{"id":"https://openalex.org/W1997946324","doi":"https://doi.org/10.1146/annurev.neuro.23.1.579","title":"The Relationship between Neuronal Survival and Regeneration","display_name":"The Relationship between Neuronal Survival and Regeneration","publication_year":2000,"publication_date":"2000-03-01","ids":{"openalex":"https://openalex.org/W1997946324","doi":"https://doi.org/10.1146/annurev.neuro.23.1.579","mag":"1997946324","pmid":"https://pubmed.ncbi.nlm.nih.gov/10845076"},"language":"en","primary_location":{"id":"doi:10.1146/annurev.neuro.23.1.579","doi":"https://doi.org/10.1146/annurev.neuro.23.1.579","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.neuro.23.1.579","pdf_url":null,"source":{"id":"https://openalex.org/S131371711","display_name":"Annual Review of Neuroscience","issn_l":"0147-006X","issn":["0147-006X","1545-4126"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085558867","display_name":"Jeffrey Louis Goldberg","orcid":"https://orcid.org/0000-0002-1390-7360","observed_orcids":["https://orcid.org/0000-0002-1390-7360","https://orcid.org/0000-0001-5104-8141","https://orcid.org/0000-0002-3459-1545"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey L. Goldberg","raw_affiliation_strings":["Department of Neurobiology, Stanford University School of Medicine, Stanford California, 94305\u20135125;","Department of Neurobiology, Stanford University School of Medicine, California 94305-5125, USA. jlgoldbe@leland.stanford.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Stanford University School of Medicine, Stanford California, 94305\u20135125;","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Department of Neurobiology, Stanford University School of Medicine, California 94305-5125, USA. jlgoldbe@leland.stanford.edu","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027970945","display_name":"Ben A. Barres","orcid":"https://orcid.org/0000-0003-2905-4136","observed_orcids":["https://orcid.org/0000-0003-2905-4136"]},"institutions":[{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ben A. Barres","raw_affiliation_strings":["Department of Neurobiology, Stanford University School of Medicine, Stanford California, 94305\u20135125;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology, Stanford University School of Medicine, Stanford California, 94305\u20135125;","institution_ids":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3204,"has_fulltext":false,"cited_by_count":336,"citation_normalized_percentile":{"value":0.8969521,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"23","issue":"1","first_page":"579","last_page":"612"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10483","display_name":"Nerve injury and regeneration","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuronal-survival","display_name":"neuronal survival","score":0.8809999823570251},{"id":"https://openalex.org/keywords/axon-regeneration","display_name":"axon regeneration","score":0.9470000267028809},{"id":"https://openalex.org/keywords/peripheral-nervous-system","display_name":"peripheral nervous system","score":0.8809999823570251},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"central nervous system","score":0.9599999785423279},{"id":"https://openalex.org/keywords/axotomized-neurons","display_name":"axotomized neurons","score":0.746999979019165},{"id":"https://openalex.org/keywords/trophic-factors","display_name":"trophic factors","score":0.8399999737739563},{"id":"https://openalex.org/keywords/central-nervous-system-injury","display_name":"central nervous system injury","score":0.7429999709129333},{"id":"https://openalex.org/keywords/neuronal-growth","display_name":"neuronal growth","score":0.42800000309944153}],"concepts":[{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.8590085506439209},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.8391607403755188},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.6776833534240723},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6332014203071594},{"id":"https://openalex.org/C545706735","wikidata":"https://www.wikidata.org/wiki/Q9404","display_name":"Nervous system","level":2,"score":0.4840075671672821},{"id":"https://openalex.org/C17077164","wikidata":"https://www.wikidata.org/wiki/Q1185869","display_name":"Inhibitory postsynaptic potential","level":2,"score":0.4720538258552551},{"id":"https://openalex.org/C545314008","wikidata":"https://www.wikidata.org/wiki/Q169953","display_name":"Peripheral nervous system","level":3,"score":0.4122784733772278},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.12253901362419128}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001284","descriptor_name":"Atrophy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002490","descriptor_name":"Central Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004594","descriptor_name":"Electrophysiology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009416","descriptor_name":"Nerve Regeneration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010525","descriptor_name":"Peripheral Nerves","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D010525","descriptor_name":"Peripheral