010Tai Chen","orcid":"https://orcid.org/0000-0003-1571-2687","observed_orcids":["https://orcid.org/0000-0003-1571-2687"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210116750","display_name":"Jerry L. Pettis Memorial VA Medical Center","ror":"https://ror.org/02bqrry13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116750","https://openalex.org/I4210138663","https://openalex.org/I4210141570"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shin-Tai Chen","raw_affiliation_strings":["Department of Biochemistry, Loma Linda Univer-sity, Loma Linda, California, 92350, USA","Department of Medicine,","Musculoskeletal Disease Center, Jerry L. Pettis Memorial Veterans Administration Medical Center, 11201 Benton Street, Loma Linda, California, 92357 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Loma Linda Univer-sity, Loma Linda, California, 92350, USA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Department of Medicine,","institution_ids":[]},{"raw_affiliation_string":"Musculoskeletal Disease Center, Jerry L. Pettis Memorial Veterans Administration Medical Center, 11201 Benton Street, Loma Linda, California, 92357 and","institution_ids":["https://openalex.org/I4210116750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040419360","display_name":"Ryan Porte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116750","display_name":"Jerry L. Pettis Memorial VA Medical Center","ror":"https://ror.org/02bqrry13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116750","https://openalex.org/I4210138663","https://openalex.org/I4210141570"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryan Porte","raw_affiliation_strings":["Musculoskeletal Disease Center, Jerry L. Pettis Memorial Veterans Administration Medical Center, 11201 Benton Street, Loma Linda, California, 92357 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Musculoskeletal Disease Center, Jerry L. Pettis Memorial Veterans Administration Medical Center, 11201 Benton Street, Loma Linda, California, 92357 and","institution_ids":["https://openalex.org/I4210116750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111946896","display_name":"Jon E. Wergedal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210116750","display_name":"Jerry L. Pettis Memorial VA Medical Center","ror":"https://ror.org/02bqrry13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116750","https://openalex.org/I4210138663","https://openalex.org/I4210141570"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon E. Wergedal","raw_affiliation_strings":["Department of Biochemistry, Loma Linda Univer-sity, Loma Linda, California, 92350, USA","Department of Medicine,","Musculoskeletal Disease Center, Jerry L. Pettis Memorial Veterans Administration Medical Center, 11201 Benton Street, Loma Linda, California, 92357 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Loma Linda Univer-sity, Loma Linda, California, 92350, USA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Department of Medicine,","institution_ids":[]},{"raw_affiliation_string":"Musculoskeletal Disease Center, Jerry L. Pettis Memorial Veterans Administration Medical Center, 11201 Benton Street, Loma Linda, California, 92357 and","institution_ids":["https://openalex.org/I4210116750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010678507","display_name":"K.\u2010H. William Lau","orcid":"https://orcid.org/0000-0003-1109-5052","observed_orcids":["https://orcid.org/0000-0003-1109-5052"]},"institutions":[{"id":"https://openalex.org/I26347476","display_name":"Loma Linda University","ror":"https://ror.org/04bj28v14","country_code":"US","type":"education","lineage":["https://openalex.org/I26347476"]},{"id":"https://openalex.org/I4210116750","display_name":"Jerry L. Pettis Memorial VA Medical Center","ror":"https://ror.org/02bqrry13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210116750","https://openalex.org/I4210138663","https://openalex.org/I4210141570"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K.