Nerves","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019771","descriptor_name":"Axotomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1146/annurev.neuro.23.1.579","doi":"https://doi.org/10.1146/annurev.neuro.23.1.579","is_oa":false,"landing_page_url":"https://doi.org/10.1146/annurev.neuro.23.1.579","pdf_url":null,"source":{"id":"https://openalex.org/S131371711","display_name":"Annual Review of Neuroscience","issn_l":"0147-006X","issn":["0147-006X","1545-4126"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320373","host_organization_name":"Annual Reviews","host_organization_lineage":["https://openalex.org/P4310320373"],"host_organization_lineage_names":["Annual Reviews"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual Review of Neuroscience","raw_type":"journal-article"},{"id":"pmid:10845076","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10845076","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annual review of neuroscience","raw_type":"Journal Article"},{"id":"mag:2184847868","doi":null,"is_oa":false,"landing_page_url":"https://www.annualreviews.org/doi/pdf/10.1146/annurev.neuro.23.1.579","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":210,"referenced_works":["https://openalex.org/W61780358","https://openalex.org/W123342890","https://openalex.org/W163624266","https://openalex.org/W304296730","https://openalex.org/W1493298820","https://openalex.org/W1494873571","https://openalex.org/W1503813864","https://openalex.org/W1528182271","https://openalex.org/W1528196156","https://openalex.org/W1530428799","https://openalex.org/W1537205259","https://openalex.org/W1542755384","https://openalex.org/W1551549641","https://openalex.org/W1564635029","https://openalex.org/W1586855301","https://openalex.org/W1665419471","https://openalex.org/W1668855765","https://openalex.org/W1826719783","https://openalex.org/W1877556519","https://openalex.org/W1882516571","https://openalex.org/W1885709862","https://openalex.org/W1906407967","https://openalex.org/W1919375397","https://openalex.org/W1964502095","https://openalex.org/W1964674938","https://openalex.org/W1965835251","https://openalex.org/W1966245145","https://openalex.org/W1967450020","https://openalex.org/W1968725235","https://openalex.org/W1968847008","https://openalex.org/W1969634414","https://openalex.org/W1969811289","https://openalex.org/W1970380611","https://openalex.org/W1971304382","https://openalex.org/W1971466398","https://openalex.org/W1971602494","https://openalex.org/W1974068624","https://openalex.org/W1975513971","https://openalex.org/W1976666379","https://openalex.org/W1977243716","https://openalex.org/W1977707442","https://openalex.org/W1979060547","https://openalex.org/W1980329061","https://openalex.org/W1980713523","https://openalex.org/W1982784171","https://openalex.org/W1983620619","https://openalex.org/W1983894368","https://openalex.org/W1984761401","https://openalex.org/W1985683891","https://openalex.org/W1985992629","https://openalex.org/W1986785675","https://openalex.org/W1988326421","https://openalex.org/W1989558097","https://openalex.org/W1990918954","https://openalex.org/W1992529363","https://openalex.org/W1993391564","https://openalex.org/W1993902481","https://openalex.org/W1994767290","https://openalex.org/W1997257246","https://openalex.org/W1997937844","https://openalex.org/W1998312044","https://openalex.org/W1999399094","https://openalex.org/W1999788892","https://openalex.org/W2000304313","https://openalex.org/W2000314545","https://openalex.org/W2000646975","https://openalex.org/W2001630331","https://openalex.org/W2002182230","https://openalex.org/W2005627295","https://openalex.org/W2006135298","https://openalex.org/W2006184315","https://openalex.org/W2007435025","https://openalex.org/W2007442170","https://openalex.org/W2007539100","https://openalex.org/W2008184081","https://openalex.org/W2008374272","https://openalex.org/W2009191172","https://openalex.org/W2009490317","https://openalex.org/W2009870993","https://openalex.org/W2010247968","https://openalex.org/W2011172976","https://openalex.org/W2011174713","https://openalex.org/W2011275029","https://openalex.org/W2014599626","https://openalex.org/W2016446826","https://openalex.org/W2017434751","https://openalex.org/W2018065420","https://openalex.org/W2018779154","https://openalex.org/W2020308246","https://openalex.org/W2021658407","https://openalex.org/W2023583278","https://openalex.org/W2025778924","https://openalex.org/W2027759472","https://openalex.org/W2028067698","https://openalex.org/W2029768920","https://openalex.org/W2030204732","https://openalex.org/W2030291352","https://openalex.org/W2032079164","https://openalex.org/W2032304318","https://openalex.org/W2033828028","https://openalex.org/W2035303961","https://openalex.org/W2036357744","https://openalex.org/W2036650593","https://openalex.org/W2038303772","https://openalex.org/W2039355845","https://openalex.org/W2041211280","https://openalex.org/W2044043465","https://openalex.org/W2045165874","https://openalex.org/W2045330513","https://openalex.org/W2046166566","https://openalex.org/W2047102545","https://openalex.org/W2047474906","https://openalex.org/W2047960520","https://openalex.org/W2049128931","https://openalex.org/W2049312704","https://openalex.org/W2049367666","https://openalex.org/W2049962999","https://openalex.org/W2050415048","https://openalex.org/W2051393924","https://openalex.org/W2051945956","https://openalex.org/W2052938035","https://openalex.org/W2053640261","https://openalex.org/W2054773658","https://openalex.org/W2056326326","https://openalex.org/W2057158750","https://openalex.org/W2058153348","https://openalex.org/W2059714868","https://openalex.org/W2060149019","https://openalex.org/W2061257337","https://openalex.org/W2061572548","https://openalex.org/W2063561360","https://openalex.org/W2064127449","https://openalex.org/W2064540868","https://openalex.org/W2065097706","https://openalex.org/W2066287165","https://openalex.org/W2069128679","https://openalex.org/W2069268251","https://openalex.org/W2069482942","https://openalex.org/W2069527370","https://openalex.org/W2070090561","https://openalex.org/W2070564946","https://openalex.org/W2071254952","https://openalex.org/W2073465590","https://openalex.org/W2074641656","https://openalex.org/W2076382620","https://openalex.org/W2077669223","https://openalex.org/W2077954134","https://openalex.org/W2078458079","https://openalex.org/W2078956426","https://openalex.org/W2082619657","https://openalex.org/W2085941880","https://openalex.org/W2087459771","https://openalex.org/W2090505541","https://openalex.org/W2091615524","https://openalex.org/W2092061953","https://openalex.org/W2092570895","https://openalex.org/W2095324434","https://openalex.org/W2095435531","https://openalex.org/W2095438987","https://openalex.org/W2096267101","https://openalex.org/W2097530133","https://openalex.org/W2098010045","https://openalex.org/W2099319974","https://openalex.org/W2099976535","https://openalex.org/W2102410706","https://openalex.org/W2102527735","https://openalex.org/W2110102431","https://openalex.org/W2110265830","https://openalex.org/W2113122815","https://openalex.org/W2115118012","https://openalex.org/W2116181102","https://openalex.org/W2117332556","https://openalex.org/W2117962491","https://openalex.org/W2119216853","https://openalex.org/W2124077248","https://openalex.org/W2124568663","https://openalex.org/W2127938131","https://openalex.org/W2129314512","https://openalex.org/W2130274176","https://openalex.org/W2131388825","https://openalex.org/W2134863448","https://openalex.org/W2135200381","https://openalex.org/W2135725455","https://openalex.org/W2143305021","https://openalex.org/W2143514697","https://openalex.org/W2143699058","https://openalex.org/W2144178897","https://openalex.org/W2145323290","https://openalex.org/W2147114673","https://openalex.org/W2147122201","https://openalex.org/W2147149841","https://openalex.org/W2152669400","https://openalex.org/W2154745705","https://openalex.org/W2158730778","https://openalex.org/W2160765822","https://openalex.org/W2161154195","https://openalex.org/W2164591831","https://openalex.org/W2164704320","https://openalex.org/W2168344733","https://openalex.org/W2177911561","https://openalex.org/W2178562205","https://openalex.org/W2265226651","https://openalex.org/W2286026684","https://openalex.org/W2336806984","https://openalex.org/W2436448084","https://openalex.org/W2484705295","https://openalex.org/W3215981791","https://openalex.org/W4211045864","https://openalex.org/W4238839969","https://openalex.org/W4294115345"],"related_works":["https://openalex.org/W2184847868","https://openalex.org/W2106212487","https://openalex.org/W2013035816","https://openalex.org/W82040228","https://openalex.org/W136774867","https://openalex.org/W1971018095","https://openalex.org/W1993737194","https://openalex.org/W975497212","https://openalex.org/W2049116559","https://openalex.org/W960911725"],"abstract_inverted_index":{"The":[0],"ability":[1],"of":[2,22,50,60,93],"peripheral":[3],"nervous":[4,10],"system":[5,11],"(PNS)":[6],"but":[7],"not":[8],"central":[9],"(CNS)":[12],"neurons":[13],"to":[14,46,54,79,97,109],"regenerate":[15],"their":[16,107],"axons":[17],"is":[18],"a":[19],"striking":[20],"peculiarity":[21],"higher":[23],"vertebrates.":[24],"Much":[25],"research":[26],"has":[27,43],"focused":[28],"on":[29,106],"the":[30,47,56,66,80,91,94],"inhibitory":[31],"signals":[32,95],"produced":[33],"by":[34],"CNS":[35,70,112],"glia":[36],"that":[37,68],"thwart":[38],"regenerating":[39],"axons.":[40],"Less":[41],"attention":[42],"been":[44],"paid":[45],"injury-induced":[48],"loss":[49],"trophic":[51],"stimuli":[52],"needed":[53],"promote":[55,98],"survival":[57,74,100],"and":[58,71,75,101],"regeneration":[59,110],"axotomized":[61],"neurons.":[62],"Could":[63],"differences":[64],"in":[65,82],"mechanisms":[67],"control":[69],"PNS":[72],"neuronal":[73,99],"growth":[76],"also":[77],"contribute":[78],"disparity":[81],"regenerative":[83],"capacity?":[84],"Here":[85],"we":[86],"review":[87],"recent":[88],"studies":[89],"concerning":[90],"nature":[92],"necessary":[96],"growth,":[102],"with":[103],"an":[104],"emphasis":[105],"significance":[108],"after":[111],"injury.":[113]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":20},{"year":2012,"cited_by_count":20}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