-H. William Lau","raw_affiliation_strings":["Department of Biochemistry, Loma Linda Univer-sity, Loma Linda, California, 92350, USA","Department of Medicine,","Musculoskeletal Disease Center, Jerry L. Pettis Memorial Veterans Administration Medical Center, 11201 Benton Street, Loma Linda, California, 92357 and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Loma Linda Univer-sity, Loma Linda, California, 92350, USA","institution_ids":["https://openalex.org/I26347476"]},{"raw_affiliation_string":"Department of Medicine,","institution_ids":[]},{"raw_affiliation_string":"Musculoskeletal Disease Center, Jerry L. Pettis Memorial Veterans Administration Medical Center, 11201 Benton Street, Loma Linda, California, 92357 and","institution_ids":["https://openalex.org/I4210116750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3799,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.64258663,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"1","issue":"1","first_page":"14","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10658","display_name":"Bone fractures and treatments","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/retroviral-vectors","display_name":"retroviral vectors","score":0.8130000233650208},{"id":"https://openalex.org/keywords/femoral-fracture","display_name":"femoral fracture","score":0.6129999756813049},{"id":"https://openalex.org/keywords/fracture-healing","display_name":"fracture healing","score":0.8299999833106995},{"id":"https://openalex.org/keywords/transgene-expression","display_name":"transgene expression","score":0.6489999890327454},{"id":"https://openalex.org/keywords/callus-formation","display_name":"callus formation","score":0.6850000023841858},{"id":"https://openalex.org/keywords/percutaneous-injection","display_name":"percutaneous injection","score":0.7540000081062317},{"id":"https://openalex.org/keywords/kirschner-wire","display_name":"Kirschner wire","score":0.6909999847412109},{"id":"https://openalex.org/keywords/rat-fracture-model","display_name":"rat fracture model","score":0.656000018119812},{"id":"https://openalex.org/keywords/bone-morphogenetic-proteins","display_name":"bone morphogenetic proteins","score":0.7239999771118164}],"concepts":[{"id":"https://openalex.org/C92162645","wikidata":"https://www.wikidata.org/wiki/Q655955","display_name":"Intramedullary rod","level":2,"score":0.9241015911102295},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.7752924561500549},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.6357325315475464},{"id":"https://openalex.org/C2992660301","wikidata":"https://www.wikidata.org/wiki/Q4350503","display_name":"Femur fracture","level":3,"score":0.6155736446380615},{"id":"https://openalex.org/C2780554211","wikidata":"https://www.wikidata.org/wiki/Q176503","display_name":"Femur","level":2,"score":0.5883162021636963},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.49930357933044434},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.45358705520629883},{"id":"https://openalex.org/C30352789","wikidata":"https://www.wikidata.org/wiki/Q14903153","display_name":"Bone morphogenetic protein 2","level":3,"score":0.44885632395744324},{"id":"https://openalex.org/C32470452","wikidata":"https://www.wikidata.org/wiki/Q2298489","display_name":"Viral vector","level":4,"score":0.44512060284614563},{"id":"https://openalex.org/C2777674748","wikidata":"https://www.wikidata.org/wiki/Q367423","display_name":"Periosteum","level":2,"score":0.43705302476882935},{"id":"https://openalex.org/C135983454","wikidata":"https://www.wikidata.org/wiki/Q2790163","display_name":"Gene delivery","level":4,"score":0.4225546717643738},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37714675068855286},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26788949966430664},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.24975556135177612},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21768227219581604},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.20713907480239868},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0934012234210968},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07792821526527405},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06649696826934814}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.2174/1875043500801010014","doi":"https://doi.org/10.2174/1875043500801010014","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1875043500801010014","pdf_url":"http://benthamopen.com/contents/pdf/TOTERMJ/TOTERMJ-1-14.pdf","source":{"id":"https://openalex.org/S104431058","display_name":"The Open Tissue Engineering and Regenerative Medicine Journal","issn_l":"1875-0435","issn":["1875-0435"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Open Tissue Engineering and Regenerative Medicine Journal","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.2174/1875043500801010014","doi":"https://doi.org/10.2174/1875043500801010014","is_oa":true,"landing_page_url":"https://doi.org/10.2174/1875043500801010014","pdf_url":"http://benthamopen.com/contents/pdf/TOTERMJ/TOTERMJ-1-14.pdf","source":{"id":"https://openalex.org/S104431058","display_name":"The Open Tissue Engineering and Regenerative Medicine Journal","issn_l":"1875-0435","issn":["1875-0435"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Open Tissue Engineering and Regenerative Medicine Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1997956794.pdf","grobid_xml":"https://content.openalex.org/works/W1997956794.grobid-xml"},"referenced_works_count":24,"referenced_works":["https://openalex.org/W1962377023","https://openalex.org/W1969230308","https://openalex.org/W1979242330","https://openalex.org/W1983512141","https://openalex.org/W2014410963","https://openalex.org/W2020939137","https://openalex.org/W2045352674","https://openalex.org/W2054180787","https://openalex.org/W2060529951","https://openalex.org/W2061024977","https://openalex.org/W2072750640","https://openalex.org/W2080470462","https://openalex.org/W2096492030","https://openalex.org/W2102535562","https://openalex.org/W2111019735","https://openalex.org/W2118944608","https://openalex.org/W2122832095","https://openalex.org/W2134154222","https://openalex.org/W2134709004","https://openalex.org/W2141257924","https://openalex.org/W2162513940","https://openalex.org/W2321694305","https://openalex.org/W2334811311","https://openalex.org/W4242316374"],"related_works":["https://openalex.org/W7098159367","https://openalex.org/W2134154222","https://openalex.org/W314096392","https://openalex.org/W1983512141","https://openalex.org/W2122166088","https://openalex.org/W2321694305","https://openalex.org/W2122155025","https://openalex.org/W1570590074","https://openalex.org/W319128035","https://openalex.org/W2019705348"],"abstract_inverted_index":{"We":[0],"have":[1,189],"developed":[2,190],"an":[3,28,191,257],"intramedullary":[4,78,148,192],"delivery":[5,79,195],"strategy":[6,24,196,221],"to":[7,15,40,121,205,226,269],"administer":[8,227],"retroviral":[9,193],"vectors":[10,82,107],"expressing":[11,83],"a":[12,19,151,198],"therapeutic":[13,232,267],"gene":[14,90,95,217],"promote":[16,270],"healing":[17],"of":[18,27,42,80,104,111,117,137,156,169,230,248,265],"closed":[20],"rat":[21,199,259],"femur":[22,44,200],"fracture.This":[23],"involves":[25],"implantation":[26],"indwelling":[29],"catheter":[30,66],"with":[31,98,163,197],"the":[32,37,43,46,51,54,61,65,84,105,109,112,131,147,160,179,210,216],"stabilizing":[33,62],"Kirschner":[34],"(K)-wire":[35],"during":[36],"surgery":[38],"prior":[39],"fracture":[41,113,132,161,181,201,212,219,250,271],"by":[45,77,101],"three-point":[47],"bending":[48],"technique.It":[49],"uses":[50],"openings":[52],"in":[53,127,173,262],"bone":[55,74,85,144,176,185],"that":[56,203],"were":[57,96],"already":[58],"created":[59],"for":[60,261],"K-wire":[63],"and":[64,72,134,153,252],"insertion.In":[67],"this":[68],"study,":[69],"transgene":[70,125,157,207],"expression":[71,126,158,208],"callus":[73,133,143,182],"formation":[75],"induced":[76],"MLV-based":[81],"morphogenetic":[86],"protein-2/4":[87],"(BMP-2/4)":[88],"hybrid":[89],"or":[91,237,243],"-galactosidase":[92],"(":[93],"-gal)":[94],"compared":[97],"those":[99],"produced":[100,150],"percutaneous":[102,115],"injections":[103,116],"same":[106],"at":[108,159,167],"periosteum":[110],"site.The":[114],"MLV-BMP-2/4":[118],"vector":[119,194],"led":[120,204],"massive":[122],"but":[123],"asymmetric":[124,142],"surrounding":[128,170],"tissues":[129],"within":[130],"large":[135,228],"amounts":[136],"supraperiosteal":[138,184],"as":[139,141,239,241],"well":[140,240],"formation.In":[145,186],"contrast,":[146],"administration":[149],"robust":[152],"symmetric":[154],"pattern":[155],"site":[162],"very":[164],"minimal":[165],"transduction":[166],"cells":[168],"tissues,":[171],"resulting":[172],"normal":[174],"subperiosteal":[175],"development":[177],"around":[178,209],"entire":[180,211],"without":[183],"summary,":[187],"we":[188],"model":[202,260],"uniform":[206],"site,":[213],"which":[214],"optimizes":[215],"therapy-enhanced":[218],"repair.This":[220],"should":[222],"readily":[223],"be":[224,256],"adapted":[225],"dosages":[229],"any":[231],"vehicle":[233],"(therapeutic":[234],"molecules,":[235],"peptides,":[236],"proteins,":[238],"viral":[242],"non-viral":[244],"vectors)":[245],"throughout":[246],"much":[247],"early":[249],"repair,":[251],"thus":[253],"it":[254],"would":[255],"ideal":[258],"vivo":[263],"testing":[264],"various":[266],"agents":[268],"repair.":[272]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
